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Dietary treatment of thrombogenic disorders related tothe metabolic syndrome

Published online by Cambridge University Press:  09 March 2007

Peter Marckmann
Peter Marckmann*
Affiliation:
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK-1958, Frederiksberg C, Denmark
*
*Corresponding author: P. Marckmann, fax +45 3528 2483, email pma@kvl.dk
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Abstract

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The increased risk of coronary heart disease associated with the metabolic syndrome may be partially explained by prothrombotic deviations of the haemostatic system. Individuals with insulin resistance, dyslipidaemia and obesity are characterized by elevated plasma fibrinogen and factor VII coagulant activity levels and raised concentrations of plasminogen-activator inhibitor, the main inhibitor of endogenous fibrinolysis. These haemostatic abnormalities may be corrected with dietary treatment of the underlying clinical disorder. Dietary trials of diseased and healthy volunteers suggest that the optimal antithrombotic diet is a low-fat diet with a high content of foods rich in complex carbohydrates and dietary fibre. The dietary fatty acid composition has a profound effect on blood lipids, but seems of minor importance for the haemostatic system.

Keywords

Coronary heart diseaseFactor VIIFibrinolysisDietLipids: Dietary fibre
Type
Research Article
Information
British Journal of Nutrition , Volume 83 , Issue S1 , June 2000 , pp. S121 - S126
Copyright
Copyright © The Nutrition Society 2000

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