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Age-related changes in plasma lycopene concentrations, but not in vitamin E, are associated with fat mass

Published online by Cambridge University Press:  09 March 2007

Pascal Grolier ,
Yves Boirie ,
Evelyne Levadoux ,
Marion Brandolini ,
Patrick Borel ,
Véronique Azais-Braesco ,
Bernard Beaufrère  and
Patrick Ritz
Pascal Grolier
Affiliation:
Groupe Vitamines, Unité des maladies métaboliques et micronutriments, INRA, Theix, 63122 Saint-Genès-Champanelle, France†
Yves Boirie
Affiliation:
Laboratoire de Nutrition Humaine, Université d'Auvergne, BP 321, 63009 Clermont-Ferrand, France
Evelyne Levadoux
Affiliation:
Laboratoire de Nutrition Humaine, Université d'Auvergne, BP 321, 63009 Clermont-Ferrand, France
Marion Brandolini
Affiliation:
Laboratoire de Nutrition Humaine, Université d'Auvergne, BP 321, 63009 Clermont-Ferrand, France
Patrick Borel
Affiliation:
Groupe Vitamines, Unité des maladies métaboliques et micronutriments, INRA, Theix, 63122 Saint-Genès-Champanelle, France†
Véronique Azais-Braesco
Affiliation:
Groupe Vitamines, Unité des maladies métaboliques et micronutriments, INRA, Theix, 63122 Saint-Genès-Champanelle, France†
Bernard Beaufrère
Affiliation:
Laboratoire de Nutrition Humaine, Université d'Auvergne, BP 321, 63009 Clermont-Ferrand, France
Patrick Ritz*
Affiliation:
Laboratoire de Nutrition Humaine, Université d'Auvergne, BP 321, 63009 Clermont-Ferrand, France
*
*Correspondong author: Dr Patrick Ritz, present address Service de Médecine B, Centre Hospitalier Universitaire, F-49033 Angers Cedex 01, France, fax 33 2 41 35 49 69, email paritz@chu-angers.fr
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Abstract

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The aim of the present study was to assess the influence of age on plasma concentration of α-tocopherol, retinol and carotenoids with a special attention paid to natural differences in body composition. Forty healthy subjects were recruited: twenty were less than 35 years old and twenty above 60 years old. Males and females were equally represented in each age group. Subjects were kept in energy balance and received controlled diets for 36 h. Fat mass and fat-free mass were determined with the 180-enriched water dilution technique. Plasma vitamins A and E, and carotenoid levels were determined after 12 h fasting and were shown to be similar in women and men. Plasma α-tocopherol concentration increased with age (+44 % elderly v. young), and correlated with % fat mass and plasma cholesterol. After adjustment for plasma cholesterol, the effect of age and % fat mass disappeared. In contrast, plasma lycopene level was 2-fold lower in the elderly than in the young group, and was inversely correlated with fat mass. When lycopene values were adjusted for fat mass, the effect of age disappeared. These results suggest that plasma levels of vitamin E and lycopene differed in the two age groups and that differences in plasma cholesterol and fat mass might participate in such an effect. Short-term vitamin intake did not appear to influence plasma vitamin concentrations.

Keywords

AgeCarotenoidsVitamin EBody composition
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 711 - 716
Copyright
Copyright © The Nutrition Society 2000

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