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A prospective epidemiological analysis of controlling nutritional status score with the poor functional outcomes in Chinese patients with haemorrhagic stroke

Published online by Cambridge University Press:  19 August 2021

Bei Lei Zhu
Affiliation:
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Yan Zhi Wu
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Zhong Ming Cai
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Cheng-Wei Liao
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Le Qiu Sun
Affiliation:
Department of Neurology, Wenzhou Medical Univerisity Affiliated Yueqing Hospital, Wenzhou, Zhejiang, People’s Republic of China
Zhi Peng Liu
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Hao Man Chen
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Xue Rong Huang
Affiliation:
Department of Neurology, Ruian People’s Hospital, Wenzhou, Zhejiang, People’s Republic of China
Ren Qian Feng
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Sheng Lie Ye
Affiliation:
Department of First Clinical Medical School, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Qun Li Lin
Affiliation:
Department of Neurology, Yongjia People’s Hospital, Wenzhou, Zhejiang, People’s Republic of China
Xu Dong Zhou
Affiliation:
Department of Neurology, Pingyang People’s Hospital, Wenzhou, Zhejiang, People’s Republic of China
Liang Wang
Affiliation:
Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, USA
Man Man Zhang*
Affiliation:
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China
Bo Yang*
Affiliation:
School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
*
* Corresponding author: Man Man Zhang, email: zhangmanman@wmu.edu.cn; Bo Yang, email: ybzju@zju.edu.cn
* Corresponding author: Man Man Zhang, email: zhangmanman@wmu.edu.cn; Bo Yang, email: ybzju@zju.edu.cn

Abstract

Nutritional Risk Screening index is a standard tool to assess nutritional risk, but epidemiological data are scarce on controlling nutritional status (CONUT) as a prognostic marker in acute haemorrhagic stroke (AHS). We aimed to explore whether the CONUT may predict a 3-month functional outcome in AHS. In total, 349 Chinese patients with incident AHS were consecutively recruited, and their malnutrition risks were determined using a high CONUT score of ≥ 2. The cohort patients were divided into high-CONUT (≥ 2) and low-CONUT (< 2) groups, and primary outcomes were a poor functional prognosis defined as the modified Rankin Scale (mRS) score of ≥ 3 at post-discharge for 3 months. Odds ratios (OR) with 95 % confidence intervals (CI) for the poor functional prognosis at post-discharge were estimated by using a logistic analysis with additional adjustments for unbalanced variables between the high-CONUT and low-CONUT groups. A total of 328 patients (60·38 ± 12·83 years; 66·77 % male) completed the mRS assessment at post-discharge for 3 months, with 172 patients at malnutrition risk at admission and 104 patients with a poor prognosis. The levels of total cholesterol and total lymphocyte counts were significantly lower in high-CONUT patients than low-CONUT patients (P = 0·012 and < 0·001, respectively). At 3-month post discharge, there was a greater risk for the poor outcome in the high-CONUT compared with the low-CONUT patients at admission (OR: 2·32, 95 % CI: 1·28, 4·17). High-CONUT scores independently predict a 3-month poor prognosis in AHS, which helps to identify those who need additional nutritional managements.

Type
Full Papers
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

These authors contributed equally to this work.

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