Skip to main content Accessibility help
×
Home
Hostname: page-component-888d5979f-g2njx Total loading time: 0.417 Render date: 2021-10-26T03:29:55.056Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study

Published online by Cambridge University Press:  16 September 2021

Xi-Ru Zhang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Pei-Dong Zhang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Zhi-Hao Li
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Pei Yang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Xiao-Meng Wang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Hua-Min Liu
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Fen Liang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Jin-Dong Wang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Yu Sun
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Dong Shen
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Pei-Liang Chen
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Wen-Fang Zhong
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Qing-Mei Huang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Dan Liu
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Zheng-He Wang
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
Virginia Byers Kraus
Affiliation:
Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA
Chen Mao*
Affiliation:
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
*
*Corresponding author: Chen Mao, email maochen9@smu.edu.cn

Abstract

Chronic inflammation exerts pleiotropic effects in the aetiology and progression of chronic obstructive pulmonary disease (COPD). Glucosamine is widely used in many countries and may have anti-inflammatory properties. We aimed to prospectively evaluate the association of regular glucosamine use with incident COPD risk and explore whether such association could be modified by smoking in the UK Biobank cohort, which recruited more than half a million participants aged 40–69 years from across the UK between 2006 and 2010. Cox proportional hazards models with adjustment for potential confounding factors were used to calculate hazard ratios (HR) as well as 95 % CI for the risk of incident COPD. During a median follow-up of 8·96 years (interquartile range 8·29–9·53 years), 9016 new-onset events of COPD were documented. We found that the regular use of glucosamine was associated with a significantly lower risk of incident COPD with multivariable adjusted HR of 0·80 (95 % CI, 0·75, 0·85; P < 0·001). When subgroup analyses were performed by smoking status, the adjusted HR for the association of regular glucosamine use with incident COPD were 0·84 (0·73, 0·96), 0·84 (0·77, 0·92) and 0·71 (0·62, 0·80) among never smokers, former smokers and current smokers, respectively. No significant interaction was observed between glucosamine use and smoking status (P for interaction = 0·078). Incident COPD could be reduced by 14 % to 84 % through a combination of regular glucosamine use and smoking cessation.

Type
Full Papers
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

These authors contributed equally to this work

References

Labaki, WW & Rosenberg, SR (2020) Chronic obstructive pulmonary disease. Ann Intern Med 173, Itc17Itc32.CrossRefGoogle ScholarPubMed
Barnes, PJ (2016) Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Clin Immunol 138, 1627.CrossRefGoogle ScholarPubMed
Mathers, CD & Loncar, D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3, e442.CrossRefGoogle ScholarPubMed
Celli, BR, Decramer, M, Wedzicha, JA, et al. (2015) An official American Thoracic Society/European Respiratory Society Statement: research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 191, e4e27.CrossRefGoogle ScholarPubMed
Ferrera, MC, Labaki, WW & Han, MK (2021) Advances in chronic obstructive pulmonary disease. Ann Rev Med 72, 119134.CrossRefGoogle ScholarPubMed
Su, YC, Jalalvand, F, Thegerström, J, et al. (2018) The interplay between immune response and bacterial infection in COPD: focus upon non-typeable haemophilus influenzae. Front Immunol 9, 2530.CrossRefGoogle ScholarPubMed
Liu, S, Jørgensen, JT, Ljungman, P, et al. (2021) Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: the ELAPSE project. Environ Int 146, 106267.CrossRefGoogle ScholarPubMed
Zhu, T, Li, S, Wang, J, et al. (2020) Induced sputum metabolomic profiles and oxidative stress are associated with chronic obstructive pulmonary disease (COPD) severity: potential use for predictive, preventive, and personalized medicine. EPMA J 11, 645659.CrossRefGoogle ScholarPubMed
MacNee, W (2000) Oxidants/antioxidants and COPD. Chest 117, 303s317s.CrossRefGoogle ScholarPubMed
Qato, DM, Wilder, J, Schumm, LP, et al. (2016) Changes in prescription and over-the-counter medication and dietary supplement use among older adults in the United States, 2005 v. 2011. JAMA Intern Med 176, 473482.CrossRefGoogle Scholar
Sibbritt, D, Adams, J, Lui, CW, et al. (2012) Who uses glucosamine and why? A study of 266,848 Australians aged 45 years and older. PLOS ONE 7, e41540.CrossRefGoogle Scholar
Jordan, KM, Arden, NK, Doherty, M, et al. (2003) EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann Rheumatic Dis 62, 11451155.CrossRefGoogle Scholar
Blanco, FJ, Camacho-Encina, M, González-Rodríguez, L, et al. (2019) Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis. Ther Adv Dis 10, 2040622319870013.Google ScholarPubMed
Reginster, JL, Bruyere, O & Cooper, C (2018) Different glucosamine sulfate products generate different outcomes on osteoarthritis symptoms. Ann Rheumatic Dis 77, e39.CrossRefGoogle ScholarPubMed
Runhaar, J, Rozendaal, RM, van Middelkoop, M, et al. (2017) Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Ann Rheumatic Dis 76, 18621869.CrossRefGoogle ScholarPubMed
Largo, R, Alvarez-Soria, MA, Díez-Ortego, I, et al. (2003) Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes. Osteoarthritis Cartil 11, 290298.CrossRefGoogle ScholarPubMed
Chan, PS, Caron, JP, Rosa, GJ, et al. (2005) Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E(2) in articular cartilage explants. Osteoarthritis Cartil 13, 387394.CrossRefGoogle Scholar
Rajapakse, N, Kim, MM, Mendis, E, et al. (2008) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated RAW264.7 cells by carboxybutyrylated glucosamine takes place via down-regulation of mitogen-activated protein kinase-mediated nuclear factor-κB signaling. Immunology 123, 348357.CrossRefGoogle ScholarPubMed
Campo, GM, Avenoso, A, Campo, S, et al. (2003) Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats. Arthritis Res Ther 5, R122R131.CrossRefGoogle ScholarPubMed
Chou, MM, Vergnolle, N, McDougall, JJ, et al. (2005) Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Exp Biol Med 230, 255262.CrossRefGoogle Scholar
Wen, ZH, Tang, CC, Chang, YC, et al. (2010) Glucosamine sulfate reduces experimental osteoarthritis and nociception in rats: association with changes of mitogen-activated protein kinase in chondrocytes. Osteoarthritis Cartil 18, 11921202.CrossRefGoogle ScholarPubMed
Kantor, ED, Lampe, JW, Navarro, SL, et al. (2014) Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation. J Alternat Complement Med 20, 479485.CrossRefGoogle ScholarPubMed
Navarro, SL, White, E, Kantor, ED, et al. (2015) Randomized trial of glucosamine and chondroitin supplementation on inflammation and oxidative stress biomarkers and plasma proteomics profiles in healthy humans. PLOS ONE 10, e0117534.CrossRefGoogle ScholarPubMed
Kantor, ED, O’Connell, K, Du, M, et al. (2020) Glucosamine and chondroitin use in relation to C-reactive protein concentration: results by supplement form, formulation, and dose. J Alternat Complement Med 27, 150159.CrossRefGoogle ScholarPubMed
Thorat, MA & Cuzick, J (2015) Prophylactic use of aspirin: systematic review of harms and approaches to mitigation in the general population. Eur J Epidemiol 30, 518.CrossRefGoogle ScholarPubMed
Wolfe, MM, Lichtenstein, DR & Singh, G (1999) Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340, 18881899.CrossRefGoogle ScholarPubMed
Solomon, SD, Wittes, J, Finn, PV, et al. (2008) Cardiovascular risk of celecoxib in 6 randomized placebo-controlled trials: the cross trial safety analysis. Circulation 117, 21042113.CrossRefGoogle ScholarPubMed
Sudlow, C, Gallacher, J, Allen, N, et al. (2015) UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age. PLoS Med 12, e1001779.CrossRefGoogle ScholarPubMed
Fry, A, Littlejohns, TJ, Sudlow, C, et al. (2017) Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population. Am J Epidemiol 186, 10261034.CrossRefGoogle ScholarPubMed
Bassett, DR (2003) International physical activity questionnaire: 12-country reliability and validity. J Med Sci Sport Exerc 35, 1396.CrossRefGoogle ScholarPubMed
Buuren, Sv & Groothuis-Oudshoorn, K (2010) Mice: multivariate imputation by chained equations in R. J Stat Softw 45, 168.Google Scholar
Mansournia, MA & Altman, DG (2018) Population attributable fraction. BMJ 360, k757.CrossRefGoogle ScholarPubMed
Miettinen, OS (1974) Proportion of disease caused or prevented by a given exposure, trait or intervention. Am J Epidemiol 99, 325332.CrossRefGoogle ScholarPubMed
Satia, JA, Littman, A, Slatore, CG, et al. (2009) Associations of herbal and specialty supplements with lung and colorectal cancer risk in the Vitamins and Lifestyle study. Cancer Epidemiol Biomark Prev 18, 14191428.CrossRefGoogle ScholarPubMed
Brasky, TM, Lampe, JW, Slatore, CG, et al. (2011) Use of glucosamine and chondroitin and lung cancer risk in the Vitamins and Lifestyle (VITAL) cohort. Cancer Causes Contr 22, 13331342.CrossRefGoogle ScholarPubMed
Lee, DH, Cao, C, Zong, X, et al. (2020) Glucosamine and chondroitin supplements and risk of colorectal adenoma and serrated polyp. Cancer Epidemiol, Biomark Prev 29, 26932701.CrossRefGoogle ScholarPubMed
Ma, H, Li, X, Zhou, T, et al. (2020) Glucosamine use, inflammation, and genetic susceptibility, and incidence of type 2 diabetes: a prospective study in UK Biobank. Diabetes Care 43, 719725.CrossRefGoogle ScholarPubMed
Ma, H, Li, X, Sun, D, et al. (2019) Association of habitual glucosamine use with risk of cardiovascular disease: prospective study in UK Biobank. BMJ 365, l1628.CrossRefGoogle ScholarPubMed
Bell, GA, Kantor, ED, Lampe, JW, et al. (2012) Use of glucosamine and chondroitin in relation to mortality. Eur J Epidemiol 27, 593603.CrossRefGoogle Scholar
Li, ZH, Gao, X, Chung, VC, et al. (2020) Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Ann Rheumatic Dis 79, 829836.CrossRefGoogle ScholarPubMed
du Souich, P (2014) Absorption, distribution and mechanism of action of SYSADOAS. Pharmacol Ther 142, 362374.CrossRefGoogle ScholarPubMed
Zahedipour, F, Dalirfardouei, R, Karimi, G, et al. (2017) Molecular mechanisms of anticancer effects of Glucosamine. Biomed Pharmacother = Biomedecine Pharmacotherapie 95, 10511058.CrossRefGoogle ScholarPubMed
Silva, JF, Olivon, VC, Mestriner, F, et al. (2019) Acute increase in O-GlcNAc improves survival in mice with LPS-induced systemic inflammatory response syndrome. Front Physiol 10, 1614.CrossRefGoogle ScholarPubMed
Hong, H, Park, YK, Choi, MS, et al. (2009) Differential down-regulation of COX-2 and MMP-13 in human skin fibroblasts by glucosamine-hydrochloride. J Dermatol Sci 56, 4350.CrossRefGoogle ScholarPubMed
Yomogida, S, Hua, J, Sakamoto, K, et al. (2008) Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNF-α-stimulated human colonic epithelial HT-29 cells. Int J Mol Med 22, 205211.Google ScholarPubMed
Nakamura, H, Shibakawa, A, Tanaka, M, et al. (2004) Effects of glucosamine hydrochloride on the production of prostaglandin E2, nitric oxide and metalloproteases by chondrocytes and synoviocytes in osteoarthritis. Clin Exp Rheumatol 22, 293299.Google ScholarPubMed
Gouze, JN, Bordji, K, Gulberti, S, et al. (2001) Interleukin-1beta down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: influence of glucosamine on interleukin-1beta-mediated effects in rat chondrocytes. Arthritis Rheumat 44, 351360.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Zhang, T, Chen, S, Dou, H, et al. (2021) Novel glucosamine-loaded thermosensitive hydrogels based on poloxamers for osteoarthritis therapy by intra-articular injection. Mater Sci Eng C Mater Biol Appl 118, 111352.CrossRefGoogle ScholarPubMed
Romano, S, Mallardo, M & Romano, MF (2011) FKBP51 and the NF-κB regulatory pathway in cancer. Curr Opin Pharmacol 11, 288293.CrossRefGoogle ScholarPubMed
Li, Q, Withoff, S & Verma, IM (2005) Inflammation-associated cancer: NF-κB is the lynchpin. Trend Immunol 26, 318325.CrossRefGoogle ScholarPubMed
Hao, X, Shang, X, Liu, J, et al. (2021) The gut microbiota in osteoarthritis: where do we stand and what can we do? Arthritis Res Ther 23, 42.CrossRefGoogle Scholar
Coulson, S, Butt, H, Vecchio, P, et al. (2013) Green-lipped mussel extract (Perna canaliculus) and glucosamine sulphate in patients with knee osteoarthritis: therapeutic efficacy and effects on gastrointestinal microbiota profiles. Inflammopharmacology 21, 7990.CrossRefGoogle ScholarPubMed
Lee, HS, Han, SY, Ryu, KY, et al. (2009) The degradation of glycosaminoglycans by intestinal microflora deteriorates colitis in mice. Inflammation 32, 2736.CrossRefGoogle ScholarPubMed
Sicard, JF, Vogeleer, P, Le Bihan, G, et al. (2018) N-Acetyl-glucosamine influences the biofilm formation of Escherichia coli. Gut Pathogens 10, 26.CrossRefGoogle ScholarPubMed
Kantor, ED, Lampe, JW, Vaughan, TL, et al. (2012) Association between use of specialty dietary supplements and C-reactive protein concentrations. Am J Epidemiol 176, 10021013.CrossRefGoogle ScholarPubMed
Goto, T, Faridi, MK, Camargo, CA, et al. (2018) The association of aspirin use with severity of acute exacerbation of chronic obstructive pulmonary disease: a retrospective cohort study. Jpn Prim Care Respir Med 28, 7.CrossRefGoogle ScholarPubMed
Fawzy, A, Putcha, N, Aaron, CP, et al. (2019) Aspirin use and respiratory morbidity in COPD: a propensity score-matched analysis in subpopulations and intermediate outcome measures in COPD Study. Chest 155, 519527.CrossRefGoogle ScholarPubMed
McKeever, TM, Lewis, SA, Smit, HA, et al. (2005) The association of acetaminophen, aspirin, and ibuprofen with respiratory disease and lung function. Am J Respir Critical Care Med 171, 966971.CrossRefGoogle ScholarPubMed
Aaron, CP, Schwartz, JE, Hoffman, EA, et al. (2018) A longitudinal cohort study of aspirin use and progression of emphysema-like lung characteristics on CT imaging: the MESA lung study. Chest 154, 4150.CrossRefGoogle Scholar
Supplementary material: File

Zhang et al. supplementary material

Zhang et al. supplementary material

Download Zhang et al. supplementary material(File)
File 53 KB

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Glucosamine use, smoking and risk of incident chronic obstructive pulmonary disease: a large prospective cohort study
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *