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Cardiometabolic effects of early v. delayed time-restricted eating plus energetic restriction in adults with overweight and obesity: an exploratory randomised clinical trial

Published online by Cambridge University Press:  26 May 2022

Jéssica do Nascimento Queiroz Open the ORCID record for Jéssica do Nascimento Queiroz[Opens in a new window] ,
Rodrigo Cauduro Oliveira Macedo ,
Gabriela Cristina dos Santos ,
Samuel Vargas Munhoz ,
Carlos Leonardo Figueiredo Machado ,
Rodrigo Leal de Menezes ,
Elisa Nascimento Menzem ,
Cesar Eduardo Jacintho Moritz ,
Ronei Silveira Pinto  and
Grant M. Tinsley Open the ORCID record for Grant M. Tinsley[Opens in a new window]
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Jéssica do Nascimento Queiroz*
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Rodrigo Cauduro Oliveira Macedo
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil Department of Nutrition, University of Santa Cruz do Sul, Santa Cruz do Sul, Rio Grande do Sul, Brazil
Gabriela Cristina dos Santos
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Samuel Vargas Munhoz
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Carlos Leonardo Figueiredo Machado
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Rodrigo Leal de Menezes
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Elisa Nascimento Menzem
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Cesar Eduardo Jacintho Moritz
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Ronei Silveira Pinto
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
Grant M. Tinsley
Affiliation:
Department of Kinesiology & Sport Management at Texas Tech University, Lubbock, TX, USA
Alvaro Reischak de Oliveira
Affiliation:
Exercise Research Laboratory, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
*
*Corresponding author: Jéssica do Nascimento Queiroz, email jessica.queiroz@ufrgs.br
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Abstract

This exploratory study investigated the effects of early v. delayed time-restricted eating (TRE) plus caloric restriction (CR) on body weight, body composition and cardiometabolic parameters in adults with overweight and obesity. Adults (20–40 years) were randomised to one of three groups for 8 weeks: early time-restricted eating (eTRE; 08.00–16.00) plus CR, delayed time-restricted eating (dTRE; 12.00–20.00) plus CR or only CR (CR; 08.00–20.00). All groups were prescribed a 25 % energy deficit relative to daily energy requirements. Thirteen participants completed the study in the eTRE and CR groups and eleven in the dTRE group (n 37). After the interventions, there was no significant difference between the three groups for any of the outcomes. Compared with baseline, significant decreases were observed in the body weight (eTRE group: −4·2 kg; 95 % CI, −5·6, −2·7; dTRE group: −4·8 kg; 95 % CI, −5·9, −3·7; CR: −4·0 kg; 95 % CI, −5·9, −2·1), fat mass (eTRE group: −2·9 kg; 95 % CI, −3·9, −1·9; dTRE group: −3·6 kg; 95 % CI, −4·6, −2·5; CR: −3·1 kg; 95 % CI, −4·3, −1·8) and fasting glucose levels (eTRE group: −4 mg/dl; 95 % CI, −8, −1; dTRE group: −2 mg/dl; 95 % CI, −8, 3; CR: −3 mg/dl; 95 % CI, −8, 2). In a free-living setting, TRE with a energetic deficit, regardless of the time of day, promotes similar benefits in weight loss, body composition and cardiometabolic parameters. However, given the exploratory nature of our study, further investigation is needed to confirm these findings.

Keywords

Time-restricted feedingIntermittent fastingFastingDietHealthMetabolismCircadian rhythms
Type
Research Article
Information
British Journal of Nutrition , Volume 129 , Issue 4 , 28 February 2023 , pp. 637 - 649
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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