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Effects of Paroxetine on Motor and Cognitive Function Recovery in Patients with Non-Depressed Ischemic Stroke: An Open Randomized Controlled Study

Published online by Cambridge University Press:  30 May 2018

Xiao-Ling Pan
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Hong-Fang Chen
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Xing Cheng
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Chuan-Chen Hu
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Jian-Wei Wang
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Ya-Ming Fu
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Hui-Mei Kong
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
Hui-Jun Shao*
Affiliation:
Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, China
*
Address for correspondence: Hui-Jun Shao, Department of Neurology, Jinhua Hospital Affiliated to Zhejiang University, Jinhua, 321000, China. E-mail: dochuijunshao@126.com

Abstract

Introduction: To investigate the effects of paroxetine (PAR) on motor and cognitive function recovery in patients with non-depressed ischemic stroke (nD-AIS).

Methods: One hundred sixty-seven patients hospitalized for non-depressed acute ischemic stroke were selected and divided into treatment (T) and control (C) groups using a random number table. All patients received conventional secondary ischemic stroke prevention and rehabilitation training; patients in Group T additionally received treatment with PAR (10 mg/day during week 1 and 20 mg/day thereafter) for 3 months. The follow-up observation lasted 6 months. The Fugl–Meyer motor scale (FMMS), Montreal cognitive assessment (MoCA), and Hamilton depression scale (HAMD) were used on D0, D15, D90, and D180 (T0, 1, 2, and 3, respectively; D180 = 90 days after treatment cessation) after study initiation, and scores were compared between the groups.

Results: The FMMS and MoCA scores differed significantly between Groups T and C at T2 and T3 (p < .05); by contrast, these scores did not differ significantly between the groups at T1 (p > .05). Furthermore, the HAMD scores differed significantly between the two groups at T3 (p < .05), but not at T1 and T2 (p > .05).

Conclusions: PAR treatment may improve motor and cognitive function recovery in patients with nD-AIS. Moreover, PAR may reduce the occurrence of depression after stroke.

Type
Articles
Copyright
Copyright © Australasian Society for the Study of Brain Impairment 2018 

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Effects of Paroxetine on Motor and Cognitive Function Recovery in Patients with Non-Depressed Ischemic Stroke: An Open Randomized Controlled Study
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