Skip to main content Accessibility help
×
Home
Hostname: page-component-568f69f84b-8fhp6 Total loading time: 0.245 Render date: 2021-09-21T06:34:37.741Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": true, "newCiteModal": false, "newCitedByModal": true, "newEcommerce": true, "newUsageEvents": true }

The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy

Published online by Cambridge University Press:  02 January 2018

Peter E. Langdon*
Affiliation:
Tizard Centre, University of Kent, Canterbury, UK; Broadland Clinic, Hertfordshire Partnership University NHS Foundation Trust in Norfolk, Norwich, UK
Glynis H. Murphy
Affiliation:
Tizard Centre, University of Kent, Canterbury, UK, and Oxleas NHS Foundation Trust, Dartford, UK
Lee Shepstone
Affiliation:
Department of Population Health and Primary Care, Norwich Medical School, University of East Anglia, Norwich, UK
Edward C.F. Wilson
Affiliation:
School of Clinical Medicine, University of Cambridge, Cambridge, UK
David Fowler
Affiliation:
School of Psychology, University of Sussex, Brighton, UK
David Heavens
Affiliation:
Department of Clinical Psychology, Norwich Medical School, University of East Anglia, Norwich, and Norfolk and Suffolk NHS Foundation Trust, Norwich, UK
Alexandra Russell
Affiliation:
Department of Clinical Psychology, Norwich Medical School, University of East Anglia, Norwich, UK, and Norfolk and Suffolk NHS Foundation Trust, Norwich, UK
Alice Rose
Affiliation:
Tizard Centre, University of Kent, Canterbury, UK
Aida Malovic
Affiliation:
Department of Clinical Psychology, Norwich Medical School, University of East Anglia, Norwich, UK, and Hertfordshire Partnership University NHS Foundation Trust in Norfolk, Norwich, UK
Louise Mullineaux
Affiliation:
Department of Clinical Psychology, Norwich Medical School, University of East Anglia, Norwich, UK, and Hertfordshire Partnership University NHS Foundation Trust in Norfolk, Norwich, UK
*Corresponding
Peter Langdon, Tizard Centre, University of Kent, Canterbury CT2 7LR, UK. Email: P.E.Langdon@kent.ac.uk
Rights & Permissions[Opens in a new window]

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Background

There is a growing interest in using cognitive–behavioural therapy (CBT) with people who have Asperger syndrome and comorbid mental health problems.

Aims

To examine whether modified group CBT for clinically significant anxiety in an Asperger syndrome population is feasible and likely to be efficacious.

Method

Using a randomised assessor-blind trial, 52 individuals with Asperger syndrome were randomised into a treatment arm or a waiting-list control arm. After 24 weeks, those in the waiting-list control arm received treatment, while those initially randomised to treatment were followed up for 24 weeks.

Results

The conversion rate for this trial was high (1.6:1), while attrition was 13%. After 24 weeks, there was no significant difference between those randomised to the treatment arm compared with those randomised to the waiting-list control arm on the primary outcome measure, the Hamilton Rating Scale for Anxiety.

Conclusions

Trials of psychological therapies with this population are feasible. Larger definitive trials are now needed.

Type
Research Article
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY) licence (http://creativecommons.org/licenses/by/4.0/).
Copyright
Copyright © The Royal College of Psychiatrists 2016

Footnotes

Declaration of interest

None.

References

1 Rescorla, LA. Preschool psychiatric disorders: diagnostic classification and symptom patterns. J Am Acad Child Adolesc Psychiatry 1986; 25: 162–9.CrossRefGoogle ScholarPubMed
2 Russell, E, Sofronoff, K. Anxiety and social worries in children with Asperger syndrome. Aust N Z J Psychiatry 2005; 39: 633–8.CrossRefGoogle ScholarPubMed
3 Szatmari, P, Archer, L, Fisman, S, Streiner, D, Wilson, F. Asperger syndrome and autism: differences in behavior, cognition and adaptive functioning. J Am Acad Child Adolesc Psychiatry 1995; 34: 1662–70.CrossRefGoogle Scholar
4 Tantam, D. Lifelong eccentricity and social isolation. Part 2: Asperger's syndrome or schizoid personality disorder? Br J Psychiatry 1988; 153: 783–91.CrossRefGoogle ScholarPubMed
5 Kim, JA, Szatmari, P, Bryson, SE, Streiner, DL, Wilson, FJ. The prevalence of anxiety and mood problems among children with autism and Asperger syndrome. Autism 2000; 4: 117–32.CrossRefGoogle Scholar
6 Green, J, Gilchrist, A, Burton, D, Cox, A. Social and psychiatric functioning in adolescents with Asperger syndrome compared with conduct disorder. J Autism Dev Disord 2000; 30: 279–93.CrossRefGoogle ScholarPubMed
7 Lugnegård, T, Hallerbäck, MU, Gillberg, C. Psychiatric comorbidity in young adults with a clinical diagnosis of Asperger syndrome. Res Dev Disabil 2011; 32: 1910–7.CrossRefGoogle ScholarPubMed
8 Sukhodolsky, DG, Bloch, MH, Panza, KE, Reichow, B. Cognitive-behavioral therapy for anxiety in children with high-functioning autism: a meta-analysis. Pediatrics 2013; 132: e134150.CrossRefGoogle ScholarPubMed
9 Cardaciotto, L, Herbert, AD. Cognitive behavior therapy for social anxiety disorder in the context of Asperger's syndrome: a single-subject report. Cogn Behav Pract 2004; 11: 7581.CrossRefGoogle Scholar
10 Weiss, JA, Lunsky, Y. Group cognitive behavioural therapy for adults with Asperger syndrome and anxiety or mood disorders: a case series. Clin Psychol Psychother 2010; 17: 438–46.CrossRefGoogle ScholarPubMed
11 Spek, AA, van Ham, NC, Nyklíček, I. Mindfulness-based therapy in adults with an autism spectrum disorder: a randomized controlled trial. Res Dev Disabil 2013; 34: 246–53.CrossRefGoogle ScholarPubMed
12 Russell, AJ, Jassi, A, Fullana, MA, Mack, H, Johnston, K, Heyman, I, et al. Cognitive behavior therapy for comorbid obsessive-compulsive disorder in high-functioning autism spectrum disorders: a randomized controlled trial. Depress Anxiety 2013; 30: 697708.CrossRefGoogle ScholarPubMed
13 McGillivray, J, Evert, H. Group cognitive behavioural therapy program shows potential in reducing symptoms of depression and stress among young people with ASD. J Autism Dev Disord 2014; 44: 2041–51.CrossRefGoogle ScholarPubMed
14 Russell, AJ, Mataix-Cols, D, Anson, M, Murphy, D. Psychological treatment for obsessive-compulsive disorder in people with autism spectrum disorders – a pilot study. Psychother Psychosom 2009; 78: 5961.CrossRefGoogle ScholarPubMed
15 Wechsler, D. Wechsler Abbreviated Scale of Intelligence. The Psychological Corporation, 1999.Google Scholar
16 Langdon, PE, Murphy, GH, Wilson, E, Shepstone, L, Fowler, D, Heavens, D, et al. Asperger syndrome and anxiety disorders (PAsSA) treatment trial: a study protocol of a pilot, multicentre, single-blind, randomised crossover trial of group cognitive behavioural therapy. BMJ Open 2013; 3, e003449.CrossRefGoogle ScholarPubMed
17 Heavens, D, Murphy, GH, Langdon, PE. People with Asperger Syndrome and Anxiety (PAsSA) Trial Treatment Manual (Version 3.0). University of East Anglia, 2012.Google Scholar
18 Hamilton, M. The assessment of anxiety states by rating. BMJ 1959; 32: 50–5.Google ScholarPubMed
19 Connor, KM, Davidson, JRT, Churchill, LE, Sherwood, A, Weisler, RH, Foa, E. Psychometric properties of the Social Phobia Inventory (SPIN). Br J Psychiatry 2000; 176: 379–86.CrossRefGoogle Scholar
20 Heimberg, RG, Horner, KJ, Juster, HR, Safren, SA, Brown, EJ, Schneier, FR, et al. Psychometric properties of the Liebowtiz Social Anxiety Scale. Psychol Med 1999; 29: 199212.CrossRefGoogle Scholar
21 Rutter, M, LeCouteur, A, Lord, C, MacDonald, H, Rios, P, Folstein, S. Diagnosis and sub-classification of autism: concepts and instrument development. In Diagnosis and Assessment in Autism (eds Schopler, E, Mesibov, GB): 239–59. Springer, 1988.Google Scholar
22 Heimberg, RG, Mueller, GP, Holt, CS, Hope, DA, Liebowitz, MR. Assessment of anxiety in social interaction and being observed by others: the Social Interaction Anxiety Scale and the Social Phobia Scale. Behav Ther 1992; 23: 5373.CrossRefGoogle Scholar
23 Brown, EJ, Turovsky, J, Heimberg, RG, Juster, HR, Brown, TA, Barlow, DH. Validation of the Social Interaction Anxiety Scale and the Social Phobia Scale across the anxiety disorders. Psycholl Assess 1997; 9: 21–7.Google Scholar
24 Marks, IM, Matthews, AM. Brief standard self-rating scale for phobic patients. Behav Res Ther 1979; 17: 263–7.CrossRefGoogle Scholar
25 Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23: 5662.CrossRefGoogle ScholarPubMed
26 Hofmann, SG, Smits, JA. Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry 2008; 69: 621.CrossRefGoogle ScholarPubMed
27 Hróbjartsson, A, Gøtzsche, PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med 2001; 344: 1594–602.CrossRefGoogle ScholarPubMed
28 Wampold, BE, Minami, T, Tierney, SC, Baskin, TW, Bhati, KS. The placebo is powerful: estimating placebo effects in medicine and psychotherapy from randomized clinical trials. J Clin Psychol 2005; 61: 835–54.CrossRefGoogle Scholar
29 National Institute for Health and Care Excellence. Autism: Recognition, Referral, Diagnosis Rand Management of Adults on the Autism Spectrum NICE Clinical Guideline 142. British Psychological Society & The Royal College of Psychiatrists, 2012.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.
You have Access
Open access
6
Cited by

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive–behavioural therapy
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *