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Comparison of outcomes for patients with and without a serious mental illness presenting to hospital for chronic obstruction pulmonary disease: retrospective observational study using administrative data

Published online by Cambridge University Press:  17 July 2023

Sara Goldman
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Anastasia Saoulidi
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Sridevi Kalidindi
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Getting It Right First Time Programme, NHS England, London, UK; and South London and Maudsley NHS Foundation Trust, London, UK
Eugenia Kravariti
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK
Fiona Gaughran*
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; and South London and Maudsley NHS Foundation Trust, London, UK
Tim W. R. Briggs
Getting It Right First Time Programme, NHS England, London, UK; and Department of Surgery, Royal National Orthopaedic Hospital, Stanmore, London, UK
William K. Gray
Getting It Right First Time Programme, NHS England, London, UK
Correspondence: Fiona Gaughran. Email:
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There are few data on the profile of those with serious mental illness (SMI) admitted to hospital for physical health reasons.


To compare outcomes for patients with and without an SMI admitted to hospital in England where the primary reason for admission was chronic obstructive pulmonary disease (COPD).


This was a retrospective, observational analysis of the English Hospital Episodes Statistics data-set for the period from 1 April 2018 to 31 March 2019, for patients aged 18–74 years with COPD as the dominant reason for admission. Patient with an SMI (psychosis spectrum disorder, bipolar disorder) were identified.


Data were available for 54 578 patients, of whom 2096 (3.8%) had an SMI. Patients with an SMI were younger, more likely to be female and more likely to live in deprived areas than those without an SMI. The burden of comorbidity was similar between the two groups. After adjusting for covariates, SMI was associated with significantly greater risk of length of stay than the median (odds ratio 1.24, 95% CI 1.12–1.37, P ≤ 0.001) and with 30-day emergency readmission (odds ratio 1.51, 95% confidence interval 1.34–1.69, P ≤ 0.001) but not with in-hospital mortality.


Clinicians should be aware of the potential for poorer outcomes in patients with an SMI even when the SMI is not the primary reason for admission. Collaborative working across mental and physical healthcare provision may facilitate improved outcomes for people with SMI.

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Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists

Severe mental illnesses (SMIs) are a cluster of mental disorders including schizophrenia, schizoaffective disorder and bipolar disorder that can result in substantial deterioration of social and occupational functioning, long-term disability and reduction in quality of life.Reference Walker, McGee and Druss1 In the UK, the prevalence of SMI is estimated to be around 0.9%.2 Apart from the psychosocial effects, premature mortality appears to occur more often in people with SMI compared with those with other mental disorders and/or the general population, with a reduction in life expectancy of as much as 10 years.Reference Walker, McGee and Druss1 A large proportion of the observed premature deaths can be accounted for by physical health problems. Evidence suggests that as many as 61.8% of all SMI deaths occur because of circulatory and respiratory disorders and cancers.Reference John, McGregor, Jones, Lee, Walters and Owen3

A report by the Nuffield Trust looked at the differences in hospital use in people aged less than 75 years with mental health difficulties (SMI and non-SMI) and physical health problems.Reference Dorning, Davies and Blunt4 They found that people with mental health difficulties were almost four times more likely to use emergency care services than other patient groups, with the most care needed for physical health problems. Among all hospital patients with mental health difficulties, those with SMI had higher rates of emergency in-patient admissions and out-patient care. Furthermore, levels of socioeconomic deprivation were highly associated with emergency care use, and patients with SMI had higher levels of deprivation compared with those with other mental health difficulties and physical health problems. Hospital patients with mental health difficulties were also more likely to stay in hospital for a longer period. There is evidence that people with SMI are more likely than the general population to have physical multimorbidity (more than one comorbid physical condition), which can also contribute to adverse health outcomes and affect hospital use.Reference Filipcic, Bajic and Filipcic5

Although there is a good evidence base for adverse health and hospital use outcomes in people with SMI, there has been much less work to assess the interactions between various factors associated with outcomes. Furthermore, there appears to be a gap in research regarding the differences among patients within different SMIs. In the general population, evidence suggests that the overall relative mortality risk is higher for people with schizophrenia compared with people with bipolar disorder.Reference Correll, Solmi, Croatto, Schneider, Rohani-Montez and Fairley6,Reference Laursen7 Within hospital populations, a study of 43 817 Medicaid enrolees in the USA found that people with schizophrenia had longer hospital stays, a greater number of physical comorbidities and higher 30-day hospital readmission rates compared with people with bipolar and depressive disorders.Reference Cook, Burke-Miller, Jonikas, Aranda and Santos8 However, data from the USA may not readily translate to countries with different healthcare funding models. Greater understanding of the factors associated with discrepancies in health outcomes for people with SMIs can inform the development of strategies to address them.

The aim of the current study was to analyse an administrative data-set for England to explore factors associated with poor outcomes from hospital admission for younger adult patients (18–74 years old) with a specific physical health condition, chronic obstructive pulmonary disease (COPD), focusing on the presence of SMI and subgroups of SMIs. Our interest was in hospital admissions for reasons other than an SMI but where the SMI could be a complicating factor in symptom management. COPD was chosen as it is a common physical health condition with relatively high rates of hospital admission owing to exacerbation of symptoms. People with SMI have been shown to have high rates of respiratory disease, and that respiratory disease is associated with premature mortality in people with SMI.Reference Suetani, Honarparvar, Siskind, Hindley, Veronese and Vancampfort9 People with schizophrenia have higher rates of COPD than the general population and are more likely to die of infections such as pneumonia and influenza, common precipitants for COPD.Reference Olfson, Gerhard, Huang, Crystal and Stroup10 Our primary hypothesis was that people admitted to hospital with COPD who also had a SMI would have poorer outcomes than those admitted with COPD who did not have a SMI. The findings of the study should help clinicians and service managers to better understand the needs of people with a SMI when they are admitted to hospital, even if the primary reason for the admission was not the SMI.



Data analysis and presentation conformed to the current guidelines recommended by the National Health Service (NHS) in relation to using Hospital Episodes Statistics (HES) data-sets for care quality improvement purposes.11,12 The data were anonymised to the required level recommended by the ISB1523 Anonymisation Standard for Publishing Health and Social Care Data.13 Formal ethical approval for the study was not required because it did not directly involve human participants. This study was completed in accordance with the Helsinki Declaration as revised in 2013. Informed consent was not sought for the present study because it was an analysis of routine clinical data and did not directly involve human participants.

Study design and data collection

This was an exploratory, retrospective cohort study using administrative hospital activity data. Patients were followed up post-discharge through data linkage to subsequent hospital stays at a patient level. NHS Digital collects HES data for all patients admitted to hospitals in England where patient care is funded by the NHS. This includes patients admitted to private hospitals where their care was funded by the NHS. The data are collected predominantly to allow NHS trusts (which govern secondary and tertiary care hospitals in England) to be funded for providing hospital care. Data collection is mandatory, and data are entered by trained clinical coders from each trust.

Timing, case ascertainment, inclusion and exclusion criteria

HES data were extracted for the period from 1 April 2018 to 31 March 2019 for patients aged 18–74 years with COPD as the dominant diagnosis recorded as the disorder leading to the hospital stay. The discharge date, rather than the admission date, defined the data collection period, and patients who died during their stay were included. The study period was chosen as it was the last complete financial year of data prior to the COVID-19 pandemic, and this defined the sample size. COPD was identified using the ICD-10 codes J40–J44 inclusive. The descriptions associated with these codes are given in Supplementary Table 1 available at Patients aged ≥75 years were excluded as it was felt that issues related to age-related decline would otherwise dominate the data-set. This strategy is consistent with that of an earlier Nuffield Trust study on this topic.Reference Dorning, Davies and Blunt4 In instances where a patient underwent repeated hospital admissions over the course of the study period, only the first admission was retained. This ensured that all data points were independent at a patient level and avoided biasing the data with repeat admissions.


The primary exposure of interest was an SMI diagnosis recorded during the admission. Patients were identified as having an SMI if they had any of the following ICD-10 codes recorded in any position in their diagnostic record during the hospital stay: F20–29 (psychosis spectrum disorder), F30–31 (bipolar disorder). The descriptions associated with these codes are given in Supplementary Table 1.

In the sub-analysis, those with a non-affective psychosis spectrum disorder and those with a bipolar disorder were compared. Individuals who did not have an SMI or who had diagnoses of a psychosis spectrum disorder and a bipolar disorder were excluded from this sub-analysis (see results section for number of patients).


For this exploratory analysis, three outcome measures, where data were available, were deemed relevant.

  1. (a) Length of stay greater than the median (2 days). Length of stay data were dichotomised as the data were non-normally distributed with a long tail of long stays but little variability for the majority of patients, meaning that it was not possible to normalise the distribution.

  2. (b) Emergency readmission within 30 days of discharge. This was only recorded where the patient stayed for 1 night or more in hospital and was recorded for any cause. The occurrence of the event was recorded if one or more readmissions occurred.

  3. (c) In-hospital mortality. Mortality data were available from the UK Office for National Statistics and were recorded for any cause.

The values report for readmission and mortality can be thought of in terms of cumulative incidence. Although all three outcomes were chosen a priori and are NHS England standard outcome metrics, the exact method of analysis for length of stay was decided post hoc based on the data distribution.


  1. (a) Age: categorised into the following age groups: 18–49 years, 50–54 years, 55–59 years, 60–64 years, 65–69 years, and 70–74 years. Categorisation of the data was felt to make it more meaningful and easier to interpret for this exploratory analysis.

  2. (b) Sex: male or female.

  3. (c) Deprivation: recorded using the Index of Multiple Deprivation for the lower-layer super output area (LSOA) of the patient's home address, with scores categorised into quintiles based on national averages.14 England is divided into 32 844 geographically defined LSOAs by the Office for National Statistics, each with typically 1400–2000 residents.

  4. (d) Comorbidities: 17 comorbidities were taken from those used to construct the Charlson Comorbidity Index.Reference Quan, Li, Couris, Fushimi, Graham and Hider15 The index uses ICD-10 codes to identify the following comorbidities: peripheral vascular disease, chronic heart failure, acute myocardial infarction, cerebrovascular disease, dementia, pulmonary disease, connective tissue disease, peptic ulcer, diabetes (with and without chronic complications), hemiplegia/paraplegia, renal disease, primary cancer, metastatic cancer, mild liver disease, severe liver disease and HIV/AIDS. A comorbidity was deemed present if it was recorded in HES as a secondary diagnosis in the index admission or as a primary or secondary diagnosis in any admission during the previous year.Reference Quan, Li, Couris, Fushimi, Graham and Hider15

  5. (e) Elective or emergency admission. Elective admissions are planned admissions, often for a surgical procedure, and include day-case surgery.16

Data management and statistical analyses

Standard statistical software was used to conduct the analysis: Microsoft Excel (Microsoft Corp.), Stata (StataCorp LLC) and IBM SPSS (version 27, IBM Corp.). In the descriptive analysis, data were categorised as detailed above and summarised in terms of frequency and percentage. Length of stay was summarised using the median and interquartile range. Relationships between presence of an SMI and outcomes were explored with a multilevel, multivariable logistic regression model, using the melogit command in Stata. A two-level (patients nested within NHS hospital trusts) intercept-only model was constructed. NHS hospital trust was entered as a random effect to allow for clustering of cases within trusts. All models were adjusted for the covariates age (categorised into six age bands as described above), sex, deprivation quintile, the 17 comorbidities listed above (each entered as separate covariate as dichotomous variables (disease present versus disease absent)) and emergency versus elective admission.

Only in the case of deprivation were there missing values. These were for patients who did not have a permanent residence in England. Given the small numbers involved, no attempt was made to impute missing values. The models were summarised in terms of odds ratios and 95% confidence intervals. Confidence intervals were calculated based on the observed information matrix (inverse of the negative Hessian matrix) for the log-likelihood. Statistical significance was indicated by an odds ratio of a 95% confidence interval not crossing 1.


The data extraction process yielded a data-set of 54 578 patients, of whom 2096 (3.8%) had an SMI. Table 1 summarises the demographic, socioeconomic and comorbidity profiles of the cohort according to whether they had or did not have an SMI. Compared with those without an SMI, those with an SMI had a noticeably younger age profile and were slightly more likely to be female and from a more deprived area. In both the SMI and non-SMI groups, almost all admissions were non-elective. Unsurprisingly, pulmonary disease was the most common comorbidity. Although the SMI group had a younger age profile, many age-related comorbidities were more common in this group than in the non-SMI group. These included pulmonary disease, diabetes, chronic heart failure, liver disease, renal disease and dementia.

Table 1 Demographic and comorbidity profiles and outcomes of COPD patients with and without an SMI

SMI, serious mental illness; IQR, interquartile range.

a. Deprivation quintile is based on the Index of Multiple Deprivation score.

b. For the Charlson Comorbidity Index items, only those with the disease are listed. Individual patients can appear in multiple disease categories.

Patient outcomes are also summarised in Table 1. Median stay was longer for patients with SMI than those without. Despite the younger age structure of the SMI group, they had a higher rate of 30-day emergency readmissions and a similar mortality rate to the non-SMI group.

The exploratory multilevel, multivariable logistic regression model outputs are summarised in Table 2. SMI was associated with significantly greater odds of a length of stay greater than the median and 30-day emergency readmission but not in-hospital mortality.

Table 2 Summary of multivariable multilevel logistic regression modelsa for factors associated with SMI

SMI, serious mental illness.

a All models were adjusted for age, sex, deprivation, comorbidities and elective versus emergency admission.

A sub-analysis compared those with non-affective psychosis spectrum disorders only (n = 1188, 2.2%) and bipolar disorders only (n = 712, 1.3%). Both diagnoses were recorded in 196 (0.4%) patients, and these patients were excluded. Those with bipolar disorders were more likely to be female, although the groups were similar across other demographic variables and in terms of their comorbidity profile (Table 3). Multilevel, multivariable logistic regression model outputs are shown in Table 2. The odds of in-hospital mortality in those with bipolar disorder were significantly lower than in those with non-affective psychosis spectrum disorders. There was no difference in the odds of 30-day emergency readmissions or length of stay greater than the median.

Table 3 Demographic and comorbidity profile and outcomes of COPD patients with non-affective psychosis spectrum disorder and bipolar disorder

IQR, interquartile range.

a. Deprivation quintile is based on the Index of Multiple Deprivation score.

b. Charlson Index comorbidities are those recorded as a secondary diagnosis in the index admission or as a primary or secondary diagnosis in any admission during the previous year.


Our study explored the associations between the presence or absence of a SMI and outcomes for people aged 18–74 years who were admitted to hospital, where the primary reason for admission was not the SMI but a physical health condition. Focusing on a specific physical health condition, COPD, meant that our study cohort was relatively homogenous. We were also able to adjust for the presence of potential confounders. The presence of an SMI was associated with longer hospital stay and higher odds of early emergency readmissions. In the sub-analysis, patients with non-affective psychosis had higher odds of mortality than those with bipolar disorder.

Our work builds on the 2015 Nuffield Trust study by exploring in detail a specific physical health condition.Reference Dorning, Davies and Blunt4 There is limited published material regarding outcomes for people with an SMI who are admitted to hospital, and most such studies have been small scale and/or single site.Reference AbuRuz, Momani and Shajrawi17,Reference Sugawara, Metoki, Hagii, Saito, Shiroto and Tomita18 However, some larger-scale studies have been published. A retrospective analysis of administrative data from 16 898 patients admitted to hospital in Tasmania, Australia, was published in 2018.Reference Siddiqui, Dwyer, Stankovich, Peterson, Greenfield and Si19 The authors investigated length of stay for patients admitted with five chronic health conditions (lung or colorectal cancer, COPD, type II diabetes, ischaemic heart disease and stroke) and identified a significantly longer hospital stay for patients with a mental illness compared with those without. A Canadian study of 12 283 patients aged 65 years and older admitted to an acute care hospital in Newfoundland noted longer stay, higher readmission rates and greater cost of care for patients with mental illness.Reference Adams, Koop, Quan and Norris20 Overall, 8.3% of the older adults admitted to hospital had a mental illness. The Nuffield Trust report identified that SMI patients experienced 6.7 times more emergency admissions and greater length of stay than patients without an SMI.Reference Dorning, Davies and Blunt4 A study using the US Nationwide Readmissions Database for 6 328 613 medical and surgical admissions reported a 30-day medical readmission rate of 23.1% for patients with SMI versus 13.8% for patients without a SMI (adjusted odds ratios, 1.80, 95% CI 1.77–1.83).Reference Germack, Noor, Wang and Hanrahan21 Our study broadly supports the findings of all these previous studies despite methodological differences and differences in setting.

Our study did not seek to explore possible causes of poorer outcomes for people with an SMI who are admitted to hospital. However, previous research has suggested that impaired patient cognition, lack of involvement in patient self-care and rehabilitation, and perceived social stigma around raising SMI as a potential factor in hospital care could all contribute.Reference Baker, Grant and Gopalan22 Healthcare systems often require patients to actively seek help and support. This might pose a challenge for individuals with a diagnosis of SMI for a variety of reasons. Certain symptom profiles, such as difficulties with executive functioning, lack of knowledge, stigma and reduced social support can affect people's awareness, insight, motivation and ability to explain physical experiences.Reference Filipcic, Bajic and Filipcic5,Reference Anderson, Fuhrer and Malla23 This can prevent help-seeking. Once help has been sought, although healthcare professionals report good understanding of the importance of addressing physical health needs in people with SMI, lack of training, uncertainty and limited resources have been identified as barriers to care provision.Reference Butler, de Cassan, Turner, Lennox, Hayward and Glogowska24 Further investigation of the mechanisms by which an SMI influences outcomes of hospital admissions is needed if outcomes are to be improved.

We report a significantly higher mortality rate in patients with non-affective psychosis compared with those with bipolar disorder. Overall, the increased mortality rate and risk in schizophrenia found in the current study is consistent with the existing literature. One comprehensive study of all people diagnosed with schizophrenia or bipolar disorder in Denmark from 1965 to 2014 found that the standardised mortality ratio for schizophrenia was two times higher than that for bipolar disorder.Reference Lomholt, Andersen, Sejrsgaard-Jacobsen, Ozdemir, Graff and Schjerning25 A systematic review and meta-analysis of factors associated with mortality in schizophrenia found that whereas there were no differences in risk between schizophrenia and other psychiatric disorders overall, there was a difference in risk ratios between schizophrenia and bipolar disorder specifically, with people with schizophrenia being at a higher risk of mortality.Reference Correll, Solmi, Croatto, Schneider, Rohani-Montez and Fairley6

We were unable to comment on the effect of medication use, as such data are not collected in HES. Although use of second-generation antipsychotics has been linked to increased risk of pneumonia in people with SMI,Reference Correll, Detraux, De Lepeleire and De Hert26 all-cause mortality is higher in people with schizophrenia who are not prescribed anti-psychotic medication, and long-term benefits of treatment adherence in schizophrenia appear to counter the load created by adverse effects of medication.Reference Correll, Detraux, De Lepeleire and De Hert26,Reference Correll, Rubio and Kane27 One observational study showed that compared with people with bipolar disorder, people with schizophrenia had lower insight; this contributed to poorer medication adherence and worse therapeutic alliance with healthcare professionals, which may adversely affect physical health outcomes.Reference Novick, Montgomery, Treuer, Aguado, Kraemer and Haro28 Although medication may affect mortality rates and other adverse health outcomes in schizophrenia, its effects are likely to be dependent on a variety of factors, including attitudes towards medication and insight, dosing load, polypharmacy and potential medication interactions, as well as person-specific vulnerability factors. People with schizophrenia are more likely to have a poor diet, smoke more and exercise less, irrespective of socioeconomic status and medication use; this may also affect outcomes.Reference Osborn, Nazareth and King29

The SMI cohort was younger than the non-SMI cohort. Younger age may reflect the additional health burden of SMI, with COPD becoming more of a health burden at a younger age. The SMI cohort were also more likely to be female, although most of this excess was due to a large predominance of females in the subgroup of patients with bipolar disorder. Affective SMIs are known to be more common in females.Reference Boyd, Van de Velde, Vilagut, de Graaf, O'Neill and Florescu30

Strengths and limitations

This study has many strengths. It is the largest study of its kind to date. Furthermore, the study augments the paucity of data on length of stay for patients with COPD and an SMI. It is also the first study to investigate hospital usage in COPD patients with SMI compared with the reference population. We analysed data for the entire hospital-admitted population of a national healthcare system and were able to link outcomes over time and over different healthcare providers; thus, the risk of bias in the patient population when considering hospital-admitted populations should be low, at least within England and other countries with similar healthcare funding models. Further, our results may have relevance beyond acute hospital care, although we would caution against interpreting them as directly relevant to other settings. Studies examining the outcomes of patients with SMI in the ambulatory and community setting are warranted.

We chose to exclude patients aged <18 years and ≥75 years from our cohort. For older patients, it was felt that age-related health problems would be the dominant influence on outcomes and so mask associations in younger patients. Although findings would probably be quite different if the study were repeated in patients aged ≥75 years, we do not suggest that older patients with COPD and a SMI would not have poorer outcomes than those with COPD without an SMI, just that any association may be harder to identify. A similar study in older age groups and for people with different physical health conditions is merited.

Several limitations must also be acknowledged. As this was a retrospective study, the data were collected for administrative purposes and not primarily for research. As such, some SMIs and comorbidities may not have been recorded in the diagnostic record. Although validation of large administrative data-sets is difficult owing to the lack of a criterion standard against which to assess accuracy, members of our team have recently published a study investigating the consistency of coding diagnoses that are mandatory in HES.Reference Hardy, Heyl, Tucker, Hopper, Marcha and Briggs31,Reference Heyl, Hardy, Tucker, Hopper, Marcha and Liew32 Levels of consistency of coding of diagnoses from the first to a subsequent hospital stay varied from 91.4% for diabetes to 56.3% for autism, suggesting that this is an important issue for some conditions.

The administrative nature of the data meant there was a limited amount of information regarding presentation. Therefore, we were not able to quantify the severity of presenting COPD symptoms in each patient, nor the seriousness of each patient's mental health symptoms. Furthermore, the study only considered hospital usage and thus included very little information about care beyond the acute sector. There is a lack of data on some patient characteristics such as smoking status and health-related behaviours. Tobacco use is not consistently recorded in HES, and so we chose not to include it as a covariate in modelling. Current smoking status may well confound our findings, for example, if current smoking was more common in patients with SMI.Reference McDonald33,Reference Williams, Ziedonis, Abanyie, Steinberg, Foulds and Benowitz34 However, as the vast majority of our cohort will have been moderate or heavy tobacco smokers (even if not currently), this is unlikely to fully explain our findings. Given evidence that smoking cessation interventions can be successful in people with SMI,Reference Peckham, Brabyn, Cook, Tew and Gilbody35,Reference Gilbody, Peckham, Bailey, Arundel, Heron and Crosland36 the link between smoking and outcomes for people with SMI who are admitted to hospital should be further investigated.


Patients with COPD and a comorbidity of SMI had poorer outcomes than those with COPD and no SMI. Patients with a diagnosis of schizophrenia had higher mortality rates when admitted for their COPD than those with a diagnosis of bipolar disorder. Understanding more clearly the reasons for this will be key to improving patient outcomes. Clinicians need to be aware that people with an SMI are at particular risk of poor outcomes when admitted to hospital and should seek specialist advice to support medication adherence, make suitable adjustments to care provision during a hospital stay and ensure effective discharge planning.

As we move to integrated care boards across England, there is an opportunity to provide more holistic and joined-up physical healthcare for people with SMI, with the aims over time of taking a more preventive approach, reducing the premature mortality gap and supporting improved use of healthcare resources.

Supplementary material

Supplementary material is available online at

Data availability

Requests for any underlying data used in our analysis cannot be granted by the authors as the data are calculated from data under licence from NHS Digital, where conditions of use (and further use) apply. Therefore, we are unable to make our data available in a repository. However, HES data are available from NHS Digital upon request. The analytic code supporting the findings has not been made available to other researchers within a repository as it is relatively trivial. Sufficient details are presented in the Method section to allow reproduction of our analysis.


We acknowledge the UK Office for National Statistics and NHS Digital for permission to use their data in this report. We also thank all staff within individual NHS trusts who collected and entered the data used in this study.

Author contributions

This study was designed and organised by S.G., A.S., F.G., W.K.G., E.K. and S.K. Data cleaning, analysis and writing of the first draft were done by A.S. and S.G., supported by W.K.G. All authors critically reviewed the manuscript and agreed to submission of the final draft.


This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. S.G. and A.S. completed this work as part of an MSc degree at King's College London.

Declaration of interest

F.G. is a member of the BJPsych Open editorial board. F.G. did not take part in the review or decision-making process for this paper.



These authors contributed equally.


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Figure 0

Table 1 Demographic and comorbidity profiles and outcomes of COPD patients with and without an SMI

Figure 1

Table 2 Summary of multivariable multilevel logistic regression modelsa for factors associated with SMI

Figure 2

Table 3 Demographic and comorbidity profile and outcomes of COPD patients with non-affective psychosis spectrum disorder and bipolar disorder

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