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Meta-analytical study of productive and nutritional interactions of mycotoxins in growing pigs

Published online by Cambridge University Press:  28 November 2011

I. Andretta ,
M. Kipper ,
C. R. Lehnen ,
L. Hauschild ,
M. M. Vale  and
P. A. Lovatto
I. Andretta*
Affiliation:
Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
M. Kipper
Affiliation:
Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
C. R. Lehnen
Affiliation:
Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
L. Hauschild
Affiliation:
Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
M. M. Vale
Affiliation:
Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
P. A. Lovatto
Affiliation:
Grupo de Modelagem Animal, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil
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Abstract

A meta-analysis was carried out in order to study the association of mycotoxins with performance and organ weights in growing pigs. A total of 85 articles published between 1968 and 2010 were used, totaling 1012 treatments and 13 196 animals. The meta-analysis followed three sequential analyses: graphical, correlation and variance–covariance. The presence of mycotoxins in diets was seen to reduce the feed intake by 18% and the weight gain in 21% compared with the control group. Deoxynivalenol and aflatoxins were the mycotoxins with the greatest impact on the feed intake and growth of pigs, reducing by 26% and 16% in the feed intake and by 26% and 22% in the weight gain. The mycotoxin concentration in diets and the animal age at challenge were the variables that more improved the coefficient of determination in equations for estimating the effect of mycotoxins on weight gain. The mycotoxin effect on growth proved to be greater in younger animals. In addition, the residual analysis showed that the greater part of the variation in weight gain was explained by the variation in feed intake (87%). The protein and methionine levels in diets could influence the feed intake and the weight gain in challenged animals. The weight gain in challenged pigs showed a positive correlation with the methionine level in diets (0.68). The mycotoxin effect on growth was greater in males compared with the effect on females. The reduction in weight gain was of 15% in the female group and 19% in the male group. Mycotoxin presence in pig diets has interfered in the relative weight of the liver, the kidneys and the heart. Mycotoxins have an influence on performance and organ weight in pigs. However, the magnitude of the effects varies with the type and concentration of mycotoxin, sex and the animal age, as well as nutritional factors.

Keywords

aflatoxinsdeoxynivalenolnutritionswinetrichothecenes
Type
Full Paper
Information
animal , Volume 6 , Issue 9 , September 2012 , pp. 1476 - 1482
Copyright
Copyright © The Animal Consortium 2012

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References

Akande, KE, Abubakar, MM, Adegbola, TA, Bogoro, SE 2006. Nutritional and health implications of mycotoxins in animal feeds: a review. Pakistan Journal of Nutrition 5, 398–403.Google Scholar
Andretta, I, Lovatto, PA, Hauschild, L, Dilkin, P, Garcia, GG, Lanferdini, E, Cavazini, NC, Mallmann, CA 2008. Alimentação de leitoas pré-púberes com dietas contendo zearalenona. Arquivo Brasileiro de Medicina Veterinária e Zootecnia 60, 1227–1233.CrossRefGoogle Scholar
Behroozikha, M, Saidee, M, Allameh, A 1992. Comparison of aflatoxin B1-DNA binding and glutathione conjugate formation by liver preparations from rats of different ages. Cancer Letters 66, 69–76.CrossRefGoogle ScholarPubMed
Brown, D, Mount, LE 1982. The metabolic body size of the growing pig. Livestock Production Science 9, 389–398.CrossRefGoogle Scholar
Bryden, WL, Cumming, RB, Lloyd, AB 1980. Sex and strain responses to aflatoxin B1 in the chicken. Avian Pathology 9, 539–550.CrossRefGoogle ScholarPubMed
Castegnaro, M, Mohr, U, Pfohl-Leszkowicz, A, Estève, J, Steinmann, J, Tillmann, T, Michelon, J, Bartsch, H 1998. Sex- and strain-specific induction of renal tumors by ochratoxin A in rats correlates with DNA adduction. International Journal of Cancer 77, 70–75.3.0.CO;2-D>CrossRefGoogle ScholarPubMed
Coffey, MT, Hagler, WM Jr, Cullen, JM 1989. Influence of dietary protein, fat or amino acids on the response of weanling swine to aflatoxin B1. Journal of Animal Science 67, 465–472.CrossRefGoogle ScholarPubMed
Cote, LM, Beasley, VR, Bratich, PM, Swanson, SP, Shivaprasad, HL, Buck, WB 1985. Sex-related reduced weight gains in growing swine fed diets containing deoxynivalenol. Journal of Animal Science 61, 942–950.CrossRefGoogle ScholarPubMed
Coulombe, RA Jr 1993. Biological action of mycotoxins. Journal of Dairy Science 76, 880–891.CrossRefGoogle ScholarPubMed
Council for Agricultural Science and Technology (CAST) 2003. Mycotoxins: risks in plant, animal, and human systems. Task Force Report no. 139.Google Scholar
D'Mello, JPF, Placinta, CM, Macdonald, AMC 1999. Fusarium mycotoxins: a review of global implications for animal health, welfare and productivity. Animal Feed Science and Technology 80, 183–205.CrossRefGoogle Scholar
Dersjant-Li, Y, Verstegen, MWA, Gerrits, WJJ 2003. The impact of low concentrations of aflatoxin, deoxynivalenol or fumonisin in diets on growing pigs and poultry. Nutrition Research Reviews 16, 223–239.CrossRefGoogle ScholarPubMed
Dortant, PM, Peters-Volleberg, GWM, Van Loveren, H, Marquardt, RR, Speijers, GJA 2001. Age-related differences in the toxicity of ochratoxin A in female rats. Food and Chemical Toxicology 39, 55–65.CrossRefGoogle ScholarPubMed
Fatemi, F, Allameh, A, Dadkhah, A, Forouzandeh, M, Kazemnejad, S, Sharifi, R 2006. Changes in hepatic cytosolic glutathione S-transferase activity and expression of its class-P during prenatal and postnatal period in rats treated with aflatoxin B1. Archives of Toxicology 80, 572–579.CrossRefGoogle ScholarPubMed
Forbes, JM 2007. Voluntary food intake and diet selection of farm animals. CAB International, Wallingford, UK.CrossRefGoogle Scholar
Gurtoo, HL, Motycka, L 1976. Effect of sex difference on the in vitro and in vivo metabolism of aflatoxin B1 by the rat. Cancer Research 36, 4663–4671.Google ScholarPubMed
Hamilton, PB 1977. Interrelationships of mycotoxins with nutrition. Federation Proceedings 36, 1899–1902.Google ScholarPubMed
Hauschild, L, Lovatto, PA, Kunrath, MA, Carvalho, AÁ, Garcia, GG, Mallmann, CA 2006. Digestibilidade de dietas e balanços metabólicos de suínos alimentados com dietas contendo aflatoxinas. Ciência Rural 36, 1570–1575.CrossRefGoogle Scholar
Hedman, R, Thuvander, A, Gadhasson, I, Reverter, M, Pettersson, H 1997. Influence of dietary nivalenol exposure on gross pathology and selected immunological parameters in young pigs. Natural Toxins 5, 238–246.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Hussein, HS, Brasel, JM 2001. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167, 101–134.CrossRefGoogle ScholarPubMed
Klein, PJ, Van Vleet, TR, Hall, JO, Coulombe, JRA 2002. Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B1. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 132, 193–201.Google Scholar
Lin, WC, Liao, YC, Liau, MC, Lii, CK, Sheen, LY 2006. Inhibitory effect of CDA-II, a urinary preparation, on aflatoxin B1-induced oxidative stress and DNA damage in primary cultured rat hepatocytes. Food and Chemical Toxicology 44, 546–551.CrossRefGoogle Scholar
Lindemann, MD, Blodgett, DJ, Kornegay, ET, Schurig, GG 1993. Potential ameliorators of aflatoxicosis in weanling/growing swine. Journal of Animal Science 71, 171–178.CrossRefGoogle ScholarPubMed
Lovatto, PA, Lehnen, CR, Andretta, I, Carvalho, ADA, Hauschild, L 2007. Meta-análise em pesquisas científicas – enfoque em metodologias. Revista Brasileira de Zootecnia 36, 285–294.CrossRefGoogle Scholar
Marin, DE, Taranu, I, Pascale, F, Lionide, A, Burlacu, R, Bailly, J-D, Oswald, IP 2006. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. British Journal of Nutrition 95, 1185–1192.CrossRefGoogle ScholarPubMed
Meissonnier, GM, Laffitte, J, Loiseau, N, Benoit, E, Raymond, I, Pinton, P, Cossalter, AM, Bertin, G, Oswald, IP, Galtier, P 2007. Selective impairment of drug-metabolizing enzymes in pig liver during subchronic dietary exposure to aflatoxin B1. Food and Chemical Toxicology 45, 2145–2154.CrossRefGoogle ScholarPubMed
Newberne, PM, Butler, WH 1969. Acute and chronic effects of aflatoxin on the liver of domestic and laboratory animals: a review. Cancer Research 29, 236–250.Google ScholarPubMed
Noblet, J, Karege, C, Dubois, S, Van Milgen, J 1999. Metabolic utilization of energy and maintenance requirements in growing pigs: effects of sex and genotype. Journal of Animal Science 77, 1208–1216.CrossRefGoogle ScholarPubMed
Reed, DJ 1990. Glutathione: toxicological implications. Annual Review of Pharmacology and Toxicology 30, 603–631.CrossRefGoogle ScholarPubMed
Rotter, B, Thompson, B, Prelusky, D, Trenholm, H, Stewart, B, Miller, J, Savard, M 1996. Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. Journal of Natural Toxins 4, 42–50.CrossRefGoogle ScholarPubMed
Sauvant, D, Schmidely, P, Daudin, JJ 2005. Les méta-analyses des données expérimentales: applications en nutrition animale. INRA Productions Animales 18, 63–73.CrossRefGoogle Scholar
Sauvant, D, Schmidely, P, Daudin, JJ, St-Pierre, NR 2008. Meta-analyses of experimental data in animal nutrition. Animal 2, 1203–1214.CrossRefGoogle ScholarPubMed
Seligson, FH, Rotruck, JT 1983. Tissue nonprotein sulfhydryl content and weight gain of rats as affected by dietary methionine level. Journal of Nutrition 113, 98–104.CrossRefGoogle ScholarPubMed
Walle, JVD, Sergent, T, Piront, N, Toussaint, O, Schneider, Y-J, Larondelle, Y 2010. Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis. Toxicology and Applied Pharmacology 245, 291–298.CrossRefGoogle ScholarPubMed