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Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Published online by Cambridge University Press:  01 September 2008

S. G. Gebhardt-Henrich*
Division of Animal Housing and Welfare, Vetsuisse Faculty Bern, P.0. Box, CH-3001 Bern, Switzerland
J. F. Edwards
Institute of Animal Pathology, Vetsuisse Faculty Bern, P.O. Box, CH-3001 Bern, Switzerland
T. R. Famula
Department of Animal Science, University of California Davis, Davis, California 95616, USA
H.-P. Lipp
Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
A. Steiger
Division of Animal Housing and Welfare, Vetsuisse Faculty Bern, P.0. Box, CH-3001 Bern, Switzerland
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Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified. However, when a binary score (hydrocephalus, no hydrocephalus) was used, no such major locus could be detected and results of test matings were not consistent with Mendelian inheritance. Golden hamsters with severe forms of hydrocephalus had a dorsally compressed and ventrally intact hippocampus. Implications for the behavior and well-being of affected hamsters are unknown but researchers using this strain should be aware of the likely presence of hydrocephalus.

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animal , Volume 2 , Issue 9 , September 2008 , pp. 1265 - 1272
Copyright © The Animal Consortium 2008

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