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Identification of early predictors of carriers of the Booroola gene in sheep using a mixed inheritance model

Published online by Cambridge University Press:  02 September 2010

G. J. Nieuwhof ,
A. H. Visscher ,
B. Engel ,
J. H. J. van der Werf ,
F. H. de Jong  and
M. Dijkstra
G. J. Nieuwhof
Affiliation:
ID-DLO, Institute for Animal Science and Health, PO Box 65, 8200 AB Lelystad, The Netherlands
A. H. Visscher
Affiliation:
ID-DLO, Institute for Animal Science and Health, PO Box 65, 8200 AB Lelystad, The Netherlands
B. Engel
Affiliation:
ID-DLO, Institute for Animal Science and Health, PO Box 65, 8200 AB Lelystad, The Netherlands
J. H. J. van der Werf
Affiliation:
ID-DLO, Institute for Animal Science and Health, PO Box 65, 8200 AB Lelystad, The Netherlands
F. H. de Jong
Affiliation:
Department of Endocrinology and Reproduction, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands
M. Dijkstra
Affiliation:
ID-DLO, Institute for Animal Science and Health, PO Box 65, 8200 AB Lelystad, The Netherlands
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Abstract

A study was conducted to find early predictors of the Booroola gene in several generations of a crossbred sheep population. Merino carriers of the Booroola gene were mated with Texel sheep to improve prolificacy of the latter. Ovulation rate at 8 months of age, litter size at 1 and 2 years of age and FSH and inhibin levels at 3, 4, 5 and 6 weeks of age were determined in about 700 females.

Gibbs sampling was applied for inference in a mixed inheritance model. Estimates for the gene effect in heterozygous females were +1·5 corpora lutea and +1·3 lambs at 2 years of age. The gene effect on litter size at 1 year was small. The only significant major gene effect for hormone levels found was for lnINH4 (–0·66).

A number of hormone levels and combinations of hormone levels appeared to be useful predictors of carrier status of individual animals. In comparison with a situation where only parents' genotype is known, posterior probabilities for non-carriers were on average increased from 50 to over 95% when FSH levels were used. However, the combined posterior probabilities of carriers and non-carriers increased only up to 67%. So in general, classification with Gibbs sampling resulted in too few animals being identified as carrier. The sum of FSH levels at 3, 4, 5 and 6 weeks of age is proposed as a predictor of presence of the Booroola gene in an animal. Multivariate analysis of mixed inheritance models could help to find more effective combinations.

Keywords

Booroola geneFSHinheritanceinhibinsheep
Type
Research Article
Information
Animal Science , Volume 67 , Issue 2 , October 1998 , pp. 317 - 325
Copyright
Copyright © British Society of Animal Science 1998

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