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A review of foot-and-mouth disease virus (FMDV) testing in livestock with an emphasis on the use of alternative diagnostic specimens

Published online by Cambridge University Press:  22 October 2018

Korakrit Poonsuk Open the ORCID record for Korakrit Poonsuk [Opens in a new window] ,
Luis Giménez-Lirola  and
Jeffrey J. Zimmerman
Korakrit Poonsuk*
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
Luis Giménez-Lirola
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
Jeffrey J. Zimmerman
Affiliation:
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA
*
Author for correspondence: Korakrit Poonsuk, Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA. E-mail: poonsuk@iastate.edu
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Abstract

Foot-and-mouth disease virus (FMDV) remains an important pathogen of livestock more than 120 years after it was identified, with annual costs from production losses and vaccination estimated at €5.3–€17 billion (US$6.5–US$21 billion) in FMDV-endemic areas. Control and eradication are difficult because FMDV is highly contagious, genetically and antigenically diverse, infectious for a wide variety of species, able to establish subclinical carriers in ruminants, and widely geographically distributed. For early detection, sustained control, or eradication, sensitive and specific FMDV surveillance procedures compatible with high through-put testing platforms are required. At present, surveillance relies on the detection of FMDV-specific antibody or virus, most commonly in individual animal serum, vesicular fluid, or epithelial specimens. However, FMDV or antibody are also detectable in other body secretions and specimens, e.g., buccal and nasal secretions, respiratory exhalations (aerosols), mammary secretions, urine, feces, and environmental samples. These alternative specimens offer non-invasive diagnostic alternatives to individual animal sampling and the potential for more efficient, responsive, and cost-effective surveillance. Herein we review FMDV testing methods for contemporary and alternative diagnostic specimens and their application to FMDV surveillance in livestock (cattle, swine, sheep, and goats).

Keywords

DiagnosisFMDVfoot-and-mouth disease virusreviewspecimensurveillance
Type
Review Article
Information
Animal Health Research Reviews , Volume 19 , Issue 2 , December 2018 , pp. 100 - 112
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Copyright
Copyright © Cambridge University Press 2018 

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References

Alexandersen, S and Donaldson, AI (2002) Further studies to quantify the dose of natural aerosols of foot-and-mouth disease virus for pigs. Epidemiology and Infection 128, 313–323.Google Scholar
Alexandersen, S and Mowat, N (2005) Foot-and-mouth disease: host range and pathogenesis. In Compans, RW, Cooper, MD, Honjo, T, Melchers, F, Olsnes, S and Vogt, PK (eds), Foot-and-Mouth Disease Virus. Berlin: Springer-Verlag Berlin Heidelberg, pp. 9–42.Google Scholar
Alexandersen, S, Oleksiewicz, MB and Donaldson, AI (2001) The early pathogenesis of foot-and-mouth disease in pigs infected by contact: a quantitative time-course study using TaqMan RT-PCR. Journal of General Virology 82, 747–755.Google Scholar
Alexandersen, S, Zhang, Z and Donaldson, AI (2002 a) Aspects of the persistence of foot-and-mouth disease virus in animals – the carrier problem. Microbes and Infection 4, 1099–1110.Google Scholar
Alexandersen, S, Brotherhood, I and Donaldson, AI (2002 b) Natural aerosol transmission of foot-and-mouth disease virus to pigs: minimal infectious dose for strain O 1 lausanne. Epidemiology and Infection 128, 301–312.Google Scholar
Alexandersen, S, Zhang, Z, Reid, SM, Hutchings, GH and Donaldson, AI (2002 c) Quantities of infectious virus and viral RNA recovered from sheep and cattle experimentally infected with foot-and-mouth disease virus O UK 2001. Journal of General Virology 83, 1915–1923.Google Scholar
Alexandersen, S, Zhang, Z, Donaldson, AI and Garland, AJM (2003 a) The pathogenesis and diagnosis of foot-and-mouth disease. Journal of Comparative Pathology 129, 1–36.Google Scholar
Alexandersen, S, Quan, M, Murphy, C, Knight, J and Zhang, Z (2003 b) Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus. Journal of Comparative Pathology 129, 268–282.Google Scholar
Amadori, M, Haas, B, Moos, A and Zerbini, I (2000) IgA response of cattle to FMDV infection in probang and saliva samples. EU FMD, Ras Gr, Borovets Appendix 9, 88–106.Google Scholar
Archetti, IL, Amadori, M, Donn, A, Salt, J and Lodetti, E (1995) Detection of foot-and-mouth disease virus-infected cattle by assessment of antibody response in oropharyngeal fluids. Journal of Clinical Microbiology 33, 79–84.Google Scholar
Armstrong, RM (1997) The detection of antibodies against foot-and-mouth disease virus in sheep milk. Journal of Virological Methods 69, 45–51.Google Scholar
Armstrong, RM and Mathew, ES (2001) Predicting herd protection against foot-and-mouth disease by testing individual and bulk tank milk samples. Journal of Virological Methods 97, 87–99.Google Scholar
Armstrong, RM, Cox, SJ, Aggarwal, N, Mackay, DJ, Davies, PR, Hamblin, PA and Paton, DJ (2005) Detection of antibody to the foot-and-mouth disease virus (FMDV) non-structural polyprotein 3ABC in sheep by ELISA. Journal of Virological Methods 125, 153–163.Google Scholar
Arzt, J, Baxt, B, Grubman, MJ, Jackson, T, Juleff, N, Rhyan, J, Rieder, E, Waters, R and Rodriguez, LL (2011 a) The pathogenesis of foot-and-mouth disease II: viral pathways in swine small ruminants and wildlife; myotropism chronic syndromes and molecular virus–host interactions. Transboundary and Emerging Diseases 58, 305–326.Google Scholar
Arzt, J, Juleff, N, Zhang, Z and Rodriguez, LL (2011 b) The pathogenesis of foot-and-mouth disease I: viral pathways in cattle. Transboundary and Emerging Diseases 58, 291–304.Google Scholar
Bachanek-Bankowska, K, Mero, HR, Wadsworth, J, Mioulet, V, Sallu, R, Belsham, GJ, Kasanga, CJ, Knowles, NJ and King, DP (2016) Development and evaluation of tailored specific real-time RT-PCR assays for detection of foot-and-mouth disease virus serotypes circulating in East Africa. Journal of Virological Methods 237, 114–120.Google Scholar
Bachrach, HL (1968) Foot-and-mouth disease. Annual Review of Microbiology 22, 201–244.Google Scholar
Bachrach, HL (1977). Foot and mouth disease virus: properties molecular biology and immunogenicity. In Diener, TO and Romberger, JA (eds), Beltsville Symposia in Agricultural Research. I. Virology in Agriculture, vol. 1. New Jersey: Abacus Press, pp. 3–32.Google Scholar
Bachrach, HL, Hess, WR and Callis, JJ (1955) Foot-and-mouth disease virus: its growth and cytopathogenicity in tissue culture. Science 122, 1269–1270.Google Scholar
Bastos, ADS, Boshoff, CI, Keet, DF, Bengis, RG and Thomson, GR (2000) Natural transmission of foot-and-mouth disease virus between African buffalo (Syncerus caffer) and impala (Aepyceros melampus) in the Kruger National Park South Africa. Epidemiology and Infection 124, 591–598.Google Scholar
Baxt, B and Mason, PW (1995) Foot-and-mouth disease virus undergoes restricted replication in macrophage cell cultures following Fc receptor-mediated adsorption. Virology 207, 503–509.Google Scholar
Bedson, SP and Maitland, HB (1927) Further observations on foot and mouth disease section D experiments on the cultivation of the virus of foot and mouth disease. Journal of Comparative Pathology and Therapeutics 40, 79–93.Google Scholar
Bergmann, IE, Malirat, V, Neitzert, E and Melo, EC (2004) Vaccination: foot-and-mouth disease experience in South America. Developments in Biologicals (Basel) 119, 273–282.Google Scholar
Biswas, JK, Paton, DJ, Taylor, G and Parida, S (2008) Detection of persistently foot-and-mouth disease infected cattle by salivary IgA test: the global control of FMD – Tools ideas and ideals. In Open session of the EU FMD Standing Technical Committee, Erice, Italy, 14–17 October 2008, pp. 377–382.Google Scholar
Blackwell, JH, Wool, S and Kosikowski, FV (1981) Vesicular exocytosis of foot-and-mouth disease virus from mammary gland secretory epithelium of infected cows. Journal of General Virology 56, 207–212.Google Scholar
Blackwell, JH, McKercher, PD, Kosikowski, FV, Carmichael, LE and Gorewit, RC (1982) Concentration of foot-and-mouth disease virus in milk of cows infected under simulated field conditions. Journal of Dairy Science 65, 1624–1631.Google Scholar
Brehm, KE, Ferris, NP, Lenk, M, Riebe, R and Haas, B (2009) Highly sensitive fetal goat tongue cell line for detection and isolation of foot-and-mouth disease virus. Journal of Clinical Microbiology 47, 3156–3160.Google Scholar
Brito, BP, Rodriguez, LL, Hammond, JM, Pinto, J and Perez, AM (2017) Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014. Transboundary and Emerging Diseases 64, 316–332.Google Scholar
Brocchi, E, Bergmann, IE, Dekker, A, Paton, DJ, Sammin, DJ, Greiner, M, Grazioli, S, De Simone, F, Yadin, H, Haas, B and Bulut, N (2006) Comparative evaluation of six ELISAs for the detection of antibodies to the non-structural proteins of foot-and-mouth disease virus. Vaccine 24, 6966–6979.Google Scholar
Brooksby, J (1958) The virus of foot-and-mouth disease. In Smith, K and Lauffer, M (eds), Advances in Virus Research, vol. 5. Cambridge: Academic Press, pp. 1–37.Google Scholar
Brooksby, JB (1982) Portraits of viruses: foot-and-mouth disease virus. Intervirology 18, 1–23.Google Scholar
Brooksby, JB and Rogers, J (1957) Methods used in typing the virus of foot-and-mouth disease at Pirbright, 1950–1955. Methods of Typing and Cultivation of Foot-and-Mouth Disease Virus. Project 208 of OEEC, Paris, pp. 31–34.Google Scholar
Brown, CC, Meyer, RF, Olander, HJ, House, C and Mebus, CA (1992) A pathogenesis study of foot-and-mouth disease in cattle, using in situ hybridization. Canadian Journal of Veterinary Research 56, 189–193.Google Scholar
Brown, F (2003) The history of research in foot-and-mouth disease. Virus Research 91, 3–7.Google Scholar
Burrows, R (1968) The persistence of foot-and-mouth disease virus in sheep. Epidemiology and Infection 66, 633–640.Google Scholar
Burrows, R, Mann, JA, Greig, A, Chapman, WG and Goodridge, D (1971) The growth and persistence of foot-and-mouth disease virus in the bovine mammary gland. Epidemiology and Infection 69, 307–321.Google Scholar
Burrows, R, Mann, JA, Garland, AJM, Greig, A and Goodridge, D (1981) The pathogenesis of natural and simulated natural foot-and-mouth disease infection in cattle. Journal of Comparative Pathology 91, 599–609.Google Scholar
Callahan, JD, Brown, F, Osorio, FA, Sur, JH, Kramer, E, Long, GW, Lubroth, J, Ellis, SJ, Shoulars, KS, Gaffney, KL and Rock, DL (2002) Use of a portable real-time reverse transcriptase-polymerase chain reaction assay for rapid detection of foot-and-mouth disease virus. Journal of the American Veterinary Medical Association 220, 1636–1642.Google Scholar
Callens, M and De Clercq, K (1999) Highly sensitive detection of swine vesicular disease virus based on a single tube RT-PCR system and DIG-ELISA detection. Journal of Virological Methods 77, 87–99.Google Scholar
Callens, M, De Clercq, K, Gruia, M and Danes, M (1998) Detection of foot-and-mouth disease by reverse transcription polymerase chain reaction and virus isolation in contact sheep without clinical signs of foot-and-mouth disease. Veterinary Quarterly 20 (Suppl. 2), 37–40.Google Scholar
Capstick, PB, Telling, RC, Chapman, WG and Stewar, DL (1962) Growth of a cloned strain of hamster kidney cells in suspended cultures and their susceptibility to the virus of foot-and-mouth disease. Nature 195, 1163–1164.Google Scholar
Cardassis, J, Pappous, C, Brovas, D, Strouratis, P and Seimenis, A (1966) Test of infectivity and dosage of foot and mouth disease vaccine in sheep. Bulletin De L'office International Des Épizooties 65, 427–438.Google Scholar
Carrillo, C, Tulman, ER, Delhon, G, Lu, Z, Carreno, A, Vagnozzi, A and Rock, DL (2005) Comparative genomics of foot-and-mouth disease virus. Journal of Virology 79, 6487–6504.Google Scholar
Cartwright, B, Chapman, WG and Brown, F (1980) Serological and immunological relationships between the 146S and 12S particles of foot-and-mouth disease virus. Journal of General Virology 50, 369–375.Google Scholar
Christensen, LS, Normann, P, Thykier-Nielsen, S, Sørensen, JH, de Stricker, K and Rosenørn, S (2005) Analysis of the epidemiological dynamics during the 1982–1983 epidemic of foot-and-mouth disease in Denmark based on molecular high-resolution strain identification. Journal of General Virology 86, 2577–2584.Google Scholar
Ciuca, A (1929) The reaction of complement fixation in foot-and-mouth disease as a means of identifying the different types of virus. Epidemiology and Infection 28, 325–339.Google Scholar
Cottral, GE (1969) Persistence of foot-and-mouth disease virus in animals, their products and the environment. Bulletin De L'office International Des Épizooties 70, 549–568.Google Scholar
Cottral, GE and Bachrach, HL (1968) Foot-and-mouth disease viremia. Proceedings of the Annual Meeting of the United States Livestock Sanitary Association 67, 463–472.Google Scholar
Crowther, JR and Abu-El Zein, EME (1979) Detection and quantification of foot and mouth disease virus by enzyme labelled immunosorbent assay techniques. Journal of General Virology 42, 597–602.Google Scholar
Crowther, JR and Elzein, EA (1979) Application of the enzyme linked immunosorbent assay to the detection and identification of foot-and-mouth disease viruses. Epidemiology and Infection 83, 513–519.Google Scholar
Crowther, JR and Elzein, EA (1980) Detection of antibodies against foot-and-mouth disease virus using purified Staphylococcus A protein conjugated with alkaline phosphatase. Journal of Immunological Methods 34, 261–267.Google Scholar
De Leeuw, PW, Van Bekkum, JG and Tiessink, JWA (1978) Excretion of foot-and-mouth disease virus in oesophageal-pharyngeal fluid and milk of cattle after intranasal infection. Epidemiology and Infection 81, 415–426.Google Scholar
De Rueda, CB, De Jong, MC, Eblé, PL and Dekker, A (2015) Quantification of transmission of foot-and-mouth disease virus caused by an environment contaminated with secretions and excretions from infected calves. Veterinary Research 46, 43. doi: 10.1186/ s13567-015-0156-5.Google Scholar
Dinka, SK, Swaney, LM and McVicar, JW (1977) Selection of a stable clone of the MVPK-1 fetal porcine kidney cell for assays of foot-and-mouth disease virus. Canadian Journal of Microbiology 23, 295–299.Google Scholar
Doel, CMA, Gloster, J and Valarcher, JF (2009) Airborne transmission of foot-and-mouth disease in pigs: evaluation and optimisation of instrumentation and techniques. The Veterinary Journal 179, 219–224.Google Scholar
Doel, T (2003) FMD vaccines. Virus Research 91, 81–99.Google Scholar
Domingo, E, Baranowski, E, Escarmís, C and Sobrino, F (2002) Foot-and-mouth disease virus. Comparative Immunology Microbiology and Infectious Diseases 25, 297–308.Google Scholar
Donaldson, AI and Alexandersen, S (2002) Predicting the spread of foot and mouth disease by airborne virus. Revue Scientifique et Technique-Office International Des Épizooties 21, 569–578.Google Scholar
Donaldson, AI and Ferris, NP (1980) Sites of release of airborne foot-and-mouth disease virus from infected pigs. Research in Veterinary Science 29, 315–319.Google Scholar
Donaldson, AI, Gibson, CF, Oliver, R, Hamblin, C and Kitching, RP (1987) Infection of cattle by airborne foot-and-mouth disease virus: minimal doses with O1 and SAT 2 strains. Research in Veterinary Science 43, 339–346.Google Scholar
Eblé, PL, Bouma, A, Weerdmeester, K, Stegeman, JA and Dekker, A (2007) Serological and mucosal immune responses after vaccination and infection with FMDV in pigs. Vaccine 25, 1043–1054.Google Scholar
Elzein, EA and Crowther, JR (1978) Enzyme-labelled immunosorbent assay techniques in foot-and-mouth disease virus research. Epidemiology and Infection 80, 391–399.Google Scholar
Fayed, AAA, Abdel-Halim, MM and Shaker, N (2013) Value of individual and bulk milk serology for surveillance and evaluation of vaccination programs used in dairy farms in Egypt to control FMD virus infection. International Journal of Veterinary Medicine 2013, 1–11. doi: 10.5171/2013.730973.Google Scholar
Fenner, F (1990) Poxviruses. In Fields, BN, Knipe, DM, Chanock, RM, Hirsch, MS, Melnick, J, Monath, TP, and Roizman, B (eds), Virology. New York: Raven Press, pp. 2113–2133.Google Scholar
Fenner, FJ, Gibbs, PJ, Murphy, FA, Rott, R, Studdert, MJ and White, DO (1993). Herpesviridae. In Fenner, F, Bachmann, PA and Gibbs, PJ (eds), Veterinary Virology. London: Academic Press, pp. 337–368.Google Scholar
Ferris, NP and Dawson, M (1988) Routine application of enzyme-linked immunosorbent assay in comparison with complement fixation for the diagnosis of foot-and-mouth and swine vesicular diseases. Veterinary Microbiology 16, 201–209.Google Scholar
Ferris, NP and Donaldson, AI (1992) The World Reference Laboratory for Foot and Mouth Disease: a review of thirty-three years of activity (1958–1991). Revue Scientifique Et Technique-Office International Des Epizooties 11, 657–657.Google Scholar
Ferris, NP, King, DP, Reid, SM, Hutchings, GH, Shaw, AE, Paton, DJ, Goris, N, Haas, B, Hoffmann, B, Brocchi, E and Bugnetti, M (2006 a) Foot-and-mouth disease virus: a first inter-laboratory comparison trial to evaluate virus isolation and RT-PCR detection methods. Veterinary Microbiology 117, 130–140.Google Scholar
Ferris, NP, King, DP, Reid, SM, Shaw, AE and Hutchings, GH (2006 b) Comparisons of original laboratory results and retrospective analysis by real-time reverse transcriptase-PCR of virological samples collected from confirmed cases of foot-and-mouth disease in the UK in 2001. The Veterinary Record 159, 373–378.Google Scholar
Ferris, NP, Nordengrahn, A, Hutchings, GH, Reid, SM, King, DP, Ebert, K, Paton, DJ, Kristersson, T, Brocchi, E, Grazioli, S and Merza, M (2009) Development and laboratory validation of a lateral flow device for the detection of foot-and-mouth disease virus in clinical samples. Journal of Virological Methods 155, 10–17.Google Scholar
Ferris, NP, Nordengrahn, A, Hutchings, GH, Paton, DJ, Kristersson, T, Brocchi, E, Grazioli, S and Merza, M (2010) Development and laboratory validation of a lateral flow device for the detection of serotype SAT 2 foot-and-mouth disease viruses in clinical samples. Journal of Virological Methods 163, 474–476.Google Scholar
Francis, MJ and Black, L (1983) Antibody response in pig nasal fluid and serum following foot-and-mouth disease infection or vaccination. Epidemiology and Infection 91, 329–334.Google Scholar
Frenkel, HS (1947) La culture du virus de la fièvre aphteuse sur l’épithelium de la langue des bovidés. Bulletin De L'office International Des Épizooties 28, 155–162.Google Scholar
Fukai, K, Yamada, M, Morioka, K, Ohashi, S, Yoshida, K, Kitano, R, Yamazoe, R and Kanno, T (2015) Dose-dependent responses of pigs infected with foot-and-mouth disease virus O/JPN/2010 by the intranasal and intraoral routes. Archives of Virology 160, 129–139.Google Scholar
Galloway, IA, Henderson, WM and Brooksby, JB (1948) Strains of the virus of foot-and-mouth disease recovered from outbreaks in Mexico. Proceedings of the Society for Experimental Biology and Medicine 69: 57–64.Google Scholar
Garland, AJ (1974) The Inhibitory Activity of Secretions in Cattle against Foot and Mouth Disease Virus (Doctoral dissertation). School of Hygiene & Tropical Medicine, London. doi: 10.17037/PUBS.00878722.Google Scholar
Gebauer, F, De La Torre, JC, Gomes, I, Mateu, MG, Barahona, H, Tiraboschi, B, Bergmann, I, De Mello, PA and Domingo, E (1988) Rapid selection of genetic and antigenic variants of foot-and-mouth disease virus during persistence in cattle. Journal of Virology 62, 2041–2049.Google Scholar
Geering, WA (1967) Foot-and-mouth disease in sheep. Australian Veterinary Journal 43, 485–489.Google Scholar
Gibbs, EPJ, Herniman, KA, Lawman, MJ and Sellers, RF (1975 a) Foot-and-mouth disease in British deer: transmission of virus to cattle sheep and deer. The Veterinary Record 96, 558–563.Google Scholar
Gibbs, EPJ, Herniman, KAJ and Lawman, MJP (1975 b) Studies with foot-and-mouth disease virus in British deer (muntjac and sika): clinical disease recovery of virus and serological response. Journal of Comparative Pathology 85, 361–366.Google Scholar
Gibson, CF and Donaldson, AI (1986) Exposure of sheep to natural aerosols of foot-and-mouth disease virus. Research in Veterinary Science 41, 45–49.Google Scholar
Golding, SM, Hedger, RS and Talbot, P (1976) Radial immuno-diffusion and serum-neutralisation techniques for the assay of antibodies to swine vesicular disease. Research in Veterinary Science 20, 142–147.Google Scholar
Grau, FR, Schroeder, ME, Mulhern, EL, McIntosh, MT and Bounpheng, MA (2015) Detection of African swine fever classical swine fever and foot-and-mouth disease viruses in swine oral fluids by multiplex reverse transcription real-time polymerase chain reaction. Journal of Veterinary Diagnostic Investigation 27, 140–149.Google Scholar
Grubman, MJ (2005) Development of novel strategies to control foot-and-mouth disease: marker vaccines and antivirals. Biologicals 33, 227–234.Google Scholar
Grubman, MJ and Baxt, B (2004) Foot-and-mouth disease. Clinical Microbiology Reviews 17, 465–493.Google Scholar
Hamblin, C, Armstrong, RM and Hedger, RS (1984) A rapid enzyme-linked immunosorbent assay for the detection of foot-and-mouth disease virus in epithelial tissues. Veterinary Microbiology 9, 435–443.Google Scholar
Henderson, LM (2005) Overview of marker vaccine and differential diagnostic test technology. Biologicals 33, 203–209.Google Scholar
Henderson, WM and Brooksby, JB (1948) The survival of foot-and-mouth disease virus in meat and offal. Epidemiology and Infection 46, 394–402.Google Scholar
Hindson, BJ, Reid, SM, Baker, BR, Ebert, K, Ferris, NP, Tammero, LFB and Hullinger, PJ (2008) Diagnostic evaluation of multiplexed reverse transcription-PCR microsphere array assay for detection of foot-and-mouth and look-alike disease viruses. Journal of Clinical Microbiology 46, 1081–1089.Google Scholar
Höfner, MC, Carpenter, WC and Donaldson, AI (1993) Detection of foot-and-mouth disease virus RNA in clinical samples and cell culture isolates by amplification of the capsid coding region. Journal of Virological Methods 42, 53–61.Google Scholar
House, C and House, JA (1989) Evaluation of techniques to demonstrate foot-and-mouth disease virus in bovine tongue epithelium: comparison of the sensitivity of cattle mice primary cell cultures cryopreserved cell cultures and established cell lines. Veterinary Microbiology 20, 99–109.Google Scholar
Howson, ELA, Armson, B, Madi, M, Kasanga, CJ, Kandusi, S, Sallu, R, Chepkwony, E, Siddle, A, Martin, P, Wood, J and Mioulet, V (2017) Evaluation of two lyophilized molecular assays to rapidly detect foot-and-mouth disease virus directly from clinical samples in field settings. Transboundary and Emerging Diseases 64, 861–871.Google Scholar
Howson, ELA, Armson, B, Lyons, NA, Chepkwony, E, Kasanga, CJ, Kandusi, S, Ndusilo, N, Yamazaki, W, Gizaw, D, Cleaveland, S and Lembo, T (2018) Direct detection and characterization of foot-and-mouth disease virus in East Africa using a field-ready real-time PCR platform. Transboundary and Emerging Diseases 65, 221–231.Google Scholar
Hughes, GJ, Mioulet, V, Kitching, RP, Woolhouse, MEJ, Alexandersen, S and Donaldson, AI (2002) Foot-and-mouth disease virus infection of sheep: implications for diagnosis and control. Veterinary Records 150, 724–727.Google Scholar
Jiang, T, Liang, Z, Ren, W, Chen, J, Zhi, X, Qi, G and Cai, X (2011) Development and validation of a lateral flow immunoassay using colloidal gold for the identification of serotype-specific foot-and-mouth disease virus O A and Asia 1. Journal of Virological Methods 171, 74–80.Google Scholar
Juleff, N, Windsor, M, Reid, E, Seago, J, Zhang, Z, Monaghan, P, Morrison, IW and Charleston, B (2008) Foot-and-mouth disease virus persists in the light zone of germinal centres. PLoS ONE 3, e3434.Google Scholar
Kim, AY, Tark, D, Kim, H, Kim, JS, Lee, JM, Kwon, M, Bae, S, Kim, B and Ko, YJ (2017) Determination of optimal age for single vaccination of growing pigs with foot-and-mouth disease bivalent vaccine in South Korea. Journal of Veterinary Medical Science 79, 1822–1825.Google Scholar
King, DP, Ferris, NP, Shaw, AE, Reid, SM, Hutchings, GH, Giuffre, AC and Beckham, TR (2006) Detection of foot-and-mouth disease virus: comparative diagnostic sensitivity of two independent real-time reverse transcription-polymerase chain reaction assays. Journal of Veterinary Diagnostic Investigation 18, 93–97.Google Scholar
Kitching, RP (1998) A recent history of foot-and-mouth disease. Journal of Comparative Pathology 118, 89–108.Google Scholar
Kitching, RP (2002 a) Clinical variation in foot and mouth disease: cattle. Revue Scientifique et Technique-Office International Des Epizooties 21, 499–502.Google Scholar
Kitching, RP (2002 b) Identification of foot and mouth disease virus carrier and subclinically infected animals and differentiation from vaccinated animals. Revue Scientifique Et Technique-Office International Des Epizooties 21, 531–535.Google Scholar
Kitching, RP and Alexandersen, S (2002) Clinical variation in foot and mouth disease: pigs. Revue Scientifique Et Technique-Office International Des Epizooties 21, 513–516.Google Scholar
Kitching, RP and Hughes, GJ (2002) Clinical variation in foot and mouth disease: sheep and goats. Revue Scientifique Et Technique-Office International Des Epizooties 21, 505–510.Google Scholar
Kittawornrat, A, Prickett, J, Chittick, W, Wang, C, Engle, M, Johnson, J, Patnayak, D, Schwartz, T, Whitney, D, Olsen, C, Schwartz, K and Zimmerman, J (2010) Porcine reproductive and respiratory syndrome virus (PRRSV) in serum and oral fluid samples from individual boars: will oral fluid replace serum for PRRSV surveillance? Virus Research 154, 170–176.Google Scholar
Knight-Jones, TJD, McLaws, M and Rushton, J (2017) Foot-and-mouth disease impact on smallholders – what do we know what don't we know and how can we find out more? Transboundary and Emerging Diseases 64, 1079–1094.Google Scholar
Korn, G (1957) Experimentelle untersuchungen zum virusnachweis im inkubationsstadium der maul-und klauenseuche und zu ihrer pathogenese. Archiv Fur Experimentelle Veterinarmedizin 11, 637–649.Google Scholar
Laor, O, Torgersen, H, Yadin, H and Becker, Y (1992) Detection of FMDV RNA amplified by the polymerase chain reaction (PCR). Journal of Virological Methods 36, 197–207.Google Scholar
LaRocco, M, Krug, PW, Kramer, E, Ahmed, Z, Pacheco, JM, Duque, H, Baxt, B and Rodriguez, LL (2013) A continuous bovine kidney cell line constitutively expressing bovine αvβ6 integrin has increased susceptibility to foot-and-mouth disease virus. Journal of Clinical Microbiology 51, 1714–1720.Google Scholar
Littlejohn, AI (1970) Foot and mouth disease in sheep. The State Veterinary Journal 25, 3–12, 75–115.Google Scholar
Loeffier, F and Frosch, P (1897) Summarischer Bericht Ober die Ergebnisse der Untersuchungen der Kommission zur Erforschung der Maul-und Klauenseuche bei dem Institut for Infektionskrankheiten in Berlin Zentralblatt Fur Bakteriologie Mikrobiologie Und Hygiene. Series A-Medical Microbiology Infectious Diseases Virology Parasitology 1, 257–259.Google Scholar
Longjam, N, Deb, R, Sarmah, AK, Tayo, T, Awachat, VB and Saxena, VK (2011) A brief review on diagnosis of foot-and-mouth disease of livestock: conventional to molecular tools. Veterinary Medicine International 2011, 905768. doi: 10.4061/2011/905768.Google Scholar
Mahy, BW (2005) Introduction and history of foot-and-mouth disease virus. In: Mahy BW (ed) Foot-and-Mouth Disease Virus. Current Topics in Microbiology and Immunology 288: 1–8.Google Scholar
Marquardt, O, Straub, OC, Ahl, R and Haas, B (1995) Detection of foot-and-mouth disease virus in nasal swabs of asymptomatic cattle by RT-PCR within 24 h. Journal of Virological Methods 53, 255–261.Google Scholar
McColl, KA, Westbury, HA, Kitching, RP and Lewis, VM (1995) The persistence of foot-and-mouth disease virus on wool. Australian Veterinary Journal 72, 286–292.Google Scholar
McCullough, KC, Pullen, L and Parkinson, D (1992) The immune response against foot-and-mouth disease virus: influence of the T lymphocyte growth factors IL-1 and IL-2 on the murine humoral response in vivo. Immunology Letters 31, 41–46.Google Scholar
McVicar, JW (1977) The pathobiology of foot and mouth disease in cattle: a review. Bltn Centr Panam Fiebre Aftosa 26, 9–14.Google Scholar
McVicar, JW and Sutmoller, P (1969) The epizootiological importance of foot-and-mouth disease carriers. Archives of Virology 26, 217–224.Google Scholar
McVicar, JW and Sutmoller, P (1972). Foot-and-mouth disease in sheep and goats: early virus growth in the pharynx and udder. Proceedings of the Annual Meeting of the Unites States Livestock Sanitary Association 73: 400–406.Google Scholar
McVicar, JW and Sutmoller, P (1976) Growth of foot-and-mouth disease virus in the upper respiratory tract of non-immunized, vaccinated, and recovered cattle after intranasal inoculation. Epidemiology and Infection 76, 467–481.Google Scholar
Meyer, RF, Brown, CC, House, C, House, JA and Molitor, TW (1991) Rapid and sensitive detection of foot-and-mouth disease virus in tissues by enzymatic RNA amplification of the polymerase gene. Journal of Virological Methods 34, 161–172.Google Scholar
Mohan, MS, Gajendragad, MR, Kishore, S, Chockalingam, AK, Suryanarayana, VVS, Gopalakrishna, S and Singh, N (2008) Enhanced mucosal immune response in cattle persistently infected with foot-and-mouth disease virus. Veterinary Immunology and Immunopathology 125, 337–343.Google Scholar
Mohapatra, JK, Pandey, LK, Rai, DK, Das, B, Rodriguez, LL, Rout, M, Subramaniam, S, Sanyal, A, Rieder, E and Pattnaik, B (2015) Cell culture adaptation mutations in foot-and-mouth disease virus serotype A capsid proteins: implications for receptor interactions. Journal of General Virology 96, 553–564.Google Scholar
Moniwa, M, Clavijo, A, Li, M, Collignon, B and Kitching, RP (2007) Performance of a foot-and-mouth disease virus reverse transcription-polymerase chain reaction with amplification controls between three real-time instruments. Journal of Veterinary Diagnostic Investigation 19, 9–20.Google Scholar
Moniwa, M, Embury-Hyatt, C, Zhang, Z, Hole, K, Clavijo, A, Copps, J and Alexandersen, S (2012) Experimental foot-and-mouth disease virus infection in white tailed deer. Journal of Comparative Pathology 147, 330–342.Google Scholar
Moonen, P and Schrijver, R (2000) Carriers of foot-and-mouth disease virus: a review. Veterinary Quarterly 22: 193–197.Google Scholar
Moonen, P, Jacobs, L, Crienen, A and Dekker, A (2004) Detection of carriers of foot-and-mouth disease virus among vaccinated cattle. Veterinary Microbiology 103, 151–160.Google Scholar
Morioka, K, Fukai, K, Sakamoto, K, Yoshida, K and Kanno, T (2014) Evaluation of monoclonal antibody-based sandwich direct ELISA (MSD-ELISA) for antigen detection of foot-and-mouth disease virus using clinical samples. PLoS ONE 9, e94143.Google Scholar
Moss, A and Haas, B (1999) Comparison of the plaque test and reverse transcription nested PCR for the detection of FMDV in nasal swabs and probang samples. Journal of Virological Methods 80, 59–67.Google Scholar
Mouchantat, S, Haas, B, Böhle, W, Globig, A, Lange, E, Mettenleiter, TC and Depner, K (2014) Proof of principle: non-invasive sampling for early detection of foot-and-mouth disease virus infection in wild boar using a rope-in-a-bait sampling technique. Veterinary Microbiology 172, 329–333.Google Scholar
Murphy, C, Bashiruddin, JB, Quan, M, Zhang, Z and Alexandersen, S (2010) Foot-and-mouth disease viral loads in pigs in the early acute stage of disease. The Veterinary Record 166, 10–14.Google Scholar
Nair, SP (1987) Studies on the susceptibility and growth pattern of foot-and-mouth disease virus vaccine strains in two pig kidney cell lines. Indian Journal of Comparative Microbiology Immunology and Infectious Diseases 8, 76–81.Google Scholar
Nordberg, BK and Schjerning-Thiesen, K (1956) Detection of complement fixing antibodies against foot-and-mouth disease in cattle serum. The Journal of Infectious Diseases 98, 266–269.Google Scholar
Oem, JK, Kye, SJ, Lee, KN, Kim, YJ, Park, JY, Park, JH, Joo, YS and Song, HJ (2005) Development of a Lightcycler-based reverse transcription polymerase chain reaction for the detection of foot-and-mouth disease virus. Journal of Veterinary Science 6, 207–212.Google Scholar
Oem, JK, Ferris, NP, Lee, KN, Joo, YS, Hyun, BH and Park, JH (2009) Simple and rapid lateral-flow assay for the detection of foot-and-mouth disease virus. Clinical and Vaccine Immunology 16, 1660–1664.Google Scholar
OIE (World Organisation for Animal Health) (2008) Manual of Standards for Diagnostic Tests and Vaccines, 4th Edn. Paris: OIE, 957 pp.Google Scholar
OIE (World Organisation for Animal Health) (2012) Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, 7th Edn. Paris.Google Scholar
OIE (World Organisation for Animal Health) (2017) Resolution No 22: Recognition of the Foot and Mouth Disease Status of Member Countries 85th General Session of World Assembly May 2017.Google Scholar
Oleksiewicz, MB, Donaldson, AI and Alexandersen, S (2001) Development of a novel real-time RT-PCR assay for quantitation of foot-and-mouth disease virus in diverse porcine tissues. Journal of Virological Methods 92, 23–35.Google Scholar
Oliver, RE, Donaldson, AI, Gibson, CF, Roeder, PL, Le, PBS and Hamblin, C (1988) Detection of foot-and-mouth disease antigen in bovine epithelial samples: comparison of sites of sample collection by an enzyme linked immunosorbent assay (ELISA) and complement fixation test. Research in Veterinary Science 44, 315–319.Google Scholar
Ouldridge, E, Barnett, P and Rweyemamu, MM (1982) Relative efficiency of two ELISA techniques for the titration of FMD antigen. Veterinary Medicine and Animal Science 22, 142–151.Google Scholar
Ouldridge, EJ, Barnett, PV, Parry, NR, Syred, A, Head, M and Rweyemamu, MM (1984) Demonstration of neutralizing and non-neutralizing epitopes on the trypsin-sensitive site of foot-and-mouth disease virus. Journal of General Virology 65, 203–207.Google Scholar
Pacheco, JM, Arzt, J and Rodriguez, LL (2010) Early events in the pathogenesis of foot-and-mouth disease in cattle after controlled aerosol exposure. The Veterinary Journal 183, 46–53.Google Scholar
Pacheco, JM, Brito, B, Hartwig, E, Smoliga, GR, Perez, A, Arzt, J and Rodriguez, LL (2017) Early detection of foot-and-mouth disease virus from infected cattle using a dry filter air sampling system. Transboundary and Emerging Diseases 64, 564–573.Google Scholar
Parida, S, Anderson, J, Cox, SJ, Barnett, PV and Paton, DJ (2006) Secretory IgA as an indicator of oro-pharyngeal foot-and-mouth disease virus replication and as a tool for post vaccination surveillance. Vaccine 24, 1107–1116.Google Scholar
Parida, S, Fleming, L, Oh, Y, Mahapatra, M, Hamblin, P, Gloster, J, Doel, C, Gubbins, S and Paton, DJ (2007) Reduction of foot-and-mouth disease (FMD) virus load in nasal excretions saliva and exhaled air of vaccinated pigs following direct contact challenge. Vaccine 25, 7806–7817.Google Scholar
Parker, J (1971) Presence and inactivation of foot-and-mouth disease virus in animal faeces. Veterinary Record 88, 659–662.Google Scholar
Pattnaik, B and Venkataramanan, R (1989) Indirect enzyme-linked immunosorbent assay for the detection of foot-and-mouth-disease virus antigen. Indian Journal of Animal Sciences 59, 317–322.Google Scholar
Pay, TWF (1988) Foot and mouth disease in sheep and goats: a review. Foot-and-mouth disease Bulletin 26, 2–13.Google Scholar
Pereira, HG (1981) Foot-and-mouth disease virus. In Gibbs, RPG (ed.), Virus Diseases of Food Animals, vol. 2. New York: Academic Press, pp. 333–363.Google Scholar
Prickett, JR and Zimmerman, JJ (2010) The development of oral fluid-based diagnostics and applications in veterinary medicine. Animal Health Research Reviews 11, 207–216.Google Scholar
Prickett, J, Simer, R, Christopher-Hennings, J, Yoon, KJ, Evans, RB and Zimmerman, JJ (2008) Detection of Porcine reproductive and respiratory syndrome virus infection in porcine oral fluid samples: a longitudinal study under experimental conditions. Journal of Veterinary Diagnostic Investigation 20, 156–163.Google Scholar
Rai, A and Lahiri, DK (1981) A micro-enzyme-lavelled immunosorbent assay (MICORELISA) for the detection of foot-and-mouth disease virus antigen and antibody. Acta Virologica 25, 49–52.Google Scholar
Reid, SM, Forsyth, MA, Hutchings, GH and Ferris, NP (1998) Comparison of reverse transcription polymerase chain reaction enzyme linked immunosorbent assay and virus isolation for the routine diagnosis of foot-and-mouth disease. Journal of Virological Methods 70, 213–217.Google Scholar
Reid, SM, Hutchings, GH, Ferris, NP and De Clercq, K (1999) Diagnosis of foot-and-mouth disease by RT-PCR: evaluation of primers for serotypic characterisation of viral RNA in clinical samples. Journal of Virological Methods 83, 113–123.Google Scholar
Reid, SM, Ferris, NP, Hutchings, GH, Samuel, AR and Knowles, NJ (2000) Primary diagnosis of foot-and-mouth disease by reverse transcription polymerase chain reaction. Journal of Virological Methods 89, 167–176.Google Scholar
Reid, SM, Ferris, NP, Brüning, A, Hutchings, GH, Kowalska, Z and Åkerblom, L (2001) Development of a rapid chromatographic strip test for the pen-side detection of foot-and-mouth disease virus antigen. Journal of Virological Methods 96, 189–202.Google Scholar
Reid, SM, Ferris, NP, Hutchings, GH, Zhang, Z, Belsham, GJ and Alexandersen, S (2002) Detection of all seven serotypes of foot-and-mouth disease virus by real-time, fluorogenic reverse transcription polymerase chain reaction assay. Journal of Virological Methods 105, 67–80.Google Scholar
Reid, SM, Parida, S, King, DP, Hutchings, GH, Shaw, AE, Ferris, NP, Zhang, Z, Hillerton, JE and Paton, DJ (2006) Utility of automated real-time RT-PCR for the detection of foot-and-mouth disease virus excreted in milk. Veterinary Research 37, 121–132.Google Scholar
Reid, SM, Mioulet, V, Knowles, NJ, Shirazi, N, Belsham, GJ and King, DP (2014) Development of tailored real-time RT-PCR assays for the detection and differentiation of serotype O, A and Asia-1 foot-and-mouth disease virus lineages circulating in the Middle East. Journal of Virological Methods 207, 146–153.Google Scholar
Rémond, M, Kaiser, C and Lebreton, F (2002) Diagnosis and screening of foot-and-mouth disease. Comparative Immunology Microbiology and Infectious Diseases 25, 309–320.Google Scholar
Rice, CE and Brooksby, JB (1953) Studies of the complement-fixation reaction in virus systems. V: In foot and mouth disease using direct and indirect methods. The Journal of Immunology 71, 300–310.Google Scholar
Rodrigo, MJ and Dopazo, J (1995) Evolutionary analysis of the picornavirus family. Journal of Molecular Evolution 40, 362–371.Google Scholar
Rodríguez, A, Dopazo, J, Saiz, JC and Sobrino, F (1994) Immunogenicity of non-structural proteins of foot-and-mouth disease virus: differences between infected and vaccinated swine. Archives of Virology 136, 123–131.Google Scholar
Rodriguez, LL and Gay, CG (2011) Development of vaccines toward the global control and eradication of foot-and-mouth disease. Expert Review of Vaccines 10, 377–387.Google Scholar
Roeder, PL and Le, PBS (1987) Detection and typing of foot-and-mouth disease virus by enzyme-linked immunosorbent assay: a sensitive rapid and reliable technique for primary diagnosis. Research in Veterinary Science 43, 225–232.Google Scholar
Rosenbusch, CT, Decamps, A and Gelormini, N (1948) Intradermal foot-and-mouth disease vaccine; results obtained from the first million head of cattle vaccinated. Journal of the American Veterinary Medical Association 112, 45–47.Google Scholar
Rueckert, RR (1996) Picornaviridae: the viruses and their replication. Fields Virology 1, 609–654.Google Scholar
Rweyemamu, MM, Pay, TWF and Simms, MJ (1982) The control of foot-and-mouth disease by vaccination. Veterinary Annual 22, 63–80.Google Scholar
Ryan, MD, Belsham, GJ and King, AM (1989) Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing. Virology 173, 35–45.Google Scholar
Sáiz, JC, Cairó, J, Medina, M, Zuidema, D, Abrams, C, Belsham, GJ, Domingo, E and Vlak, JM (1994) Unprocessed foot-and-mouth disease virus capsid precursor displays discontinuous epitopes involved in viral neutralization. Journal of Virology 68, 4557–4564.Google Scholar
Sakaki, K, Suphavilai, P and Tokuda, G (1977) Antibody estimation by indirect complement fixation test for foot-and-mouth disease in cattle. National Institute of Animal Health Quarterly 17, 45–53.Google Scholar
Sakaki, K, Suphavilai, P and Chandarkeo, T (1978) Inactivated-concentrated virus antigen for indirect complement fixation test of foot-and-mouth disease. National Institute of Animal Health Quarterly 18, 128–134.Google Scholar
Sakamoto, K, Kanno, T, Yamakawa, M, Yoshida, K, Yamazoe, R and Murakami, Y (2002) Isolation of foot-and-mouth disease virus from Japanese black cattle in Miyazaki Prefecture Japan 2000. Journal of Veterinary Medical Science 64, 91–94.Google Scholar
Salt, JS (1993) The carrier state in foot and mouth disease – an immunological review. British Veterinary Journal 149, 207–223.Google Scholar
Salt, JS, Mulcahy, G and Kitching, RP (1996) Isotype-specific antibody responses to foot-and-mouth disease virus in sera and secretions of ‘carrier’ and ‘non-carrier’ cattle. Epidemiology and Infection 117, 349–360.Google Scholar
Sellers, RF (1955) Growth and titration of the viruses of foot-and-mouth disease and vesicular stomatitis in kidney monolayer tissue cultures. Nature 176, 547–549.Google Scholar
Sellers, RF and Parker, J (1969) Airborne excretion of foot-and-mouth disease virus. Epidemiology and Infection 67, 671–677.Google Scholar
Sellers, RF, Herniman, KA and Mann, JA (1971) Transfer of foot-and-mouth disease virus in the nose of man from infected to non-infected animals. Veterinary Record 89, 447–449.Google Scholar
Senthilkumaran, C, Yang, M, Bittner, H, Ambagala, A, Lung, O, Zimmerman, J, Giménez-Lirola, LG and Nfon, C (2017) Detection of genome antigen and antibodies in oral fluids from pigs infected with foot-and-mouth disease virus. Canadian Journal of Veterinary Research 81, 82–90.Google Scholar
Shaw, AE, Reid, SM, King, DP, Hutchings, GH and Ferris, NP (2004) Enhanced laboratory diagnosis of foot and mouth disease by real-time polymerase chain reaction. Revue Scientifique et Technique 23, 1003–1009.Google Scholar
Shaw, AE, Reid, SM, Ebert, K, Hutchings, GH, Ferris, NP and King, DP (2007) Implementation of a one-step real-time RT-PCR protocol for diagnosis of foot-and-mouth disease. Journal of Virological Methods 143, 81–85.Google Scholar
Snowdon, WA (1966) Growth of foot-and-mouth disease virus in monolayer cultures of calf thyroid cells. Nature 210, 1079.Google Scholar
Snowdon, WA (1968) The susceptibility of some Australian fauna to infection with foot-and-mouth disease virus. The Australian Journal of Experimental Biology and Medical Science 46, 667–687.Google Scholar
Sobrino, F, Sáiz, M, Jiménez-Clavero, MA, Núñez, JI, Rosas, MF, Baranowski, E and Ley, V (2001) Foot-and-mouth disease virus: a long known virus but a current threat. Veterinary Research 32, 1–30.Google Scholar
Sørensen, JH, Mackay, DKJ, Jensen, CØ and Donaldson, AI (2000) An integrated model to predict the atmospheric spread of foot-and-mouth disease virus. Epidemiology and Infection 124, 577–590.Google Scholar
Stenfeldt, C, Lohse, L and Belsham, GJ (2013) The comparative utility of oral swabs and probang samples for detection of foot-and-mouth disease virus infection in cattle and pigs. Veterinary Microbiology 162, 330–337.Google Scholar
Stenfeldt, C, Pacheco, JM, Smoliga, GR, Bishop, E, Pauszek, SJ, Hartwig, EJ, Rodriguez, LL and Arzt, J (2016) Detection of foot-and-mouth disease virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transboundary and Emerging Diseases 63, 152–164.Google Scholar
Stone, SS and DeLay, PD (1960) Serum and colostral antibody levels in cattle convalescent from foot-and-mouth disease: tests in calves and fetal tissue. The Journal of Immunology 84, 458–462.Google Scholar
Straver, PJ, Bool, PH, Claessens, AMJM and Van Bekkum, JG (1970) Some properties of carrier strains of foot-and-mouth disease virus. Archiv für die Gesamte Virusforschung 29, 113–126.Google Scholar
Subramanian, BM, Madhanmohan, M, Sriraman, R, Reddy, RC, Yuvaraj, S, Manikumar, K, Rajalakshmi, S, Nagendrakumar, SB, Rana, SK and Srinivasan, VA (2012) Development of foot-and-mouth disease virus (FMDV) serotype O virus-like-particles (VLPs) vaccine and evaluation of its potency. Antiviral Research 96, 288–295.Google Scholar
Sumption, K, Rweyemamu, M and Wint, W (2008) Incidence and distribution of foot-and-mouth disease in Asia, Africa and South America; combining expert opinion, official disease information and livestock populations to assist risk assessment. Transboundary and Emerging Diseases 55, 5–13.Google Scholar
Sutmoller, P and Gaggero, A (1965) Foot-and mouth diseases carriers. Veterinary Record 77, 968–969.Google Scholar
Sutmoller, P and McVicar, JW (1976) Pathogenesis of foot-and-mouth disease: the lung as an additional portal of entry of the virus. Epidemiology and Infection 77, 235–243.Google Scholar
Sutmoller, P, Barteling, SS, Olascoaga, RC and Sumption, KJ (2003) Control and eradication of foot-and-mouth disease. Virus Research 91, 101–144.Google Scholar
Swaney, LM (1976) Susceptibility of a new fetal pig kidney cell line (MVPK-1) to foot-and-mouth disease virus. American Journal of Veterinary Research 37, 1319–1322.Google Scholar
Thomson, GR, Vosloo, W and Bastos, ADS (2003) Foot and mouth disease in wildlife. Virus Research 91, 145–161.Google Scholar
Thurmond, MC and Perez, AM (2006) Modeled detection time for surveillance for foot-and-mouth disease virus in bulk tank milk. American Journal of Veterinary Research 67, 2017–2024.Google Scholar
Traub, E and Mohlmann, H (1943) Typenbestimmung bei Maul-und Klauenseuche mit Hilfe der Komplementbindungsprobe I Mitt: Versuche mit Seren und Antigenen von Meerschweinchen. Zentralblatt für Bakteriologie Mikrobiologie und Hygiene: I. Abt. Originale 150, 289–299.Google Scholar
Tseng, CC and Li, CS (2005) Collection efficiencies of aerosol samplers for virus-containing aerosols. Journal of Aerosol Science 36, 593–607.Google Scholar
Uttenthal, Å, Parida, S, Rasmussen, TB, Paton, DJ, Haas, B and Dundon, WG (2010) Strategies for differentiating infection in vaccinated animals (DIVA) for foot-and-mouth disease classical swine fever and avian influenza. Expert Review of Vaccines 9, 73–87.Google Scholar
Vallée, H, Carré, H and Rinjard, P (1926) Vaccination against FMD by means of formalinised virus. Journal of Comparative Pathology 39, 326–329.Google Scholar
Van Bekkum, JG, Frenkel, HS, Frederiks, HHJ and Frenkel, S (1959) Observations on the carrier state of cattle exposed to foot-and-mouth disease virus. Tijdschrift voor Diergeneeskunde 84, 1159–1164.Google Scholar
Verreault, D, Moineau, S and Duchaine, C (2008) Methods for sampling of airborne viruses. Microbiology and Molecular Biology Reviews 72, 413–444.Google Scholar
Vosloo, W, Morris, J, Davis, A, Giles, M, Wang, J, Nguyen, HTT, Kim, PV, Quach, NV, Le, PTT, Nguyen, PHN and Dang, H (2015) Collection of oral fluids using cotton ropes as a sampling method to detect foot-and-mouth disease virus infection in pigs. Transboundary and Emerging Diseases 62, e71–e75.Google Scholar
Waldmann, O and Trautwein, K (1926) Experimentelle Untersuchungen über die Pluralität des Maul-und Klauenseuchevirus. Berl Tierärztl Wochenschrift 42, 569–571.Google Scholar
Yilma, T (1980) Morphogenesis of vesiculation in foot-and-mouth disease. American Journal of Veterinary Research 41, 1537–1542.Google Scholar
Zhang, Z and Bashiruddin, JB (2009) Quantitative analysis of foot-and-mouth disease virus RNA duration in tissues of experimentally infected pigs. The Veterinary Journal 180, 130–132.Google Scholar
Zhang, ZD and Kitching, RP (2001) The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx. Journal of Comparative Pathology 124, 89–94.Google Scholar