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Plasmid-mediated colistin resistance in animals: current status and future directions

Published online by Cambridge University Press:  18 April 2018

Jian Sun ,
Ximin Zeng ,
Xing-Ping Li ,
Xiao-Ping Liao ,
Ya-Hong Liu  and
Jun Lin
Jian Sun
Affiliation:
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China
Ximin Zeng
Affiliation:
Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA
Xing-Ping Li
Affiliation:
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China
Xiao-Ping Liao
Affiliation:
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China
Ya-Hong Liu*
Affiliation:
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China
Jun Lin*
Affiliation:
Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA
*
*Corresponding author. E-mail: jlin6@utk.edu and lyh@scau.edu.cn
*Corresponding author. E-mail: jlin6@utk.edu and lyh@scau.edu.cn
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Abstract

Colistin, a peptide antibiotic belonging to the polymyxin family, is one of the last effective drugs for the treatment of multidrug resistant Gram-negative infections. Recent discovery of a novel mobile colistin resistance gene, mcr-1, from people and food animals has caused a significant public health concern and drawn worldwide attention. Extensive usage of colistin in food animals has been proposed as a major driving force for the emergence and transmission of mcr-1; thus, there is a worldwide trend to limit colistin usage in animal production. However, despite lack of colistin usage in food animals in the USA, mcr-1-positive Escherichia coli isolates were still isolated from swine. In this paper, we provided an overview of colistin usage and epidemiology of mcr-1 in food animals, and summarized the current status of mechanistic and evolutionary studies of the plasmid-mediated colistin resistance. Based on published information, we further discussed several non-colistin usage risk factors that may contribute to the persistence, transmission, and emergence of colistin resistance in an animal production system. Filling the knowledge gaps identified in this review is critical for risk assessment and risk management of colistin resistance, which will facilitate proactive and effective strategies to mitigate colistin resistance in future animal production systems.

Keywords

Colistin resistanceMCR-1epidemiologyanimalrisk factors
Type
Review Article
Information
Animal Health Research Reviews , Volume 18 , Special Issue 2: Antimicrobial resistance: from basic science to translational innovation , December 2017 , pp. 136 - 152
Copyright
Copyright © Cambridge University Press 2018 

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Footnotes

†

The authors contributed equally to this paper.

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