Hostname: page-component-8448b6f56d-mp689 Total loading time: 0 Render date: 2024-04-19T14:35:12.734Z Has data issue: false hasContentIssue false
  • English
  • Français

Zygosity Partitioning of Small Twin Samples

Published online by Cambridge University Press:  01 August 2014

Gordon Allen  and
Zdenek Hrubec
Gordon Allen*
Affiliation:
9326 West Parkhill Drive, Bethesda, Maryland
Zdenek Hrubec
Affiliation:
Radiation Epidemiology Branch, National Cancer Institute, Bethesda, Maryland
*
9326 West Parkhill Drive, Bethesda, MD 20814, USA

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

When the Weinberg estimate of the proportion of monozygotic pairs is quite deviant from that in the source population, it is likely to be wrong because Weinberg's difference is much less stable than the zygosity proportions. A formula is proposed for the probability distribution of possible compositions of a small sample of twins based on sex concordance in the sample and zygosity proportions in the source population.

Keywords

Twin samplesZygosityLikelihood methodWeinberg's difference
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 34 , Issue 3-4 , October 1985 , pp. 167 - 174
Copyright
Copyright © The International Society for Twin Studies 1985

References

REFERENCES

1. Allen, G (1981): Errors of Weinberg's difference method. In Gedda, L, Parisi, P, Nance, WE (eds): Twin Research 3: Part A, Twin Biology and Multiple Pregnancy. New York: Alan R. Liss, pp. 71–74.Google Scholar
2. Allen, G, Pettigrew, KD (1973): Heritability of IQ by social class: evidence inconclusive. Science 182:1042–1044.CrossRefGoogle Scholar
3. Bulmer, MG (1970): The Biology of Twinning in Man. Oxford: Clarendon Press.Google Scholar
4. Eaves, LJ, Jinks, JL (1972): Insignificance of evidence for differences in heritability of IQ between races and social classes. Nature 240:84–88.CrossRefGoogle ScholarPubMed
5. Heuser, RL (1967): Multiple Births: United States 1964. Washington: US Government Printing Office (Public Health Service Publication No 1000, Series 21, No 14).Google Scholar
6. James, WH (1979): Is Weinberg's differential rule valid? Acta Genet Med Gemellol 28:69–71.Google Scholar
7. Lentner, C (ed) (1981): Geigy Scientific Tables. Basle: Ciba-Geigy.Google Scholar
8. Weinberg, W (1901–1902): Beiträge zur Physiologie und Pathologie der Mehrlingsgeburten beim Menschen. Arch Ges Physiol 88:346–430.CrossRefGoogle Scholar