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Genetic and Environmental Effects on Blood Cells

Published online by Cambridge University Press:  01 August 2014

G.M.D. Dal Colletto*
Institute of Biomedical Science, University of Sao Paulo
D.W. Fulker
Institute for Behavioral Genetics, University of Colorado
O.C. de O. Barretto
University of Sao Paulo, Medical School
M. Kolya
Institute of Biomedical Science, University of Sao Paulo
Instituto de Ciencias Biomedical -Universidade de São Paulo, Av. Lineu Prestes, 2415 — CEP 05508-900 São Paulo - SP, Brasil


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In a sample of 105 concordant sex MZ and DZ twin pairs, the following characteristics were measured: red cell count, haemoglobin concentration, package cell volume, mean cell volume, mean cell haemoglobin, mean cell haemoglobin concentration, reticulocytes, platelets, white cell count and the six types of leucocytes, lymphocytes, monocytes, band and segmented neutrophils, eosinophils and basophils. The statistical model employed in the univariate twin analysis allows for three sources of variation: genetic (h2), shared environmental (c2) and specific environmental influences (e2). A genetic component was significant for red cell count, haemoglobin and mean cell haemoglobin (0.64, 0.60 and 0.46 respectively), with heritable variation suggested for package cell volume, mean cell volume, mean cell haemoglobin, lymphocytes and monocytes. Shared environmental variation was only present for neutrophils.

Research Article
Copyright © The International Society for Twin Studies 1993



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