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Numerical Study on the Dynamics and Oxygen Uptake of Healthy and Malaria-Infected Red Blood Cells

Published online by Cambridge University Press:  21 July 2015

P. G. Jayathilake ,
Gang Liu ,
Zhijun Tan  and
B. C. Khoo
P. G. Jayathilake
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Kent Ridge Crescent, Singapore 119260, Singapore
Gang Liu
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Kent Ridge Crescent, Singapore 119260, Singapore
Zhijun Tan*
Affiliation:
Guangdong Province Key Laboratory of Computational Science and School of Mathematics and Computational Science, Sun Yat-sen University, Guangzhou 510275, China
B. C. Khoo
Affiliation:
Department of Mechanical Engineering, National University of Singapore, Kent Ridge Crescent, Singapore 119260, Singapore Singapore-MIT Alliance, 4 Engineering Drive 3, National University of Singapore, Singapore 117576, Singapore
*
*Corresponding author. Email: pgjayathilake@gmail.com (P. G. Jayathilake), mpeliuga@nus.edu.sg (G. Liu), tzhij@mail.sysu.edu.cn (Z. J. Tan), mpekbc@nus.edu.sg (B. C. Khoo)
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Abstract

Red blood cells (RBCs) are very important due to their role of oxygen transport from lungs. As the malaria parasite grows in the malaria-infected red blood cells (IRBCs), the properties of the cells change. In the present work, the oxygen uptake by RBCs and IRBCs at the pulmonary capillaries is simulated using a numerical technique based on the two-dimensional immersed interface method. The results for the oxygen uptake by a stationary single RBC have fair agreements with the previously reported results. The numerical results show that the malaria infection could significantly cause deterioration on the oxygen uptake by red blood cells. The results also suggest that the oxygen uptake by individual stationary RBC/IRBC would not be significantly affected by the neighboring cells provided the separation distance is about the dimension of the cell. Furthermore, it appears that the oxygen uptake by both RBCs and IRBCs is dominated by mass diffusion over the convection although the Peclet number is of the order of unity.

Keywords

76Z0576M2076D0576R9965M0674F1092C10Red blood cellmalariaoxygenbiomechanicsnumerical simulation
Type
Research Article
Information
Advances in Applied Mathematics and Mechanics , Volume 7 , Issue 5 , October 2015 , pp. 549 - 568
Copyright
Copyright © Global-Science Press 2015 

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