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Peripheral interleukin-6 promotes resilience versus susceptibility to inescapable electric stress

Published online by Cambridge University Press:  28 May 2015

Chun Yang ,
Yukihiko Shirayama ,
Ji-Chun Zhang ,
Qian Ren  and
Kenji Hashimoto
Chun Yang
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Yukihiko Shirayama
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan Department of Psychiatry, Teikyo University Chiba Medical Center, Ichihara, Japan
Ji-Chun Zhang
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Qian Ren
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
Kenji Hashimoto*
Affiliation:
Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
*
Dr. Kenji Hashimoto, Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba 260-8670, Japan. Tel: +81 43 226 2517; Fax: +81 43 226 2561; E-mail: hashimoto@faculty.chiba-u.jp
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Abstract

Objective

Accumulating evidences suggest that pro-inflammatory cytokines such as interleukin-6 (IL-6) play a role in the pathophysiology of depression. In the learned helplessness (LH) paradigm, ~35% rats are resilient to inescapable stress.

Methods

Levels of IL-6 in the serum and medial prefrontal cortex (mPFC) of LH rats (susceptible) and non-LH rats (resilience) were measured using enzyme-linked immunosorbent assay and western blot analysis, respectively.

Results

Serum levels of IL-6 in the LH rats were significantly higher than those of control and non-LH rats. In contrast, tissue levels of IL-6 in the mPFC were not different among three groups.

Conclusion

The results suggest that peripheral IL-6 may contribute to resilience versus susceptibility to inescapable stress.

Keywords

interleukin-6 (IL-6)learned helplessnessresiliencesusceptible
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 27 , Issue 5 , October 2015 , pp. 312 - 316
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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