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Olfactory identification in young relatives at risk for schizophrenia

Published online by Cambridge University Press:  24 June 2014

Matcheri S. Keshavan ,
Anvi Vora ,
Debra Montrose ,
Vaibhav A. Diwadkar  and
John Sweeney
Matcheri S. Keshavan*
Affiliation:
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Beth Israel and Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Anvi Vora
Affiliation:
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA
Debra Montrose
Affiliation:
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Vaibhav A. Diwadkar
Affiliation:
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
John Sweeney
Affiliation:
University of Illinois School of Medicine, Chicago, IL, USA
*
Matcheri S. Keshavan, Department of Psychiatry, Beth Israel Deaconess Medical Center Landmark Building, 401 Park Ave, Boston MA 02215, USA. Tel: 617 998 5036; Fax: 617 998 5007; E-mail: mkeshava@bidmc.harvard.edu
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Abstract

Objective:

Olfactory identification deficits (OIDs) are seen in schizophrenia, but it is unclear whether they are state- or trait-related.

Methods:

We examined the prevalence of OIDs, as assessed by the University of Pennsylvania Smell Identification Test (UPSIT), and their correlations with prodromal symptoms in young relatives at risk for schizophrenia or schizoaffective disorder (HR-S).

Results:

UPSIT scores were lower in HR- S than in healthy controls, but were non-significant after covarying the effects of age, gender and IQ. OID deficits in HR-S were correlated, after covarying out the effects of age and IQ, with prodromal disorganisation.

Conclusion:

The potential value of OID deficits as markers of psychopathological vulnerability in young relatives at risk for schizophrenia deserves further investigation.

Keywords

cognitionolfactory identificationprodromeschizophrenia
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 21 , Issue 3 , June 2009 , pp. 121 - 124
Copyright
Copyright © 2009 Blackwell Munksgaard

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