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HTR2A gene polymorphisms and Inward and Outward Personal Meaning Organisations

Published online by Cambridge University Press:  24 June 2014

Bernardo Nardi ,
Francesco Piva ,
Chiara Turchi ,
Matteo Giulietti ,
Gianni Castellucci ,
Emidio Arimatea ,
David Rocchetti ,
Gianfranco Rocchetti ,
Giovanni Principato  and
Adriano Tagliabracci
...Show all authors
Bernardo Nardi
Affiliation:
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
Francesco Piva*
Affiliation:
Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, Ancona, Italy
Chiara Turchi
Affiliation:
Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy
Matteo Giulietti
Affiliation:
Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, Ancona, Italy
Gianni Castellucci
Affiliation:
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
Emidio Arimatea
Affiliation:
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
David Rocchetti
Affiliation:
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
Gianfranco Rocchetti
Affiliation:
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
Giovanni Principato
Affiliation:
Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, Ancona, Italy
Adriano Tagliabracci
Affiliation:
Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy
Cesario Bellantuono
Affiliation:
Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy
*
Francesco Piva Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, Ancona 60131, Italy. Tel: +390712204641; Fax: +390712204609; E-mail: f.piva@univpm.it
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Nardi B, Piva F, Turchi C, Giulietti M, Castellucci G, Arimatea E, Rocchetti D, Rocchetti G, Principato G, Tagliabracci A, Bellantuono C. HTR2A gene polymorphisms and Inward and Outward Personal Meaning Organisations.

Objective: Caregiver behaviours and emotional expressions may induce development of two basic categories of constructing identity and of regulating cognitive and emotional processes: an Inward or an Outward Personal Meaning Organisation (PMO). Inwards read environmental signals through their internal activations. Their emotions are more distinct, and reciprocity is more based on physical distance (protection, loneliness). Outwards read internal activations through the environment. Their emotions are more blurred, and reciprocity is more based on a semantic sight of relations (approval, rules).

It has recently been shown that PMO development may also have physiological and genetic bases. In a functional magnetic resonance imaging (fMRI) study, Inward and Outward subjects showed different amygdala activation patterns and an association with the SLC6A4 serotonin transporter gene 5-HTTLPR polymorphism.

Methods: In this work, 149 healthy subjects were examined with respect to Inward and Outward PMOs. We explored the association with 10 serotonin receptor 2A (HTR2A) gene single nucleotide polymorphisms (SNPs) selected by bioinformatics methods.

Results: An intronic SNP (rs55948462) was found to be significantly associated with an Inward and an Outward PMOs development. However, after statistical adjustments, these results did not remain significant.

Conclusion: We did not find associations between considered SNPs and Inward/Outward PMOs. However, the role of HTR2A polymorphisms was not considered in this study and that of the other serotonin-related genes should be valued.

Keywords

genetic association studiespersonalityserotonin
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 6 , December 2012 , pp. 336 - 343
Copyright
Copyright © Cambridge University Press 2011

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