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Emoties en het Hart; resultaten van neurocardiologisch onderzoek bij de Biologische Psychiatrie Groningen

Published online by Cambridge University Press:  11 January 2019

Samenvatting

Autonome functies en emoties worden beide gestuurd door het limbische systeem; een groep kernen in de voorhersenen die voor het eerst als zodanig beschreven zijn door Papez in 1937. Ondanks jarenlang fundamenteel wetenschappelijk onderzoek rijzen nog steeds vele vragen over de bouw en functies van het limbische systeem, met inline waar het de rol van dit systeem betreft bij emotionele stoornissen zoals angst en depressie. Fundamenteel neurobiologisch onderzoek van cardiovasculaire autonome sturing biedt de mogelijkheid inzicht le verkrijgen in de bouw van limbische neuronale circuits. In deze publicatie wordt een overzicht gegeven van de vorderingen op dit gebied. De bouw van de limbische cardiovasculaire circuits zal worden beschreven aan de hand van resultaten verkregen met verschillende - moderne - neurobiologische technieken. Ook het effect van typische en atypische antipsychotica in deze circuits zal warden gepresenteerd.

Summary

Summary

The limbic system is considered the ‘command center’ for autonomic functions and emotions. This was first recognized by Papez in 1937 who described a group of related forebrain nuclei participating in emotional responses. Questions regarding the neuroanatomy of the limbic system and its various functions remain, regardless of many years of fundamental research. Neurobiological characterization of cardiovascular neuronal circuitry may contribute to our understanding of limbic circuitry underlying emotional responses. In this paper our recent progress is described regarding the anatomy of limbic cardiovascular circuitry. Also, effects of typical and atypical antipsychotic drugs on the limbic cardiovascular areas are presented.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1998

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References

Literatuur

1. Ter Horst, GJ, Postigo, A. Stroke: Prevalence and mechanisms of cell death. In: Ter Horst, GJ, Korf, J, eds. Clinical Pharmacology of Cerebral Ischemia. Totowa: Humana Press Inc. Totowa, 1997: 130.Google Scholar
2. Moser, DK, Dracup, K. Is anxiety early after myocardial infarction associated with subsequent ischemic and arrhythmic events? Psychosom Med 1996; 58: 395403.Google Scholar
3. Ladwig, KH, Roell, G, Breithardt, G. et al. Post-infarction depression and incomplete recovery 6 moths after acute myocardial infarction, Lancet 1994; 343: 20-3.Google Scholar
4. Garcia, L, Valdes, M, Jodar, I, et al. Psychological factors and vulnerability to psychiatric morbidity after myocardial infarction. Psychother Psychosom 1994; 61: 187-94.Google Scholar
5. Papez, JW. A proposed mechanism of emotion. Arch Neurol Psychiat 1937; 38: 725-43.Google Scholar
6. McLean, PD. The limbic system (“visceral brain”) and emotional behaviour. Arch Neurol Psychiat 1955: 73: 130-4.Google Scholar
7. Kupferman, I. Hypothalamus and limbic system; peptidergic neurons, homeostasis and emotional behaviour. In: Kandell, ER, Schwartz, JH, Jessell, TM eds. Principles of Neural Science. 3rd ed. Amsterdam: Elsevier, 1991: 736-48.Google Scholar
8. Card, JP, Rinaman, L, Lynn, RB, et al. Pseudorabies virus infection of the rat central nervous system: ultrastructural characterization of viral replication, transport and pathogenesis. J Neurosci 1993; 13: 2515-39.Google Scholar
9. Ter Horst, GJ, Van den Brink, A, Homminga, SA, et al. Transneuronal viral labelling of heart left ventricle controlling pathways. NeuroReport 1993; 4: 1307-10.Google Scholar
10. Ter Horst, GJ, Hautvast, RWM, DeJongste, MJL, et al. Neuroanatomy of cardiac activity-regulating circuitry: A transneuronal retrograde viral labelling study in the rat. Eur J Neurosci 1996; 8; 2029-41.Google Scholar
11. Ter Horst, GJ, Luiten, PGM, Kuipers, F. Descending pathways from the hypothalamus to the dorsal motor vagus and ambiguus nuclei in the rat. J auton nerv Syst 1984; 11: 5975.Google Scholar
12. Luiten, PGM, Ter Horst, GJ, Steffens, AB. The hypothalamus; intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog Neurobiol 1987; 28: 154.Google Scholar
13. Ter Horst, GJ, Arkies, BJ, Kemper, RHA, et al. Nociception of heart pain in conscious rats. Soc Neurosci Abstr 1996; 22: 869.Google Scholar
14. Meller, ST, Gebhart, GF. A critical review of the afferent pathways and the potential clinical mediators involved in cardiac pain. Neurosci 1992; 48: 501-24.Google Scholar
15. Korf, J. Hersenschade in beeld. Acta neuropsychiat 1997; 9: 919.Google Scholar
16. Rosen, SD, Paulesu, E, Nihoyannopoulos, P, et al. Silent ischemia as a central problem: Regional brain activation compared in silent and painful myocardial ischemia. Ann intern Med 1996; 124: 939-49.Google Scholar
17. Hautvast, RWM, Ter Horst, GJ, DeJong, BM, et al. Relative changes in regional cerebral blood flow during spinal cord stimulation in patients with refractory angina pectoris. Eur J Neurosci 1997; 9: 1178-83.Google Scholar
18. Rechlin, T, Claus, D, Weis, M. Heart rate variability in schizophrenic patients and changes in autonomic heart rate parameters during treatment with clozapine. Biol Psychiat 1994; 35: 888-92.Google Scholar
19. Zahn, TP, Pickar, D. Autonomic effects of clozapine in schizophrenia: Comparison with placebo and fluphenazine. Biol Psychiat 1993; 34: 312.Google Scholar
20. Sebens, JB, Koch, T, Ter Horst, GJ, et al. Differential Fos protein induction in rat forebrain regions after acute and chronic halo-peridol and clozapine treatment. Eur J Pharmacol 1995; 273: 175-82.Google Scholar
21. Sebens, JB, Korf, J. De regionaal-cerebrale expressie van Fos eiwit voor de classificatie van antipsychotica. Acta neuropsychiat 1997; 9: 143-50.Google Scholar
22. Jansen, ASP, Van Nguyen, X, Karpitslky, V, et al. Central command neurons of the sympathetic nervous system: basis for the fight-or-flighl response. Science 1995; 270: 644-6.Google Scholar
23. Oppenheimer, SM, Wilson, JX, Guiraudon, C, et al. Insular cortex stimulation produces lethal cardiac arrhythmias: A mechanism of sudden death. Brain Res 1991; 550:115-21.Google Scholar
24. Oppenheimer, SM, Gelb, A, Girvin, JP, et al. Cardiovascular effects of human insular cortex stimulation. Neurol 1992; 42: 1727-32.Google Scholar