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Effects of post-training modafinil administration in a discriminative avoidance task in mice

Published online by Cambridge University Press:  23 March 2015

Helaine Arrais Fernandes ,
Karina Agustini Zanin ,
Camilla de Lima Patti ,
Leonardo Brito Lopes-Silva ,
Carolina Souza Bizerra ,
Lia Rita Azeredo Bittencourt ,
Sergio Tufik  and
Roberto Frussa-Filho
Helaine Arrais Fernandes
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Karina Agustini Zanin
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Camilla de Lima Patti*
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil
Leonardo Brito Lopes-Silva
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Carolina Souza Bizerra
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil
Lia Rita Azeredo Bittencourt
Affiliation:
Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Sergio Tufik
Affiliation:
Department of Psychobiology, Federal University of São Paulo, SP, Brazil
Roberto Frussa-Filho
Affiliation:
Department of Pharmacology, Federal University of São Paulo, SP, Brazil Department of Psychobiology, Federal University of São Paulo, SP, Brazil
*
Camilla L. Patti, Departamento de Farmacologia – UNIFESP, Rua Botucatu, 862, Ed. Leal Prado, 1º andar, 04023062, São Paulo, SP, Brazil. Tel/Fax: +55 011 5549 4122; E-mail: camila.patti@unifesp.br; clpatti@gmail.com
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Abstract

Objective

Although the cognitive-enhancing abilities after modafinil have been demonstrated, its effects on memory consolidation remain overlooked. We investigated the effects of repeated modafinil administration on consolidation of a discriminative avoidance task.

Methods

Mice were trained in the plus-maze discriminative avoidance task. After training, mice received intraperitonial modafinil (doses of 32, 64 or 128 mg/kg). Animals were treated for more 9 consecutive days; 30 min after the last injection, testing was performed. In addition, the effects of 32 mg/kg modafinil on consolidation at different time points were examined.

Results

The smaller dose of modafinil (32 mg/kg) impaired memory consolidation, without modifying anxiety or locomotion. Still, modafinil post-training administration at 1 or 2 h impaired memory persistence.

Conclusions

Modafinil impaired memory consolidation in a dose- and time-dependent fashion.

Keywords

anxietylocomotionmemory consolidationmicemodafinil
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 27 , Issue 4 , August 2015 , pp. 235 - 241
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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Footnotes

*

The first two authors contributed equally to this work.

†

In memoriam.

References

1.Ferraro, L, Antonelli, T, O’Connor, WT, Tanganelli, S, Rambert, FA, Fuxe, K. The effects of modafinil on striatal, pallidal and nigral GABA and glutamate release in the conscious rat: evidence for a preferential inhibition of striato-pallidal GABA transmission. Neurosci Lett 2008;253:15–18.Google Scholar
2.Kraft, GH, Bowen, J. Modafinil for fatigue in MS: a randomized placebo-controlled double-blind study. Neurology 2005;65:1995–1997.CrossRefGoogle Scholar
3.Turner, DC, Clark, L, Pomarol-Clotet, E, Mckenna, P, Robbins, TW, Sahakian, BJ. Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology 2004;29:1363–1373.CrossRefGoogle ScholarPubMed
4.Taylor, FB, Russo, J. Efficacy of modafinil compared to dextroamphetamine for the treatment of attention deficit hyperactivity disorder in adults. J Child Adolesc Psychopharmacol 2000;10:311–320.CrossRefGoogle ScholarPubMed
5.Joos, L, Docx, L, Schmaal, L, Sabbe, BG, Dom, G. Modafinil in psychiatric disorders: the promising state reconsidered. Tijdschr Psychiatr 2010;52:763–773.Google ScholarPubMed
6.Cakic, V. Smart drugs for cognitive enhancement: ethical and pragmatic considerations in the era of cosmetic neurology. J Med Ethics 2009;35:611–615.CrossRefGoogle ScholarPubMed
7.Béracochéa, D, Celerier, A, Peres, M, Piérard, C. Enhancement of learning processes following an acute modafinil injection in mice. Pharmacol Biochem Behav 2003;76:473–479.CrossRefGoogle ScholarPubMed
8.Béracochéa, D, Cagnard, B, Celerier, A, Merrer, J, Peres, M, Piérard, C. First evidence of a delay-dependent working memory – enhancing effect of modafinil in mice. Neuroreport 2001;12:375–378.CrossRefGoogle ScholarPubMed
9.Béracochéa, D, Celerier, A, Borde, N, Valleau, M, Peres, M, Piérard, C. Improvement of learning processes following chronic systemic administration of modafinil in mice. Pharmacol Biochem Behav 2002;73:723–728.CrossRefGoogle ScholarPubMed
10.Shuman, T, Wood, SC, Anagnostaras, SG. Modafinil and memory: effects of modafinil on Morris water maze learning and Pavlovian fear conditioning. Behav Neurosci 2009;123:257–266.CrossRefGoogle ScholarPubMed
11.Fernandes, HA, Zanin, KA, Patti, CLet al. Inhibitory effects of modafinil on emotional memory in mice. Neuropharmacol 2013;64:365–370.CrossRefGoogle ScholarPubMed
12.Patti, CL, Zanin, KA, Sanday, Let al. Effects of sleep deprivation on memory in mice: role of state-dependent learning. Sleep 2010;33:1669–1679.CrossRefGoogle ScholarPubMed
13.Gulick, D, Gould, TJ. Nicotine acts in the anterior cingulate, but not dorsal or ventral hippocampus, to reverse ethanol-induced learning impairments in the plus-maze discriminative avoidance task. Addict Biol 2011;16:176–188.CrossRefGoogle ScholarPubMed
14.Zanin, KA, Patti, CL, Sanday, Let al. Effects of zolpidem on sedation, anxiety, and memory in the plus-maze discriminative avoidance task. Psychopharmacology (Berl) 2013;226:459–474.CrossRefGoogle ScholarPubMed
15.Carvalho, RC, Patti, CL, Takatsu-Coleman, ALet al. Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments. Brain Res 2006;29:179–183.CrossRefGoogle Scholar
16.Silva, RH, Bellot, RG, Vital, MA, Frussa-Filho, R. Effects of long-term ganglioside GM1 administration on a new discriminative avoidance test in normal adult mice. Psychopharmacology (Berl) 1997;129:322–328.Google ScholarPubMed
17.Claro, FT, Silva, RH, Frussa-Filho, R. Bovine brain phosphatidylserine attenuates scopolamine-induced amnesia. Physiol Behav 1999;67:551–554.CrossRefGoogle ScholarPubMed
18.Wuo-Silva, R, Fukushiro, DF, Borçoi, ARet al. Addictive potential of modafinil and cross-sensitization with cocaine: a pre-clinical study. Addict Biol 2011;16:565–579.CrossRefGoogle ScholarPubMed
19.Burgos, H, Castillo, A, Flores, Oet al. Effect of modafinil on learning performance and neocortical long-term potentiation in rats. Brain Res Bull 2010;83:238–244.CrossRefGoogle ScholarPubMed
20.Bekinschtein, P, Cammarota, M, Igaz, LMet al. Persistence of long-term memory storage requires a late protein synthesis- and BDNF-dependent phase in the hippocampus. Neuron 2007;53:261–277.CrossRefGoogle ScholarPubMed
21.Bekinschtein, P, Cammarota, M, Katche, Cet al. BDNF is essential to promote persistence of long-term memory storage. Proc Natl Acad Sci U S A 2008;105:2711–2716.CrossRefGoogle ScholarPubMed
22.Bekinschtein, P, Katche, C, Slipczuk, Let al. Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures. Neurotox Res 2010;18:377–385.CrossRefGoogle ScholarPubMed
23.Mignot, E, Nishino, S, Guilleminault, C, Dement, WC. Modafinil binds to the dopamine uptake carrier site with low affinity. Sleep 1994;17:436–437.CrossRefGoogle Scholar
24.Zolkowska, D, Jain, R, Rothman, RBet al. Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther 2009;329:738–746.CrossRefGoogle ScholarPubMed
25.Andersen, ML, Kessler, E, Murnane, KS, McClung, JC, Tufik, S, Howell, LL. Dopamine transporter-related effects of modafinil in rhesus monkeys. Psychopharmacology (Berl) 2010;210:439–448.CrossRefGoogle ScholarPubMed
26.Volkow, ND, Fowler, JS, Logan, Jet al. Effects of modafinil on dopamine and dopamine transporters in the male human brain: clinical implications. JAMA 2009;301:1148–1154.CrossRefGoogle ScholarPubMed
27.TM, Jay. Dopamine: a potential substrate for synaptic plasticity and memory mechanisms. Prog Neurobiol 2003;69:375–390.Google Scholar
28.O’Carroll, CM, Martin, SJ, Sandin, J, Frenguelli, B, Morris, RG. Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. Learn Mem 2006;13:760–769.CrossRefGoogle ScholarPubMed