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Differential semantic processing in patients with schizophrenia versus bipolar disorder: an N400 study

Published online by Cambridge University Press:  16 September 2019

D. Raucher-Chéné Open the ORCID record for D. Raucher-Chéné [Opens in a new window] ,
S. Terrien ,
P. Gobin ,
F. Gierski ,
S. Caillies ,
A. Kaladjian  and
C. Besche-Richard
D. Raucher-Chéné*
Affiliation:
Department of Psychiatry, Reims University Hospital, Reims, France Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France
S. Terrien
Affiliation:
Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France
P. Gobin
Affiliation:
Department of Psychiatry, Reims University Hospital, Reims, France Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France
F. Gierski
Affiliation:
Department of Psychiatry, Reims University Hospital, Reims, France Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France
S. Caillies
Affiliation:
Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France
A. Kaladjian
Affiliation:
Department of Psychiatry, Reims University Hospital, Reims, France Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France Faculty of Medicine, Reims Champagne-Ardenne University, Reims, France
C. Besche-Richard
Affiliation:
Cognition, Health & Society Laboratory, Reims Champagne-Ardenne University, Reims, France
*
Author for correspondence: D. Raucher-Chéné, Email: draucherchene@chu-reims.fr
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Abstract

Objective:

Both bipolar disorder (BD) and schizophrenia (SZ) are associated with language and thought symptoms that probably reflect a semantic memory-related impairment. We conducted a preliminary study to explore the nature of semantic processing in these disorders, using event-related potentials (ERPs).

Methods:

Twelve patients with BD, 10 patients with SZ and a matched group of 21 healthy controls (HC) underwent EEG recording while they heard sentences containing homophones or control words and performed a semantic ambiguity resolution task on congruent or incongruent targets.

Results:

Mean N400 amplitude differed between groups for homophones. Patients with SZ made more resolution errors than HC and exhibited a greater N400 congruity effect in ambiguous conditions than BD. In BD, the opposite N400 congruity effect was observed in ambiguous conditions.

Conclusion:

Results indicated differences in semantic processing between BD and SZ. Further studies with larger populations are needed in order to develop neurophysiological markers of these disorders.

Significant Outcomes

  • In ambiguous conditions, patients with SZ exhibited a greater N400 difference between congruent and incongruent conditions than patients with BD.

  • In ambiguous conditions, patients with SZ exhibited greater N400 amplitude in incongruent conditions than in congruent ones, whereas patients with BD exhibited the opposite N400 congruity effect.

  • Ambiguity resolution results suggest that patients with SZ have difficulty considering the context, while patients with BD overactivate the dominant meaning of homophones and have difficulty inhibiting it.

Keywords

bipolar disorderN400semanticsschizophrenia
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 31 , Issue 6 , December 2019 , pp. 337 - 342
Copyright
© Scandinavian College of Neuropsychopharmacology 2019 

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References

American Psychiatric Association (2000) Diagnostic and Statistical Manual, 4th Edn. Text revision (DSM-IV-TR). Washington: American Psychiatric Association.Google Scholar
Andreasen, NC (1979) Thought, language, and communication disorders I: clinical assessment, definition of terms, and evaluation of their reliability. Archives Of General Psychiatry 36, 1315–1321.Google Scholar
Andreou, C, Bozikas, VPP, Ramnalis, A, Giannakou, M and Fokas, K (2013) Semantic priming in remitted patients with bipolar disorder. Journal of Behavior Therapy and Experimental Psychiatry 44, 48–52.Google Scholar
Barton, K (2018) MuMIn: multi-model inference. R package version 1.42.1. Available at https://cran.r-project.org/package=MuMIn (Accessed 22 January 2019).Google Scholar
Bates, D, Mächler, M, Bolker, B and Walker, S (2015) Fitting linear mixed-effects models using lme4. Journal of Statistical Software 67, 1–48.Google Scholar
Beck, AT, Ward, C and Mendelson, M (1961) Beck depression inventory (BDI). Archives of General Psychiatry 4, 561–571.Google Scholar
Bortolato, B, Miskowiak, KW, Köhler, CA, Vieta, E and Carvalho, AF (2015) Cognitive dysfunction in bipolar disorder and schizophrenia: a systematic review of meta-analyses. Neuropsychiatric Disease and Treatment 11, 3111–3125.Google Scholar
Brown, M and Kuperberg, GR (2015) A hierarchical generative framework of language processing: linking language perception, interpretation, and production abnormalities in schizophrenia. Frontiers in Human Neuroscience 9, 1–23.Google Scholar
Cermolacce, M, Faugere, M, Micoulaud-Franchi, JA, Belzeaux, R, Maurel, M, Naudin, J, Azorin, JM, Vion-Dury, J (2014) Natural speech comprehension in bipolar disorders: an event-related brain potential study among manic patients. Journal of Affective Disorders 158, 161–171.Google Scholar
De Rosario-Martinez, H (2015) phia: post-hoc interaction analysis. R package version 0.2-1. Available at https://cran.r-project.org/package=phia (Accessed 22 January 2019).Google Scholar
Hoenig, K and Scheef, L (2009) Neural correlates of semantic ambiguity processing during context verification. Neuroimage 45, 1009–1019.Google Scholar
Howard, D, Nickels, L, Coltheart, M and Cole-Virtue, J (2006) Cumulative semantic inhibition in picture naming: experimental and computational studies. Cognition 100, 464–482.Google Scholar
Jamadar, S, O’Neil, KM, Pearlson, GD, Ansari, M, Gill, A, Jagannathan, K, Assaf, M (2013) Impairment in semantic retrieval is associated with symptoms in schizophrenia but not bipolar disorder. Biological Psychiatry 73, 555–564.Google Scholar
Kay, SR, Fiszbein, A and Opler, LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13(2), 261–276.Google Scholar
Kircher, T, Krug, A, Stratmann, M, Ghazi, S, Schales, C, Frauenheim, M, Turner, L, Fährmann, P, Hornig, T, Katzev, M, Grosvald, M, Müller-Isberner, R, Nagels, A (2014) A rating scale for the assessment of objective and subjective formal thought and language disorder (TALD). Schizophrenia Research 160, 216–221.Google Scholar
Kutas, M and Federmeier, KD (2011) Thirty years and counting: finding meaning in the N400 component of the event-related brain potential (ERP). Annual Review of Psychology 62, 621–647.Google Scholar
Neumann, E and DeSchepper, BG (1991) Costs and benefits of target activation and distractor inhibition in selective attention. Journal of Experimental Psychology: Learning, Memory, and Cognition 17, 1136–1145.Google Scholar
Piguet, C, Desseilles, M, Cojan, Y, Sterpenich, V, Dayer, A, Bertschy, G, Vuilleumier, P (2014) Neural correlates of generation and inhibition of verbal association patterns in mood disorders. Social Cognitive and Affective Neuroscience 10, 978–986.Google Scholar
Raucher-Chéné, D, Terrien, S, Gobin, P, Gierski, F, Kaladjian, A and Besche-Richard, C (2017) Modulation of the N400 component in relation to hypomanic personality traits in a word meaning ambiguity resolution task. Psychiatry and Clinical Neurosciences 71, 637–677.Google Scholar
R Core Team (2017) R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing.Google Scholar
Revelle, WR (2017) psych: procedures for personality and psychological research. Available at https://www.scholars.northwestern.edu/en/publications/psych-procedures-for-personality-and-psychological-research (accessed 2 December 2018).Google Scholar
Ryu, V, An, SK, Ha, RY, Kim, JA, Ha, K and Cho, HS (2012) Differential alteration of automatic semantic processing in treated patients affected by bipolar mania and schizophrenia: an N400 study. Progress in Neuro-Psychopharmacology & Biological Psychiatry 38, 194–200.Google Scholar
Salisbury, DF (2010) N400 to lexical ambiguity and semantic incongruity in schizophrenia. International Journal of Psychophysiology 75, 127–132.Google Scholar
Schneegans, H, Hoenig, K, Ruchsow, M, Spitzer, M, Connemann, BJ and Kiefer, M (2018) Semantic ambiguity resolution in patients with bipolar disorder—an event-related potential study. Frontiers in Psychology 9, 270.Google Scholar
Stefaniak, N (2018) easieR: an R metapackage. Available at https://github.com/NicolasStefaniak/easieR (Accessed 22 January 2019).Google Scholar
Wang, K, Song, LL, Cheung, EF, Lui, SS, Shum, DH and Chan, RC (2013) Bipolar disorder and schizophrenia share a similar deficit in semantic inhibition: a meta-analysis based on Hayling Sentence Completion Test performance. Progress in Neuro-Psychopharmacology & Biological Psychiatry 46, 153–160.Google Scholar
Young, RC, Biggs, JT, Ziegler, VE and Meyer, DA (1978) A rating scale for mania: reliability, validity and sensitivity. The British Journal of Psychiatry : The Journal of Mental Science 133, 429–435.Google Scholar
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