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Borna disease virus and deficit schizophrenia

Published online by Cambridge University Press:  24 June 2014

Yong-Ku Kim ,
Sang-Hyun Kim ,
Chang-Su Han ,
Heon-Jeong Lee ,
Hyung-Seob Kim ,
Sung-Chul Yoon ,
Dai-Jin Kim ,
Ki-Joon Song ,
Michael Maes  and
Jin-Won Song
Yong-Ku Kim*
Affiliation:
Department of Psychiatry
Sang-Hyun Kim
Affiliation:
Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University, Seoul
Chang-Su Han
Affiliation:
Department of Psychiatry
Heon-Jeong Lee
Affiliation:
Department of Psychiatry
Hyung-Seob Kim
Affiliation:
Yong-In Mental Hospital, Yong-In Institute, Kyunggido
Sung-Chul Yoon
Affiliation:
Keyo Mental Hospital
Dai-Jin Kim
Affiliation:
Department of Psychiatry, College of Medicine, The Catholic University, Seoul, Korea
Ki-Joon Song
Affiliation:
Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University, Seoul
Michael Maes
Affiliation:
Department of Psychiatry, University of Maastricht, Maastricht, the Netherlands
Jin-Won Song
Affiliation:
Department of Microbiology, Institute for Viral Diseases, College of Medicine, Korea University, Seoul
*
Department of Psychiatry, Korea University Medical Center Ansan Hospital, 516, Go-Jan Dong, Ansan city, Kyunggi Province, 425–070, Korea. Tel: + 82-31-412-5140; Fax: + 82-31-412-5144; E-mail: yongku@korea.ac.kr
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Abstract

Background:

It is controversial whether Borna disease virus (BDV) infects humans and causes psychiatric disorders.

Objectives:

The relationship between BDV infection and schizophrenia with deficit syndrome was investigated.

Study design:

Using the Schedule for the Deficit Syndrome, 62 schizophrenic in-patients were selected from three psychiatric hospitals. RNA was extracted from peripheral blood mononuclear cells and analyzed using nested reverse transcriptase-polymerase chain reaction with primers to detect BDV p24 and p40.

Results and conclusions:

BDV transcripts were not detected in samples from any of the 62 schizophrenic patients. These data do not support an etiologic association between BDV infection and the deficit form of schizophrenia.

Keywords

Borna disease virusdeficit syndromePBMCRT-PCRschizophrenia
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 5 , October 2003 , pp. 262 - 265
Copyright
Copyright © 2003 Blackwell Munksgaard

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