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Acute tryptophan depletion in bipolar disorders; literature review and directives for further research

Published online by Cambridge University Press:  18 September 2015

S. Sobczak ,
A. Honig  and
W.J. Riedel
S. Sobczak
Affiliation:
Institute Brain and Behaviour, Dept. of Psychiatry, Maastricht, The Netherlands
A. Honig*
Affiliation:
Institute Brain and Behaviour, Dept. of Psychiatry, Maastricht, The Netherlands
W.J. Riedel
Affiliation:
Institute Brain and Behaviour, Dept. of Psychiatry, Maastricht, The Netherlands
*
Institute Brain and Behaviour, AZM Dept. of Psychiatry P.O. Box 5800 6202 AZ Maastricht, The Netherlands
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Abstract

Serotonin (5-HT) has been implicated in the pathophysiology of bipolar disorders. Acute tryptophan depletion (ATD), which decreases serotonergic turnover, is an established paradigm to study serotonergic vulnerability in affective disorders. Literature on the application of ATD as a research tool in bipolar patients is limited to three studies, which revealed inconsistent results on mood modification. These inconsistencies may be attributed to differences in methodological procedures and / or characteristics of included patients. Patient selection, methodological aspects and procedures of these studies are critically considered and recommendations given. A research protocol to test the 5-HT vulnerability in bipolar disorder is proposed.

Keywords

bipolar disordersfamily historymaniamoodserotonintryptophan depletion
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 69 - 72
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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