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Possible association between G-protein β3 subunit C825T polymorphism and antipsychotic-induced restless legs syndrome in schizophrenia

Published online by Cambridge University Press:  24 June 2014

Seung-Gul Kang
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
Heon-Jeong Lee*
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, South Korea
Jung-Eun Choi
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea Division of Brain Korea 21 Biomedical Science, Korea University College of Medicine, Seoul, South Korea
Jae-Hong Park
Affiliation:
Department of Psychiatry, National Bugok Hospital, Gyeongsangnam-do, South Korea
Sang-Shin Lee
Affiliation:
Department of Psychiatry, National Bugok Hospital, Gyeongsangnam-do, South Korea
Changsu Han
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
Yong-Ku Kim
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
Seung-Hyun Kim
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
Min-Soo Lee
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
Sook-Haeng Joe
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
In-Kwa Jung
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
Leen Kim
Affiliation:
Department of Psychiatry, Korea University College of Medicine, Seoul, South Korea
*
Heon-Jeong Lee, Department of Psychiatry, Anam Hospital, Korea University College of Medicine, Anam-dong 5-ga, Seongbuk-gu, Seoul 136-705, Korea. Tel: +82 2 9205815; Fax: +82 2 9297679; E-mail: leehjeong@korea.ac.kr

Abstract

Objective:

The incidence of restless legs syndrome (RLS) is presumed to be higher among people with schizophrenia who take antipsychotic medication, most of which blocks the dopamine D2 receptor. The purpose of this study was to determine whether the G-protein β3 subunit (GNB3) C825T polymorphism is associated with antipsychotic-induced RLS in schizophrenia.

Methods:

We examined 178 Korean patients with schizophrenia. All of the subjects were evaluated using the diagnostic criteria of the International Restless Legs Syndrome Study Group and the International Restless Legs Scale. Genotyping was performed for the C825T polymorphism in the GNB3 gene.

Results:

The genotype distribution did not differ significantly between antipsychotic-induced RLS patients and patients who had no-RLS symptoms (χ2 = 4.30, p = 0.116). The genotypes of the C825T single-nucleotide polymorphism (SNP) were classified into two groups: C+ (CC and CT genotypes) and C– (TT genotype). The presence of the C allele (C+) was associated with an increased likelihood of RLS (χ2 = 4.14, p = 0.042; odds ratio = 2.56, 95% confidence interval = 1.02–6.47).

Conclusions:

These results suggest that the GNB3 C825T SNP is associated with RLS in schizophrenia. However, confirming this association requires future larger scale studies in which the effects of medication are strictly controlled.

Type
Research Article
Copyright
Copyright © 2007 Blackwell Munksgaard

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