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The influence of cognitive impairment on health-related quality of life in neurological disease

Published online by Cambridge University Press:  24 June 2014

Alex J. Mitchell*
Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
Steven Kemp
St James' University Hospital, Leeds, UK
Julián Benito-León
Department of Neurology, University Hospital ‘12 de Octubre’, Madrid, Spain; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain
Markus Reuber
University of Sheffield, Sheffield, UK
Alex J. Mitchell, Department of Liaison Psychiatry, Leicester General Hospital, Leicester LE5 4PW, UK. Tel/Fax: +0116 2951951; E-mail:


Mitchell AJ, Kemp S, Benito-León J, Reuber M. The influence of cognitive impairment on health-related quality of life in neurological disease.


Cognitive impairment is the most consistent neurological complication of acquired and degenerative brain disorders. Historically, most focus was on dementia but now has been broadened to include the important construct of mild cognitive impairment.


Systematic search and review of articles linked quality of life (QoL) and cognitive complications of neurological disorders. We excluded QoL in dementia.


Our search identified 249 publications. Most research examined patients with brain tumours, stroke, epilepsy, head injury, Huntington's disease, motor neuron disease, multiple sclerosis and Parkinson's disease. Results suggested that the majority of patients with epilepsy, motor neuron disease, multiple sclerosis, Parkinson's disease, stroke and head injury have subtle cognitive deficits early in their disease course. These cognitive complaints are often overlooked by clinicians. In many cases, the cognitive impairment is progressive but it can also be relapsing-remitting and in some cases reversible. Despite the importance of severe cognitive impairment in the form of dementia, there is now increasing recognition of a broad spectrum of impairment, including those with subclinical or mild cognitive impairment. Even mild cognitive difficulties can have functional and psychiatric consequences–especially when they are persistent and untreated. Specific cognitive deficits such an inattention, dysexecutive function and processing speed may affect a number of quality of life (QoL) domains. For example, cognitive impairment influences return to work, interpersonal relationships and leisure activities. In addition, fear of future cognitive decline may also impact upon QoL.


We recommend further development of simple tools to screen for cognitive impairments in each neurological condition. We also recommend that a thorough cognitive assessment should be a part of routine clinical practice in those caring for individuals with neurological disorders.

Review article
Copyright © 2010 John Wiley & Sons A/S

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Heilman, K, Valenstein, E.Clinical Neuropsychology (Medicine) (Hardcover). New York: Oxford University Press, 2004. Google Scholar
Matotek, K, Saling, MM, Gates, P, Sedal, L.Subjective complaints, verbal fluency, and working memory in mild multiple sclerosis. Appl Neuropsychol 2001;8:204210. CrossRefGoogle ScholarPubMed
Marrie, RA, Chelune, GJ, Miller, DM, Cohen, JA.Subjective cognitive complaints relate to mild impairment of cognition in multiple sclerosis. Mult Scler 2005;11:6975. CrossRefGoogle ScholarPubMed
Hendriks, MPH, Aldenkamp, AP, Alpherts, WCJ, Ellis, J, Vermeulen, J, Van Der Vlugt, H.Relationships between epilepsy-related factors and memory impairment. Acta Neurol Scand 2004;110:291300. CrossRefGoogle ScholarPubMed
Gass, CS, Apple, C.Cognitive complaints in closed-head injury: relationship to memory test performance and emotional disturbance. J Clin Exp Neurophyschol 1997;19: 290299. CrossRefGoogle ScholarPubMed
Mitchell, AJ.Neuropsychiatry and behavioural neurology explained. Edinburgh: W. B. Saunders, 2004. Google Scholar
Fisher, RS, Vickrey, BG, Gibson, Pet al. The impact of epilepsy from the patients' perspective Part I: descriptions and subjective perceptions. Epilepsy Res 2000;41:3951. CrossRefGoogle Scholar
Halbertsma, J, Heerkens, YF, Hirs, WM, De Kleijn-de Vrankrijker, MW, Dorine Van Ravensberg, CD, Napel, HT.Towards a new ICIDH [International Classification of Impairments, Disabilities and Handicaps]. Disabil Rehabil. 2000 Feb 15;22:144156. CrossRefGoogle Scholar
Geyh, S, Kurt, T, Brockow, Tet al. Identifying the concepts contained in outcome measures of clinical trials on stroke using the international classification of functioning, disability and health as a reference. J Rehabil Med 2004; 36(Suppl. 44):5662. CrossRefGoogle Scholar
Gottlieb, A, Golander, H, Bar-Tal, Y, Gottlieb, D.The influence of social support and perceived control on handicap and quality of life after stroke. Aging Clin Exp Res 2001;13:1115. CrossRefGoogle ScholarPubMed
World Health Organization. International Classification of Impairments, Disabilities and Handicaps. Geneva: WHO, 1980. Google ScholarPubMed
Assessment, Classification and Epidemiology Group. International Classification of Functioning and Disability (ICIDH-2) Beta-2 draft Full Version. July, 1999. Geneva: WHO. Google Scholar
Grosset, KA, Grosset, DG.Patient-perceived involvement and satisfaction in Parkinson's disease: effect on therapy decisions and quality of life. Movement Disorders 2005;20:616619. CrossRefGoogle ScholarPubMed
Mitchell, AJ, Benito-Leon, J, Gonzalez, JMMet al. Quality of life and its assessment in multiple sclerosis: integrating physical and psychological components of wellbeing. Lancet Neurol 2005;4:556566. CrossRefGoogle ScholarPubMed
Dijkers, M.Quality of life after spinal cord injury: a metaanalysis of the effects of disablement components. Spinal Cord 1997;35:829840. CrossRefGoogle Scholar
Taphoorn, MJB, Klein, M.Cognitive deficits in adult patients with brain tumors. Lancet Neurol 2004;3:159168. CrossRefGoogle Scholar
Brown, PD, Buckner, JC, O'Fallon, JRet al. Effects of radiotherapy on cognitive function in patients with low-grade glioma measured by the Folstein Mini-Mental State Examination. J Clin Oncol 2003;21:25192524. CrossRefGoogle ScholarPubMed
Falleti, MG, Sanfilippo, A, Maruff, P, et al. The nature and severity of cognitive impairment associated with adjuvant chemotherapy in women with breast cancer: A meta-analysis of the current literature. Brain Cogn 2005;59:6070. CrossRefGoogle ScholarPubMed
Bartolomei, F, Bosma, I, Mein, Met al. How do brain tumors alter functional connectivity? A magnetoencephalography study. Ann Neurol 2006;59:128138. CrossRefGoogle ScholarPubMed
Klein, M, Engelberts, NHJ, Van Der Ploeg, HM, Trenite, DGAKNet al. Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life. Ann Neurol 2003;54:514520. CrossRefGoogle ScholarPubMed
Meyers, CA, Hess, KR, Yung, WKA, Levin, VA.Cognitive function as a predictor of survival in patients with recurrent malignant glioma. J Clin Oncol 2000;18:646650. CrossRefGoogle ScholarPubMed
Armstrong, CL, Goldstein, B, Shera, D, Ledakis, GE, Tallent, EM.The predictive value of longitudinal neuropsychologic assessment in the early detection of brain tumor recurrence. Cancer 2003;97:649656. CrossRefGoogle ScholarPubMed
Meyers, CA, Hess, KR.Multifaceted end points in brain tumor clinical trials: cognitive deterioration precedes MRI progression. Neuro-oncol 2003;5:8995. Google ScholarPubMed
Olson, RA, Chhanabhai, T, McKenzie, M.Feasibility study of the Montreal Cognitive Assessment (MoCA) in patients with brain metastases. Support Care Cancer 2008; 16:12731278. CrossRefGoogle ScholarPubMed
Giovagnoli, AR, Boiardi, A.Cognitive impairment and quality-of-life in long-term survivors of malignant brain-tumors. Italian J Neurol Sci 1994;15:481488. CrossRefGoogle ScholarPubMed
Brown, PD, Maurer, MJ, Rummans, TAet al. A prospective study of quality of life in adults with newly diagnosed high-grade gliomas: the impact of the extent of resection on quality of life and survival. Neurosurgery 2005;57: 495503. CrossRefGoogle Scholar
Osoba, D, Brada, M, Prados, MD, Yung, WKA.Effect of disease burden on health-related quality of life in patients with malignant gliomas. Neuro-oncol 2000;2:221228. Google ScholarPubMed
Pelletier, G, Verhoef, MJ, Khatri, N, Hagen, N.Quality of life in brain tumor patients: the relative contributions of depression, fatigue, emotional distress, and existential issues. J Neuro-oncol 2002;57:4149. CrossRefGoogle ScholarPubMed
Giovagnoli, AR, Silvani, A, Colombo, Eet al. Facets and determinants of quality of life in patients with recurrent high grade glioma. J Neurol Neurosurg Psychiatry 2005;76:562568. CrossRefGoogle ScholarPubMed
Li, J, Bentzen, SM, Li, JLet al. Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis. Int J Rad Oncol Biol Phys 2008;71:6470. CrossRefGoogle ScholarPubMed
Mauer, ME, Bottomley, A, Taphoorn, MJBEvaluating health-related quality of life and symptom burden in brain tumour patients: instruments for use in experimental trials and clinical practice. Curr Opin Neurol 2008;21:745753. CrossRefGoogle ScholarPubMed
Gehring, K, Sitskoorn, MM, Aaronson, NKet al. Interventions for cognitive deficits in adults with brain tumours. Lancet Neurol 2008;7 548560. CrossRefGoogle ScholarPubMed
Shaw, EG, Rosdhal, R, D'Agostino, RB, Lovato, J, Naughton, MJ, Robbins, ME, Rapp, SR.Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life. J Clin Oncol 2006;24:14151420. CrossRefGoogle Scholar
Locke Dona, EC, Cerhan, JH, Wu, Wet al. Cognitive rehabilitation and problem-solving to improve quality of life of patients with primary brain tumors: a pilot study. J Support Oncol 2008;6:383391. Google Scholar
Vermeer, SE, Prins, ND, Den Heijer, T, Hofman, A, Koudstaal, PJ, Breteler, MM.Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003;348:12151222. CrossRefGoogle ScholarPubMed
Paul, SL, Sturm, JW, Dewey, HM, Donnan, GA, Macdonell, RAL, Thrift, AG.Long-term outcome in the north east Melbourne stroke incidence study—predictors of quality of life at 5 years after stroke. Stroke 2005;36: 20822086. CrossRefGoogle Scholar
Melkas, S, Oksala, NKJ, Jokinen, Het al. Poststroke dementia predicts poor survival in long-term follow-up: influence of prestroke cognitive decline and previous stroke. J Neurol Neurosurg Psychiatry 2009;80:865870. CrossRefGoogle ScholarPubMed
Nichols-Larsen, DS, Clark, PC, Zeringue, A, Greenspan, A, Blanton, S.Factors influencing stroke survivors' quality of life during subacute recovery. Stroke 2005;36:14801484. CrossRefGoogle ScholarPubMed
Madureira, S, Guerreiro, M, Ferro, JM.Dementia and cognitive impairment three months after stroke. Eur J Neurol 2001;8:621627. CrossRefGoogle ScholarPubMed
Patel, M, Coshall, C, Rudd, AGet al. Post-stroke cognitive impairment: clinical determinants and its associations with long-term stroke outcomes. J Neurol Sci 2001; 187(Suppl. 1):S23. Google Scholar
Hénon, H, Durieu, I, Guerouaou, Det al. Poststroke dementia incidence and relationship to prestroke cognitive decline. Neurology 2001;57:12161222. CrossRefGoogle ScholarPubMed
Tatemichi, TK, Paik, M, Bagiella, Eet al. Dementia after stroke is a predictor of long-term survival. Stroke 1994;25:19151919. CrossRefGoogle ScholarPubMed
Fatoye, FO, Komolafe, MA, Eegunranti, BAet al. Cognitive impairment and quality of life among stroke survivors in Nigeria. Psychol Rep 2007;100:876882. CrossRefGoogle ScholarPubMed
Moon, YS, Kim, SJ, Kim, HC, Won, MH, Kim, DH.Correlates of quality of life after stroke. J Neurol Sci 2004; 224:3741. CrossRefGoogle ScholarPubMed
Kwa, VIH, Limburg, M, De Haan, RJ.The role of cognitive impairment in the quality of life after ischaemic stroke. J Neurol 1996;243:599604. CrossRefGoogle ScholarPubMed
Jonkman, EJ, De Weerd, AW, Vrijens, NLH.Quality of life after a first ischemic stroke—long-term developments and correlations with changes in neurological deficit, mood and cognitive impairment. Acta Neurol Scand 1998;98:169175. CrossRefGoogle ScholarPubMed
Hochstenbach, JB, Anderson, PG, Van Limbeek, J, Mulder, TT.Is there a relation between neuropsychologic variables and quality of life after stroke? Arch Phys Med Rehabil 2001;82:13601366. CrossRefGoogle Scholar
Hochstenbach, JB, Mulder, TW.Cognitive recovery after stroke: a 2-year follow-up. Arch Phys Med Rehabil 2003;84:14991504. CrossRefGoogle ScholarPubMed
Kauhanen, ML, Korpelainen, JT, Hiltunen, Pet al Domains and determinants of quality of life after stroke caused by brain infarction. Arch Phys Med Rehabil 2000;81:15411546. CrossRefGoogle ScholarPubMed
Hilari, K, Wiggins, RD, Roy, P, Byng, S, Smith, SC.Predictors of health-related quality of life (HRQL) in people with chronic aphasia. Aphasiology 2003;17:365381. CrossRefGoogle Scholar
Nys, GMS; Van Zandvoort, MJE; Van Der Worp, HBet al. Early cognitive impairment predicts long-term depressive symptoms and quality of life after stroke. J Neurol Sci 2006;247:149156. CrossRefGoogle ScholarPubMed
Randhawa, S, Walterfang, M, Miller, Ket al. The development and validation of a carer questionnaire to assess cognitive function in neuropsychiatric patients. J Psychosom Res 2007;63:9398. CrossRefGoogle ScholarPubMed
Te Winkel-Witlox, ACM, Post, MWM, Visser-Meily, JMAet al. Efficient screening of cognitive dysfunction in stroke patients: comparison between the CAMCOG and the R-CAMCOG, Mini Mental State Examination and Functional Independence Measure-cognition score. Disabil Rehabil 2008;30:13861391. CrossRefGoogle ScholarPubMed
Tang, WK; Mok, V; Chan, SSMet al. Screening of dementia in stroke patients with Lacunar infarcts: comparison of the Mattis Dementia Rating Scale and the Mini-Mental State Examination. J Geriatr Psychiatry Neurol 2005;18:37. CrossRefGoogle ScholarPubMed
Adunsky, A, Fleissig, Y, Levenkrohn, Set al. Clock drawing task, mini-mental state examination and cognitive-functional independence measure: relation to functional outcome of stroke patients. Arch Gerontol Geriatr 2002;35: 153160. CrossRefGoogle ScholarPubMed
Olsson, G, Sunnerhagen, B, Stibrant, K.Functional and cognitive capacity and health-related quality of life 2 years after day hospital rehabilitation for stroke: a prospective study. J Stroke Cerebrovasc Dis 2007;16:208215. CrossRefGoogle Scholar
Lutz, MT, Helmstaedter, C.EpiTrack: tracking cognitive side effects of medication on attention and executive functions in patients with epilepsy. Epilepsy Behav 2005;7:708714. CrossRefGoogle ScholarPubMed
Andersson-Roswall, L, Engman, E, Samuelsson, Het al. Verbal memory decline and adverse effects on cognition in adult patients with pharmacoresistant partial epilepsy: a longitudinal controlled study of 36 patients. Epilepsy Behav 2004;5:677686. CrossRefGoogle ScholarPubMed
Perrine, K, Hermann, BP, Meador, KJet al. The relationship of neuropsychological functioning to quality-of-life in epilepsy. Arch Neurol 1995;52:9971003. CrossRefGoogle ScholarPubMed
Giovagnoli, AR, Avanzini, G.Quality of life and memory performance in patients with temporal lobe epilepsy. Acta Neurol Scand 2000;101:295300. CrossRefGoogle ScholarPubMed
Engelberts, NHJ, Klein, M, Van Der Ploeg, HMet al. Cognition and health-related quality of life in a well-defined subgroup of patients with partial epilepsy. J Neurol 2002;249:294299. CrossRefGoogle Scholar
Engelberts, NHJ, Klein, M, Van Der Ploeg, HMet al. Cognition and health-related quality of life in chronic well-controlled patients with partial epilepsy on carbamazepine monotherapy. Epilepsy Behav 2002;3:316321. CrossRefGoogle ScholarPubMed
Piazzini, A, Beghi, E, Turner, Ket al. Health-related quality of life in epilepsy: findings obtained with a new Italian instrument. Epilepsy Behav 2008;13:119126. CrossRefGoogle ScholarPubMed
Meneses, RF, Pais-Ribeiro, JL, da Silva, AMet al. Neuropsychological predictors of quality of life in focal epilepsy. Seizure-European J Epilepsy 2009;18:313319. Google Scholar
Selai, CE, Elstner, K, Trimble, MR.Quality of life pre and post epilepsy surgery. Epilepsy Res 2000;38:6774. CrossRefGoogle ScholarPubMed
Lowe, AJ, David, E, Kilpatrick, CJet al. Epilepsy surgery for pathologically proven hippocampal sclerosis provides long-term seizure control and improved quality of life. Epilepsia 2004;45:237242. CrossRefGoogle ScholarPubMed
Aydemir, N, Ozkara, C, Canbeyli, R, Tekcan, A.Changes in quality of life and self-perspective related to surgery in patients with temporal lobe epilepsy. Epilepsy Behav 2004;5:735742. CrossRefGoogle ScholarPubMed
Ojemann, GA.Dodrill, CB.Verbal memory deficits after left temporal lobectomy for epilepsy. Mechanism and intraoperative prediction. J Neurosurg 1985;62:101107. CrossRefGoogle ScholarPubMed
Joo, EY, Han, HJ, Lee, EKet al. Resection extent versus postoperative outcomes of seizure and memory in mesial temporal lobe epilepsy. Seizure-European J Epilepsy 2005;14:541551. Google Scholar
Helmstaedter, C, Reuber, M, Elger, CCE.Interaction of cognitive aging and memory deficits related to epilepsy surgery. Ann Neurol 2002;52:8994. CrossRefGoogle ScholarPubMed
Davies, KG, Bell, BD, Bush, AJ, Wyler, AR.Prediction of verbal memory loss in individuals after anterior temporal lobectomy. Epilepsia 1998;39:820828. CrossRefGoogle ScholarPubMed
Helmstaedter, C, Elger, CE.Cognitive consequences of two-thirds anterior temporal lobectomy on verbal memory in 144 patients: a three-month follow-up study. Epilepsia 1996;37 2: 171180. CrossRefGoogle ScholarPubMed
Helmstaedter, C, Kurthen, M, Lux, S, Reuber, M, Elger, CE.Chronic epilepsy and cognition: a longitudinal study in temporal lobe epilepsy. Ann Neurol 2003;54: 425432. CrossRefGoogle ScholarPubMed
Wilson, JTL, Pettigrew, LEL, Teasdale, GM.Emotional and cognitive consequences of head injury in relation to the Glasgow outcome scale. J Neurol Neurosurg Psychiatry 2000;69:204209. CrossRefGoogle ScholarPubMed
McCarthy, ML, Dikmen, SS, Langlois, JA, Selassie, AW, Gu, JK, Horner, MD.Self-reported psychosocial health among adults with traumatic brain injury. Arch Phys ed Rehab 2006;87:953961. CrossRefGoogle ScholarPubMed
Belanger, HG, Curtiss, G, Demery, JA, Lebowitz, BK, Vanderploeg, RD.Factors moderating neuropsychological outcomes following mild traumatic brain injury: a meta-analysis. J Int Neuropsychol Soc 2005;11:215227. CrossRefGoogle ScholarPubMed
Kemp, S, Goulding, P, Spencer, Jet al. Unusually rapid and severe cognitive deterioration after mild traumatic brain injury. Brain Injury 2005;19:12691276. CrossRefGoogle ScholarPubMed
Frencham, KAR, Fox, AM, Maybery, MT.Neuropsychological studies of mild traumatic brain injury: a meta-analytic review of research since 1995. J Clin Exp Neuropsychol 2005;27 334351. CrossRefGoogle Scholar
Christensen, BK, Colella, B, Illness, Eet al. Recovery of cognitive function after traumatic brain injury: a multilevel modeling analysis of canadian outcomes. Arch Phys Med Rehab 2008;89:S3S15. CrossRefGoogle ScholarPubMed
MacKenzie, EJ, McCarthy, ML, Ditunno, JFet al. Using the SF-36 for characterizing outcome after multiple trauma involving head injury. J Trauma-Injuiry Infec Crit Care 2002;52:527533. CrossRefGoogle ScholarPubMed
Dawson, DR, Levine, B, Schwartz, ML, Stuss, DT.Acute predictors of real-world outcomes following traumatic brain injury: a prospective study. Brain Injury 2004;18:221238. CrossRefGoogle ScholarPubMed
Atchison, TB, Sander, AM, Struchen, MAet al. Relationship between neuropsychological test performance and productivity at 1-year following traumatic brain injury. Clin Neuropsychol 2004;18:249265. CrossRefGoogle ScholarPubMed
Dijkers, MP.Quality of life after traumatic brain injury: a review of research approaches and findings. Arch Phys Med Rehabil 2004;85(Suppl. 2):S21S35. CrossRefGoogle ScholarPubMed
Lannoo, E, Van Rietvelde, F, Colardyn, F, Lemmerling, M, Vandekerckhove, T, Jannes, C, De Soete, G.Early predictors of mortality and morbidity after severe closed head injury. J Neurotrauma May 2000;17:403414. CrossRefGoogle ScholarPubMed
Tate, RL, Broe, GA.Psychosocial adjustment after traumatic brain injury: what are the important variables? Psychol Med 1999;29:713725. CrossRefGoogle ScholarPubMed
Wood, RLL, Rutterford, NA.Demographic and cognitive predictors of long-term psychosocial outcome following traumatic brain injury. J Int Neuropsychol Soc 2006;12: 350358. CrossRefGoogle ScholarPubMed
Blalock, AC, McDaniel, JS, Farber, EW.Effect of employment on quality of life and psychological functioning in patients with HIV/AIDS. Psychosomatics 2002; 43:400404. CrossRefGoogle ScholarPubMed
Blake, C, Codd, MB, Cassidy, A, O'Meara, YM.Physical function, employment and quality of life in end-stage renal disease. J Nephrol 2000;3:142149. Google Scholar
Orbon, KH, Schermer, TR, Van Der Gulden, JWet al. Employment status and quality of life in patients with chronic obstructive pulmonary disease. Int Arch Occup Env Health 2005;78:467474. CrossRefGoogle ScholarPubMed
Johansson, U, Bernspang, B.Life satisfaction related to work re-entry after brain injury: a longitudinal study. Brain Injury 2003;17:9911002. CrossRefGoogle ScholarPubMed
Ownsworth, T, McKenna, K.Investigation of factors related to employment outcome following traumatic brain injury: a critical review and conceptual model. Disabil Rehabil 2004;26:765784. CrossRefGoogle ScholarPubMed
Devitt, R, Colantonio, A, Dawson, Det al. Prediction of long-term occupational performance outcomes for adults after moderate to severe traumatic brain injury. Disabil Rehabil 2006;28:547559. CrossRefGoogle ScholarPubMed
Green, RE, Colella, B, Hebert, DAet al Prediction of return to productivity after severe traumatic brain injury: investigations of optimal neuropsychological tests and timing of assessment. Arch Phys Med Rehabil 2008;89(Suppl. 2):S51S60. CrossRefGoogle ScholarPubMed
Sherer, M, Novack, TA, Sander, AM, Struchen, MA, Alderson, A, Thompson, RN.Neuropsychological assessment and employment outcome after traumatic brain injury: a review. Clin Neuropsychol 2002;16:157178. CrossRefGoogle ScholarPubMed
Simpson, A, Schmitter-Edgecombe, MPrediction of employment status following traumatic brain injury using a behavioural measure of frontal lobe functioning. Brain Injury 2002;16:10751091. CrossRefGoogle ScholarPubMed
Drake, AI, Gray, N, Yoder, S, Pramuka, M, Llewellyn, M.Factors predicting return to work following mild traumatic brain injury: a discriminant analysis. J Head Trauma Rehabil 2000;15:11031112. CrossRefGoogle ScholarPubMed
Ponsford, J, Olver, J, Ponsford, M, Nelms, R.Long-term adjustment of families following traumatic brain injury where comprehensive rehabilitation has been provided. Brain Injury 2003;17:453468. CrossRefGoogle ScholarPubMed
Svendsen, HA, Teasdale, TWThe influence of neuropsychological rehabilitation on symptomatology and quality of life following brain injury: a controlled long-term follow-up. Brain Injury 2006;20:12951306. CrossRefGoogle ScholarPubMed
Rohling, ML, Faust, ME, Beverly, Bet al. Effectiveness of cognitive rehabilitation following acquired brain injury: a meta-analytic re-examination of cicerone et al.'s (2000, 2005) Systematic teviews. Neuropsychology 2009;23:2039. CrossRefGoogle Scholar
Cicerone, KD, Mott, T, Azulay, Jet al. A randomized controlled trial of holistic neuropsychologic rehabilitation after traumatic brain injury. Arch Phys Med Rehabil 2008;89:22392249. CrossRefGoogle ScholarPubMed
Paulsen, JS, Zhao, H, Stout, JCet al. Clinical markers of early disease in persons near onset of Huntington's disease. Neurology 2001;57:658662. CrossRefGoogle ScholarPubMed
Helder, DI, Kaptein, AA, Van Kempen, GMJet al. Impact of Huntington's disease on quality of life. Mov Disord 2001;16:325330. CrossRefGoogle ScholarPubMed
Ho, AK, Gilbert, AS, Mason, SLet al. Health-related quality of life in huntington's disease: which factors matter most? Mov Disord 2009;24:574578. CrossRefGoogle ScholarPubMed
Salmon, DP, Kwoonyuen, PF, Heindel, WC.Differentiation of Alzheimers-disease and huntingtons-disease with the dementia rating-scale. Arch Neurol 1989;46: 12041208. CrossRefGoogle ScholarPubMed
Paulsen, JS, Stout, JC; TawfikReedy, Zet al. The utility of the Frontal Lobe Personality Scale (FLOPS) for characterizing behavior in dementia of the Alzheimer's type (DAT) and Huntington's disease (HD). Arch Clin Neuropsychol 1996;11:434435. CrossRefGoogle Scholar
Ho, AK, Robbins, AOG, Walters, SJ, Kaptoge, S, Sahakian, BJ, Barker, RA.Health-related quality of life in Huntington's disease: a comparison of two generic instruments, SF-36 and SIP. Mov Disorders 2004;19: 13411348. CrossRefGoogle Scholar
Higgins, DS, Nickerson, C, Molho, ES, Factor, SA.Health-related quality of life in Huntington disease: preliminary examination of the PDQ39. Mov Disorders 2005;20(Suppl. 10):S174S174. Google Scholar
Neary, D, Snowden, JS, Mann, DMA.Cognitive change in motor neurone disease / amyotrophic lateral sclerosis (MND/ALS). J Neurol Sci 2000;180:1520. CrossRefGoogle Scholar
Abrahams, S, Leigh, PN, Goldstein, LH.Cognitive change in ALS—a prospective study. Neurology 2005;64: 12221226. CrossRefGoogle ScholarPubMed
Barson, FP, Kinsella, GJ, Ong, B, Mathers, SE.A neuropsychological investigation of dementia in motor neurone disease (MND). J Neurol Sci 2000;180:107113. CrossRefGoogle Scholar
Garraux, G, Salmon, E, Degueldre, Cet al. Medial temporal lobe metabolic impairment in dementia associated with motor neuron disease. J Neurol Sci 1999;168: 145150. CrossRefGoogle ScholarPubMed
Duque, P, Parama, D, Borges, Get al. Neuropsychological disorders in amyotrophic lateral sclerosis. Don't they exist or do they just go undetected? Rev Neurol 2003;36:38. Google ScholarPubMed
Pessin, H, Rosenfeld, B, Burton, L, Breitbart, W.The role of cognitive impairment in desire for hastened death: a study of patients with advanced AIDS. Gen Hosp Psychiatry 2003;25:194199. CrossRefGoogle ScholarPubMed
Goldstein, LH, Atkins, L, Leigh, PN.Correlates of quality of life in people with motor neuron disease (MND). Amyotroph Lateral Scler Other Motor Neuron Disord 2002;3:123129. CrossRefGoogle Scholar
Lou, JS, Reeves, A, Benice, T, Sexton, G.Fatigue and depression are associated with poor quality of life in ALS. Neurology 2003;60:122123. CrossRefGoogle ScholarPubMed
Kubler, A, Winter, S, Ludolph, AC, Hautzinger, M, Birbaumer, NSeverity of depressive symptoms and quality of life in patients with amyotrophic lateral sclerosis. Neurorehabil Neural Repair 2005;19:182193. CrossRefGoogle ScholarPubMed
Epton, J, Harris, R, Jenkinson, C.Quality of life in amyotrophic lateral sclerosis/motor neuron disease: a structured review. Amyotroph Lateral Scler Other Motor Neuron Disord 2009;10:1526. CrossRefGoogle ScholarPubMed
Rogers, JM, Panegyres, PKCognitive impairment in multiple sclerosis: evidence-based analysis and recommendations. J Clin Neurosci 2007;14:919927. CrossRefGoogle ScholarPubMed
Chiaravalloti, ND, DeLuca, JCognitive impairment in multiple sclerosis. Lancet Neurology 2008;7:11391151. CrossRefGoogle ScholarPubMed
Brassington, JC, Marh, NV.Neuropsychological aspects of multiple sclerosis. Neuropsychol Rev 1998;8:4377. CrossRefGoogle ScholarPubMed
Shevil, E, Finlayson, M.Perceptions of persons with multiple sclerosis on cognitive changes and their impact on daily life. Disabil Rehabil 2006 28:779788. CrossRefGoogle ScholarPubMed
Lyon-Caen, O, Jouvent, R, Hauser, Set al. Cognitive functions in recent-onset demyelinating diseases. Arch Neurol 1986;43:11381141. CrossRefGoogle ScholarPubMed
Ruggieri, RM, Palermo, R, Vitello, G, Gennuso, M, Settipani, N, Piccoli, F.Cognitive impairment in patients suffering from relapsing-remitting multiple sclerosis with EDSS< 3.5. Acta Neurol Scand 2003;108:323326. CrossRefGoogle Scholar
Shawaryn, MA, Schiaffino, KM, LaRocca, NG, Johnston, MV.Determinants of health-related quality of life in multiple sclerosis: the role of illness intrusiveness. Mult Scler 2002;8:310318. CrossRefGoogle ScholarPubMed
Amato, MP, Ponziani, G, Siracusa, G, Sorbi, S.Cognitive dysfunction in early onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 2001;58:16021606. CrossRefGoogle ScholarPubMed
Cutajar, R, Ferriani, E, Scandellari, C, et al. Cognitive function and quality of life in multiple sclerosis patients. J Neurovirol 2000;6(Suppl):S186S190. Google ScholarPubMed
Gold, SM, Schulz, H, Monch, A, Schulz, KH, Heesen, C.Cognitive impairment in multiple sclerosis does not affect reliability and validity of self-report health measures. Mult Scler 2003;9:404410. CrossRefGoogle Scholar
O'Connor, P, Lee, L, Ng, PT, Narayana, P, Wolinsky, JS.Determinants of overall quality of life in secondary progressive MS: a longitudinal study. Neurology 2001;57:889891. CrossRefGoogle ScholarPubMed
Benedict, RHB, Wahlig, E, Bakshic, al. Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change. J Neurol Sci 2005;231:2934. CrossRefGoogle ScholarPubMed
Mitchell, AJ; Benito-Leon, J; Rivera-Navarro, J, et al. What degree of cognitive impairment predicts poor quality of life in multiple sclerosis?: The GEDMA study. Neurology 2006;66:A239A239. Google Scholar
Patti, F; Ciancio, MR; Reggio, E, et al. The impact of outpatient rehabilitation on quality of life in multiple sclerosis. J Neurol 2002;249:10271033. CrossRefGoogle ScholarPubMed
Martinez-Martin, P.Impact of the cognitive impairment on the quality of life in patients with Parkinson's disease. Rev Neurol 2006;43:168172. Google ScholarPubMed
Mindham, R.H.S. & Hughes, T.A.. Cognitive impairment in Parkinson's disease. Int Rev Psychiatry 2000;12: 281289. CrossRefGoogle Scholar
Aarsland, D, Ballard, C, and Glenda Halliday, G.Are Parkinson's Disease With Dementia and Dementia With Lewy Bodies the Same Entity? J Geriatr Psychiatry Neurol 2004;17:137145. CrossRefGoogle ScholarPubMed
Bruck, A, Kurki, T, Kaasinen, V, Vahlberg, T, Rinne, JO.Hippocampal and prefrontal atrophy in patients with early non-demented Parkinson's disease is related to cognitive impairment. J Neurol Neurosurg Psychiatry 75: 14671469. CrossRefGoogle ScholarPubMed
Emre, M, Aarsland, D, Brown, R, et al. Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord 2007;22:16891707. CrossRefGoogle ScholarPubMed
Schrag, A, Jahanshahi, M, Quinn, NJ.What contributes to quality of life in patients with Parkinson's disease? J Neurol Neurosurg Psychiatry 2000;69:308312. CrossRefGoogle ScholarPubMed
Croyle, KL, Fields, J, Lyons, K, Straits-Troster, K, Koller, W, Pahwa, R, Troster, AI.Cognitive functioning predicts quality of life in Parkinson's disease. Clin Neuropsychol 2001;15:270270. Google Scholar
Weintraub, D, Moberg, PJ, Duda, JE, Katz, IR, Stern, MB.Effect of psychiatric and other nonmotor symptoms on disability in Parkinson's disease. J Am Geriatr Soc 2004;52:784788. CrossRefGoogle ScholarPubMed
Klepac, N; Trkulja, V; Relja, M, et al. Is quality of life in non-demented Parkinson's disease patients related to cognitive performance? A clinic-based cross-sectional study. Eur J Neurol 2008;15:128133. CrossRefGoogle ScholarPubMed
Emre, M, Aarsland, D, Albanese, A, et al Rivastigmine for dementia associated with Parkinson's disease. New England J Med 2004;351:25092518. Google Scholar
Sinforiani, E, Banchieri, L, Zucchella, C, Pacchetti, C, Sandrini, G.Cognitive rehabilitation in Parkinson's disease. Arch Gerontol Geriatr 2004;387391. CrossRefGoogle ScholarPubMed
Albert, SM, Michaels, K, Padilla, M, et al. Functional significance of mild cognitive impairment in elderly patients without a dementia diagnosis American J Geriatr Psychiatry 1999;7:213220. CrossRefGoogle Scholar
Chodosh, J, Petitti, DB, Elliott, M, Hays, RD, Crooks, VC, Reuben, DB, Buckwalter, JG, Wenger, N.Physician recognition of cognitive impairment: Evaluating the need for improvement. J Am Geriatr Soc 2004;52:10511059. CrossRefGoogle Scholar
Valcour, VG, Masaki, KH, Curb, JD, Blanchette, PL.The detection of dementia in the primary care setting. Arch Intern Med 2000;160:29642968. CrossRefGoogle ScholarPubMed
Feil, D, Marmon, T, Unutzer, J.Cognitive impairment, chronic medical illness, and risk of mortality in an elderly cohort. American J Geriatr Psychiatry 2003; 11:551560. CrossRefGoogle Scholar
Cacciatore, F, Abete, P, De Santis, D, Longobardi, G, Ferrara, N, Rengo, F.Mortality and blood pressure in elderly people with and without cognitive impairment. Gerontology 2005;51:5361. CrossRefGoogle ScholarPubMed
Henon, H, Durieu, I, Lebert, F, Pasquier, F, Leys, D.Influence of prestroke dementia on early and delayed mortality in stroke patients. J Neurol 2003;250:1016. CrossRefGoogle ScholarPubMed
Kiessling, A, Henriksson, P.Perceived cognitive function is a major determinant of health related quality of life in a non-selected population of patients with coronary artery disease - a principal components analysis. Qual Life Res 2004;13:16211631. CrossRefGoogle Scholar
Kiessling, A, Henriksson. Perceived cognitive function in coronary artery disease - An unrecognised predictor of unemployment. Qual Life Res 2005;14:14811488. CrossRefGoogle ScholarPubMed
Rabkin, JG, McElhiney, M, Ferrando, SJ, Van Gorp, W, Hsing, S.Predictors of employment of men with HIV/AIDS: A longitudinal study. Psychosom Med 2004;66:7278. CrossRefGoogle ScholarPubMed
Artero, S, Touchon, J, Ritchie, K 2001 Disability and mild cognitive impairment: a longitudinal population-based study. International J Geriatr Psychiatry 16: 10921097. CrossRefGoogle Scholar
Possl, O, Jurgensmeyer, S, Karlbauer, F, Wenz, C, Goldenberg, G.Stability of employment after brain injury: a 7-year follow-up study. Brain Injury 2001;15: 1527. CrossRefGoogle ScholarPubMed
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