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Empirical tests of natural selection-based evolutionary accounts of ADHD: a systematic review

Published online by Cambridge University Press:  08 April 2016

Marthe S. Thagaard
Affiliation:
Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
Stephen V. Faraone
Affiliation:
Departments of Psychiatry and of Neuroscience and Physiology, State University of New York (SUNY) Upstate Medical University, Syracuse, New York, USA K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway
Edmund J. Sonuga-Barke
Affiliation:
Academic Unit of Psychology, University of Southampton, Southampton, UK Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium
Søren D. Østergaard*
Affiliation:
Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark Department of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark
*
Søren Dinesen Østergaard, Psychosis Research Unit, Department of Clinical Medicine, Aarhus University Hospital, Skovagervej 2, 8240 Risskov, Denmark. Tel: +45 61282753; Fax: +45 7847 1609; E-mail: soeoes@rm.dk

Abstract

Objective

ADHD is a prevalent and highly heritable mental disorder associated with significant impairment, morbidity and increased rates of mortality. This combination of high prevalence and high morbidity/mortality seen in ADHD and other mental disorders presents a challenge to natural selection-based models of human evolution. Several hypotheses have been proposed in an attempt to resolve this apparent paradox. The aim of this study was to review the evidence for these hypotheses.

Methods

We conducted a systematic review of the literature on empirical investigations of natural selection-based evolutionary accounts for ADHD in adherence with the PRISMA guideline. The PubMed, Embase, and PsycINFO databases were screened for relevant publications, by combining search terms covering evolution/selection with search terms covering ADHD.

Results

The search identified 790 records. Of these, 15 full-text articles were assessed for eligibility, and three were included in the review. Two of these reported on the evolution of the seven-repeat allele of the ADHD-associated dopamine receptor D4 gene, and one reported on the results of a simulation study of the effect of suggested ADHD-traits on group survival. The authors of the three studies interpreted their findings as favouring the notion that ADHD-traits may have been associated with increased fitness during human evolution. However, we argue that none of the three studies really tap into the core symptoms of ADHD, and that their conclusions therefore lack validity for the disorder.

Conclusions

This review indicates that the natural selection-based accounts of ADHD have not been subjected to empirical test and therefore remain hypothetical.

Type
Review Article
Copyright
© Scandinavian College of Neuropsychopharmacology 2016 

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References

1. Polanczyk, G, de Lima, MS, Horta, BL, Biederman, J, Rohde, LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007;164:942948.CrossRefGoogle Scholar
2. Harpin, VA. The effect of ADHD on the life of an individual, their family, and community from preschool to adult life. Arch Dis Child 2005;90(Suppl 1):i2i7.CrossRefGoogle Scholar
3. Fletcher, J, Wolfe, B. Long-term consequences of childhood ADHD on criminal activities. J Ment Health Policy Econ 2009;12:119138.Google Scholar
4. Murray, CJ, Vos, T, Lozano, R, Naghavi, M, Flaxman, AD, Michaud, C et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380:21972223.CrossRefGoogle Scholar
5. American Psychiatric Association. Diagnostic and statistical manual of mental disorders 5, DSM-5, American Psychiatric Association, Washington, DC, 2013.Google Scholar
6. Dalsgaard, S, Ostergaard, SD, Leckman, JF, Mortensen, PB, Pedersen, MG. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet 2015;385:21902196.CrossRefGoogle Scholar
7. Tajima-Pozo, K, Ruiz-Manrique, G, Yus, M, Arrazola, J, Montanes-Rada, F. Correlation between amygdala volume and impulsivity in adults with attention-deficit hyperactivity disorder. Acta Neuropsychiatr 2015;27:362367.CrossRefGoogle ScholarPubMed
8. Freitag, CM, Rohde, LA, Lempp, T, Romanos, M. Phenotypic and measurement influences on heritability estimates in childhood ADHD. Eur Child Adolesc Psychiatry 2010;19:311323.CrossRefGoogle ScholarPubMed
9. Bienvenu, OJ, Davydow, DS, Kendler, KS. Psychiatric ‘diseases’ versus behavioral disorders and degree of genetic influence. Psychol Med 2011;41:3340.CrossRefGoogle ScholarPubMed
10. Faraone, SV, Asherson, P, Banaschewski, T et al. Attention-deficit/hyperactivity disorder. Nature Reviews Disease Primers 2015;1:123.Google ScholarPubMed
11. Keller, MC, Miller, G. Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best? Behav Brain Sci 2006;29:385404.CrossRefGoogle Scholar
12. Jensen, PS, Mrazek, D, Knapp, PK et al. Evolution and revolution in child psychiatry: ADHD as a disorder of adaptation. J Am Acad Child Adolesc Psychiatry 1997;36:16721679.CrossRefGoogle ScholarPubMed
13. Bradshaw, JL, Sheppard, DM. The neurodevelopmental frontostriatal disorders: evolutionary adaptiveness and anomalous lateralization. Brain Lang 2000;73:297320.CrossRefGoogle ScholarPubMed
14. Crawford, C, Salmon, C. Psychopathology or adaptation? Genetic and evolutionary perspectives on individual differences and psychopathology. Neuro Endocrinol Lett 2002;23(Suppl 4):3945.Google ScholarPubMed
15. Hartmann, T. Attention deficit disorder: a different perception, 1st edn. California, USA: Underwood Books, 1993.Google Scholar
16. Stolzer, J. ADHD in America: a bioecological analysis. Eth Human Psychol Psychiatry 2005;7:6575.Google Scholar
17. Glover, V. Annual research review: prenatal stress and the origins of psychopathology: an evolutionary perspective. J Child Psychol Psychiatry 2011;52:356367.CrossRefGoogle Scholar
18. Shelley-Tremblay, JF, Rosen, LA. Attention deficit hyperactivity disorder: an evolutionary perspective. J Genet Psychol 1996;157:443453.CrossRefGoogle Scholar
19. Morgan, E. The descent of woman. New York: Stein and Day, 1972.Google Scholar
20. Hamshere, ML, Langley, K, Martin, J et al. High loading of polygenic risk for ADHD in children with comorbid aggression. Am J Psychiatry 2013;170:909916.CrossRefGoogle ScholarPubMed
21. van Goozen, SH, Langley, K, Northover, C et al. Identifying mechanisms that underlie links between COMT genotype and aggression in male adolescents with ADHD. J Child Psychol Psychiatry 2015;57:472480.CrossRefGoogle ScholarPubMed
22. Young, S, Thome, J. ADHD and offenders. World J Biol Psychiatry 2011;12(Suppl 1):124128.CrossRefGoogle ScholarPubMed
23. Moher, D, Liberati, A, Tetzlaff, J, Altman, DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. Ann Intern Med 2009;151:264269.CrossRefGoogle Scholar
24. Ding, YC, Chi, HC, Grady, DL et al. Evidence of positive selection acting at the human dopamine receptor D4 gene locus. Proc Natl Acad Sci USA 2002;99:309314.CrossRefGoogle Scholar
25. Faraone, SV, Doyle, AE, Mick, E, Biederman, J. Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder. Am J Psychiatry 2001;158:10521057.CrossRefGoogle Scholar
26. Kluger, AN, Siegfried, Z, Ebstein, RP. A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry 2002;7:712717.CrossRefGoogle ScholarPubMed
27. Li, D, Sham, PC, Owen, MJ, He, L. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 2006;15:22762284.CrossRefGoogle Scholar
28. Wu, J, Xiao, H, Sun, H, Zou, L, Zhu, LQ. Role of dopamine receptors in ADHD: a systematic meta-analysis. Mol Neurobiol 2012;45:605620.CrossRefGoogle ScholarPubMed
29. Wang, E, Ding, YC, Flodman, P et al. The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. Am J Hum Genet 2004;74:931944.CrossRefGoogle ScholarPubMed
30. Harpending, H, Rogers, A. Genetic perspectives on human origins and differentiation. Annu Rev Genomics Hum Genet 2000;1:361385.CrossRefGoogle Scholar
31. Asghari, V, Sanyal, S, Buchwaldt, S, Paterson, A, Jovanovic, V, Van Tol, HH. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995;65:11571165.CrossRefGoogle ScholarPubMed
32. Swanson, J, Posner, M, Fusella, J, Wasdell, M, Sommer, T, Fan, J. Genes and attention deficit hyperactivity disorder. Curr Psychiatry Rep 2001;3:92100.CrossRefGoogle ScholarPubMed
33. Williams, J, Taylor, E. The evolution of hyperactivity, impulsivity and cognitive diversity. J R Soc Interface 2006;3:399413.CrossRefGoogle ScholarPubMed
34. Gizer, IR, Ficks, C, Waldman, ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 2009;126:5190.CrossRefGoogle ScholarPubMed
35. Neale, BM, Medland, SE, Ripke, S et al. Meta-analysis of genome-wide association studies of attention deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2010;49:884897.CrossRefGoogle ScholarPubMed
36. Kofler, MJ, Rapport, MD, Sarver, DE et al. Reaction time variability in ADHD: a meta-analytic review of 319 studies. Clin Psychol Rev 2013;33:795811.CrossRefGoogle ScholarPubMed
37. Rutter, M. Developmental catch-up, and deficit, following adoption after severe global early privation. English and Romanian Adoptees (ERA) Study Team. J Child Psychol Psychiatry 1998;39:465476.CrossRefGoogle ScholarPubMed
38. Kreppner, JM, O’Connor, TG, Rutter, M, English and Romanian Adoptees Study Team. Can inattention/overactivity be an institutional deprivation syndrome? J Abnorm Child Psychol 2001;29:513528.CrossRefGoogle ScholarPubMed
39. Rutter, M, O’Connor, TG, English and Romanian Adoptees (ERA) Study Team. Are there biological programming effects for psychological development? Findings from a study of Romanian adoptees. Dev Psychol 2004;40:8194.CrossRefGoogle ScholarPubMed
40. Stevens, SE, Sonuga-Barke, EJ, Kreppner, JM et al. Inattention/overactivity following early severe institutional deprivation: presentation and associations in early adolescence. J Abnorm Child Psychol 2008;36:385398.CrossRefGoogle ScholarPubMed
41. Laucht, M, Skowronek, MH, Becker, K et al. Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sample. Arch Gen Psychiatry 2007;64:585590.CrossRefGoogle ScholarPubMed
42. Stevens, SE, Kumsta, R, Kreppner, JM, Brookes, KJ, Rutter, M, Sonuga-Barke, EJ.. Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: developmental continuities in gene-environment interplay. Am J Med Genet B Neuropsychiatr Genet 2009;150B:753761.CrossRefGoogle ScholarPubMed
43. Grizenko, N, Fortier, ME, Zadorozny, C et al. Maternal stress during pregnancy, ADHD symptomatology in children and genotype: gene-environment interaction. J Can Acad Child Adolesc Psychiatry 2012;21:915.Google ScholarPubMed
44. Li, JJ, Lee, SS. Interaction of dopamine transporter gene and observed parenting behaviors on attention-deficit/hyperactivity disorder: a structural equation modeling approach. J Clin Child Adolesc Psychol 2013;42:174186.CrossRefGoogle ScholarPubMed
45. Nikitopoulos, J, Zohsel, K, Blomeyer, D et al. Are infants differentially sensitive to parenting? Early maternal care, DRD4 genotype and externalizing behavior during adolescence. J Psychiatr Res 2014;59:5359.CrossRefGoogle ScholarPubMed
46. Barkley, RA, Fischer, M, Smallish, L, Fletcher, K. Young adult outcome of hyperactive children: adaptive functioning in major life activities. J Am Acad Child Adolesc Psychiatry 2006;45:192202.CrossRefGoogle ScholarPubMed
47. Flory, K, Molina, BS, Pelham, WE Jr, Gnagy, E, Smith, B. Childhood ADHD predicts risky sexual behavior in young adulthood. J Clin Child Adolesc Psychol 2006;35:571577.CrossRefGoogle ScholarPubMed
48. Sarver, DE, McCart, MR, Sheidow, AJ, Letourneau, EJ. ADHD and risky sexual behavior in adolescents: conduct problems and substance use as mediators of risk. J Child Psychol Psychiatry 2014;55:13451353.CrossRefGoogle Scholar
49. Pfiffner, LJ, Haack, LM. Behavior management for school-aged children with ADHD. Child Adolesc Psychiatr Clin N Am 2014;23:731746.CrossRefGoogle ScholarPubMed
50. Evans, SW, Langberg, JM, Egan, T, Molitor, SJ. Middle school-based and high school-based interventions for adolescents with ADHD. Child Adolesc Psychiatr Clin N Am 2014;23:699715.CrossRefGoogle ScholarPubMed
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