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Cognitive performance following fluoxetine treatment in depressed patients post myocardial infarction

Published online by Cambridge University Press:  24 June 2014

Jacqueline J. M. H. Strik*
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Adriaan Honig
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Edwin Klinkenberg
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Jeanette Dijkstra
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
Jelle Jolles
Affiliation:
Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands
*Corresponding
Jacqueline Strik, MD, PhD, RIAGG Maastricht, Parallelweg 45/47, 6221 BD Maastricht, The Netherlands. Tel: +31 43 3299699; Fax: +31 43 3299656; E-mail: jacqueline.strik@np.unimaas.nl

Abstract

Background:

As depression is a considerable risk factor for an unfavourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue.

Objective:

The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression.

Methods:

Cognitive performance of 54 depressed patients post first-MI, treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of treatment using the Visual Verbal Learning Test, Concept Shifting Task, Stroop Colour-Word Test and Letter-Digit-Substitution Test.

Results:

The median number of cardiovascular drugs taken by MI patients was 4.9. There were no differences between the fluoxetine and the placebo group on cognitive performance.

Conclusion:

In sum, there were no negative side effects of fluoxetine compared with placebo on cognition in depressed MI patients, simultaneously treated with cardiac drugs.

Type
Research Article
Copyright
Copyright © 2006 Blackwell Munksgaard

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