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Are oxidative stress markers useful to distinguish schizoaffective disorder from schizophrenia and bipolar disorder?

Published online by Cambridge University Press:  09 September 2013

Feridun Bulbul*
Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Osman Virit
Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Gokay Alpak
Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Ahmet Unal
Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Mahmut Bulut
Department of Psychiatry, School of Medicine, Dicle University, Dicle, Turkey
Mehmet Cemal Kaya
Department of Psychiatry, School of Medicine, Dicle University, Dicle, Turkey
Abdurrahman Altindag
Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Hakim Celik
Department of Biochemistry, School of Medicine, Harran University, Harran, Turkey
Haluk A. Savas
Department of Psychiatry, School of Medicine, Gaziantep University, Gaziantep, Turkey
Feridun Bulbul, Department of Psychiatry, School of Medicine, Gaziantep University, 27310 Şahinbey, Gaziantep, Turkey. Tel: +0342 3606060/76362; Fax: +0342 3603928; E-mail:



Schizoaffective disorder is a disease with both affective and psychotic symptoms. In this study, we aimed to compare oxidative metabolism markers of schizoaffective disorder, bipolar disorder and schizophrenic patients. Furthermore, we also aimed to investigate whether schizoaffective disorder could be differentiated from schizophrenia and bipolar disorder in terms of oxidative metabolism.


Total oxidant status (TOS) and total antioxidant status (TAS) were measured in the blood samples that were collected from schizoaffective patients (n = 30), bipolar disorder patients (n = 30) and schizophrenic patients (n = 30). Oxidative stress index (OSI) was calculated by dividing TOS by TAS.


TOS and OSI were found to be higher in patients with schizoaffective disorder compared with those in schizophrenia and bipolar disorder patients. TAS was not significantly different between the groups.


Schizoaffective disorder was found to be different from bipolar disorder and schizophrenia in terms of oxidative parameters. This result may indicate that schizoaffective disorder could differ from bipolar disorder and schizophrenia in terms of biochemical parameters. Increased TOS levels observed in schizoaffective disorder may suggest poor clinical course and may be an indicator of poor prognosis.

Original Articles
Copyright © Scandinavian College of Neuropsychopharmacology 2013 

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