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In 2006, Daniel Gibbs, author of A Tattoo on my Brain: A Neurologist's Personal Battle against Alzheimer's Disease (soon to be a documentary produced by MTV/Paramount+), first noticed symptoms which he now knows to have been early signs of his Alzheimer's Disease. Daniel still writes every day, something he credits with keeping his mind sharper and his demons at bay. This book is a personal collection of essays written over the past two years that describe his own personal experiences, first treating patients with Alzheimer's, and now living with the disease himself. The book presents an up-to-date discussion of recent advances and setbacks in Alzheimer's research. Humane and hopeful, this book offers evidence-based information on how it may be possible even now to slow progression of the disease.
With advances in medicine and medical innovation, the face of neurosurgery has changed dramatically. A new era of surgeons value the need to undertake research in everyday practice and actively participate in the clinic and laboratory in order to improve patient prognosis. Highlighting the principles of basic neuroscience and its application to neurosurgical disease, this book breaks down neurological conditions into current academic themes and advances. The book is split into two sections, with the first covering basic and computational neuroscience including neuroanatomy, neurophysiology, and the growing use of artificial intelligence. The second section concentrates on specific conditions, such as gliomas, degenerative cervical myelopathy and peripheral nerve injury. Outlining the pathophysiological underpinnings of neurosurgical conditions and the key investigative tools used to study disease burden, this book will be an invaluable source for the academic neurosurgeon undertaking basic and translational research.
Providing practical, visually oriented guidance on the benefits of botulinum toxin in a wide variety of disorders, some new and unexpected, this new edition of Manual of Botulinum Toxin Therapy is fully updated in scope and detail. Chapters discuss the pathophysiology of each condition, summarizing the rationale for botulinum toxin, and describing the injection approach. Clear illustrations of the injection sites are included, using a 'clinician's eye' perspective, which allows physicians to readily identify anatomical landmarks and approach angles for injection. Dosing tables for available toxin formulations are included. The Manual covers cosmetic treatment of the upper and lower face, as well as aesthetic smile correction. Extensive guidance on how to use ultrasound and how cadaveric dissections can assist localization and targeting of injections is provided. Designed for teaching and bedside guidance, the Manual is useful to a diverse range of clinicians looking to use botulinum toxin in their practice.
Cambridge Textbook of Neuroscience for Psychiatrists is a 'one stop shop' for what any psychiatrist needs to know about the brain. Understanding the brain and mind requires a vast array of techniques and conceptual approaches. The Editors have assembled a team of basic neuroscientists, geneticists, psychologists, psychiatrists, neurologists, neurosurgeons and endocrinologists who bring you the cutting edge of translational neuroscience that addresses the material most relevant to current or future psychiatric practice. The book showcases what is known, highlights aspects that are less well understood and defines key outstanding questions. A revolution in our understanding of the brain has, so far, done little to disrupt mainstream psychiatric practice. That is set to change. The chapters align with the UK MRCPsych neuroscience syllabus and link to the USA National Neuroscience Curriculum Initiative (NNCI). Highly illustrated and accessible, this book will appeal to psychiatrists, neuroscientists, psychologists, other healthcare students and professionals.
The principles of electromyography, including single-fibre electromyography and nerve conduction studies, are described simply, supported by clear diagrams and screenshots of high quality recordings. After a brief overview of anatomy, physiology, pathology and technical matters including electrodes, amplifiers and volume conduction, the way these principles aid the diagnosis of disorders of nerves, muscles and neuromuscular junctions is explained. The book concludes with the findings in common clinical conditions and explores the concept of normal vs abnormal values. This is an invaluable introductory text for trainees in clinical neurophysiology. Clinicians in specialties such as neurology, orthopaedic surgery, rheumatology, general medicine, physical medicine and rehabilitation will benefit from guidance on selecting patients for referral and assistance with the interpretation of the results. Based on the expertise of an author who has spent 25 years practising and teaching the subject, readers can be assured of a wealth of knowledge within these pages.
Why is deciding to do something sometimes so slow and difficult? How do we make decisions when lacking key information? When making decisions, the higher areas of the brain deliberately suppress lower areas capable of generating much faster but ill-considered responses while they develop ones that are more sophisticated, based on what can be gained in return. In this engaging book, the authors explore the increasingly popular neural model that may explain these mechanisms: the linear approach to threshold ergodic rate (LATER). Presenting a detailed description of the neurophysiological processes involved in decision-making and how these link to the LATER model, this is the first major resource covering the applications in describing human behaviour. With over 100 illustrations and a thorough discussion of the mathematics supporting the model, this is a rigorous yet accessible resource for psychologists, cognitive neuroscientists and neurophysiologists interested in decision-making.
There is increasing evidence that mental health problems such as schizophrenia, depression and anxiety are linked with poor nutrition. At present, very few psychiatrists provide nutritional advice for their patients, despite such advice complimenting drug and psychological therapies. This edited volume is the first book to provide a comprehensive overview of the relationship between nutrition and mental health, for mental health professionals. Featuring contributions from leading authorities in the field, the book examines the link between diet and the microbiome-gut brain axis and how this correlates with a variety of psychiatric disorders. The book explores how enhancing the beneficial bacteria in the gut, through the use of psychobiotics, prebiotics or dietary change can improve mood and reduce anxiety. The book will appeal to psychiatrists and psychologists, behavioural scientists, neuroscientists and nutritionists.
How do the billions of connections between neurons in our brain change as we learn and remember? This is the story of the discovery and the discoverer of synaptic pruning, the process of synapse elimination central to making us who we are. Taking the reader from Professor Peter Huttenlocher's childhood in wartime and post-war Germany to his emigration to the US to reunite with his mother and the launch and progress of a career in medicine and research, we uncover the motivations and process of scientific discovery that led to an unexpected leap in our understanding of the human brain. Decades after the discovery, the importance of synaptic pruning to early learning, autism, schizophrenia, Alzheimer's disease and other conditions are now in the process of being uncovered.
Patients with neurologic symptoms are frequently seen in the emergency department and require rapid and thorough evaluation. Appropriate assessment with tailored history-taking, localization of the neurological problem, differential diagnosis, focused testing, and urgent treatment when indicated are essential to prevent patient morbidity. Neurological examination and testing of patients are covered in-depth, along with common neurological presentations using a symptom-based approach, such as coma, dizziness and gait disturbance. Specific neurological disorders are also explored, including traumatic brain injury, ischemic stroke and transient ischemic attack and neurotoxicology. Chapters follow a basic outline, including an introduction and a pearls and pitfalls section, providing a succinct overview and key takeaway points for the busy clinician. This well organized handbook will serve as a concise, valued reference for the clinician to use in assisting the evaluation of the most common neurology related emergency department visits.
This illuminating book clarifies controversial topics in challenging and often confusing areas of neurology for all who are interested in clinical neuroscience. It provides an organized approach to neurological conditions such as amnesic syndrome, aphasia, agnosia and apraxia, it includes previously unpublished data on grasp reflex and Wernicke disease is presented. Written by an internationally renowned author, the book draws on his extensive personal experience to orient neurological clinicians to a variety of conditions by putting less accessible literature into context with recent advances and information from interviews undertaken throughout his career. This book will appeal to general and specialist neurologists, nurse practitioners, physician's assistants and those training to specialise in neurology.
Written by a neurologist with 20 years of experience working in a general hospital, this engaging and informative book brings together 55 example cases from a general hospital setting with differential diagnoses. The case report format facilitates up to date management including modern neuroimaging, but also allows the reader to consider the potential diagnoses before turning the page to determine the correct diagnosis and treatment. The history, epidemiology as well as diagnostic criteria and management of specific neurological disorders are provided in an accompanying comment section. Unusual for a book of neurology, patients have had an opportunity to explain how neurological illness impacted their physical, psychological and social activities (provided by a relative/carer when the patient could not contribute). The themes provide a personal and truthful testament of the immediate and longer-term real-life impact of neurological illness, giving readers an insight into the effects of neurological diagnoses on their patients.
Dementia is a topic of enormous medical, legal and ethical importance with considerable human and economic cost. Its importance grows with the change in demographics of the aging population and that people with dementia receive care in a wide range of settings. The legal and ethical problems raised in treating patients with dementia are diverse and complex and are dealt with by many practitioners on a daily basis. This book is a 'how-to' guide to understanding how the law applies to people with dementia, from diagnosis through to end-of-life. It explores the practical problems that people experience, and practitioners face, giving an accurate account of statute, court cases and other inquiries, to give readers an up-to-date account of the law and how it applies in this area. An essential read for clinicians and practitioners that work with patients with dementia, including psychiatrists, primary care physicians, nurses, social workers and advocates.
The plethora of miscommunication and disinformation about how SARS-CoV-2 (COVID-19) spreads suggests a widespread misunderstanding of how viruses work. This book will focus on the interpretation of scientific and medical results, giving the reader guidance on interpreting virological data, including the concepts of 'live' versus infectious virus. The first section covers the background of virology and immunology, introducing the reader to the science of virology (using COVID-19 as an illustration) and considers the measurement of infectious disease, using polymerase chain reaction (PCR), molecular biology and the immune system. The second section looks at clinical virology and neurovirology. Taking a novel perspective on how viruses may play a role in evolution, this book discusses antivirals and how autoimmune disorders may be caused or triggered by viruses. Concise and practical, this is a key resource for those working in neurology, infectious disease and virology.
Stroke, as known today, is caused by occlusion or rupture of one or more blood vessels in the brain. Its manifestations were reported as long as medical records exist; sudden collapse, loss of movement and sensation, with preserved respiration and heart action. The book chronicles how ideas about events in the brain or its blood vessels evolved over 400 years. Starting with the revival of ancient medicine in the middle of the 16th century, the narrative ends in the 20th century, when techniques for brain scanning heralded the possibility of treatment for cerebrovascular disease. The narrative is exclusively based on primary sources and shows how this part of medical knowledge evolved, including byways and blind alleys. Frequent accounts from original sources assist the reader in following how clashes of opinions led to improved understanding, making this an indispensable reference for the history of stroke research.
Since the early 2000s, a growing body of scientific studies in neuropathology, neurology, neurosurgery, biomechanics, statistics, criminology and psychology has cast doubt on the forensic reliability of medical determinations of Shaken Baby Syndrome (SBS), more recently termed Abusive Head Trauma (AHT). Studies have increasingly documented that accidental short falls and a wide range of medical conditions, can cause the same symptoms and findings associated with this syndrome. Nevertheless, inaccurate diagnoses, unrealistic confidence expression, and wrongful convictions continue to this day. Bringing together contributions from a multidisciplinary expert panel of 32 professionals across 8 countries in 16 different specialties, this landmark book tackles the highly controversial topic of SBS, which lies at the intersection of medicine, science, and law. With comprehensive coverage across multiple disciplines, it explains the scientific evidence challenging SBS and advances efforts to evaluate how deaths and serious brain injuries in infants should be analysed and investigated.
Sex is everywhere in modern society, yet it remains taboo. We all have questions about sex that are too uncomfortable to ask – how do we get reliable answers? In this go-to guide Drs Grant and Chamberlain use their clinical expertise to answer the questions you wish you could ask about sex. Questions like: Is my sex drive or sex behavior normal? Can someone have too much sex? Or too little? How has Internet dating and pornography changed sex? This go-to guide will help you understand common sexual issues, know when to worry (or not) about different sexual behaviors, and learn how our sex lives adapt to changing technology or in times of crisis. It also provides step-by-step advice for dealing with a range of sexual issues, and practical strategies for strengthening relationships.
Epilepsy is a frequently encountered disease, affecting 1-2% of the population, but one that is often mistreated due to misunderstandings of specific diagnoses and treatments. This practical manual provides a succinct and clinically relevant reference of routine clinical epilepsy care. The book is designed around the four main aspects of an epilepsy patient's care: first seizure, inpatient epilepsy care, outpatient epilepsy care, and diagnostic modalities. These four aspects are carefully delineated to illustrate the key differences in best practice management. Rational use of EEG and imaging testing is thoroughly covered to guide improved utility of these results. Caring for the mental health of epilepsy patients is also covered, as this is pertinent at every stage and location of epilepsy patient care. An excellent resource for neurology trainees at the resident, fellow, and medical student level as well as advanced practice providers.
Epilepsy has a fascinating history. To the medical historian Oswei Temkin it was 'the paradigm of the suffering of both body and soul in disease'. It is justifiably considered a window on brain function. And yet its story is more than simply a medical narrative, but one influenced also by scientific, societal and personal themes. Written for a medical and non-medical readership, this book describes the major developments in epilepsy between 1860–2020, a turbulent era in which science dominated as an explanatory model, medical theories and practices steered an erratic course, and societal attitudes and approaches to epilepsy fluctuated dramatically. In the middle of this maelstrom was the person with epilepsy at the mercy of social attitudes and legislation, and at times harmed as well as helped by medicine and science. So entangled is the history that intriguingly, as an entity, epilepsy may now be thought not even to exist.