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Chapter 7 - Physical Activity and Exercise for Older Adults

from Section I - General Approach to the Care of the Elderly

Published online by Cambridge University Press:  30 June 2022

Jan Busby-Whitehead
Affiliation:
University of North Carolina, Chapel Hill
Samuel C. Durso
Affiliation:
The Johns Hopkins University, Maryland
Christine Arenson
Affiliation:
Thomas Jefferson University, Philadelphia
Rebecca Elon
Affiliation:
The Johns Hopkins University School of Medicine
Mary H. Palmer
Affiliation:
University of North Carolina, Chapel Hill
William Reichel
Affiliation:
Georgetown University Medical Center
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Summary

Physical activity is fundamental for achieving healthy aging. Exercise offers older adults substantial benefits, such as reducing risks of all-cause mortality and chronic disease, preserving functional capacity, improving management of chronic conditions, and reducing health-care costs. Given the prevalence of physical inactivity and sedentary behavior among adults 65 and over, exercise needs to be more thoroughly integrated into care plans and counseling in primary care settings. A practical, three-step approach to exercise counseling is recommended. Older adults should strive to do at least 150 minutes of moderate-intensity aerobic exercise weekly, muscle-strengthening and flexibility activities twice weekly, and for those at risk of falls or with mobility problems, balance activities at least three times per week. Older adults with functional restrictions or chronic conditions should be as physically active as their abilities and conditions allow. Any amount of moderate-to-vigorous physical activity gains some health benefits. Appropriate physical activity counseling, prescription, and referral must be tailored for each patient and must take into account such factors as fitness levels, goals and motivations, access to exercise-related facilities and programs, chronic diseases, prescribed medications, common injuries, and hip and knee arthroplasties.

Type
Chapter
Information
Reichel's Care of the Elderly
Clinical Aspects of Aging
, pp. 64 - 80
Publisher: Cambridge University Press
Print publication year: 2022

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References

US Dept of Health and Human Services. Physical Activity and Health: A Report of the Surgeon General. Atlanta, GA: US Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, 1996.Google Scholar
Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee Report, 2008. Washington, DC: US Dept of Health and Human Services, 2008.Google Scholar
US Department of Health and Human Services. 2008 Physical Activity Guidelines for Americans. Washington, DC: US Dept of Health and Human Services, 2008.Google Scholar
US Department of Health and Human Services. Step It Up! The Surgeon General’s Call to Action to Promote Walking and Walkable Communities. Washington, DC: Office of the Surgeon General, 2015.Google Scholar
2018 Physical Activity Guidelines Advisory Committee. 2018 Physical Activity Guidelines Advisory Committee Scientific Report. Washington, DC: US Department of Health and Human Services, 2018.Google Scholar
US Department of Health and Human Services. 2018 Physical Activity Guidelines for Americans. Washington, DC: US Department of Health and Human Services, 2018.Google Scholar
Watson, KB, Carlson, SA, Gunn, JP, et al. Physical inactivity among adults aged 50 years and older: United States, 2014. MMWR Morb Mortal Wkly Rep. 2016; 65:954958.Google Scholar
Ward, BW, Schiller, JS, Goodman, RA. Multiple chronic conditions among US adults: A 2012 update. Prev. Chronic Dis. 2014; 11:130389.Google Scholar
US Burden of Disease Collaborators. The state of US health, 1990–2010: Burden of diseases, injuries, and risk factors. JAMA. 2013; 310(6):591608.Google Scholar
Gerteis, J, Izrael, D, Deitz, D, et al. Multiple Chronic Conditions Chartbook. AHRQ Publications No. Q14-0038. Rockville, MD: Agency for Healthcare Research and Quality, 2014.Google Scholar
Buttorff, C, Ruder, T, Bauman, M. Multiple Chronic Conditions in the United States. RAND Publications No, TL221. Santa Monica, CA: RAND Corporation, 2017.Google Scholar
He, Z, Bian, J, Carretta, HJ, Lee, J, Hogan, WR, Shenkman, E, Charness, N. Prevalence of multiple chronic conditions among older adults in Florida and the United States: Comparative analysis of the OneFlorida Data Trust and national inpatient sample. J Med Internet Res. 2018; 20(4):e137.Google Scholar
Wolff, JL, Starfield, B, Anderson, G. Prevalence expenditures, and complications of multiple chronic conditions in the elderly. Arch Intern Med. 2002; 162(20):22692276.Google Scholar
Blumberg, LJ, Waidmann, TA, Blavin, F, Roth, J. Trends in health care financial burdens, 2001 to 2009. Milbank Q. 2014; 92(1):88113.Google Scholar
Paez, KA, Zhao, L, Hwang, W. Rising out-of-pocket spending for chronic conditions: A ten-year trend. Health Aff. 2009; 28(1):1525.Google Scholar
Wolff, JL, Spillman, BC, Freedman, VA, Kasper, JD. A national profile of family and unpaid caregivers who assist older adults with health care activities. JAMA Intern Med. 2016 (Mar.); 176(3):372379.Google Scholar
Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System. www.cdc.gov/brfss. Accessed on 7/5/2020.Google Scholar
Harvey, JA, Chastin, SF, Skelton, DA. How sedentary are older people? A systematic review of the amount of sedentary behavior. J Aging Phys Act. 2015 (Jul.); 23(3):471487.Google Scholar
Centers for Disease Control and Prevention National Center for Health. Trends in Meeting the 2008 Physical Activity Guidelines, 2008–2018. Division of Nutrition, Physical Activity, and Obesity. Last rev. Jan. 14, 2020. www.cdc.gov/physicalactivity/downloads/trends-in-the-prevalence-of-physical-activity-508.pdf.Google Scholar
Du, Y, Liu, B, Sun, Y, Snetselaar, LG, Wallace, RB, Bao, W. Trends in adherence to the physical activity guidelines for Americans for aerobic activity and time spent on sedentary behavior among US adults, 2007 to 2016. JAMA Netw Open. 2019 (Jul. 3); 2(7):e197597.Google Scholar
Valencia, WM, Stoutenberg, M, Florez, H. Weight loss and physical activity for disease prevention in obese older adults: An important role for lifestyle management. Curr Diab Rep. 2014; 14(10):539.CrossRefGoogle ScholarPubMed
Gill, DL, Hammond, CC, Reifsteck, EJ, et al. Physical activity and quality of life. J Prev Med Public Health. 2013; 46(Suppl. 1):S28S34.Google Scholar
Lee, IM, Skerrett, PJ. Physical activity and all-cause mortality: What is the dose–response relation? Med Sci Sports Exerc. 2001; 33(6 Suppl.):S459–71; discussion S493–4.CrossRefGoogle ScholarPubMed
Garatachea, N, Pareja-Galeano, H, Sanchis-Gomar, F, et al. Exercise attenuates the major hallmarks of aging. Rejuvenation Res. 2015; 18(1):5789.Google Scholar
Thune, I, Furberg, AS. Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med Sci Sports Exerc. 2001; 33(6 Suppl.):S530–50; discussion S609–10.Google Scholar
Cadore, EL, Rodríguez-Mañas, L, Sinclair, A, Izquierdo, M. Effects of different exercise interventions on risk of falls, gait ability, and balance in physically frail older adults: A systematic review. Rejuvenation Res. 2013; 16(2):105114.Google Scholar
Mora, JC, Ciocon, J. Elder care: A resource for interprofessional providers – Physical exercise guidelines for older adults. POGOe. 2013. www.pogoe.org/productid/21715. Accessed on 7/5/2020.Google Scholar
Mora, JC, Valencia, WM. Exercise and older adults. Clin Geriatr Med. 2018 (Feb.); 34(1):145162.CrossRefGoogle ScholarPubMed
Gibala, MJ, Little, JP, van Essen, M, et al. Short-term sprint interval versus traditional endurance training: Similar initial adaptations in human skeletal muscle and exercise performance. J Physiol. 2006; 575(3):901911.Google Scholar
Cobley, JN, Mount, PR, Burniston, JG, et al. Exercise improves mitochondrial and redox-regulated stress responses in the elderly: Better late than never! Biogerontology. 2015; 16:249264.Google Scholar
Rakobowchuk, M, Tanguay, S, Burgomaster, KA, et al. Sprint interval and traditional endurance training induce similar improvements in peripheral arterial stiffness and flow-mediated dilation in healthy humans. Am J Physiol Regul Integr Comp Physiol. 2008; 295:R236R242.Google Scholar
Hussain, SR, Macaluso, A, Pearson, SJ. High-intensity interval training versus moderate-intensity continuous training in the prevention/management of cardiovascular disease. Cardiol Rev. 2016; 24:273281.Google Scholar
Davies, EJ, Moxham, T, Rees, K, et al. Exercise training for systolic heart failure: Cochrane systematic review and meta-analysis. Eur J Heart Fail. 2010; 12:706715.CrossRefGoogle ScholarPubMed
Taylor, RS, Sagar, VA, Davies, EJ, et al. Exercise-based rehabilitation for heart failure. Cochrane Database Syst Rev. 2014; 4:CD003331.Google Scholar
Yusuf, S, Hawken, S, Ounpuu, S, et al. INTERHEART Study Investigators. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (INTERHEART study): Case-control study. Lancet. 2004; 364(9438):937952.Google Scholar
Foley, TR, Armstrong, EJ, Waldo, SW. Contemporary evaluation and management of lower extremity peripheral artery disease. Heart. 2016; 102:14361441.Google Scholar
Diaz, KM, Shimbo, D. Physical activity and the prevention of hypertension. Curr Hypertens. 2013; 15(6):659668.Google Scholar
Myers, J. Exercise and cardiovascular health. Circulation. 2003; 107:2e5.Google Scholar
Goldstein, LB, Bushnell, CD, Adams, RJ, et al. Guidelines for the primary prevention of stroke: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011; 42:517584.Google Scholar
Furie, KL, Kasner, SE, Adams, RJ, et al. Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011; 42:227276.Google Scholar
Erickson, KI, Voss, MW, Prakash, RS, et al. Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci U S A. 2011; 108(7):30173022.Google Scholar
Reid, KJ, Baron, KG, Lu, B, et al. Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia. Sleep Med. 2010; 11(9):934940.Google Scholar
Hamer, M, Chida, Y. Physical activity and risk of neurodegenerative disease: A systematic review of prospective evidence. Psychol Med. 2009; 39:311.CrossRefGoogle ScholarPubMed
Guure, CB, Ibrahim, NA, Adam, MB, Said, SM. Impact of physical activity on cognitive decline, dementia, and its subtypes: Meta-analysis of prospective studies. Biomed Res Int. 2017; 9016924.Google Scholar
Sattler, C, Erickson, KI, Toro, P, Schröeder, J. Physical fitness as a protective factor for cognitive impairment in a prospective population-based study in Germany. J Alzheimer Dis. 2011; 26:709718.Google Scholar
Norton, S, Matthews, FE, Barnes, DE, et al. Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol. 2014; 13:788794.Google Scholar
Valencia, WM, Sood, R. Obesity and weight gain in older persons. In: Pachana, NA, ed. Encyclopedia of Geropsychology. New York: Springer, 2016.Google Scholar
Valencia, WM, Florez, H. Endocrinology and metabolism. In: Burton, J, Lee, A, Potter, J, eds. Geriatrics for Specialists. New York: Springer, 2017, pp. 269282.Google Scholar
Valencia, WM, Florez, H. Pharmacological treatment of diabetes in older people. Diabetes Obes Metab. 2014; 16(12):11921203.Google Scholar
Valencia, WM, Florez, HJ. How to prevent the microvascular complications of type 2 diabetes beyond glucose control. BMJ. 2017; 356:i6505.Google Scholar
Davis, N, Ma, Y, Delahanty, LM, et al. Predictors of sustained reduction in energy and fat intake in the Diabetes Prevention Program Outcomes Study intensive lifestyle intervention. J Acad Nutr Diet. 2013; 113:14551464.Google Scholar
Garber, CE, Blissmer, B, Deschenes, MR, et al. American College of Sports Medicine position stand: Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011; 43(7):13341359.Google Scholar
Howe, TE, Shea, B, Dawson, LJ, et al. Exercise for preventing and treating osteoporosis in postmenopausal women. Cochrane DB Syst Rev. 2011; 7:CD000333.Google Scholar
Kim, HK, Suzuki, T, Saito, K, et al. Long-term effects of exercise and amino acid supplementation on muscle mass, physical function and falls in community-dwelling elderly Japanese sarcopenic women: A 4-year follow-up study. Geriatr Gerontol Int. 2016; 16:175181.Google Scholar
Crane, JD, Macneil, LG, Tarnopolsky, MA. Long-term aerobic exercise is associated with greater muscle strength throughout the life span. J Gerontol A Biol Sci Med Sci. 2013; 68:631638.Google Scholar
Blair, SN. Physical inactivity: The biggest public health problem of the 21st century. Br J Sports Med. 2009; 43(1):12.Google Scholar
Ding, D, Lawson, KD, Kolbe-Alexander, TL, et al. The economic burden of physical inactivity: A global analysis of major non-communicable diseases. Lancet. 2016; 388(10051):13111324.Google Scholar
Orrow, G, Kinmonth, AL, Sanderson, S, Sutton, S. Effectiveness of physical activity promotion based in primary care: Systematic review and meta-analysis of randomised controlled trials. BMJ. 2012 (Mar. 26); 344:e1389.Google Scholar
Shuval, K, Leonard, T, Drope, J, Katz, DL, Patel, AV, Matin-Shepard, M, Amir, O, Grinstein, A. Physical activity counseling in primary care: Insights from public health and behavioral economics. CA Cancer J Clin. 2017 (May 6); 67(3):233244.Google Scholar
Abramson, S, Stein, J, Schaufele, M, Frates, E, Rogan, S. Personal exercise habits and counseling practices of primary care physicians: A national survey. Clin J Sport Med. 2000 (Jan.); 10(1):4048.Google Scholar
Douglas, F, Torrance, N, van Teijlingen, E, Meloni, S, Kerr, A. Primary care staff’s views and experiences related to routinely advising patients about physical activity: A questionnaire survey. BMC Public Health. 2006 (May 23); 6:138.Google Scholar
Berra, K, Rippe, J, Manson, JE. Making physical activity counseling a priority in clinical practice: The time for action is now. JAMA. 2015; 314(24):26172618.Google Scholar
Phillips, EM, Kennedy, MA. The exercise prescription: A tool to improve physical activity. PM R. 2012; 4(11):818825.Google Scholar
Crump, C, Sundquist, K, Sundquist, J, Winkleby, MA. Exercise is medicine: Primary care counseling on aerobic fitness and muscle strengthening. J Am Board Fam Med. 2019 (Jan.–Feb.); 32(1):103107.Google Scholar
Jerdén, L, Dalton, J, Johansson, H, Sorensen, J, Jenkins, P, Weinehall, L. Lifestyle counseling in primary care in the United States and Sweden: A comparison of patients’ expectations and experiences. Glob Health Action. 2018; 11(1):1438238.Google Scholar
Dacey, ML, Kennedy, MA, Polak, R, Phillips, EM. Physical activity counseling in medical school education: a systematic review. Med Ed Online. 2014; 19(1).Google Scholar
Brecken, JD, Johnston, LH, Hutchison, A. Physical activity counseling content and competency: A systematic review. J Phys Act Health. 2008 (May); 5(3):398417.Google Scholar
Omura, JD, Bellissimo, MP, Watson, KB, Loustalot, F, Fulton, JE, Carlson, SA. Primary care providers’ physical activity counseling and referral practices and barriers for cardiovascular disease prevention. Prev Med. 2018 (Mar.); 108:115122.Google Scholar
The Patient Protection and Affordable Care Act of 2010. Pub L No. 111–148, 124 Stat 119. 42, §18001. 2010 (www.gpo.gov/fdsys/pkg/PLAW-111publ148/pdf/PLAW-111publ148.pdf). Accessed on 7/5/2020.Google Scholar
AuYoung, M, Linke, SE, Pagoto, S, Buman, MP, Craft, LL, Richardson, CR, Hutber, A, Marcus, BH, Estabrooks, P, Sheinfeld Gorin, S. Integrating physical activity in primary care practice. Am J Med. 2016 (Oct.); 129(10):10221029.Google Scholar
Schutzer, KA, Graves, BS. Barriers and motivations to exercise in older adults. Prev Med. 2004 (Nov.); 39(5):10561061.Google Scholar
Powell, LM, Slater, S, Chaloupka, FJ, Harper, D. Availability of physical activity-related facilities and neighborhood demographic and socioeconomic characteristics: A national study. Am J Public Health. 2006; 96(9):16761680.Google Scholar
Valencia, WM, Danet, M, Florez, H, Bourdel-Marchasson, I. Assessment procedures including comprehensive geriatric assessment. In: Sinclair, A, Dunning, T, Rodríguez Mañas, L, Munshi, M, eds. Diabetes in Old Age. 4th edition. Chichester; Hoboken, NJ: Wiley-Blackwell, 2017.Google Scholar
Taylor, D. Physical activity is medicine for older adults. Postgrad. Med. J. 2014; 90:2632.Google Scholar
Cavanaugh, JT, Kochi, N, Stergiou, N. Nonlinear analysis of ambulatory activity patterns in community-dwelling older adults. J Gerontol A Biol Sci. 2010; 65A(2):197203.Google Scholar
National Institute of Aging. Exercise and Physical Activity. National Institutes of Health. Go4Life from the National Institute on Aging at NIH. www.nia.nih.gov/health/exercise-physical-activity. Accessed on 7/8/2020.Google Scholar
Nelson, ME, Rejeski, WJ, Blair, SN, et al. Physical activity and public health in older adults: Recommendation from the American College of Sports Medicine and the American Heart Association. Circulation. 2007; 116:10941105.Google Scholar
Woods, JA, Wilund, KR, Martin, SA, Kistler, BM. Exercise, inflammation and aging. Aging Dis. 2012 (Feb.); 3(1):130140.Google Scholar
Cadore, EL, Casas-Herrero, A, Zambom-Ferraresi, F, et al. Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians. Age (Dordr). 2013; 36(2):773785.Google Scholar
Gammack, JK. Physical activity in older persons. Mo Med. 2017; 114(2):105109.Google Scholar
Dos Santos, L, Cyrino, ES, Antunes, M, Santos, DA, Sardinha, LB. Sarcopenia and physical independence in older adults: The independent and synergic role of muscle mass and muscle function. J Cachexia Sarcopenia Muscle. 2017; 8(2):245250.Google Scholar
Varvalho, AR, Assini, T. Improvement of functional capacity among elderly people undergoing isostretching intervention. Braz J Phys Ther. 2008; 12(4):268273.Google Scholar
Stathokostas, L, McDonald, MW, Little, RM, Paterson, DH. Flexibility of older adults aged 55–86 years and the influence of physical activity. J Aging Res. 2013; 2013:743843.Google Scholar
He, Z, Bian, J, Carretta, HJ, Lee, J, Hogan, WR, Shenkman, E, Charness, N. Prevalence of multiple chronic conditions among older adults in Florida and the United States: Comparative analysis of the OneFlorida Data Trust and national inpatient sample. J Med Internet Res. 2018 (Apr.); 20(4):e137.Google Scholar
Koltyn, KF. Using physical activity to manage pain in older adults. J Aging Phys Act. 2002; 10(2):226239.Google Scholar
Cheung, C, Wyman, JF, Resnick, B, Savik, K. Yoga for managing knee osteoarthritis in older women: A pilot randomized controlled trial. BMC Complement Altern Med. 2014; 14(1):160.Google Scholar
Lee, PG, Jackson, EA, Richardson, CR. Exercise prescriptions in older adults. Am Fam Physician. 2017; 95(7):425432.Google Scholar
Chodzko-Zajko, WJ, Proctor, DN, Fiatarone Singh, MA, et al. American College of Sports Medicine position stand: Exercise and physical activity for older adults. Med Sci Sports Exerc. 2009; 41(7):15101530.Google Scholar
Fletcher, GF, Ades, PA, Kligfield, P, et al. Exercise standards for testing and training: A scientific statement from the American Heart Association. Circulation. 2013; 128:873934.Google Scholar
Valencia, WM. Preventing hypoglycemia in the older adult with diabetes. Geriatric Fast Facts #65. www.geriatricfastfacts.com/fast-facts/preventing-hypoglycemia-older-adult-diabetes. Accessed on 6/2/2017.Google Scholar
Colberg, SR, Albright, AL, Blissmer, BJ, et al. Exercise and type 2 diabetes: American College of Sports Medicine and the American Diabetes Association: Joint position statement. Med Sci Sports Exerc. 2010; 42(12):22822303.Google ScholarPubMed
Bridle, C, Spanjers, K, Patel, S, et al. Effect of exercise on depression severity in older people: Systematic review and meta-analysis of randomised controlled trials. Br J Psychiatry. 2012; 201:180185.Google Scholar
US Preventive Services Task Force. Screening for osteoporosis: US Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2011; 154(5):356364.Google Scholar
Diab, DL, Watts, NB. Diagnosis and treatment of osteoporosis in older adults. Endocrinol Metab Clin N Am. 2013; 42(2):305317.Google Scholar
Watts, NB, Bilezikian, JP, Camacho, PM, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of postmenopausal osteoporosis. Endocr Pract. 2010; 16(Suppl. 3):137.Google Scholar
Kendrick, D, Kumar, A, Carpenter, H, et al. Exercise for reducing fear of falling in older people living in the community. Cochrane DB Syst Rev. 2014; 11:CD009848.Google Scholar
Gillespie, LD, Robertson, M, Gillespie, WJ, et al. Interventions for preventing falls in older people living in the community. Cochrane DB Syst Rev. 2012; 9:CD007146.Google Scholar
Stevens, JA, Burns, E. A CDC Compendium of Effective Fall Interventions: What Works for Community-Dwelling Older Adults. 3rd edition. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, 2015. www.cdc.gov/homeandrecreationalsafety/falls/compendium.html.Google Scholar
Cai, H, Li, G, Hua, S, et al. Effect of exercise on cognitive function in chronic disease patients: A meta-analysis and systematic review of randomized controlled trials. Clin Interv Aging. 2017; 11:773783.Google Scholar
Wayne, PM, Walsh, JN, Taylor-Piliae, RE, et al. The impact of tai chi on cognitive performance in older adults: A systematic review and meta-analysis. J Am Geriatr Soc. 2014; 62(1):2539.Google Scholar
Lozano-Montoya, I, Correa-Pérez, A, Abraha, I, et al. Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: A systematic overview – The SENATOR Project ONTOP Series. Clin Interv Aging. 2017; 12:721740.Google Scholar
Aguirre, LE, Villareal, DT. Physical exercise as therapy for frailty. Nestle Nutr Inst Workshop Ser. 2015; 83:8392.Google Scholar
Spruit, MA, Burtin, C, De Boever, P, et al. COPD and exercise: Does it make a difference? Breathe. 2016; 12(2):e38e49.Google Scholar
US Department of Health and Human Services: National Institute on Aging. Exercise and Physical Activity: Your Everyday Guide from the National Institute on Aging! Gaithersburg, MD: National Institute on Aging Information Center, 2013. No. 094258. https://go4life.nia.nih.gov/sites/default/files/nia_exercise_and_physical_activity.pdf. Accessed on 6/12/2017.Google Scholar
Kantor, ED, Rehm, CD, Haas, JS, et al. Trends in prescription drug use among adults in the United States from 1999–2012. JAMA. 2015; 314(17):18181831.Google Scholar
Railhac, JJ, Zaim, M, Saurel, AS, Vial, J, Fournie, B. Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: A randomized, double-blind, placebo-controlled pilot study using MRI. Clin Rheumatol. 2012 (Sep.); 31(9):13471357. Erratum in: Clin Rheumatol. 2014 (Oct.); 33(10):1527.Google Scholar
Mueller, PS. Symptomatic myopathy due to red yeast rice. Ann Intern Med. 2006 (Sep. 19); 145(6):474475.Google Scholar
Gullestad, L, Hallen, J, Medbø, JI, et al. The effect of acute vs chronic treatment with beta-adrenoceptorblockade on exercise performance, haemodynamic and metabolic parameters in healthy men and women. Br J Clin Pharmacol. 1996; 41:5767.Google Scholar
Chick, TW, Halperin, AK, Gacek, EM. The effect of antihypertensive medications on exercise performance: A review. Med Sci Sports Exerc. 1988; 20(5):447454.Google Scholar
Parker, BA, Capizzi, JA, Grimaldi, AS, et al. The effect of statins on skeletal muscle function. Circulation. 2013; 127(1):96103.Google Scholar
Deichmann, RE, Lavie, CJ, Asher, T, et al. The interaction between statins and exercise: Mechanisms and strategies to counter the musculoskeletal side effects of this combination therapy. Ochsner J. 2015; 15(4):429437.Google Scholar
Kristensen, JM, Larsen, S, Helge, JW, et al. Two weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type mice. PLoS One. 2013; 8(1):e53533.Google Scholar
Arabyat, RM, Raisch, DW, McKoy, JM, Bennett, CL. Fluoroquinolone-associated tendon-rupture: A summary of reports in the Food and Drug Administration’s adverse event reporting system. Expert Opin Drug Saf. 2015; 14(11):16531660.Google Scholar
Toh, JWT, Ong, E, Wilson, R. Hypomagnesaemia associated with long-term use of proton pump inhibitors. Gastroenterol Rep (Oxf). 2015; 3(3):243253.Google Scholar
Snyder, M, Kish, T. Sertraline-Induced rhabdomyolysis: A case report and literature review. Am J Ther. 2016; 23(2):e561565.Google Scholar
Montgomery, LC, Deuster, PA. Effects of antihistamine medications on exercise performance: Implications for sportspeople. Sports Med. 1993; 15(3):179195.Google Scholar
Marcum, ZA, Perera, S, Thorpe, JM, et al. Antidepressant use and recurrent falls in community-dwelling older adults: Findings from the health ABC study. Ann Pharmacother. 2016; 50(7):525533.Google Scholar
Gebara, MA, Lipsey, KL, Karp, JK, et al. Cause or effect? Selective serotonin reuptake inhibitors and falls in older adults: A systematic review. Am J Geriatr Psychiatry. 2015; 23(10):10161028.Google Scholar
Baldwin, AC, Stevenson, SW, Dudley, GA. Nonsteroidal anti-inflammatory therapy after eccentric exercise in healthy older individuals. J Gerontol A Biol Sci Med Sci. 2001; 56(8):M510513.Google Scholar
Jankowski, CM, Shea, K, Barry, DW, et al. Timing of ibuprofen use and musculoskeletal adaptations to exercise training in older adults. Bone Rep. 2015; 1:18.Google Scholar
Smith, KL, Carr, K, Wiseman, A, Calhoun, K, McNevin, NH, Weir, PL. Barriers are not the limiting factor to participation in physical activity in Canadian seniors. J Aging Res. 2012; 2012:890679.Google Scholar
Little, RM, Paterson, DH, Humphreys, DA, Stathokostas, L. A 12-month incidence of exercise-related injuries in previously sedentary community-dwelling older adults following an exercise intervention. BMJ Open. 2013 (Jun. 20); 3(6).Google Scholar
McCarthy, MM, Hannafin, JA. The mature athlete: Aging tendon and ligament. Sports Health. 2014; 6(1):4148.Google Scholar
Prescott, JW, Yu, JS. The aging athlete: Part 1, boomeritis of the lower extremity. Am J Roentg. 2012; 199(3):W294306.Google Scholar
Quatman, C, Yu, JS. The aging athlete: Part 2, boomeritis of the upper extremity. Am J Roentg. 2012; 199(3):W307321.Google Scholar
Pozzi, F, Snyder-Mackler, L, Zeni, J. Physical exercise after knee arthroplasty: A systematic review of controlled trials. Eur J Phys Rehabil Med. 2013; 49(6):877892.Google Scholar
Walsh, M, Woodhouse, LJ, Thomas, SG, Finch, E. Physical impairments and functional limitations: A comparison of individuals 1 year after total knee arthroplasty with control subjects. Phys Ther. 1998; 78(3):248258.Google Scholar
Dagneaux, L, Bourlez, J, Degeorge, B, Canovas, F. Return to sport after total or unicompartmental knee arthroplasty: An informative guide for residents to patients. EFORT Open Rev. 2017; 2(12):496501.Google Scholar
Jassim, SS, Douglas, SL, Haddad, FS. Athletic activity after lower limb arthroplasty: A systematic review of current evidence. Bone Joint J. 2014; 96(7):923927.Google Scholar
Healy, WL, Iorio, R, Lemos, MJ. Athletic activity after joint replacement. Am J Sports Med. 2001 (May–Jun.); 29(3):377388.Google Scholar
Healy, WL, Sharma, S, Schwartz, B, Iorio, R. Athletic activity after total joint arthroplasty. J Bone Joint Surg Am. 2008 (Oct.); 90(10):22452252.Google Scholar
Vogel, LA, Carotenuto, G, Basti, JJ, Levine, WN. Physical activity after total joint arthroplasty. Sports Health. 2011; 3(5):441450.Google Scholar
Papalia, R, Del Buono, A, Zampogna, B, Maffulli, N, Denaro, V. Sport activity following joint arthroplasty: A systematic review. Br. Med. Bull. 2012 (Mar.); 101(1):81103.Google Scholar
Terwee, CB, Bouwmeester, W, van Elsland, SL, et al. Instruments to assess physical activity in patients with osteoarthritis of the hip or knee: A systematic review of measurement properties. Osteoarthritis Cartilage. 2011; 19(6):620633.CrossRefGoogle ScholarPubMed
Williams, DH, Greidanus, NV, Masri, BA, et al. Predictors of participation in sports after hip and knee arthroplasty. Clin Orthop Relat Res. 2012; 470(2):555561.Google Scholar
Malcolm, TL, Szubski, CR, Nowacki, AS, et al. Activity levels and functional outcomes of young patients undergoing total hip arthroplasty. Orthopedics. 2014; 37(11):e983992.Google Scholar
Administration for Community Living’s Administration on Aging; US Department of Health and Human Services. 2017 Profile of Older Americans. April 2018. https://acl.gov/sites/default/files/Aging%20and%20Disability%20in%20America/2017OlderAmericansProfile.pdf. Accessed on 7/8/2020.Google Scholar
Ong, AD, Uchino, BN, Wethington, E. Loneliness and health in older adults: A mini-review and synthesis. Gerontology. 2016; 62(4):443449.Google Scholar
Uchino, BN: Social support and health: A review of physiological processes potentially underlying links to disease outcomes. J Behav Med. 2006; 29:377387.Google Scholar
Hawkley, LC, Cacioppo JT. Loneliness matters: A theoretical and empirical review of consequences and mechanisms. Ann Behav Med. 2010; 40:218227.Google Scholar
Berkman, LF, Glass, T, Brissette, I, Seeman TE. From social integration to health: Durkheim in the new millennium. Soc Sci Med. 2000; 51:843857.Google Scholar
Cacioppo, JT, Cacioppo, S. Older adults reporting social isolation or loneliness show poorer cognitive function 4 years later. Evid Based Nurs. 2014 (Apr.); 17(2):5960.Google Scholar
Cacioppo, JT, Cacioppo, S. The growing problem of loneliness. Lancet. 2018; 391(10119):426.Google Scholar
Cacioppo, JT, Cacioppo, S. Loneliness in the modern age: An evolutionary theory of loneliness (ETL). J Exp Soc Psychol. 2018; 58:127197.Google Scholar
Cacioppo, S, Capitanio, JP, Cacioppo, JT. Toward a neurology of loneliness. Psych Bull. 2014; 140(6):14641504.Google Scholar
Cacioppo, S, Grippo, AJ, London, S, et al. Loneliness: Clinical import and interventions. Perspect Psychol Sci. 2015; 10(2):238249.Google Scholar
Schrempft, S, Jackowska, M, Hamer, M, Steptoe, A. Associations between social isolation, loneliness, and objective physical activity in older men and women. BMC Public Health. 2019 (Jan. 16); 19(1):74.Google Scholar
Holt-Lunstad, J, Smith, TB, Layton, JB. Social relationships and mortality risk: A meta-analytic review. PLoS Med. 2010 (Jul. 27); 7(7).Google Scholar
Brady, S, D’Ambrosio, LA, Felts, A, Rula, EY, Kell, KP, Coughlin, JF. Reducing isolation and loneliness through membership in a fitness program for older adults: Implications for health. J Appl Gerontol. 2020; 39(3):301310.Google Scholar
US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Coronavirus disease 2019 (COVID-19): Older adults. Last updated June 25, 2020. www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/older-adults.html. Accessed on 7/9/2020.Google Scholar
Hua, Qian, Te, Miao, Li, LIU, Xiaohong, Zheng, Danting, Luo, Yuguo, Li. Indoor transmission of SARS-CoV-2. Indoor Air. 2021; 31(3):639645.Google Scholar
US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Coronavirus disease 2019 (COVID-19): Social distancing. Last updated July 6, 2020. www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/social-distancing.html. Accessed on 7/9/2020.Google Scholar
US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Coronavirus disease 2019 (COVID-19): Use of cloth face coverings to help slow the spread of COVID-19. Last updated June 28, 2020. www.cdc.gov/coronavirus/2019-ncov/prevent-getting-sick/diy-cloth-face-coverings.html. Accessed on 7/9/2020.Google Scholar
US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases. Coronavirus disease 2019 (COVID-19): When and how to wash your hands. Last updated April 2, 2020. www.cdc.gov/handwashing/when-how-handwashing.html. Accessed on 7/9/2020.Google Scholar

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