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5c - Attention deficit hyperactivity disorder: a lifespan synthesis

from Section II - Disorders

Published online by Cambridge University Press:  07 May 2010

Jacobus Donders
Affiliation:
Mary Free Bed Rehabilitation Hospital
Scott J. Hunter
Affiliation:
University of Chicago
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Summary

Introduction

Taken together, the data presented in the previous two chapters paint a clear picture of attention deficit hyperactivity disorder (ADHD) as a highly prevalent, heterogeneous, and oftentimes lifelong neurobehavioral disorder that results in considerable functional impairment for afflicted individuals. Further, while efficacious treatments are available, most provide limited long-term benefits. As discussed in the prior chapters, ADHD is quite prevalent in childhood, making it more the rule than the exception that classrooms will have at least one child with the disorder. Prevalence rates are generally estimated to be lower among adults, but it is this group that is beginning to be clinically referred and identified at much higher rates in recent years, and this primarily accounts for the substantial increase in medication prescriptions written to treat ADHD. Yet knowledge regarding continuity between the childhood, adolescent, and adult conditions in ADHD remains quite limited.

That ADHD is a heterogeneous disorder is generally well accepted throughout the scientific literature, and these multiple sources of variability are problematic for the diagnosis, study, and treatment of ADHD. This heterogeneity is perhaps most apparent phenomenologically with regard to the core defining symptom domains, as evidenced by the three distinct subtypes (predominantly inattentive [ADHD-I], predominantly hyperactive/impulsive [ADHD-HI], and combined [ADHD-C]), as well as with regard to associated features and comorbidities. As described in the previous chapters, it is the exception rather than the rule when an individual with ADHD does not meet criteria for at least one other psychiatric disorder and/or a learning disability.

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Publisher: Cambridge University Press
Print publication year: 2010

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References

Lijffijt, M, et al. A meta-analytic review of stopping performance in attention-deficit/hyperactivity disorder: deficient inhibitory motor control?J Abnorm Psychology 2005;114(2):216–22.CrossRefGoogle ScholarPubMed
Shaw, P, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc Natl Acad Sci USA 2007;104(49):19649–54.CrossRefGoogle ScholarPubMed
Castellanos, FX, et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 2002;288(14):1740–8.CrossRefGoogle ScholarPubMed
Polanczyk, G, Rohde, . Epidemiology of attention-deficit/hyperactivity disorder across the lifespan. Curr Opi Psychiatry 2007;20(4):386–92.CrossRefGoogle ScholarPubMed
Halperin, JM, et al. Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls. J Child Psychol Psychiatry 2008;49(9):958–66.CrossRefGoogle ScholarPubMed
Halperin, JM, Schulz, KP.Revisiting the role of the prefrontal cortex in the pathophysiology of attention-deficit/hyperactivity disorder. Psycholog Bull 2006;132(4):560–81.CrossRefGoogle ScholarPubMed
Still, GF.Some abnormal psychical conditions in children: excerpts from three lectures. J Atten Disord 2006;10(2):126–36.CrossRefGoogle ScholarPubMed
Barkley, RA.Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psycholog Bull 1997;121(1):65–94.CrossRefGoogle ScholarPubMed
Sergeant, J.The cognitive-energetic model: an empirical approach to attention-deficit hyperactivity disorder. Neurosci Biobehav Rev 2000;24(1):7–12.CrossRefGoogle ScholarPubMed
Sonuga-Barke, EJ, et al. Hyperactivity and delay aversion – I. The effect of delay on choice. J Child Psychol Psychiatry 1992;33(2):387–98.CrossRefGoogle ScholarPubMed
Dickstein, SG, et al. The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis. J Child Psychol Psychiatry 2006;47(10):1051–62.CrossRefGoogle ScholarPubMed
Pennington, BF, Ozonoff, S.Executive functions and developmental psychopathology. J Child Psychol Psychiatry 1996;37(1):51–87.CrossRefGoogle ScholarPubMed
Biederman, J, Mick, E, Faraone, SV.Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry 2000;157(5):816–8.CrossRefGoogle ScholarPubMed
Todd, RD, Huang, H, Henderson, CA.Poor utility of the age of onset criterion for DSM-IV attention deficit/hyperactivity disorder: recommendations for DSM-V and ICD-11. J Child Psychol Psychiatry 2008;49(9):942–9.CrossRefGoogle ScholarPubMed
Lahey, BB, et al. Instability of the DSM-IV Subtypes of ADHD from preschool through elementary school. Arch Gen Psychiatry 2005;62(8):896–902.CrossRefGoogle ScholarPubMed
McBurnett, K, Pfiffner, LJ, Frick, PJ.Symptom properties as a function of ADHD type: an argument for continued study of sluggish cognitive tempo. J Abnorm Child Psychol 2001;29(3):207–13.CrossRefGoogle ScholarPubMed
Solanto, MV, et al. Neurocognitive functioning in AD/HD, predominantly inattentive and combined subtypes. J Abnorm Child Psychol 2007;35(5):729–44.CrossRefGoogle ScholarPubMed
Huang-Pollock, CL, Nigg, JT, Halperin, JM.Single dissociation findings of ADHD deficits in vigilance but not anterior or posterior attention systems. Neuropsychology 2006;20(4):420–9.CrossRefGoogle ScholarPubMed
Kooij, JJ, et al. Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychol Med 2005;35(6):817–27.CrossRefGoogle Scholar
Giedd, JN, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 1999;2(10):861–3.CrossRefGoogle ScholarPubMed
Brody, BA, et al. Sequence of central nervous system myelination in human infancy. I. An autopsy study of myelination. J Neuropathol Exp Neurol 1987;46(3):283–301.CrossRefGoogle ScholarPubMed
Huttenlocher, PR, Courten, C.The development of synapses in striate cortex of man. Hum Neurobiol 1987;6(1):1–9.Google Scholar
Mrzljak, L, et al. Neuronal development in human prefrontal cortex in prenatal and postnatal stages. Prog Brain Res 1990;85:185–222.CrossRefGoogle ScholarPubMed
Giedd, JN, et al. Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cereb Cortex 1996;6(4):551–60.CrossRefGoogle ScholarPubMed
Rhee, SH, et al. Testing hypotheses regarding the causes of comorbidity: examining the underlying deficits of comorbid disorders. J Abnorm Psychol 2005;114(3):346–62.CrossRefGoogle ScholarPubMed
Spencer, TJ.ADHD and comorbidity in childhood. J Clin Psychiatry 2006;67 Suppl 8:27–31.Google ScholarPubMed
Marks, DJ, Newcorn, JH, Halperin, JM.Comorbidity in adults with attention-deficit/hyperactivity disorder. Ann N Y Acad Sci 2001;931:216–38.CrossRefGoogle ScholarPubMed
Mannuzza, S, et al. Significance of childhood conduct problems to later development of conduct disorder among children with ADHD: a prospective follow-up study. J Abnorm Child Psychol 2004;32(5):565–73.CrossRefGoogle ScholarPubMed
Biederman, J, et al. New insights into the comorbidity between ADHD and major depression in adolescent and young adult females. J Am Acad Child Adolesc Psychiatry 2008;47(4):426–34.CrossRefGoogle ScholarPubMed
Miller, CJ, et al. Childhood attention-deficit/hyperactivity disorder and the emergence of personality disorders in adolescence: a prospective follow-up study. J Clin Psychiatry 2008;69(9):1477–84.CrossRefGoogle ScholarPubMed
Biederman, J.Impact of comorbidity in adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry 2004;65 Suppl 3:3–7.Google ScholarPubMed
Willcutt, EG, et al. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 2005;57(11):1336–46.CrossRefGoogle ScholarPubMed
Alderson, RM, Rapport, MD, Kofler, MJ.Attention-deficit/hyperactivity disorder and behavioral inhibition: a meta-analytic review of the stop-signal paradigm. J Abnorm Child Psychol 2007;35(5):745–58.CrossRefGoogle ScholarPubMed
Martinussen, R, et al. A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolescent Psychiatry, 2005;44(4):377–84.CrossRefGoogle ScholarPubMed
Hervey, AS, Epstein, JN, Curry, JF.Neuropsychology of adults with attention-deficit/hyperactivity disorder: a meta-analytic review. Neuropsychology 2004;18(3):485–503.CrossRefGoogle ScholarPubMed
Schoechlin, C, Engel, RR.Neuropsychological performance in adult attention-deficit hyperactivity disorder: meta-analysis of empirical data. Arch Clin Neuropsychology 2005;20(6):727–44.CrossRefGoogle ScholarPubMed
Nigg, JT, et al. Causal heterogeneity in attention-deficit/hyperactivity disorder: do we need neuropsychologically impaired subtypes? Biol Psychiatry 2005;57(11):1224–30.CrossRefGoogle ScholarPubMed
Halperin, JM, et al. Specificity of inattention, impulsivity, and hyperactivity to the diagnosis of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 1992;31(2):190–6.CrossRefGoogle Scholar
Solanto, MV, et al. The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: a supplement to the NIMH multimodal treatment study of AD/HD. J Abnorm Child Psychol 2001;29(3):215–28.CrossRefGoogle ScholarPubMed
Sonuga-Barke, EJ.The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics. Neurosci Biobehav Rev 2003;27(7):593–604.CrossRefGoogle ScholarPubMed
Crosbie, J, et al. Validating psychiatric endophenotypes: inhibitory control and attention deficit hyperactivity disorder. Neurosci Biobehav Rev 2008;32(1):40–55.CrossRefGoogle ScholarPubMed
Winsler, A, et al. Verbal self-regulation over time in preschool children at risk for attention and behavior problems. J Child Psychol Psychiatry 2000;41(7):875–86.CrossRefGoogle ScholarPubMed
Mariani, MA, Barkley, RA.Neuropsychological and academic functioning in preschool boys with attention deficit hyperactivity disorder. Dev Neuropsychol 1997;13:111–29.CrossRefGoogle Scholar
Marks, DJ, et al. Neuropsychological correlates of ADHD symptoms in preschoolers. Neuropsychology 2005;19(4):446–55.CrossRefGoogle ScholarPubMed
Berwid, OG, et al. Sustained attention and response inhibition in young children at risk for Attention Deficit/Hyperactivity Disorder. J Child Psychol Psychiatry 2005;46(11):1219–29.CrossRefGoogle ScholarPubMed
Lansbergen, MM, Kenemans, JL, Engeland, H.Stroop interference and attention-deficit/hyperactivity disorder: a review and meta-analysis. Neuropsychology 2007;21(2):251–62.CrossRefGoogle ScholarPubMed
Schwartz, K, Verhaeghen, P.ADHD and Stroop interference from age 9 to age 41 years: a meta-analysis of developmental effects. Psychol Med 2008;38(11):1607–16.CrossRefGoogle ScholarPubMed
Mourik, R, Oosterlaan, J, Sergeant, JA.The Stroop revisited: a meta-analysis of interference control in AD/HD. J Child Psychol Psychiatry 2005;46(2):150–65.CrossRefGoogle ScholarPubMed
Huang-Pollock, CL, Nigg, JT.Searching for the attention deficit in attention deficit hyperactivity disorder: the case of visuospatial orienting. Clin Psychol Rev 2003;23(6):801–30.CrossRefGoogle ScholarPubMed
Frazier, TW, Demaree, HA, Youngstrom, EA.Meta-analysis of intellectual and neuropsychological test performance in attention-deficit/hyperactivity disorder. Neuropsychology 2004;18(3):543–55.CrossRefGoogle ScholarPubMed
Rommelse, NN, et al. Are motor inhibition and cognitive flexibility dead ends in ADHD? J Abnorm Child Psychol 2007;35(6):957–67.CrossRefGoogle ScholarPubMed
Martel, M, Nikolas, M, Nigg, JT.Executive function in adolescents with ADHD. J Am Acad Child Adolesc Psychiatry 2007;46(11):1437–44.Google ScholarPubMed
Loo, SK, et al. Executive functioning among Finnish adolescents with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2007;46(12):1594–604.CrossRefGoogle ScholarPubMed
Fischer, M, et al. Executive functioning in hyperactive children as young adults: attention, inhibition, response perseveration, and the impact of comorbidity. Dev Neuropsychol 2005;27(1):107–33.CrossRefGoogle ScholarPubMed
Hinshaw, SP, et al. Neuropsychological functioning of girls with attention-deficit/hyperactivity disorder followed prospectively into adolescence: evidence for continuing deficits?Neuropsychology 2007;21(2):263–73.CrossRefGoogle ScholarPubMed
Carr, , Nigg, JT, Henderson, JM.Attentional versus motor inhibition in adults with attention-deficit/hyperactivity disorder. Neuropsychology 2006;20(4):430–41.CrossRefGoogle ScholarPubMed
Sonuga-Barke, EJ, et al. Parent-based therapies for preschool attention-deficit/hyperactivity disorder: a randomized, controlled trial with a community sample. J Am Acad Child Adolesc Psychiatry 2001;40(4):402–8.CrossRefGoogle ScholarPubMed
Greenhill, L, et al. Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD. J Am Acad Child Adolesc Psychiatry 2006;45(11):1284–93.CrossRefGoogle ScholarPubMed
American Academy of Pediatrics/American Heart Association clarification of statement on cardiovascular evaluation and monitoring of children and adolescents with heart disease receiving medications for ADHD: May 16, 2008. J Dev Behav Pediatr 2008;29(4):335.CrossRef
A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry 1999;56(12):1073–86.CrossRef
Pietrzak, RH, et al. Cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder. Neurosci Biobehav Rev 2006;30(8):1225–45.CrossRefGoogle ScholarPubMed
Rapport, MD, Kelly, KL.Psychostimulant effects on learning and cognitive function: Findings and implications for children with Attention Deficit Hyperactivity Disorder. Clin Psychol Rev 1991;11(1):61–92.CrossRefGoogle Scholar
Chamberlain, SR, et al. Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biol Psychiatry 2007;62(9):977–84.CrossRefGoogle ScholarPubMed
Faraone, SV, et al. Atomoxetine and Stroop task performance in adult attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2005;15(4):664–70.CrossRefGoogle ScholarPubMed
Spencer, T, et al. Effectiveness and tolerability of Atomoxetine in adults with attention deficit hyperactivity disorder. Am J Psychiatry 1998;155(5):693–5.CrossRefGoogle ScholarPubMed
Gualtieri, CT, Johnson, LG.Medications do not necessarily normalize cognition in ADHD patients. J Atten Disord 2008;11(4):459–69.CrossRefGoogle Scholar
Bedard, AC, Tannock, R.Anxiety, methylphenidate response, and working memory in children with ADHD. J Atten Disord 2008;11(5):546–57.CrossRefGoogle ScholarPubMed
Scheres, A, et al. The effect of methylphenidate on three forms of response inhibition in boys with AD/HD. J Abnorm Child Psychol 2003;31(1):105–20.CrossRefGoogle ScholarPubMed
Bedard, AC, et al. Effects of methylphenidate on working memory components: influence of measurement. J Child Psychol Psychiatry 2007;48(9):872–80.CrossRefGoogle Scholar
Rhodes, SM, Coghill, DR, Matthews, K.Methylphenidate restores visual memory, but not working memory function in attention deficit-hyperkinetic disorder. Psychopharmacology (Berl) 2004;175(3):319–30.CrossRefGoogle Scholar
Mannuzza, S, Klein, RG, Moulton, JL.Persistence of Attention-Deficit/Hyperactivity Disorder into adulthood: what have we learned from the prospective follow-up studies? J Atten Disord 2003;7(2):93–100.CrossRefGoogle ScholarPubMed
Fischer, M, et al. The adolescent outcome of hyperactive children diagnosed by research criteria: II. Academic, attentional, and neuropsychological status. J Consult Clin Psychol 1990;58(5):580–8.CrossRefGoogle ScholarPubMed
Toplak, ME, et al. Review of cognitive, cognitive-behavioral, and neural-based interventions for Attention-Deficit/Hyperactivity Disorder (ADHD). Clin Psychol Rev 2008;28(5):801–23.CrossRefGoogle Scholar
Shalev, L, Tsal, Y, Mevorach, C.Computerized progressive attentional training (CPAT) program: effective direct intervention for children with ADHD. Child Neuropsychol 2007;13(4):382–8.CrossRefGoogle ScholarPubMed
O'Connell, RG, et al. Cognitive remediation in ADHD: effects of periodic non-contingent alerts on sustained attention to response. Neuropsychol Rehabil 2006;16(6):653–65.CrossRefGoogle ScholarPubMed
Rapport, MD, et al. Methylphenidate and attentional training. Comparative effects on behavior and neurocognitive performance in twin girls with attention-deficit/hyperactivity disorder. Behav Mod 1996;20(4):428–30.CrossRefGoogle ScholarPubMed
Kerns, K, Eso, K, Thomson, J.Investigation of a direct intervention for improving attention in children with ADHD. Dev Neuropsychol 1999;16:273–95.CrossRefGoogle Scholar
Thorell, LB, et al. Training and transfer effects of executive functions in preschool children. Dev Sci 2009;12(1):106–13.CrossRefGoogle ScholarPubMed
Klingberg, T, et al. Computerized training of working memory in children with ADHD – a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 2005;44(2):177–86.CrossRefGoogle ScholarPubMed
Klingberg, T, Forssberg, H, Westerberg, H.Training of working memory in children with ADHD. J Clin Exp Neuropsychol 2002;24(6):781–91.CrossRefGoogle ScholarPubMed
Olesen, PJ, Westerberg, H, Klingberg, T.Increased prefrontal and parietal activity after training of working memory. Nat Neurosci 2004;7(1):75–9.CrossRefGoogle ScholarPubMed

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