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Chapter 11 - Neuromuscular Specimens

from Prosection Techniques

Published online by Cambridge University Press:  07 August 2021

Mirna Lechpammer ,
Marc Del Bigio  and
Rebecca Folkerth
By
Mirna Lechpammer
Mirna Lechpammer
Affiliation:
New York University School of Medicine
Marc Del Bigio
Affiliation:
University of Manitoba, Canada
Rebecca Folkerth
Affiliation:
New York University School of Medicine
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Summary

In a routine practice, neuromuscular specimens obtained by biopsy may be analyzed by light and electron microscopy, including enzyme histochemistry, as well as by molecular and biochemical procedures. In all cases, neuromuscular biopsy must be correlated with patient’s clinical history and current neuromuscular exam, including electro-diagnostic findings. Handling of tissue obtained by neuromuscular biopsy is critical for a successful pathological analysis, and thus triaging, orienting, snap-freezing and preserving of specimens need to be clearly specified and performed with great care [1, 2, 3]. In this chapter, we describe recommended steps and procedures for the handling of neuromuscular biopsy specimens in preparation for gross and histopathological analyses, including tips for preventing common artifacts (e.g., formation of ice crystals).

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Perinatal Neuropathology , pp. 53 - 55
Publisher: Cambridge University Press
Print publication year: 2021

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References

De Girolami, U, Frosch, M, Amato, AA. Biopsy of nerve and muscle. In Samuels, M, Feske, S (eds). Office Practice of Neurology, 2nd ed. Philadelphia: Harcourt Health Sciences, 2003, pp. 217–25.Google Scholar
Engel, AG. The muscle biopsy. In Engel, AG, Franzini-Armstrong, C (eds). Myology, 3rd ed. New York: McGraw-Hill, 2004, pp. 681–90.Google Scholar
Nix JS, Moore SA. What every neuropathologist needs to know: the muscle biopsy. J Neuropathol Exp Neurol. 79:719–733, 2020.Google Scholar
Carpenter, S, Karpati, G. Pathology of Skeletal Muscle, 2nd ed. New York: Oxford, 2001.Google Scholar

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