Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Approach to Autopsy of the Perinatal Nervous System
- Ancillary Studies
- Prosection Techniques
- Chapter 9 Brain Prosection
- Chapter 10 Spinal Cord Prosection
- Chapter 11 Neuromuscular Specimens
- Chapter 12 Eye Specimens
- Tissue Selection
- Reporting
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Chapter 9 - Brain Prosection
from Prosection Techniques
Published online by Cambridge University Press: 07 August 2021
Book contents
- Perinatal Neuropathology
- Perinatal Neuropathology
- Copyright page
- Contents
- Preface
- Acknowledgments
- Abbreviations
- Section I Techniques and Practical Considerations
- Approach to Autopsy of the Perinatal Nervous System
- Ancillary Studies
- Prosection Techniques
- Chapter 9 Brain Prosection
- Chapter 10 Spinal Cord Prosection
- Chapter 11 Neuromuscular Specimens
- Chapter 12 Eye Specimens
- Tissue Selection
- Reporting
- Section 2 Human Nervous System Development
- Section 3 Stillbirth
- Section 4 Disruptions / Hypoxic-Ischemic Injury
- Section 5 Malformations
- Section 6 Perinatal Neurooncology
- Section 7 Spinal and Neuromuscular Disorders
- Section 8 Eye Disorders
- Section 9 Infections: In Utero Infections
- Section 10 Metabolic / Toxic Disorders: Storage Diseases
- Section 11 Forensic Neuropathology
- Appendix 1 Technical Considerations in Perinatal CNS
- Index
- References
Summary
The ability to conduct an autopsy safely and competently must be established. Guidelines for doing so have been published by a variety of national oversight organizations such as the College of American Pathologists and the Royal College of Pathologists (United Kingdom). The autopsy area must have adequate space and lighting, adequate temperature control and ventilation, adequate storage provisions (including pre-autopsy refrigeration and post-autopsy retention of tissues), appropriately sized instruments for dissection (which must be clean and sharp), a calibrated scale for reliable weighing of organs, photographic equipment, rigorous safety policies and procedures, the ability to clean and decontaminate the autopsy area, and a procedure for disposal of tissues. For medicolegal autopsies, the facility must be able to ensure a chain of custody of all specimens.
- Type
- Chapter
- Information
- Perinatal Neuropathology , pp. 45 - 49Publisher: Cambridge University PressPrint publication year: 2021
References
Cohen, MC, Scheimberg, I. The Pediatric and Perinatal Autopsy Manual: Cambridge University Press; 2014.CrossRefGoogle Scholar
Gilbert-Barness, E, Spicer, DE, Steffensen, TS. Handbook of Pediatric Autopsy Pathology, 2nd ed.: Springer; 2014.Google Scholar
Khong, TY, Malcomson, RDG, editors. Keeling’s Fetal and Neonatal Pathology, 5th ed.: Springer; 2015.Google Scholar
Collins, KA, Byard, RW, editors. Forensic Pathology of Infancy and Childhood: Springer; 2014.Google Scholar
Vlasyuk, VV. Features of opening the skull and extracting the brain from the skull. In: Vlasyuk, VV, editor. Birth Trauma and Perinatal Brain Damage: Springer; 2019. pp. 137–45.Google Scholar
Vlasyuk, VV. The method of opening the skull and extraction of the brain in fetuses and newborns. EC Neurology. 2018;10:6.Google Scholar
Giannini, C, Okazaki, H. Nervous system. In: Waters, BL, editor. Handbook of Autopsy Practice, 4th ed.: Humana Press / Springer; 2009. pp.51–68.CrossRefGoogle Scholar
Ashmead, JW. Postmortem perinatal brain removal: the value of the posterior approach method. Pediatr Pathol. 1993;13(6):875–80.Google Scholar
Prahlow, JA, Ross, KF, Salzberger, L, Lott, EG, Guileyardo, JM, Barnard, JJ. Immersion technique for brain removal in perinatal autopsies. J Forensic Sci. 1998;43(5):1056–60.CrossRefGoogle ScholarPubMed
Sebire, NJ, Weber, MA, Thayyil, S, Mushtaq, I, Taylor, A, Chitty, LS. Minimally invasive perinatal autopsies using magnetic resonance imaging and endoscopic postmortem examination (“keyhole autopsy”): feasibility and initial experience. J Matern Fetal Neonatal Med. 2012;25(5):513–18.Google Scholar
Wainwright, HC. My approach to performing a perinatal or neonatal autopsy. J Clin Pathol. 2006;59(7):673–80.Google Scholar
Oehmichen, M, Auer, RN, König, HG. Forensic Neuropathology and Associated Neurology: Springer-Verlag; 2006.Google Scholar
Sarnat, HB, Flores-Sarnat, L, Trevenen, CL. Synaptophysin immunoreactivity in the human hippocampus and neocortex from 6 to 41 weeks of gestation. J Neuropathol Exp Neurol. 2010;69(3):234–45.Google Scholar
Start, RD, Layton, CM, Cross, SS, Smith, JH. Reassessment of the rate of fixative diffusion. J Clin Pathol. 1992;45(12):1120–21.Google Scholar
Dawe, RJ, Bennett, DA, Schneider, JA, Vasireddi, SK, Arfanakis, K. Postmortem MRI of human brain hemispheres: T2 relaxation times during formaldehyde fixation. Magn Reson Med. 2009;61(4):810–18.Google Scholar
Scott, IS, MacDonald, AW. An evaluation of overnight fixation to facilitate neuropathological examination in Coroner’s autopsies: our experience of over 200 cases. J Clin Pathol. 2013;66(1):50–3.Google Scholar
Adickes, ED, Folkerth, RD, Sims, KL. Use of perfusion fixation for improved neuropathologic examination. Arch Pathol Lab Med. 1997;121(11):1199–206.Google Scholar
Sharma, M, Grieve, JH. Rapid fixation of brains: a viable alternative? J Clin Pathol. 2006;59(4):393–5.CrossRefGoogle ScholarPubMed
Barrett, C, Brett, F, Grehan, D, McDermott, MB. Heat-accelerated fixation and rapid dissection of the pediatric brain at autopsy: a pragmatic approach to the difficulties of organ retention. Pediatr Dev Pathol. 2004;7(6):595–600.Google Scholar
Bass, T, Bergevin, MA, Werner, AL, Liuzzi, FJ, Scott, DE. In situ fixation of the neonatal brain and spinal cord. Pediatr Pathol. 1993;13(5):699–705.Google Scholar
Cimmino, A, Parisi, G, Mastropasqua, MG, Ricco, R. A new technique for foetal brain fixation and extraction. Pathologica. 2002;94(6):320–4.CrossRefGoogle ScholarPubMed
Nicholls, JM. Rapid method for fetal brain fixation. J Clin Pathol. 1988;41(9):1019–20.Google Scholar