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Chapter 49 - Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome in Pregnancy

from Section 8 - Connective Tissue Disorders in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Oseme Etomi  and
Catherine Nelson-Piercy
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 28-year-old nulligravida is referred by her primary care provider to your high-risk obstetrics clinic for preconception counseling for known systemic lupus erythematosus (SLE).

Keywords

Preconception counselingSystemic lupus erythematosus (SLE)Antiphospholipid antibody syndrome (APLAS)Catastrophic APLASComorbiditiesImmune featuresPharmacology, treatment, hydroxychloroquine, heparinsPreeclampsia, low-dose aspirin, vitamin DDrug-induced lupusPerinatal risks, complications, maternal-fetal morbidity, adverse outcomeInvestigations, prenatalPreconception counsellingFlare, antenatalNeonatal lupus syndromeNeonatal cutaneous lupus syndromeCongenital heart blockContraception
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 619 - 634
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Andreoli, L, Bertsias, GK, Agmon-Levin, N, et al. EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome. Ann Rheum Dis. 2017;76(3):476–485.CrossRefGoogle ScholarPubMed
Do, SC, Druzin, ML. Systemic lupus erythematosus in pregnancy: high risk, high reward. Curr Opin Obstet Gynecol. 2019;31(2):120–126.CrossRefGoogle ScholarPubMed
Flint, J, Panchal, S, Hurrell, A, et al. BSR and BHPR guideline on prescribing drugs in pregnancy and breastfeeding-Part I: standard and biologic disease modifying anti-rheumatic drugs and corticosteroids. Rheumatology (Oxford). 2016;55(9):1693–1697.CrossRefGoogle ScholarPubMed
Giles, I, Yee, CS, Gordon, C. Stratifying management of rheumatic disease for pregnancy and breastfeeding. Nat Rev Rheumatol. 2019;15(7):391–402.Google Scholar
Knight, CL, Nelson-Piercy, C. Management of systemic lupus erythematosus during pregnancy: challenges and solutions. Open Access Rheumatol. 2017;9:37–53.Google Scholar
Lazzaroni, MG, Dall’Ara, F, Fredi, M, et al. A comprehensive review of the clinical approach to pregnancy and systemic lupus erythematosus. J Autoimmun. 2016;74:106–117.CrossRefGoogle ScholarPubMed
Nahal, SK, Selmi, C, Gershwin, ME. Safety issues and recommendations for successful pregnancy outcome in systemic lupus erythematosus. J Autoimmun. 2018;93:16–23.Google Scholar
Nelson-Piercy’s Handbook of Obstetric Medicine, 6th ed. London: Taylor and Francis; 2020.Google Scholar
Petri, M. Pregnancy and systemic lupus erythematosus. Best Pract Res Clin Obstet Gynaecol. 2020;64:24–30.CrossRefGoogle ScholarPubMed
Sammaritano, LR, Bermas, BL, Chakravarty, EE, et al. 2020 American College of Rheumatology guideline for the management of reproductive health in rheumatic and musculoskeletal diseases. Arthritis Rheumatol. 2020;72(4):529–556.Google Scholar

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