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Chap. 17 - CALCIUM HYDROXYLAPATITE (RADIESSE): A DERMASURGEON'S APPROACH

from PART THREE - FILLERS AND NEUROTOXINS

Published online by Cambridge University Press:  06 July 2010

Sorin Eremia
Affiliation:
University of California, Los Angeles, School of Medicine
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Summary

With a soaring increase in the U.S. aging population, there has been a parallel increase in interest in cosmetic procedures. Many people interested in rejuvenation are not prepared to undergo aggressive surgical interventions and elect for less invasive, yet aesthetically appreciable rejuvenation techniques. Soft tissue fillers have become increasingly popular given their ease of administration, immediate aesthetic enhancement capabilities, safety profiles, and relative affordability. Calcium hydroxylapatite (CaHA), manufactured as Radiesse, is one of the more versatile injectables.

THE PRODUCT

Radiesse is composed of 30% CaHA microspheres (25–45 μm diameter) suspended in a gel carrier composed of carboxymethylcellulose, glycerin, and water. CaHA is an inorganic compound with a chemical structure identical to components found in bone and teeth. Hence CaHA injectables are considered nonimmunogenic, minimizing any risk of allergic reaction to the product.

While approved for laryngeal augmentation and correction of urinary incontinence, CaHA was used safely as a soft tissue filler until December 2006, when it gained Food and Drug Administration (FDA) approval for this purpose. It is manufactured in 1.3-cc and 0.3-cc correction-sized syringes.

PATIENT INDICATIONS

CaHA is FDA approved for nasolabial folds and for lipoatrophy secondary to HIV. However, because of its viscosity and length of duration, it has many off-label indications. It is particularly effective for deeper nasolabial folds. In most patients, one syringe is sufficient, and the results will last for nearly twelve months. It can also be used for the marionette lines and, with care, the glabellar crease.

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Publisher: Cambridge University Press
Print publication year: 2010

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References

Ahn, MS. Calcium hydroxylapatite: Radiesse. Facial Plast. Surg. Clin. North Am. 2007;15:85–90.CrossRefGoogle ScholarPubMed
Alam, M, Yoo, SS. Technique for calcium hydroxylapatite injection for correction of nasolabial fold depressions. J. Am. Acad. Deramtol. 2007;56:285–9.CrossRefGoogle ScholarPubMed

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