This chapter focuses on the application of neuroimaging approaches in sleep-related epilepsy, to help further understand the pathophysiological investigation of sleep and epilepsy. Electroencephalography (EEG) is the most useful diagnostic procedure for epilepsy, and the most general method to diagnose and manage the epileptiform discharges. Simultaneous EEG and functional magnetic resonance imaging (fMRI) scanning opens an opportunity to uncover the regions of the brain showing changes in the fMRI signal in response to epileptic spikes seen in the EEG. The analysis of functional and structural connectivity networks provides new avenues for assessing complex network properties of healthy and diseased brain. Indeed, altered brain network topology has been shown in several psychiatric and neurological diseases. Simultaneous EEG and fMRI, and brain network approaches along with data acquisition during sleep in patients with epilepsy will be powerful means to evaluate the complicated relationships in the future.