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Chapter 14 - Medication-Resistant Epilepsy in Adults

Published online by Cambridge University Press:  20 August 2020

John M. Stern
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Raman Sankar
Affiliation:
Geffen School of Medicine at UCLA, Los Angeles, CA
Michael Sperling
Affiliation:
Jefferson Hospital for Neurosciences, Philadelphia, PA
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Summary

The temporal lobe epilepsies (TLE) are widely heterogeneous with regard to aetiology, age at onset, prognosis and response to treatment. An important distinction on topographic grounds is made between mesial (MTLE) and lateral temporal lobe epilepsy (LTLE).

Type
Chapter
Information
Medication-Resistant Epilepsy
Diagnosis and Treatment
, pp. 158 - 170
Publisher: Cambridge University Press
Print publication year: 2020

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References

French, JA, Williamson, PD, Thadani, VM, et al. Characteristics of medial temporal lobe epilepsy: I. Results of history and physical examination. Ann Neurol 1993;34:774780CrossRefGoogle ScholarPubMed
Sperling, MR. Autonomic Seizures. In: Panayiotopoulos, CP (ed.), Atlas of Epilepsies. London: Springer; 2010:467470.Google Scholar
Stern, JM. Focal Seizures with Olfactory Hallucinations. In: Panayiotopoulos, CP (ed.), Atlas of Epilepsies. London: Springer; 2010;453455.CrossRefGoogle Scholar
ILAE Commission on Neurosurgery of Epilepsy, Wieser, HG. ILAE Commission Report: Mesial temporal lobe epilepsy with hippocampal sclerosis. Epilepsia 2004;45(6):695-714Google ScholarPubMed
Krendl, R, Lurger, S, Baumgartner, C. Absolute spike frequency predicts surgical outcome in TLE with unilateral hippocampal atrophy. Neurology 2008;71:413418CrossRefGoogle ScholarPubMed
Williamson, PD, French, JA, Thadani, VM, et al. Characteristics of medial temporal lobe epilepsy: II. Interictal and ictal scalp electroencephalography, neuropsychological testing, neuroimaging, surgical results, and pathology. Ann Neurol 1993;34:781787Google Scholar
Lewis, DV, Shinnar, S, Hesdorffer, DC, et al. Hippocampal sclerosis after febrile status epilepticus: the FEBSTAT study. Ann Neurol 2014;75:178185Google Scholar
Le Blanc, FE, Rasmussen, T. Cerebral seizures and brain tumors. In: Vinken, P, Bruyn, GW (eds.), Handbook of Clinical Neurology. Amsterdam: Elsevier, 1974;295301Google Scholar
Semah, F, Picot, MC, Adam, C, et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology 1998;51:12561262Google Scholar
Engel, J, McDermott, MP, Wiebe, S, et al. Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. J Am Med Assoc 2012;307:922930CrossRefGoogle ScholarPubMed
Effectiveness and Efficiency of Surgery for Temporal Lobe Epilepsy Study Group, Wiebe, S, Blume, WT, Girvin, JP, Eliasziw, M. A randomized, controlled trial of surgery for temporal-lobe epilepsy. N Engl J Med 2001;345:311318Google Scholar
Jobst, BC, Cascino, GD. Resective epilepsy surgery for drug-resistant focal epilepsy: a review. J Am Med Assoc 2015;313:285293Google Scholar
[No authors listed] Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1989;30:389399Google Scholar
Manford, M, Fish, DR, Shorvon, SD. An analysis of clinical seizure patterns and their localizing value in frontal and temporal lobe epilepsies. Brain 1996;119:1740Google Scholar
Leung, H, Schindler, K, Clusmann, H, et al. Mesial frontal epilepsy and ictal body turning along the horizontal body axis. Arch Neurol 2008;65:7177Google Scholar
Unnwongse, K, Wehner, T, Foldvary-Schaefer, N. Mesial frontal lobe epilepsy. J Clin Neurophysiol 2012;29:371378Google Scholar
Salanova, V, Andermann, F, Rasmussen, T, et al. Parietal lobe epilepsy: clinical manifestations and outcome in 82 patients treated surgically between 1929 and 1988. Brain 1995;118:607627CrossRefGoogle ScholarPubMed
Beleza, P, Pinho, J. Frontal lobe epilepsy. J Clinl Neuroscience 2011;18:593600CrossRefGoogle ScholarPubMed
Foldvary, N, Klem, G, Hammel, J, et al. The localizing value of ictal EEG in focal epilepsy. Neurology 2001;57:20222028Google Scholar
Holtkamp, M, Sharan, A, Sperling, MR. Intracranial EEG in predicting surgical outcome in frontal lobe epilepsy. Epilepsia 2012;53:17391745CrossRefGoogle ScholarPubMed
Salanova, V, Andermann, F, Olivier, A, et al. Occipital lobe epilepsy: electroclinical manifestations, electrocorticography, cortical stimulation and outcome in 42 patients treated between 1930 and 1991. Surgery of occipital lobe epilepsy. Brain 1992;115:16551680Google Scholar
Perucca, P, Dubeau, F, Gotman, J. Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology. Brain 2014;137:183196CrossRefGoogle ScholarPubMed
Munari, C, Kahane, P, Francione, S, et al. Role of the hypothalamic hamartoma in the genesis of gelastic fits (a video-stereo-EEG study). Electroencephalogr Clin Neurophysiol 1995;95:154160Google Scholar
Gascon, GG, Lombroso, CT. Epileptic (gelastic) laughter. Epilepsia 1971;12:6376Google Scholar
Kuzniecky, R, Guthrie, B, Mountz, J, et al. Intrinsic epileptogenesis of hypothalamic hamartomas in gelastic epilepsy. Ann Neurol 1997;42:6067CrossRefGoogle ScholarPubMed
Fenoglio, KA, Wu, J, Simeone, TA, et al. Hypothalamic hamartoma: basic mechanisms of intrinsic epileptogenesis. Semin Pediatr Neurol 2007;14:5159CrossRefGoogle ScholarPubMed
Kim, DY, Fenoglio, KA, Simeone, TA, et al. GABAA receptor-mediated activation of L-type calcium channels induces neuronal excitation in surgically resected human hypothalamic hamartomas. Epilepsia 2008;49:861871Google Scholar
Drees, C, Chapman, K, Prenger, E, et al. Seizure outcome and complications following hypothalamic hamartoma treatment in adults: endoscopic, open, and Gamma Knife procedures. J Neurosurg 2012;117:255261CrossRefGoogle ScholarPubMed
Curry, DJ, Raskin, J, Ali, I, Wilfong, AA. MR-guided laser ablation for the treatment of hypothalamic hamartomas. Epilepsy Res 2018;142:131134CrossRefGoogle ScholarPubMed

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