Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I Introduction: definition and classification of the human herpesviruses
- Part II Basic virology and viral gene effects on host cell functions: alphaherpesviruses
- 5 Genetic comparison of human alphaherpesvirus genomes
- 6 Alphaherpes viral genes and their functions
- 7 Entry of alphaherpesviruses into the cell
- 8 Early events pre-initiation of alphaherpes viral gene expression
- 9 Initiation of transcription and RNA synthesis, processing and transport in HSV and VZV infected cells
- 10 Alphaherpesvirus DNA replication
- 11 Envelopment of HSV nucleocapsids at the inner nuclear membrane
- 12 The egress of alphaherpesviruses from the cell
- 13 The strategy of herpes simplex virus replication and takeover of the host cell
- Part II Basic virology and viral gene effects on host cell functions: betaherpesviruses
- Part II Basic virology and viral gene effects on host cell functions: gammaherpesviruses
- Part III Pathogenesis, clinical disease, host response, and epidemiology: HSV-1 and HSV-2
- Part III Pathogenesis, clinical disease, host response, and epidemiology: VZU
- Part III Pathogenesis, clinical disease, host response, and epidemiology: HCMV
- Part III Pathogenesis, clinical disease, host response, and epidemiology: HHV- 6A, 6B, and 7
- Part III Pathogenesis, clinical disease, host response, and epidemiology: gammaherpesviruses
- Part IV Non-human primate herpesviruses
- Part V Subversion of adaptive immunity
- Part VI Antiviral therapy
- Part VII Vaccines and immunothgerapy
- Part VIII Herpes as therapeutic agents
- Index
- Plate section
- References
11 - Envelopment of HSV nucleocapsids at the inner nuclear membrane
from Part II - Basic virology and viral gene effects on host cell functions: alphaherpesviruses
Published online by Cambridge University Press: 24 December 2009
Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I Introduction: definition and classification of the human herpesviruses
- Part II Basic virology and viral gene effects on host cell functions: alphaherpesviruses
- 5 Genetic comparison of human alphaherpesvirus genomes
- 6 Alphaherpes viral genes and their functions
- 7 Entry of alphaherpesviruses into the cell
- 8 Early events pre-initiation of alphaherpes viral gene expression
- 9 Initiation of transcription and RNA synthesis, processing and transport in HSV and VZV infected cells
- 10 Alphaherpesvirus DNA replication
- 11 Envelopment of HSV nucleocapsids at the inner nuclear membrane
- 12 The egress of alphaherpesviruses from the cell
- 13 The strategy of herpes simplex virus replication and takeover of the host cell
- Part II Basic virology and viral gene effects on host cell functions: betaherpesviruses
- Part II Basic virology and viral gene effects on host cell functions: gammaherpesviruses
- Part III Pathogenesis, clinical disease, host response, and epidemiology: HSV-1 and HSV-2
- Part III Pathogenesis, clinical disease, host response, and epidemiology: VZU
- Part III Pathogenesis, clinical disease, host response, and epidemiology: HCMV
- Part III Pathogenesis, clinical disease, host response, and epidemiology: HHV- 6A, 6B, and 7
- Part III Pathogenesis, clinical disease, host response, and epidemiology: gammaherpesviruses
- Part IV Non-human primate herpesviruses
- Part V Subversion of adaptive immunity
- Part VI Antiviral therapy
- Part VII Vaccines and immunothgerapy
- Part VIII Herpes as therapeutic agents
- Index
- Plate section
- References
Summary
Introduction
As in all herpesviruses, Herpes simplex nucleocapsids assembled in the nucleoplasm obtain an initial envelope by budding through the inner nuclear membrane of infected cells. This chapter will focus on the proteins responsible for nucleocapsid budding in the herpes simplex virus system. Of interest is the observation that orthologs of at least the UL31 and UL34 genes of herpes simplex virus genes likely mediate similar functions in members of both the beta- and gamma herpesvirinae (Muranyi et al., 2002; Gonnella et al., 2005). Thus, it is expected that this information will be relevant to the study of nucleocapsid envelopment of all herpesviruses.
Anatomy of the nuclear membrane: it's all connected
The nuclear envelope consists of two leaflets: the inner leaflet or inner nuclear membrane (INM) partitions the nucleoplasm from the lumen of the nuclear envelope, whereas the outer leaflet (ONM) contacts the cytoplasm. The space between the leaflets is ultimately continuous with the lumen of the endoplasmic reticulum. Both leaflets are continuous with the nuclear pore membrane that serves as an anchoring point for nuclear pore complexes (NPCs), which serve as conduits to mediate protein and RNA transport between the nucleus and cytoplasm.
The nuclear lamina lines the inner surface of the INM and is maintained in this orientation by interaction with both chromatin in the nucleoplasm, and integral membrane proteins specifically concentrated in the INM. How proteins are targeted to the INM has been the focus of active research for several years (Ellenberg et al., 1997; Ostlund et al., 1999; Soullam and Worman, 1993).
- Type
- Chapter
- Information
- Human HerpesvirusesBiology, Therapy, and Immunoprophylaxis, pp. 144 - 150Publisher: Cambridge University PressPrint publication year: 2007
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