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Chapter 25 - Metabolomic Screening of Embryos to Enhance Successful Selection and Transfer

from Section 5 - Embryo Selection and Transfer

Published online by Cambridge University Press:  04 January 2019

Gabor Kovacs
Affiliation:
Monash University, Victoria
Anthony Rutherford
Affiliation:
University of Leeds
David K. Gardner
Affiliation:
University of Melbourne
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Publisher: Cambridge University Press
Print publication year: 2019

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References

Houghton, F.D., Hawkhead, J.A., Humpherson, P.G. et al., 2002. Non-invasive amino acid turnover predicts human embryo developmental capacity. Human Reproduction (Oxford, England), 17(4), pp. 9991005.Google Scholar
Guerif, F., McKeegan, P.J., Leese, H.J. & Sturmey, R.G., 2013. A simple approach for COnsumption and RElease (CORE) analysis of metabolic activity in single mammalian embryos. PloS one, 8(8), p. e67834.Google Scholar
Brison, D.R., Houghton, F.D., Falconer, D. et al., 2004. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Human Reproduction (Oxford, England), 19(10), pp. 2319–24.Google Scholar
Picton, H.M., Elder, K., Houghton, F.D. et al., 2010. Association between amino acid turnover and chromosome aneuploidy during human preimplantation embryo development in vitro. Molecular Human Reproduction, 16(8), pp. 557–69.Google Scholar
Sturmey, R.G., Brison, D.R., Leese, H.J., 2008 October. Symposium: innovative techniques in human embryo viability assessment. Assessing embryo viability by measurement of amino acid turnover. Reprod Biomed Online, 17(4), pp. 486–96.CrossRefGoogle ScholarPubMed
Sunde, A., Brison, D.R., Dumoulin, J.C.M. et al., 2016. Time to take human embryo culture seriously. Human Reproduction, 31(10), pp. 2174–82.Google Scholar
Zuelke, K.A. & Brackett, B.G., 1992. Effects of luteinizing hormone on glucose metabolism in cumulus-enclosed bovine oocytes matured in vitro. Endocrinology, 131(6), pp. 2690–96.Google Scholar
Downs, S.M. & Utecht, A.M., 1999. Metabolism of radiolabeled glucose by mouse oocytes and oocyte-cumulus cell complexes1. Biology of Reproduction, 60(6), pp. 1446–52.Google Scholar
Downs, S.M. & Hudson, E.D., 2000. Energy substrates and the completion of spontaneous meiotic maturation. Zygote (Cambridge, England), 8(4),pp. 339–51.CrossRefGoogle ScholarPubMed
Sutton, M.L., Gilchrist, R.B. & Thompson, J.G., 2003. Effects of in-vivo and in-vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity. Human Reproduction Update, 9(1), pp. 3548.Google Scholar
Hemmings, K.E., Leese, H.J. & Picton, H.M., 2012. Amino acid turnover by bovine oocytes provides an index of oocyte developmental competence in vitro1. Biology of Reproduction, 86(5), p. 165.Google Scholar
Leese, H.J. & Barton, A.M., 1984. Pyruvate and glucose uptake by mouse ova and preimplantation embryos. Reproduction, 72(1), pp. 913.Google Scholar
Maruthini, D., Harris, S.E., Barth, J.H. et al., 2014. The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome. Human Reproduction, 29(10), pp. 022316.Google Scholar
Marei, W.F.A., De Bie, J., Mohey-Elsaeed, O. et al., 2017. Alpha-linolenic acid protects the developmental capacity of bovine cumulus–oocyte complexes matured under lipotoxic conditions in vitro†. Biology of Reproduction, 96(6), pp. 1181–96.CrossRefGoogle ScholarPubMed
Gardner, D.K. & Leese, H.J., 1987 April. Assessment of embryo viability prior to transfer by the noninvasive measurement of glucose uptake. Journal of Experimental Zoology, 242(1), pp. 103–5.Google Scholar
Ferguson, E.M. & Leese, H.J., 1999. Triglyceride content of bovine oocytes and early embryos. Reproduction, 116(2), pp. 373–78.Google Scholar
Forsey, K.E., Ellis, P.J., Sargent, C.A., Sturmey, R.G. & Leese, H.J., 2013. Expression and localization of creatine kinase in the preimplantation embryo. Molecular Reproduction and Development, 80(3), pp. 185–92.Google Scholar
Gardner, D.K., Wale, P.L., Collins, R. & Lane, M., 2011. Glucose consumption of single post-compaction human embryos is predictive of embryo sex and live birth outcome. Human Reproduction, 26(8), pp. 1981–86.Google Scholar
Conaghan, J., Hardy, K., Handyside, A.H., Winston, R. M., & Leese, H.J., 1993. Selection criteria for human embryo transfer: a comparison of pyruvate uptake and morphology. Journal of Assisted …, 10(1), pp. 2130.Google ScholarPubMed
Leese, H.J., Guerif, F., Allgar, V. et al., 2016. Biological optimization, the Goldilocks principle, and how much is lagom in the preimplantation embryo. Molecular Reproduction and Development, 83(9), pp. 748–54. doi:10.1002/mrd.22684.Google Scholar
Sturmey, R.G., Bermejo-Alvarez, P., Gutierrez-Adan, A. et al., 2010. Amino acid metabolism of bovine blastocysts: a biomarker of sex and viability. Molecular Reproduction and Development, 77(3), pp. 285–96.Google Scholar
Gardner, D.K. & Wale, P.L., 2013. Analysis of metabolism to select viable human embryos for transfer. Fertility and Sterility, 99(4), pp. 1062–72.Google Scholar
Hemmings, K.E., Maruthini, D., Vyjayanthi, S. et al., 2013 April. Picton HM. Amino acid turnover by human oocytes is influenced by gamete developmental competence, patient characteristics and gonadotrophin treatment. Hum Reprod, 28(4), pp. 1031–44.Google Scholar
Van Blerkom, J., Cox, H. & Davis, P., 2006. Regulatory roles for mitochondria in the peri-implantation mouse blastocyst: possible origins and developmental significance of differential DeltaPsim. Reproduction (Cambridge, England), 131(5), pp. 961–76.Google Scholar
Fridhandler, L., Hafez, E.S.E. & Pincus, G., 1957. Developmental changes in the respiratory activity of rabbit ova. Experimental Cell Research, 13(1), pp. 132–39.Google Scholar
Tejera, A., Herrero, J., de Los Santos, M.J. et al.2011. Oxygen consumption is a quality marker for human oocyte competence conditioned by ovarian stimulation regimens. Fertility and Sterility, 96(3), pp. 618–23.e2.Google Scholar
Scott, L., Berntsen, J., Davies, D. et al., 2008. Human oocyte respiration-rate measurement – potential to improve oocyte and embryo selection? Reproductive BioMedicine Online, 17(4), pp. 461–69.Google Scholar
Lopes, A.S., Larsen, L.H., Ramsing, N. et al., 2005. Respiration rates of individual bovine in vitro-produced embryos measured with a novel, non-invasive and highly sensitive microsensor system. Reproduction (Cambridge, England), 130(5), pp. 669–79.Google Scholar
Kurosawa, H., Utsunomiya, H., Shiga, N. et al. 2016. Development of a new clinically applicable device for embryo evaluation which measures embryo oxygen consumption. Human Reproduction (Oxford, England), 31(10), pp. 2321–30.Google Scholar
Seli, E., Sakkas, D., Scott, R. et al., 2007. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertility and Sterility, 88(5), pp. 501357.Google Scholar
Seli, E., Vergouw, C.G., Morita, H. et al., 2010. Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility and Sterility, 94(2), pp. 535–42.Google Scholar
Vergouw, C.G., Botros, L.L., Judge, K. et al., 2011. Non-invasive viability assessment of day-4 frozen–thawed human embryos using near infrared spectroscopy. Reproductive BioMedicine Online, 23(6), pp. 769–76.CrossRefGoogle ScholarPubMed
Pudakalakatti, S.M., Uppangala, S., D’Souza, F. et al., 2013. NMR studies of preimplantation embryo metabolism in human assisted reproductive techniques: a new biomarker for assessment of embryo implantation potential. NMR in Biomedicine, 26(1), pp. 2027.Google Scholar
D’Souza, F., Pudakalakatti, S.M., Uppangala, S. et al. 2016. Unraveling the association between genetic integrity and metabolic activity in pre-implantation stage embryos. Scientific Reports, 6, p. 37291.Google Scholar
Wallace, M., Cottell, E., Cullinane, J. et al., 2014. 1 H NMR based metabolic profiling of day 2 spent embryo media correlates with implantation potential. Systems Biology in Reproductive Medicine, 60(1), pp. 5863.Google Scholar
Nadal-Desbarats, L., Veau, S., Blasco, H. et al., 2013. Is NMR metabolic profiling of spent embryo culture media useful to assist in vitro human embryo selection? Magnetic Resonance Materials in Physics, Biology and Medicine, 26(2), pp.193202.Google Scholar
McKeegan, P.J. & Sturmey, R.G., 2012. The role of fatty acids in oocyte and early embryo development. Reproduction, Fertility, and Development, 24(1), pp. 5967.Google Scholar
Dunning, K.R., Russell, D.L., Robker, R.L. et al., 2014. Lipids and oocyte developmental competence: the role of fatty acids and oxidation. Reproduction, 148(1), pp. R15R27.Google Scholar
Leary, C., Leese, H.J. & Sturmey, R.G., 2015. Human embryos from overweight and obese women display phenotypic and metabolic abnormalities. Human Reproduction (Oxford, England), 30, pp. 122–32.CrossRefGoogle ScholarPubMed
Lagarde, M., Géloën, A., Record, M., Vance, D. & Spener, F., 2003. Lipidomics is emerging. Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids, 1634(3), p. 61.Google Scholar
Roberts, L.D., McCombie, G., Titman, C.M. & Griffin, J.L., 2008. A matter of fat: An introduction to lipidomic profiling methods. Journal of Chromatography B, 871(2), pp. 174–81.Google Scholar
Vilella, F., Ramirez, L.B. & Simón, C., 2013. Lipidomics as an emerging tool to predict endometrial receptivity. Fertility and Sterility, 99(4), pp. 1100–06.Google Scholar
Belaz, K.R.A., Tata, A., França, M.R. et al. 2016. Phospholipid profile and distribution in the receptive oviduct and uterus during early diestrus in cattle. Biol Reprod, 95(6), pp.111.Google Scholar
Siristatidis, C., Sergentanis, T.N., Vogiatzi, P. et al., 2015. In vitro maturation in women with vs. without polycystic ovarian syndrome: A systematic review and meta-analysis F. Qu, ed. PLOS ONE, 10(8), p.e0134696.Google Scholar

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