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  • Print publication year: 2003
  • Online publication date: August 2010

27 - Ovarian cancer


Natural history

Ovarian cancer is the leading cause of death in women with gynecologic cancers. Often called the “Silent Killer” because there are no obvious symptoms until the disease is in its later stages, more than 23 400 new cases and 13 900 deaths were predicted from this disease in the US in 2001. One in 70 women in the US develop this disease, and 1 in 100 women die from ovarian cancer. Most women have a 1.8% lifetime risk of developing this cancer.

Ovarian cancer occurs most frequently in women aged 40–70, and the greatest number of cases is found in women between 50 and 59 years of age. Eight percent of the cases occur in women less than 35 years of age. A higher incidence is seen in Caucasian women, and this disease is more common in industrialized countries.

Approximately 20% of ovarian cancers are germ cell tumors and sex-cord stromal tumors; these cancers develop in the cells that form the eggs (germ cells) or in the cells that produce the female hormones and form the structure of the ovaries (sex-cord stromal cells). The remaining 80% are epithelial ovarian carcinomas, which begin in the cells that cover the surfaces of the ovaries. These cancers will be the subject of this chapter.

The exact etiology of ovarian cancer is unknown, although events related to incessant ovulatory function have been consistently reported in the literature.

Anderson, B. Quality of life in progressive ovarian cancer. Gynecol Oncol 1994;55:S151–5
FIGO Cancer Committee. Staging announcement. Gynecol Oncol 1986;25:383–95
Kornblith, A B, Thaler, H, Wong, G. Quality of life of women with ovarian cancer. Gynecol Oncol 1995;59:231–42
Patnaik, A, Doyle, C, Oza, A. Palliative therapy in advanced ovarian cancer: balancing patient expectations, quality of life and cost. Anti-Cancer Drugs 1998, 1998;9:869–78
Pettersson F. International Federation of Gynecology and Obstetrics Report. Stockholm: FIGO, 1991
Internet sites
American Cancer Society 1-800-4-CANCER
Cancer Information Service 1-800-ACS-2345
Gynecologic Cancer Foundation 1-800-444-4441
M.D. Anderson Cancer Center