Book contents
- Frontmatter
- Contents
- List of contributors
- Preface to the first edition
- Preface to the second edition
- Preface to the third edition
- How to use this book
- Acknowledgements
- List of abbreviations
- Section 1 Clinical anaesthesia
- Section 2 Physiology
- Section 3 Pharmacology
- 1 Physical chemistry
- 2 Pharmacodynamics
- 3 Pharmacokinetics
- 4 Mechanisms of drug action
- 5 Anaesthetic gases and vapours
- 6 Hypnotics and intravenous anaesthetic agents
- 7 Analgesic drugs
- 8 Neuromuscular blocking agents
- 9 Local anaesthetic agents
- 10 Central nervous system pharmacology
- 11 Autonomic nervous system pharmacology
- 12 Cardiovascular pharmacology
- 13 Respiratory pharmacology
- 14 Endocrine pharmacology
- 15 Gastrointestinal pharmacology
- 16 Intravenous fluids
- 17 Pharmacology of haemostasis
- 18 Antimicrobial therapy
- 19 Clinical trials: design and evaluation
- Section 4 Physics, clinical measurement and statistics
- Appendix: Primary FRCA syllabus
- Index
11 - Autonomic nervous system pharmacology
from Section 3 - Pharmacology
- Frontmatter
- Contents
- List of contributors
- Preface to the first edition
- Preface to the second edition
- Preface to the third edition
- How to use this book
- Acknowledgements
- List of abbreviations
- Section 1 Clinical anaesthesia
- Section 2 Physiology
- Section 3 Pharmacology
- 1 Physical chemistry
- 2 Pharmacodynamics
- 3 Pharmacokinetics
- 4 Mechanisms of drug action
- 5 Anaesthetic gases and vapours
- 6 Hypnotics and intravenous anaesthetic agents
- 7 Analgesic drugs
- 8 Neuromuscular blocking agents
- 9 Local anaesthetic agents
- 10 Central nervous system pharmacology
- 11 Autonomic nervous system pharmacology
- 12 Cardiovascular pharmacology
- 13 Respiratory pharmacology
- 14 Endocrine pharmacology
- 15 Gastrointestinal pharmacology
- 16 Intravenous fluids
- 17 Pharmacology of haemostasis
- 18 Antimicrobial therapy
- 19 Clinical trials: design and evaluation
- Section 4 Physics, clinical measurement and statistics
- Appendix: Primary FRCA syllabus
- Index
Summary
The autonomic nervous system (ANS) comprises the sympathetic and parasympathetic nervous systems. Ganglionic synaptic transmission in the ANS is mediated by the release of acetylcholine from the preganglionic neurone. Both muscarinic and nicotinic receptors are involved in mediation of the postganglionic response, as are inhibitory dopaminergic interneurones. In general, sympathetic postganglionic neurones are noradrenergic, and parasympathetic postganglionic neurones are muscarinic (cholinergic). The two systems tend to have opposite actions. Deliberate pharmacological manipulation of the ANS is therefore aimed at sites where physiological or anatomical differences exist between the two systems.
Cholinergic system
The important structural features of the neurotransmitter acetylcholine are the strongly positive quaternary amine in the choline part of the molecule and the ester component with its partial negative charge. Choline receptor antagonists have either a tertiary or a quaternary amine (or both). Acetylcholine receptors are classified as either muscarinic or nicotinic. Nicotinic receptors are widespread in the body, and are found in both sympathetic and parasympathetic nervous systems. Drug actions at the nicotinic receptors of the neuromuscular junction, which is not part of the ANS, are covered in Section 3, Chapter 8.
Muscarinic receptors
The muscarinic receptors are G-protein-coupled receptors. Five subtypes have been identified (M1–5), but the most important ones are M1, M2 and M3, which are all antagonised by atropine. M1 receptors are found in the central nervous system (CNS), autonomic ganglia and gastric parietal cells, M2 receptors are found in the heart and at presynaptic sites, and M3 receptors are found in smooth muscle, vascular endothelium (causing vasodilatation) and in exocrine glands.
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- Information
- Fundamentals of Anaesthesia , pp. 644 - 658Publisher: Cambridge University PressPrint publication year: 2009