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Introduction

from Section 2 - Features of the epileptogenic brain

Published online by Cambridge University Press:  03 May 2010

Philip A. Schwartzkroin
Affiliation:
University of Washington
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Summary

The chapters in the previous section focused on questions that could be addressed with intact-animal models of the epilepsies. In Section 2, there is an attempt to deal more directly with mechanisms that may underlie epileptiform properties that give rise to, for example, the models discussed in Section 1. Two broad issues are addressed by the chapters in this section, (a) What are the features of epileptic brain, i.e. what are the mechanisms that might underlie the production of abnormal epileptiform activities? (b) What do we know about the processes of epileptogenesis itself, i.e., how does the epileptic brain become epileptic? Most of our understanding of underlying mechanisms is derived from studies on brain (or brain tissue) that is already epileptic; we have a still minimal insight into the process of epileptogenesis. Studies have begun to establish which brain attributes are correlated with epileptiform (i.e., abnormal) activities and are providing clues about the consequences of seizure activity; however, initial ‘cause’ is, in most cases (and models) still to be determined. It has been tricky to separate the underlying features of epileptogenesis from characteristics of the already epileptic tissue.

Type
Chapter
Information
Epilepsy
Models, Mechanisms and Concepts
, pp. 200 - 208
Publisher: Cambridge University Press
Print publication year: 1993

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  • Introduction
  • Edited by Philip A. Schwartzkroin, University of Washington
  • Book: Epilepsy
  • Online publication: 03 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511663314.008
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  • Introduction
  • Edited by Philip A. Schwartzkroin, University of Washington
  • Book: Epilepsy
  • Online publication: 03 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511663314.008
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Introduction
  • Edited by Philip A. Schwartzkroin, University of Washington
  • Book: Epilepsy
  • Online publication: 03 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511663314.008
Available formats
×