This chapter deals with the evolution of entrepreneurship studies in the United States. Since Americans hold an instrumental rather than a consumption view of education, institutions of higher education inevitably got busy studying start-ups. But the motivation was twofold. People were interested – on the one hand – in how to go about starting a firm and – on the other – in entrepreneurship as an academic field of study. Before high-tech entrepreneurship itself became an important topic, the engineers and applied scientists involved in technology transfer and Japanese production methods almost ignored the subject. Then, in the 1990s, engineering and applied science faculties got interested in the process of starting firms, but they were – with some important exceptions – not preoccupied with entrepreneurship as a study field. Engineers and scientists had been attracted to the academic study of management subjects when, after World War II, US engineering schools developed the field of operations research. But OR had rigor; it required mathematically based modeling. Entrepreneurship, without the scientific credentials of OR, could not easily carve out a niche in the pedagogies of science and engineering. This left the study of entrepreneurship to others: principally those interested in management. This chapter looks primarily at entrepreneurship where it gained a place in academic business and management study programs, but it also considers the spillover of entrepreneurship studies into science and engineering in the most recent high-tech stage of development.