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14 - Enhancing Secondary Metabolite Production in Medicinal Plants Using Endophytic Elicitors: A Case Study of Centella asiatica (Apiaceae) and Asiaticoside

from Part IV - Endophytes for Novel Biomolecules and In Vitro Methods

Published online by Cambridge University Press:  01 April 2019

By
Shubhpriya Gupta  and
Preeti Chaturvedi
Edited by
Trevor R. Hodkinson ,
Fiona M. Doohan ,
Matthew J. Saunders  and
Brian R. Murphy
Trevor R. Hodkinson
Affiliation:
Trinity College Dublin
Fiona M. Doohan
Affiliation:
University College Dublin
Matthew J. Saunders
Affiliation:
Trinity College Dublin
Brian R. Murphy
Affiliation:
Trinity College Dublin
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Summary

Fungal endophytes are a vital component of the plant microbiome. The symbiotic relationship between endophytic fungi and medicinal plants can considerably influence plant secondary metabolism pathways, thus affecting their metabolite production and the quality and quantity of crude drugs produced. This chapter focuses on how fungal endophytic symbiosis can increase production of secondary metabolites during in vitro culture. Other than promoting secondary metabolite accumulation, endophytic fungi can also promote the growth of host plants and improve their resistance to abiotic and biotic stresses. Therefore, an understanding of the relationship between endophytic fungi and their host medicinal plants is of utmost importance. This knowledge can be applied in the production of novel and improved drugs from medicinally valued plants. In vitro elicitation of secondary metabolites by endophytic fungi has been reported in several medicinal plants. A case study is documented in this chapter which shows enhancement of asiaticoside by an endophytic fungal (Colletotrichum gloeosporioides) elicitor isolated from in vivo grown plants of Centella asiatica. These findings may motivate further exploitation of fungal endophytes as an effective and beneficial way to enhance the production of pharmacologically important compounds from medicinal plants.

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Endophytes for a Growing World , pp. 310 - 327
Publisher: Cambridge University Press
Print publication year: 2019

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