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  • Print publication year: 2018
  • Online publication date: May 2018

Chapter 11 - When to Stop Treatment?

Ackers, R., Besag, F. M., Hughes, E., et al. Mortality rates and causes of death in children with epilepsy prescribed antiepileptic drugs: a retrospective cohort study using the UK General Practice Research Database. Drug Saf 2011 May 1; 34(5): 403–13.
Beghi, E. AED discontinuation may not be dangerous in seizure-free patients. J Neural Transm 2011;118: 187–91.
Berg, A. T. Risk of recurrence after a first unprovoked seizure. Epilepsia 2008;49(Suppl 1): 13–8.
Berg, A. T., Shinnar, S. Relapse following discontinuation of antiepileptic drugs: a meta-analysis. Neurology 1994;44: 601–8.
Chadwick, D. Starting and stopping treatment for seizures and epilepsy. Epilepsia 2006;47(Suppl 1): 5861.
Chadwick, D., Taylor, J., Johnson, T. Outcomes after seizure recurrence in people with well-controlled epilepsy and the factors that influence it. Epilepsia 1996;37: 1043–50.
Elger, C. E., Schmidt, D. Modern management of epilepsy: a practical approach. Epilepsy Behav 2008;12: 501–39.
Jacoby, A., Johnson, A., Chadwick, D. Psychosocial outcomes of antiepileptic drug discontinuation. The Medical Research Council Antiepileptic Drug Withdrawal Study Group. Epilepsia 1992;33(6): 1123–31.
Jacoby, A., Shackley, P., Smith, D. F., et al. A randomised controlled trial examining the longer-term outcomes of standard versus new antiepileptic drugs. The SANAD Trial. Health Technol Assess 2007 Oct; 11(37): iiiiv, ixx, 1134.
Jongsma, M. J., Mommers, J. M., Renier, W. O., Maynard, H. Follow-up of psychogenic, nonepileptic seizures: a pilot study – experience in a Dutch special center for epilepsy. Seizure 1999 May; 8(3): 146–8.
Kwan, P., Arzimanoglou, A., Berg, A. T., et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010;51(6): 1069–77.
Kwan, P., Brodie, M. J. Early identification of refractory epilepsy. N Engl J Med 2000;342: 314–9.
Lamberink, H. J., Otte, W. M., Geerts, A. T., et al. Individualised prediction model of seizure recurrence and long-term outcomes after withdrawal of antiepileptic drugs in seizure-free patients: a systematic review and individual participant data meta-analysis. Lancet Neurol 2017 Jul; 16(7): 523–31.
Lossius, M. I., Hessen, E., Mowinkell, P., et al. Consequences of antiepileptic drug withdrawal: A double-blind, randomized study (Akershus Study). Epilepsia 2008;49: 455–63.
Matricardi, A., Bertamino, F., Risso, D. Discontinuation of anti-epileptic therapy: a retrospective study of 86 children and adolescents. Ital J Neurol Sci 1995;16: 613–22.
Medical Research Council (MRC) Antiepileptic Drug Withdrawal Group. Randomised study of antiepileptic drug withdrawal in patients in remission. Lancet 1991;337: 1175–80.
MRC Antiepileptic Drug Withdrawal Study Group. Prognostic index for recurrence of seizure after remission of epilepsy. BMJ 1993;306: 1374–8.
Overweg, J., Binnie, C. D., Oosting, J., Rowan, A. J. Clinical and EEG prediction of seizure recurrence following antiepileptic drug withdrawal. Epilepsy Res 1987;1: 272–83.
Ranganathan, L. N., Ramaratnam, S. Rapid versus slow withdrawal of antiepileptic drugs. Cochrane Database Syst Rev 2006 Apr 19;(2): CD005003.
Rathore, C., Panda, P. S., Sarma, S., Radhakrishnan, K. How safe is it to withdraw antiepileptic drugs following successful surgery for mesial temporal lobe epilepsy? Epilepsia 2011 Mar; 52(3): 627–35.
Schmidt, D. AED discontinuation may be dangerous for seizure-free patients. J Neural Transm 2011;118(2): 183–6.
Schmidt, D. Reduction of two-drug therapy in intractable epilepsy. Epilepsia 1983;24(3): 368–76.
Schmidt, D., Baumgartner, C., Löscher, W. Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience. Epilepsia 2004;45(2): 179–86.
Schmidt, D., Löscher, W. Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: a review of current clinical experience. Acta Neurol Scand 2005;111: 291300.
Sillanpää, M., Schmidt, D. Prognosis of seizure recurrence after stopping antiepileptic drugs in seizure-free patients: a long-term population-based study of childhood-onset epilepsy. Epilepsy & Behav 2006a; 8: 713–9.
Sillanpää, M., Schmidt, D. Natural history of treated childhood-onset epilepsy: prospective, long-term population-based study. Brain 2006b; 129: 617–24.
Sirven, J., Sperling, M. R., Wingerchuck, D. M. Early versus late antiepileptic drug withdrawal for people with epilepsy in remission. Cochrane Database of Syst Rev 2001;3: CD001902.
Specchio, L. M., Beghi, E. Should antiepileptic drugs be withdrawn in seizure-free patients? CNS Drugs 2004;18: 201–12.
Specchio, L. M., Tramacere, L., La Neve, A., Beghi, E. Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy. J Neurol Neurosurg Psychiatry 2002;72: 22–5.