This chapter reconsiders the relationship between the parts of Marlowe’s 1 & 2 Tamburlaine by focusing on the early publishing history of the plays and their materialization in printed collections. It argues that in 1590, the publisher Richard Jones sought to shape Marlowe’s two generically distinct, but narratively connected, dramas into a whole, unified series. To do so, Jones adapted the bibliographical structure and system of generic categorization from a previous dramatic collection, George Whetstone’s 1 & 2 Promos and Cassandra. The product of Jones’s efforts was the two-play collection, Tamburlaine the Great, that proffered readings of the whole series as a de casibus tragedy. By the time a third edition of the series was published in 1597, Jones had redefined his strategy for marketing the plays, their relationship to one another as serial plays, and their genre as a whole. Jones’ interventions in publishing Marlowe’s plays in the 1590s points to an underlying flexibility in the material and textual matter of serial drama in early modern England.