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Published online by Cambridge University Press: 02 September 2022
The last chapter discussed how peaks in an instrument output are converted into a DNA profile and how the random match probability is calculated using the product rule. Now we delve into how these profiles are analyzed and interpreted. Once a DNA profile has been developed from crime-scene evidence, it is compared to the profile(s) from known reference samples. These include elimination samples and samples from a person or persons of interest. If these comparisons do not provide helpful information, the profile can be submitted to a DNA database to search for investigative leads. Our focus is on DNA samples from a single person or simple mixtures such as a well-separated sample from a sexual assault case. Complex and low-level mixtures are much more challenging. We tackle those in the next chapter using the foundation we will build in this one.
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