Skip to main content Accessibility help
×
Hostname: page-component-546b4f848f-zwmfq Total loading time: 0 Render date: 2023-05-30T18:07:12.447Z Has data issue: false Feature Flags: { "useRatesEcommerce": true } hasContentIssue false

Chapter 3 - Prehospital Stroke Care and Regionalized Stroke Systems

from Part II - Systems of Care

Published online by Cambridge University Press:  15 December 2020

Jeffrey L. Saver
Affiliation:
David Geffen School of Medicine, University of Ca
Graeme J. Hankey
Affiliation:
University of Western Australia, Perth
Get access

Summary

Prehospital stroke care is the first link in the stroke chain of survival and includes symptom recognition, engagement of the Emergency Medical Services (EMS) system, timely and effective dispatcher response, and emergency medical response. Prehospital stroke screening tools are an important component in guiding the EMS response to stroke and proper triage of patients. Additionally, there is a growing body of research focused on applications for telemedicine, mobile stroke units, and diagnostic testing in the prehospital arena. Prehospital stroke care is integral to the organization of regionalized stroke systems. Implementation of stroke systems of care can lead to improved access to specialty services and improved patient health outcomes. In addition to increasing access to acute stroke care, telestroke shows great potential for integrating stroke systems of care and facilitating interactions between centres.

Type
Chapter
Information
Stroke Prevention and Treatment
An Evidence-based Approach
, pp. 35 - 58
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Abdullah, AR, Smith, EE, Biddinger, PD, Kalenderian, D, Schwamm, LH. (2008). Advance hospital notification by EMS in acute stroke is associated with shorter door-to-computed tomography time and increased likelihood of administration of tissue-plasminogen activator. Prehospital Emerg Care, 12, 426–31. doi:10.1080/10903120802290828.
Acker, JE 3rd, Pancioli, AM, Crocco, TJ, Eckstein, MK, Jauch, EC, Larrabee, H, et al. (2007). Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association Expert Panel on Emergency Medical Services Systems and the Stroke Council. Stroke, 38, 3097–115. doi:10.1161/STROKEAHA.107.186094.
Adams, J, Aldag, G, Wolford, R. (1996). Does the level of prehospital care influence the outcome of patients with altered levels of consciousness? Prehospital Disaster Med, 11, 101–4.
Adeoye, O, Albright, KC, Carr, BG, Wolff, C, Mullen, MT, Abruzzo, L, et al. (2014). Geographic access to acute stroke care in the United States. Stroke, 45, 3019–24. doi:10.1161/STROKEAHA.114.006293.
Adeoye, O, Hornung, R, Khatri, P, Kleindorfer, D. (2011). Recombinant tissue-type plasminogen activator use for ischemic stroke in the United States: a doubling of treatment rates over the course of 5 years. Stroke, 42,1952–5. doi:10.1161/STROKEAHA.110.612358.
Alexander, P, Heels-Ansdell, D, Siemieniuk, R. (2016). Hemicraniectomy versus medical treatment with large MCA infarct: a review and meta-analysis. BMJ Open, 6, e014390. doi:10.1136/bmjopen-2016-014390.
Ali, A, Zachrison, KS, Eschenfeldt, PC, Schwamm, LH, Hur, C. (2018). Optimization of prehospital triage of patients with suspected ischemic stroke. Stroke, 49, 2532–5. doi:10.1161/STROKEAHA.118.022041.
Amadi-Obi, A, Gilligan, P, Owens, N, O’Donnell, C. (2014). Telemedicine in pre-hospital care: a review of telemedicine applications in the pre-hospital environment. Int J Emerg Med, 7, 29. doi:10.1186/s12245-014-0029-0.
Anderson, ER, Smith, B, Ido, M, Frankel, M. (2013). Remote assessment of stroke using the iPhone 4. J Stroke Cerebrovasc Dis, 22, 340–4. doi:10.1016/j.jstrokecerebrovasdis.2011.09.013.
Ankolekar, S, Fuller, M, Cross, I, Renton, C, Cox, P, Sprigg, N, et al. (2013). Feasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial (RIGHT, ISRCTN66434824). Stroke, 44, 3120–8. doi:10.1161/STROKEAHA.113.001301.
Audebert, HJ, Kukla, C, Vatankhah, B, Gotzler, B, Schenkel, J, Hofer, S, et al. (2006). Comparison of tissue plasminogen activator administration management between telestroke network hospitals and academic stroke centers: the Telemedical Pilot Project for Integrative Stroke Care in Bavaria/Germany. Stroke, 37, 1822–7. doi:10.1161/01.STR.0000226741.20629.b2.
Bae, H-J, Kim, D-H, Yoo, N-T, et al. (2010). Prehospital notification from the emergency medical service reduces the transfer and intra-hospital processing times for acute stroke patients. J Clin Neurol, 6, 138. doi:10.3988/jcn.2010.6.3.138.
Bardach, NS, Olson, SJ, Elkins, JS, Smith, WS, Lawton, MT, Johnston, SC, et al. (2004). Regionalization of treatment for subarachnoid hemorrhage a cost-utility analysis. Circulation, 109, 2207–12. doi:10.1161/01.CIR.0000126433.12527.E6.
Berkowitz, AL, Mittal, MK, McLane, HC, Shen, GC, Muralidharan, R, Lyons, JL, et al. (2014). Worldwide reported use of IV tissue plasminogen activator for acute ischemic stroke. Int J Stroke, 9, 349–55. doi:10.1111/ijs.12205.
Boogaarts, HD, van Amerongen, MJ, de Vries, J, Westert, GP, Veerbeek, AL, Grotenhuis, JA, et al. (2014). Caseload as a factor for outcome in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis. J Neurosurg, 120, 605–11. doi:10.3171/2013.9.JNS13640.
Bowry, R, Parker, SA, Yamal, JM, Hwang, H, Appana, S, Rangel-Gutierrez, N, et al. (2018). Time to decision and treatment with tPA (tissue-type plasminogen activator) using telemedicine versus an onboard neurologist on a mobile stroke unit. Stroke, 49, 1528–30. doi:10.1161/STROKEAHA.117.020585.
Brandler, ES, Sharma, M, Sinert, RH, Levine, SR. (2014). Prehospital stroke scales in urban environments: a systematic review. Neurology, 82, 2241–9. doi:10.1212/WNL.0000000000000523.
Brown, DL, Barsan, WG, Lisabeth, LD, Gallery, ME, Morgenstern, LB. (2005). Survey of emergency physicians about recombinant tissue plasminogen activator for acute ischemic stroke. Ann Emerg Med, 46, 5660. doi:10.1016/j.annemergmed.2004.12.025.
Buck, BH, Starkman, S, Eckstein, M, Kidwell, CS, Haines, J, Huang, R, et al. (2009). Dispatcher recognition of stroke using the National Academy Medical Priority Dispatch System. Stroke, 40(6), 2027–30. doi:10.1161/STROKEAHA.108.545574.
Centers for Disease Control and Prevention (CDC). (2007). Prehospital and hospital delays after stroke onset – United States, 2005–2006. MMWR Morb Mortal Wkly Rep, 56, 474–8.
Chapman Smith, SN, Govindarajan, P, Padrick, MM, Lippman, JM, McMurry, TL, Resler, BL, et al.; as the iTREAT Investigators. (2016). A low-cost, tablet-based option for prehospital neurologic assessment: The iTREAT Study. Neurology, 87(1), 1926. doi:10.1212/WNL.0000000000002799.
Chiti, A, Fanucchi, S, Sonnoli, C, Barni, S, Orlandi, G. (2007). Stroke symptoms and the decision to call for an ambulance: turn on people’s minds! Stroke J Cereb Circ, 38, e5859. doi:10.1161/STROKEAHA.107.489179.
Choi, JY, Porche, NA, Albright, KC, Khaja, AM, Ho, VS, Grotta, JC. (2006). Using telemedicine to facilitate thrombolytic therapy for patients with acute stroke. Jt Comm J Qual Patient Saf, 32, 199205.
Demaerschalk, BM, Berg, J, Chong, BW, Gross, H, Nystrom, K, Adeoye, O, et al. (2017). American Telemedicine Association: telestroke guidelines. Telemed J E Health, 23, 376–89. doi:10.1089/tmj.2017.0006.
Demaerschalk, BM, Vegunta, S, Vargas, BB, Wu, Q, Channer, DD, Hentz, JG. (2012). Reliability of real-time video smartphone for assessing National Institutes of Health Stroke Scale scores in acute stroke patients. Stroke J Cereb Circ, 43, 3271–7. doi:10.1161/STROKEAHA.112.669150.
Ebinger, M, Kunz, A, Wendt, M, Rozanski, M, Winter, B, Waldschmidt, C, et al. (2015). Effects of golden hour thrombolysis: a Prehospital Acute Neurological Treatment and Optimization of Medical Care in Stroke (PHANTOM-S) Substudy. JAMA Neurol, 72, 2530. doi:10.1001/jamaneurol.2014.3188.
Ebinger, M, Winter, B, Wendt, M, Weber, JE, Waldschmidt, C, Rozanski, M, et al. (2014). Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial. JAMA, 311, 1622–31. doi:10.1001/jama.2014.2850.
Ekundayo, OJ, Saver, JL, Fonarow, GC, Schwamm, LH, Xian, Y, Zhao, X, et al. (2013). Patterns of emergency medical services use and its association with timely stroke treatment: findings from Get with the Guidelines-Stroke. Circ Cardiovasc Qual Outcomes, 6, 262–9. doi:10.1161/CIRCOUTCOMES.113.000089.
Evenson, KR, Foraker, RE, Morris, DL, Rosamond, WD. (2009). A comprehensive review of prehospital and in-hospital delay times in acute stroke care. Int J Stroke, 4, 187–99. doi:10.1111/j.1747-4949.2009.00276.x.
Falk Delgado, A, Andersson, T, Falk Delgado, A. (2017). Clinical outcome after surgical clipping or endovascular coiling for cerebral aneurysms: a pragmatic meta-analysis of randomized and non-randomized trials with short- and long-term follow-up. J Neurointerv Surg, 9, 264–77. doi:10.1136/neurintsurg-2016-012292.
Fassbender, K, Grotta, JC, Walter, S, Grunwald, IQ, Ragoschke-Schumm, A, Saver, JL. (2017). Mobile stroke units for prehospital thrombolysis, triage, and beyond: benefits and challenges. Lancet Neurol, 16, 227–37. doi:10.1016/S1474-4422(17)30008-X.
Fletcher, JJ, Kotagal, V, Mammoser, A, Peterson, M, Morgenstern, LB, Burke, JF, et al. (2015). Cost-effectiveness of transfers to centers with neurological intensive care units after intracerebral hemorrhage. Stroke, 46, 5864. doi:10.1161/STROKEAHA.114.006653.
Fonarow, GC, Liang, L, Smith, EE, Reeves, MJ, Saver, JL, Xian, Y, et al (2013). Comparison of performance achievement award recognition with primary stroke center certification for acute ischemic stroke care. J Am Heart Assoc, 2, e000451. doi:10.1161/JAHA.113.000451.
Froehler, MT, Saver, JL, Zaidat, OO, Jahan, R, Aziz-Sultan, MA, Klucznik, RP, et al. (2017). Interhospital transfer before thrombectomy is associated with delayed treatment and worse outcome in the STRATIS Registry (Systematic Evaluation of Patients Treated With Neurothrombectomy Devices for Acute Ischemic Stroke). Circulation, 136, 2311–21. doi:10.1161/CIRCULATIONAHA.117.028920.
Gadhia, R, Schwamm, LH, Viswanathan, A, Whitney, C, Moreno, A, Zachrison, KS. (2018). Evaluation of the experience of spoke hospitals in an academic telestroke network. Telemed J E Health, 25. doi:10.1089/tmj.2018.0133. [Epub ahead of print]
Goyal, M, Menon, BK, van Zwam, WH, Dippel, DW, Mitchell, PG, Demchuk, AM, et al. (2016). Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet, 387, 1723–31. doi:10.1016/S0140-6736(16)00163-X.
Gropen, TI, Boehme, A, Martin-Schild, S, Albright, K, Samai, A, Pishanidar, S, et al. (2018). Derivation and validation of the emergency medical stroke assessment and comparison of large vessel occlusion scales. J Stroke Cerebrovasc Dis, 27, 806–15. doi:10.1016/j.jstrokecerebrovasdis.2017.10.018.
Gupta, R, Manuel, M, Owada, K, Dhungana, S, Busby, L, Glenn, BA, et al. (2016). Severe hemiparesis as a prehospital tool to triage stroke severity: a pilot study to assess diagnostic accuracy and treatment times. J Neurointerv Surg, 8, 775–7. doi:10.1136/neurintsurg-2015-011940.
Hawk, A, Marco, C, Huang, M2, Chow, B. (2016). Helicopter scene response for stroke patients: a 5-year experience. Air Med J, 35, 352–4. doi:10.1016/j.amj.2016.05.007.
Hess, DC, Wang, S, Hamilton, W, Lee, S, Pardue, C, Waller, JL, et al. (2005). REACH: clinical feasibility of a rural telestroke network. Stroke, 36, 20182020. doi:10.1161/01.STR.0000177534.02969.e4
Hesselfeldt, R, Gyllenborg, J, Steinmetz, J, Do, HQ, Hejselbaek, J, Rasmussen, LS. (2014). Is air transport of stroke patients faster than ground transport? A prospective controlled observational study. Emerg Med J, 31, 268–72. doi:10.1136/emermed-2012-202270.
Hidlay, DT, McTaggart, RA, Baird, G, Yaghi, S, Hemendinger, M, Tung, EL, et al. (2018). Accuracy of smartphone-based evaluation of emergent large vessel occlusion on CTA. Clin Neurol Neurosurg, 171, 135–8. doi:10.1016/j.clineuro.2018.06.012.
Higashida, R, Alberts, MJ, Alexander, DN, Crocco, TJ, Demaerschalk, BM, Derdeyn, CP, et al. (2013). Interactions within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association. Stroke, 44, 29612984. doi:10.1161/STR.0b013e3182a6d2b2.
Hodgson, C, Lindsay, P, Rubini, F. (2007). Can mass media influence emergency department visits for stroke? Stroke J Cereb Circ, 38, 2115–22. doi:10.1161/STROKEAHA.107.484071.
Hodgson, C, Lindsay, P, Rubini, F. (2009). Using paid mass media to teach the warning signs of stroke: the long and the short of it. Health Promot J Aust Off J Aust Assoc Health Promot Prof, 20, 5864.
Holodinsky, JK, Williamson, TS, Demchuk, AM, Zhao, H, Zhu, L, Francis, MJ, et al. (2018). Modeling stroke patient transport for all patients with suspected large-vessel occlusion. JAMA Neurol, 75, 1477–86. doi:10.1001/jamaneurol.2018.2424.
Hougaard, KD, Hjort, N, Zeidler, D, Sørensen, L, Nørgaard, A, Hansen, TM, et al. (2014). Remote ischemic preconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial. Stroke, 45, 159–67. doi:10.1161/STROKEAHA.113.001346.
Hunter, RM, Davie, C, Rudd, A, Thompson, A, Walker, H, Thomson, N, et al. (2013). Impact on clinical and cost outcomes of a centralized approach to acute stroke care in London: a comparative effectiveness before and after model. PloS One, 8, e70420. doi:10.1371/journal.pone.0070420.
Hutton, CF, Fleming, J, Youngquist, S, Hutton, KC, Heiser, DM, Barton, ED. (2015). Stroke and helicopter emergency medical service transports: an analysis of 25,332 patients. Air Med J, 34, 348–56. doi:10.1016/j.amj.2015.06.011.
Johnston, KC, Worrall, BB. (2003). Teleradiology Assessment of Computerized Tomographs Online Reliability Study (TRACTORS) for acute stroke evaluation. Telemed J E Health, 9, 227233. doi:10.1089/153056203322502605.
John, S, Stock, S, Masaryk, T, Bauer, A, Cerejo, R, Uchino, K, et al. (2016). Performance of CT angiography on a mobile stroke treatment unit: implications for triage. J Neuroimaging, 26(4), 391–4. doi:10.1111/jon.12346.
Joo, H, Wang, G, George, MG. (2017). Age-specific cost effectiveness of using intravenous recombinant tissue plasminogen activator for treating acute ischemic stroke. Am J Prev Med, 53, S205S212. doi:10.1016/j.amepre.2017.06.004.
Jurkowski, JM, Maniccia, DM, Spicer, DA, Dennison, BA. (2010). Impact of a multimedia campaign to increase intention to call 9–1-1 for stroke symptoms, upstate New York, 2006–2007. Prev Chronic Dis, 7, A35.
Katz, BS, McMullan, JT, Sucharew, H, Adeoye, O, Broderick, JP. (2015). Design and validation of a prehospital scale to predict stroke severity: Cincinnati Prehospital Stroke Severity Scale. Stroke, 46, 1508–12. doi:10.1161/STROKEAHA.115.008804.
Kelly, AG, Hellkamp, AS, Olson, D, Smith, EE, Schwamm, LH. (2012). Predictors of rapid brain imaging in acute stroke: analysis of the Get with the Guidelines-Stroke program. Stroke J Cereb Circ, 43, 1279–84. doi:10.1161/STROKEAHA.111.626374.
Kidwell, CS, Saver, JL, Schubert, GB, Eckstein, M, Starkman, S. (1998). Design and retrospective analysis of the Los Angeles prehospital stroke screen (LAPSS). Prehosp Emerg Care, 2, 267–73. doi:10.1080/10903129808958878.
Kidwell, CS, Starkman, S, Eckstein, M, Weems, K, Saver, JL. (2000). Identifying stroke in the field. Prospective validation of the Los Angeles prehospital stroke screen (LAPSS). Stroke J Cereb Circ, 31, 71–6.
Kleindorfer, D, Xu, Y, Moomaw, CJ, Khatri, P, Adeoye, O, Hornung, R. (2009). US geographic distribution of rt-PA utilization by hospital for acute ischemic stroke. Stroke, 40, 3580–4. doi:10.1161/STROKEAHA.109.554626.
Knopf, L, Staff, I, Gomes, J. (2012). Impact of a neurointensivist on outcomes in critically ill stroke patients. Neurocrit Care, 16, 6371. doi:10.1007/s12028-011-9620-x.
Kothari, RU, Pancioli, A, Liu, T, Brott, T, Broderick, J. (1999). Cincinnati Prehospital Stroke Scale: reproducibility and validity. Ann Emerg Med, 33, 373–8.
Leira, EC, Ahmed, A, Lamb, DL, Olalde, HM, Callison, RC, Torner, JC, et al. (2009). Extending acute trials to remote populations a pilot study during interhospital helicopter transfer. Stroke, 40, 895901. doi:10.1161/STROKEAHA.108.530204.
Leira, EC, Lamb, DL, Nugent, AS, Azeemuddin, A, Grimsman, KJ, Clarke, WR, et al. (2006). Feasibility of acute clinical trials during aerial interhospital transfer. Stroke, 37, 2504–7. doi:10.1161/01.STR.0000239661.07675.9d.
Liman, TG, Winter, B, Waldschmidt, C, Zerbe, N, Hufnagl, P, Audebert, HJ. (2012). Telestroke ambulances in prehospital stroke management: concept and pilot feasibility study. Stroke, 43, 20862090. doi :10.1161/STROKEAHA.112.657270.
Lin, CB, Peterson, ED, Smith, EE, Saver, JL, Liang, L, Xian, Y, et al. (2012). Emergency medical service hospital prenotification is associated with improved evaluation and treatment of acute ischemic stroke. Circ Cardiovasc Qual Outcomes, 5, 514–22. doi:10.1161/CIRCOUTCOMES.112.965210.
Lindsay, MP, Norrving, B, Furie, KL, Donnan, G, Langhorne, P, Davis, S, on behalf of the World Stroke Organization Global Stroke Quality and Guidelines Advisory Committee. (2016). Global stroke guidelines and action plan: a road map for quality stroke care. www.world-stroke.org/images/GSGAAP/Global_Stroke_Guidelines_and_Action_Plan_All_in_one.pdf. Accessed December 2018.
Madsen, TE, Baird, KA, Silver, B, Gjelsvik, A. (2015). Analysis of gender differences in knowledge of stroke warning signs. J Stroke Cerebrovasc Dis, 24(7), 1540–7. doi:10.1016/j.jstrokecerebrovasdis.2015.03.017.
Madsen, TE, Sucharew, H, Katz, B, Alwell, KA, Moomaw, CJ, Kissela, BM, et al. (2016). Gender and time to arrival among ischemic stroke patients in the Greater Cincinnati/Northern Kentucky Stroke Study. J Stroke Cerebrovasc Dis, 25(3), 504–10. doi:10.1016/j.jstrokecerebrovasdis.2015.10.026.
Massachusetts Health Promotions Clearinghouse. (2018). https://massclearinghouse.ehs.state.ma.us/mm5/merchant.mvc?Session_ID=77925787535d2a643e9b77bc3fe1539d&Screen=SRCH. Accessed December 2018.
Matsuo, R, Yamaguchi, Y, Matsushita, T, Hata, J, Kiyuna, F, Fukuda, K, et al.; Fukuoka Stroke Registry Investigators. (2017). Association between onset-to-door time and clinical outcomes after ischemic stroke. Stroke, 48, 3049–56. doi:10.1161/STROKEAHA.117.018132.
McKinney, JS, Mylavarapu, K, Lane, J, Roberts, V, Ohman-Strickland, P, Merlin, MA. (2013). Hospital prenotification of stroke patients by emergency medical services improves stroke time targets. J Stroke Cerebrovasc Dis, 22, 113–18. doi:10.1016/j.jstrokecerebrovasdis.2011.06.018.
McMullan, JT, Katz, B, Broderick, J, Schmit, P, Sucharew, H, Adeoye, O. (2017). prospective prehospital evaluation of the Cincinnati Stroke Triage Assessment Tool. Prehosp Emerg Care, 21, 481–8. doi:10.1080/10903127.2016.1274349.
McTaggart, RA. Yagh, S, Cutting, SM, Hemendinger M, Baird GL, Haas RA, et al. (2017). Association of a primary stroke center protocol for suspected stroke by large-vessel occlusion with efficiency of care and patient outcomes. JAMA Neurol, 74, 793800. doi:10.1001/jamaneurol.2017.0477.
Mellon, L, Doyle, F, Rohde, D, Williams, D, Hickey, A. (2015). Stroke warning campaigns: delivering better patient outcomes? A systematic review. Patient Relat Outcome Meas, 6, 6173. doi:10.2147/PROM.S54087.
Meretoja, A, Roine, RO, Kaste, M, Linna, M, Roine, S, Juntunen, M, et al. (2010). Effectiveness of primary and comprehensive stroke centers PERFECT stroke: a nationwide observational study from Finland. Stroke, 41, 11021107. doi:10.1161/STROKEAHA.109.577718.
Meyer, BC, Raman, R, Hemmen, T, Obler, R, Zivin, JA, Rao, R, et al. (2008). Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study. Lancet Neurol, 7, 787–95. doi:10.1016/S1474-4422(08)70171-6.
Mission: Lifeline Stroke. (2017). Severity-based stroke triage algorithm for EMS. www.heart.org/idc/groups/ahaecc-public/@wcm/@gwtg/documents/downloadable/ucm_498615.pdf. Accessed December 2018.
Mitchell, JR, Sharma, P, Modi, J, Simpson, M, Thomas, M, Hill, MD, et al. (2011). A smartphone client-server teleradiology system for primary diagnosis of acute stroke. J Med Internet Res, 13, e31. doi:10.2196/jmir.1732.
Mochari‐Greenberger, H, Xian, Y, Hellkamp, AS, Schulte, PJ, Bhatt, DL, Fonarow, GC, et al. (2015). Racial/ethnic and sex differences in emergency medical services transport among hospitalized US stroke patients: analysis of the National Get with the Guidelines-Stroke registry. J Am Heart Assoc, 4, e002099. doi:10.1161/JAHA.115.002099.
Morgenstern, LB, Gonzales, NR, Maddox, KE, Brown, DL, Karim, AP, Espinosa, N, et al. (2007). A randomized, controlled trial to teach middle school children to recognize stroke and call 911: the kids identifying and defeating stroke project. Stroke J Cereb Circ, 38, 2972–8. doi:10.1161/STROKEAHA.107.490078.
Morgenstern, LB, Staub, L, Chan, W, Wein, TH, Bartholomew, LK, King, M, et al. (2002). Improving delivery of acute stroke therapy: the TLL Temple Foundation Stroke Project. Stroke J Cereb Circ, 33, 160–6.
Mosley, I, Nicol, M, Donnan, G, Dewey, H. (2007). Stroke symptoms and the decision to call for an ambulance. Stroke, 38, 361366. doi:10.1161/01.STR.0000254528.17405.cc.
Nazliel, B, Starkman, S, Liebeskind, DS, Ovbiagele, B, Kim, D, Sanossian, N, et al. (2008). A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions. Stroke, 39, 2264–7. doi:10.1161/STROKEAHA.107.508127.
Nelson, RE, Saltzman, GM, Skalabrin, EJ, Demaerschalk, BM, Majersik, JJ. (2011). The cost-effectiveness of telestroke in the treatment of acute ischemic stroke. Neurology, 77, 1590–8. doi:10.1212/WNL.0b013e318234332d.
Nishikawa, T, Okamura, T, Nakayama, H, Miyamatsu, N, Morimoto, A, Toyoda, K, et al. (2016). Effects of a public education campaign on the association between knowledge of early stroke symptoms and intention to call an ambulance at stroke onset: the Acquisition of Stroke Knowledge (ASK) Study. J Epidemiol, 26(3), 115–22. doi:10.2188/jea.JE20150040.
Noorian, AR, Sanossian, N, Shkirkova, K, Liebeskind, DS, Eckstein, M, Stratton, SJ, et al.; FAST-MAG Trial Investigators and Coordinators. (2018). Los Angeles Motor Scale to Identify Large Vessel Occlusion: prehospital validation and comparison with other screens. Stroke, 49, 565–72. doi:10.1161/STROKEAHA.117.019228.
Olson, MD, Rabinstein, AA. (2012). Does helicopter emergency medical service transfer offer benefit to patients with stroke? Stroke, 43, 878–80. doi:10.1161/STROKEAHA.111.640987.
Oostema, JA, Chassee, T, Reeves, M. (2018). Emergency dispatcher stroke recognition: associations with downstream care. Prehosp Emerg Care, 22, 466471. doi:10.1080/10903127.2017.1405131.
Oostema, JA, Konen, J, Chassee, T, Nasiri, M, Reeves, MJ. (2015). Clinical predictors of accurate prehospital stroke recognition. Stroke, 46, 1513–17. doi:10.1161/STROKEAHA.115.008650.
Pandey, AS, Gemmete, JJ, Wilson, TJ, Chaudhary, N, Thompson, BG, Morgenstern, LB, et al. (2015). High subarachnoid hemorrhage patient volume associated with lower mortality and better outcomes. Neurosurgery, 77, 462–70; doi:10.1227/NEU.0000000000000850.
Patel, MD, Rose, KM, O’Brien, EC, Rosamond, WD. (2011). Prehospital notification by emergency medical services reduces delays in stroke evaluation: findings from the North Carolina Stroke Care Collaborative. Stroke, 42, 2263–8. doi:10.1161/STROKEAHA.110.605857.
Perez de la Ossa, N, Carrera, D, Gorchs, M, Querol, M, Millan, M, Gomis, M, et al. (2014). Design and validation of a prehospital stroke scale to predict large arterial occlusion: the Rapid Arterial Occlusion Evaluation Scale. Stroke, 45, 8791. doi:10.1161/STROKEAHA.113.003071.
Phabphal, K, Hirunpatch, S. (2008). The effectiveness of low-cost teleconsultation for emergency head computer tomography in patients with suspected stroke. J Telemed Telecare, 14, 439–42. doi:10.1258/jtt.2008.080603.
Powers, WJ, Rabinstein, AA, Ackerson, T, Adeoye, OM, Bambakidis, NC, Becker, K, et al.; American Heart Association Stroke Council. (2018). 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 49, e46e110.
Puetz, V, Bodechtel, U, Gerber, JC, Dzialowski, I, Kunz, A, Wolz, M, et al. (2013). Reliability of brain CT evaluation by stroke neurologists in telemedicine. Neurology, 80, 332–8. doi:10.1212/WNL.0b013e31827f07d0.
Ramanujam, P, Guluma, KZ, Castillo, EM, Chacon, M, Jensen, MB, Patel, E, et al. (2008). Accuracy of stroke recognition by emergency medical dispatchers and paramedics – San Diego experience. Prehosp Emerg Care, 12, 307–13. doi:10.1080/10903120802099526.
Regenhardt, RW, Mecca, AP, Flavin, SA, Boulouis, G, Lauer, A, Zachrison, KS, et al. (2018). Delays in the air or ground transfer of patients for endovascular thrombectomy. Stroke, 49, 1419–25. doi:10.1161/STROKEAHA.118.020618.
Reginella, R, Crocco, T, Tadros, A, Shackleford, A, Davis, SM. (2006). Predictors of stroke during 9-1-1 calls: opportunities for improving EMS response. Prehosp Emerg Care, 10, 369–73.
Reiner-Deitemyer, V, Teuschl, Y, Matz, K, Reiter, M, Eckhardt, R, Seyfang, L, et al. (2011). Helicopter transport of stroke patients and its influence on thrombolysis rates: data from the Austrian Stroke Unit Registry. Stroke, 42, 12951300. doi:10.1161/STROKEAHA.110.604710.
Richards, CT, Wang, B, Markul, E, Albarran, F, Rottman, D, Aggarwal, NT, et al. (2017). Identifying key words in 9-1-1 calls for stroke: a mixed methods approach. Prehosp Emerg Care, 21, 761766. doi:10.1080/10903127.2017.1332124.
Rose, KM, Rosamond, WD, Huston, SL, Murphy, CV, Tegeler, CH. (2008). Predictors of time from hospital arrival to initial brain-imaging among suspected stroke patients: the North Carolina Collaborative Stroke Registry. Stroke, 39, 3262–7. doi:10.1161/STROKEAHA.108.524686.
Rudd, M, Buck, D, Ford, GA, Price, CI. (2016). A systematic review of stroke recognition instruments in hospital and prehospital settings. Emerg Med J, 33, 818822. doi:10.1136/emermed-2015-205197.
Sairanen, T, Soinila, S, Nikkanen, M, et al. (2011). Two years of Finnish Telestroke Thrombolysis at spokes equal to that at the hub. Neurology, 76, 1145–52. doi:10.1212/WNL.0b013e318212a8d4.
Sauser, K, Burke, JF, Levine, DA, Scott, PA, Meurer, WJ. (2014a). Time to brain imaging in acute stroke is improving: secondary analysis of the INSTINCT trial. Stroke J Cereb Circ, 45, 287–9. doi:10.1161/STROKEAHA.113.003678
Sauser, K, Levine, DA, Nickles, AV, Reeves, MJ. (2014b). Hospital variation in thrombolysis times among patients with acute ischemic stroke: the contributions of door-to-imaging time and imaging-to-needle time. JAMA Neurol, 71, 1155. doi:10.1001/jamaneurol.2014.1528.
Saver, JL, Starkman, S, Eckstein, M, Stratton, SJ, Pratt, FD, Hamilton, S, et al. (2015). Prehospital use of magnesium sulfate as neuroprotection in acute stroke. N Engl J Med, 372, 528536. doi:10.1056/NEJMoa1408827.
Schwab, S, Vatankhah, B, Kukla, C, Hauchwitz, M, Bogdahn, U, Furst, A, et al. (2007). Long-term outcome after thrombolysis in telemedical stroke care. Neurology, 69, 898903. doi:10.1212/01.wnl.0000269671.08423.14.
Schwamm, LH, Audebert, HJ, Amarenco, P, Chumbler, NR, Frankel, MR, George, MG, et al. (2009a). Recommendations for the implementation of telemedicine within stroke systems of care: a policy statement from the American Heart Association. Stroke, 40, 2635–60. doi:10.1161/STROKEAHA.109.192361.
Schwamm, LH, Holloway, RG, Amarenco, P, Audebert, HJ, Bakas, T, Chumbler, NR, et al. (2009b). A review of the evidence for the use of telemedicine within stroke systems of care: a scientific statement from the American Heart Association/American Stroke Association. Stroke, 40, 2616–34. doi:10.1161/STROKEAHA.109.192360.
Schwamm, LH, Pancioli, A, Acker, JE 3rd, Goldstein, LB, Zorowitz, RD, Shephard, TJ, et al. (2005). Recommendations for the establishment of stroke systems of care recommendations from the American Stroke Association’s Task Force on the Development of Stroke Systems. Stroke, 36, 690703. doi:10.1161/01.STR.0000158165.42884.4F.
Schwamm, LH, Rosenthal, ES, Hirshberg, A, Schaefer, PW, Little, EA, Dvedar, JC, et al. (2004). Virtual TeleStroke support for the emergency department evaluation of acute stroke. Acad Emerg Med, 11, 11931197. doi:10.1197/j.aem.2004.08.014.
Shafqat, S, Kvedar, JC, Guanci, MM, Chang, Y, Schwamm, LH. (1999). Role for telemedicine in acute stroke feasibility and reliability of remote administration of the NIH Stroke Scale. Stroke, 30, 2141–5. doi:10.1161/01.STR.30.10.2141.
Shireman, TI, Wang, K, Saver, JL, Goyal, M, Bonafe, A, Diener, HC, et al. (2017). Cost-effectiveness of solitaire stent retriever thrombectomy for acute ischemic stroke: results from the SWIFT-PRIME Trial (Solitaire With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke). Stroke, 48, 379–87. doi:10.1161/STROKEAHA.116.014735.
Silbergleit, R, Scott, PA, Lowell, MJ, Silbergleit, R. (2003). Cost-effectiveness of helicopter transport of stroke patients for thrombolysis. Acad Emerg Med Off J Soc Acad Emerg Med, 10, 966–72.
Silliman, SL, Quinn, B, Huggett, V, Merino, JG. (2003). Use of a field-to-stroke center helicopter transport program to extend thrombolytic therapy to rural residents. Stroke J Cereb Circ, 34, 729–33. doi:10.1161/01.STR.0000056529.29515.B2.
Smith, EE, Hassan, KA, Fang, J, Selchen, D, Kapral, MK, Saposnik, G, et al. (2010). Do all ischemic stroke subtypes benefit from organized inpatient stroke care? Neurology, 75, 456–62. doi:10.1212/WNL.0b013e3181ebdd8d.
Song, S, Fonarow, GC, Olson, DM, Liang, L, Schulte, PG, Hernandez, AF, et al. (2016). Association of Get with the Guidelines-Stroke Program participation and clinical outcomes for Medicare beneficiaries with ischemic stroke. Stroke, 47, 1294–302. doi:10.1161/STROKEAHA.115.011874.
Stroke Unit Trialists’ Collaboration. (2013). Organised inpatient (stroke unit) care for stroke. Cochrane Database Syst Rev, 9. CD000197. doi:10.1002/14651858.CD000197.pub3.
Sung, S-F, Ong, C-T, Wu, C-S, Hsu, YC, Su, YH. (2010). Increased use of thrombolytic therapy and shortening of in-hospital delays following acute ischemic stroke: experience on the establishment of a primary stroke center at a community hospital. Acta Neurol Taiwanica, 19, 246–52.
Svenson, JE, O’Connor, JE, Lindsay, MB. (2006). Is air transport faster? A comparison of air versus ground transport times for interfacility transfers in a regional referral system. Air Med J, 25, 170–2. doi:10.1016/j.amj.2006.04.003.
Switzer, JA, Hall, C, Gross, H, Waller, J, Nichols, FT, Wang, S, et al. (2009). A web-based telestroke system facilitates rapid treatment of acute ischemic stroke patients in rural emergency departments. J Emerg Med, 36, 1218. doi:10.1016/j.jemermed.2007.06.041.
Tang, Y, Yin, F, Fu, D, Gao, X, LV Z, LI X, et al. (2018). Efficacy and safety of minimal invasive surgery treatment in hypertensive intracerebral hemorrhage: a systematic review and meta-analysis. BMC Neurol, 18, 136. doi:10.1186/s12883-018-1138-9.
Thompson, MP, Zhao, X, Bekelis, K, Gottlieb, DJ, Fonarow, GC, Schulte, PJ, et al. (2017). Regional variation in 30-day ischemic stroke outcomes for Medicare beneficiaries treated in Get With the Guidelines-Stroke Hospitals. Circ Cardiovasc Qual Outcomes, 10. pii: e003604. doi:10.1161/CIRCOUTCOMES.117.003604.
Van Hooff, R-J, Cambron, M, Van Dyck, R, De Smedt, A, Moens, M, Espinoza, AV, et al. (2013). Prehospital unassisted assessment of stroke severity using telemedicine: a feasibility study. Stroke, 44, 2907–9. doi:10.1161/STROKEAHA.113.002079.
Waite, K, Silver, F, Jaigobin, C, Black, S, Lee, L, Murray, B, et al. (2006). Telestroke: a multi-site, emergency-based telemedicine service in Ontario. J Telemed Telecare, 12, 141–5.
Wall, HK, Beagan, BM, O’Neill, HJ, Foell, KM, Boddie-Willis, CL. (2008).Addressing stroke signs and symptoms through public education: the Stroke Heroes Act FAST Campaign. Prev Chronic Dis, 5, A49.
Walter, S, Kostopoulos, P, Haass, A, Keller, I, Lesmeister, M, Schlechtriemen, T, et al. (2012). Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: a randomised controlled trial. Lancet Neurol, 11, 397404. doi:10.1016/S1474-4422(12)70057-1.
Wang, S, Gross, H, Lee, SB, Pardue, C, Waller, J, Nichols, FT 3rd, et al. (2004). Remote evaluation of acute ischemic stroke in rural community hospitals in Georgia. Stroke, 35, 1763–8. doi:10.1161/01.STR.0000131858.63829.6e.
Wang, S, Lee, SB, Pardue, C, Ramsingh, D, Waller, J, Gross, H, et al. (2003). Remote evaluation of acute ischemic stroke: reliability of National Institutes of Health Stroke Scale via telestroke. Stroke J Cereb Circ, 34, e188–91. doi:10.1161/01.STR.0000091847.82140.9D.
Watkins CL, Jones SP, Leathley MJ, et al. Emergency Stroke Calls: Obtaining Rapid Telephone Triage (ESCORTT) – a programme of research to facilitate recognition of stroke by emergency medical dispatchers. Southampton (UK): NIHR Journals Library; February 2014.
Wiborg, A, Widder, B; Group for the TS. (2003). Teleneurology to improve stroke care in rural areas: the Telemedicine in Stroke in Swabia (TESS) Project. Stroke, 34, 2951–6. doi:10.1161/01.STR.0000099125.30731.97.
Williams, O, Noble, JM. (2008). ‘Hip-Hop’ stroke: a stroke educational program for elementary school children living in a high-risk community . Stroke, 39, 2809–16. doi:10.1161/STROKEAHA.107.513143.
Wu, T-C, Nguyen, C, Ankrom, C, Yang, J, Persse, D, Vahidy, F, et al. (2014). Prehospital utility of rapid stroke evaluation using in-ambulance telemedicine: a pilot feasibility study. Stroke, 45, 2342–7. doi:10.1161/STROKEAHA.114.005193.
Xian, Y. (2011). Association between stroke center hospitalization for acute ischemic stroke and mortality. JAMA, 305, 373. doi:10.1001/jama.2011.22.
Zhao, H, Coote, S, Pesavento, L, Churilov, L, Dewey, HM, Davis, SM, Campbell, BC. (2017). Large vessel occlusion scales increase delivery to endovascular centers without excessive harm from misclassifications. Stroke, 48, 568–73. doi:10.1161/STROKEAHA.116.016056.
Zhao, J, Eckenhoff, MF, Sun, WZ, Liu, R. (2018). Stroke 112: a universal stroke awareness program to reduce language and response barriers. Stroke, 49, 1766–9. doi:10.1161/STROKEAHA.118.021729.

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×