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Part III - Acute Treatment of Ischaemic Stroke and Transient Ischaemic Attack

Published online by Cambridge University Press:  15 December 2020

Jeffrey L. Saver
Affiliation:
David Geffen School of Medicine, University of Ca
Graeme J. Hankey
Affiliation:
University of Western Australia, Perth
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Stroke Prevention and Treatment
An Evidence-based Approach
, pp. 77 - 238
Publisher: Cambridge University Press
Print publication year: 2020

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References

Ahmed, N, Wahlgren, N, Brainin, M, Castillo, J, Ford, GA, Kaste, M, et al., for the SITS Investigators. (2009). Relationship of blood pressure, antihypertensive therapy, and outcome in ischaemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR). Stroke, 40, 2442–9.CrossRefGoogle Scholar
Al-Hazmi, H. (2015). Role of duration of catheterization and length of hospital stay on the rate of catheter-related hospital-acquired urinary tract infections. Res Rep Urol, 7, 41–7Google ScholarPubMed
Ali, L, Saver, JL. (2007). The ischemic stroke patient who worsens: new assessment and management approaches. Rev Neurol Dis, 4, 8591.Google ScholarPubMed
Anderson, CS, Arima, H, Lavados, P, Billot, L, Hackett, ML, Olavarria, VV, et al. (2017). Cluster-randomized, crossover trial of head positioning in acute stroke. New Engl J Med, 376, 2437–47.CrossRefGoogle ScholarPubMed
Aries, MJ, Elting, JW, Stewart, R, De Keyser, J, Kremer, B, Vroomen, P. (2013). Cerebral blood flow velocity changes during upright positioning in bed after acute stroke: an observational study. BMJ Open, 3:e002960. doi:10.1136/bmjopen-2013-002960.CrossRefGoogle ScholarPubMed
Aslanyan, S, Weir, CJ, Diener, HC, Kaste, M, Lees, KR; GAIN International Steering Committee and Investigators. (2004). Pneumonia and urinary tract infection after acute ischemic stroke: a tertiary analysis of the GAIN International trial. Eur J Neurol, 11, 4953.CrossRefGoogle Scholar
Bath, PMW, Krishnan, K. (2014). Interventions for deliberately altering blood pressure in acute stroke (Review). Cochrane Database Syst Rev, 10, CD000039. doi:10.1002/14651858.CD000039.pub3.CrossRefGoogle Scholar
Bath, PM, Lee, HS, Everton, LF. (2018). Swallowing therapy for dysphagia in acute and subacute stroke. Cochrane Database Syst Rev, 10. CD000323. doi:10.1002/14651858.CD000323.pub3.Google ScholarPubMed
Bellolio, MF, Gilmore, RM, Ganti, L. (2014). Insulin for glycaemic control in acute ischaemic stroke. Cochrane Database Syst Rev, 1, CD005346. doi:10.1002/14651858.CD005346.pub4.CrossRefGoogle ScholarPubMed
Bennett, MH, Weibel, S, Wasiak, J, Schnabel, A, French, C, Kranke, P. (2014). Hyperbaric oxygen therapy for acute ischaemic stroke. Cochrane Database Syst Rev, 11, CD004954. doi:10.1002/14651858.CD004954.pub3.CrossRefGoogle ScholarPubMed
Bruno, A, Durkalski, VL, Hall, CE, Juneja R, Barsan WG, Janis S, et al., on behalf of the SHINE Investigators. (2014). The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial protocol; a randomized, blinded, efficacy trial of standard versus intensive hyperglycemia management in acute stroke. Int J Stroke, 9, 246–51.CrossRefGoogle Scholar
Capes, SE, Hunt, D, Malmberg, K, Pathak, P, Gerstein, HC. (2001). Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke, 32, 2426–32.CrossRefGoogle ScholarPubMed
Castillo, J, Davalos, A, Marrugat, J, Noya, M. (1998). Timing for fever-related brain damage in acute ischemic stroke. Stroke, 29, 2455–60.CrossRefGoogle ScholarPubMed
Castillo, J, Leira, R, García, MM, Serena, J, Blanco, M, Dávalos, A. (2004). Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome. Stroke, 35, 520–6.CrossRefGoogle ScholarPubMed
Chen, PC, Chuang, CH, Leong, CP, Guo, SE, Hsin, YJ. (2016). Systematic review and meta-analysis of the diagnostic accuracy of the water swallow test for screening aspiration in stroke patients. J Adv Nurs, 72, 2575–86.CrossRefGoogle ScholarPubMed
Chung, HW, Kim, SK, Kim, SJ, Lee, MJ, Hwang, J, Seo, WK, et al. (2018). Therapeutic induced hypertension in acute stroke patients with non-cardioembolic stroke: a multicenter, randomized controlled trial. Eur Stroke J, 3, 7.Google Scholar
CLOTS Trials Collaboration. (2009). Effectiveness of thigh-length graduated compression stockings to reduce the risk of deep vein thrombosis after stroke (CLOTS trial 1): a multicenter, randomized controlled trial. Lancet, 373, 1958–65.Google Scholar
CLOTS Trials Collaboration. (2013). Effectiveness of intermittent pneumatic compression in reduction of risk of deep vein thrombosis in patients who have had a stroke (CLOTS 3): a multicenter randomized controlled trial. Lancet, 382, 516–24.Google Scholar
Cryer, PE, Davis, SN, Shamoon, H. (2003). Hypoglycemia in diabetes. Diabetes Care, 26, 1902–12.CrossRefGoogle ScholarPubMed
Daniels, SK, Ballo, LA, Mahoney, M-C, Foundas, AL. (2000). Clinical predictors of dysphagia and aspiration risk: outcome measures in acute stroke patients. Arch Phys Med Rehabil, 81, 1030–3.CrossRefGoogle ScholarPubMed
den Hertog, HM, van der Worp, HB, Tseng, MC, Dippel, DWJ. (2009). Cooling therapy for acute stroke. Cochrane Database Syst Rev, 1, CD001247. doi:10.1002/14651858.CD001247.pub2.CrossRefGoogle ScholarPubMed
Dennis, M, Caso, V, Kappelle, LJ, Pavlovic, A, Sandercock, P, for the European Stroke Organisation. (2016). European Stroke Organisation (ESO) guidelines for prophylaxis for venous thromboembolism in immobile patients with acute ischaemic stroke. Eur Stroke J, 1, 619.CrossRefGoogle ScholarPubMed
de Ridder, IR, den Hertog, HM, van Gemert, HM, Schreuder, AH, Ruitenberg, A, Maasland, EL, et al; Trial Organization. (2017). PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2): results of a randomized, double-blind placebo-controlled clinical trial. Stroke, 48, 977–82.Google ScholarPubMed
Ding, J, Zhou, D, Sui, M, Meng, R, Chandra, A, Han, J, et al. (2018). The effect of normobaric oxygen in patients with acute stroke: a systematic review and meta-analysis. Neurol Res, 40, 433–44. doi:10.1080/01616412.2018.1454091.CrossRefGoogle ScholarPubMed
Dirnagl, U, Pulsinelli, W. (1990). Autoregulation of cerebral blood flow in experimental focal brain ischemia. J Cereb Blood Flow Metab, 10, 327–36.CrossRefGoogle ScholarPubMed
Donnelly, J, Budohoski, KP, Smielewski, P, Czosnyka, M. (2016). Regulation of the cerebral circulation: bedside assessment and clinical implications. Crit Care, 20, 129.CrossRefGoogle ScholarPubMed
Douds, GL, Hellkamp, AS, DaiWai, M, Olson, DM, Fonarow, GC, Smith, EE, et al. (2014). Venous thromboembolism in the Get with the Guidelines-Stroke acute ischemic stroke population: incidence and patterns of prophylaxis. J Stroke Cerebrovasc, 23, 123–9.Google ScholarPubMed
Durduran, T, Zhou, C, Edlow, BL, Yu, G, Choe, R, Kim, MN, et al. (2009). Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients. Opt Express, 17, 3884–902.CrossRefGoogle ScholarPubMed
Dziewas, R, Stellato, R, van der Tweel, I, Walther, E, Werner, CJ, Braun, T, et al. (2018). Pharyngeal electrical stimulation for early decannulation in tracheotomised patients with neurogenic dysphagia after stroke (PHAST-TRAC): a prospective, single-blinded, randomised trial. Lancet Neurol, 17, 849–59.CrossRefGoogle ScholarPubMed
Edmiaston, J, Connor, LT, Steger-May, K, Ford, AL. (2014). A simple bedside dysphagia screen, validated against videofluoroscopy, detects dysphagia and aspiration with high sensitivity. J Stroke Cerobrovasc Dis, 23, 712–16.Google ScholarPubMed
Famakin, BM. (2014). The immune response to acute focal cerebral ischemia and associated post-stroke immunodepression: a focused review. Aging Dis, 5, 307–26.Google ScholarPubMed
Favilla, CG, Mesquita, RC, Mullen, M, Durduran, T, Lu, X, Kim, MN, et al. (2014). Optical bedside monitoring of cerebral blood flow in acute ischemic stroke patients during head-of-bed manipulation. Stroke, 45, 1269–74.CrossRefGoogle ScholarPubMed
FOOD Trial Collaboration. (2003). Poor nutritional status on admission predicts poor outcomes after stroke: observational data from the FOOD trial. Stroke, 34, 1450–6.Google Scholar
FOOD Trial Collaboration. (2005a). Routine oral nutritional supplementation for stroke patients in hospital (FOOD): a multi centre randomized controlled trial. Lancet, 365, 755–63.Google Scholar
FOOD Trial Collaboration. (2005b). Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomized controlled trial. Lancet, 365, 764–72.Google Scholar
Galovic, M, Leisi, N, Müller, M. (2013). Lesion location predicts transient and extended risk of aspiration after supratentorial ischemic stroke. Stroke, 44, 2760–7.CrossRefGoogle ScholarPubMed
Grau, AJ, Buggle, F, Schnitzler, P, Spiel, M, Lichy, C, Hacke, W. (1999). Fever and infection early after ischemic stroke. J Neurol Sci, 171, 115–20.CrossRefGoogle ScholarPubMed
Gray, CS, Hildreth, AJ, Sandercock, PA, O’Connell, JE, Johnston, DE, Cartlidge, NE, et al.; GIST Trialists Collaboration. (2007). Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK). Lancet Neurol, 6, 397406.CrossRefGoogle Scholar
Hansford, BG, Albert, D, Yang, E. (2013). Classic neuroimaging findings of nonketotic hyperglycemia on computed tomography and magnetic resonance imaging with absence of typical movement disorder symptoms (hemichorea-hemiballism). Radiology Case, 7, 19.CrossRefGoogle Scholar
Hillis, AE, Ulatowski, JA, Barker, PB, Torbey, M, Ziai, W, Beauchamp, NJ, et al. (2003). A pilot randomized trial of induced blood pressure elevation: effects on function and focal perfusion in acute and subacute stroke. Cerebrovasc Dis, 16, 236–46.CrossRefGoogle ScholarPubMed
Hinchey, JA, Shephard, T, Furie, K, Smith, D, Wang, D, Tonn, S, for the Stroke Practice Improvement Network Investigators. (2005). Formal dysphagia screening protocols prevent pneumonia. Stroke, 36, 1972–6.CrossRefGoogle ScholarPubMed
Huang, L-C, Ruge, D, Tsai, C-L, Wu, MN, Hsu, CY, Lai, CL, et al. (2014). Isolated aphasic status epilepticus as initial presentation of nonketotic hyperglycemia. Clin EEG Neurosci, 45, 126–8.CrossRefGoogle ScholarPubMed
Indredavik, B, Rohweder, G, Naalsund, E, Lydersen, S. (2008). Medical complications in a comprehensive stroke unit and an Early Supported Discharge Service. Stroke, 39, 414–20.CrossRefGoogle Scholar
International Stroke Trial Collaborative Group. (1997). The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet, 349, 1569–81.Google Scholar
Johnston, KC, Bruno, A, Paulis, Q, Hall, CE, Barrett, KM, Barsan, W, et al. (2019). Intensive versus standard treatment of hyperglycemia and functional outcomes in patients with acute ischemic stroke: the SHINE randomized clinical trial. JAMA, 322, 326–35.CrossRefGoogle Scholar
Joundi, RA, Martino, R, Saposnik, G, Giannakeas, V, Fang, J, Kapral, MK. (2017). Predictors of outcomes of dysphagia screening after acute ischemic stroke. Stroke, 48:900–6.CrossRefGoogle ScholarPubMed
Kakkos, SK, Caprini, JA, Geroulakos, G, Nicolaides, AN, Stansby, G, Reddy, DJ, et al. (2016). Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism. Cochrane Database Syst Rev, 9. CD005258.DOI:10.1002/14651858.CD005258.pub3.CrossRefGoogle ScholarPubMed
Kalita, J, Singh, RK, Misra, UK. (2017). Cerebral salt wasting is the most common cause of hyponatremia in stroke. J Stroke Cerebrovasc Dis, 26, 1026–32.CrossRefGoogle ScholarPubMed
Karepov, VG, Gur, AY, Bova, I, Aronovich, BD, Bornstein, NM. (2006). Stroke-in-evolution: infarct-inherent mechanisms versus systemic causes. Cerebrovasc Dis, 21, 42–6.CrossRefGoogle ScholarPubMed
Khan, MT, Ikram, A, Saeed, O, Afridi, T, Sila, CA, Smith, MS, et al. (2017). Deep vein thrombosis in acute stroke – a systemic review of the literature. Cureus, 9, e1982. doi:10.7759/cureus.1982.Google ScholarPubMed
Kim, SH, Saver, JL. (2015). Initial body temperature in ischemic stroke: nonpotentiation of tissue-type plasminogen activator benefit and inverse association with severity. Stroke, 46, 132–6.CrossRefGoogle ScholarPubMed
Kim, TJ, Ko, SB, Jeong, HG, Kim, CK, Kim, Y, Nam, K, et al. (2017). Nocturnal desaturation is associated with neurological deterioration following ischemic stroke: a retrospective observational study. J Clin Sleep Med, 13, 1273–9.CrossRefGoogle ScholarPubMed
Lee, M, Ovbiagele, B, Hong, KS, Wu, YL, Lee, JE, Rao, NM, et al. (2015). Effect of blood pressure lowering in early ischemic stroke: meta-analysis. Stroke, 46, 1883–9.CrossRefGoogle ScholarPubMed
Lin, J, Weng, Y, Li, M, Mo, Y, Zhao, J. (2018). Hydration prevents chronic hyperglycaemic patients from neurological deterioration post-ischaemic stroke. Acta Neurol Scand, 137, 557–65CrossRefGoogle ScholarPubMed
Mann, G, Hankey, GJ, Cameron, D. (1999). Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke, 30, 744–8.CrossRefGoogle ScholarPubMed
Manzanares, W, Aramendi, I, Langlois, PL, Biestro, A. (2015). Hyponatremia in the neurocritical care patient: an approach based on current evidence. Med Intensiva, 39, 234–43.Google ScholarPubMed
Marcantonio, ER. (2017). Delirium in hospitalized older adults. N Engl J Med, 377, 1456–66.CrossRefGoogle ScholarPubMed
McCormick, MT, Muir, KW, Gray, CS, Walters, MR. (2008). Management of hyperglycemia in acute stroke: how, when, and for whom? Stroke, 39, 2177–85.CrossRefGoogle Scholar
Middleton, S, McElduff, P, Ward, J, Grimshaw, JM, Dale, S, D’Este, C, et al., on behalf of the QASC Trialists Group. (2011). Implementation of evidence-based treatment protocols to manage fever, hyperglycemia, and swallowing dysfunction in acute stroke (QASC): a cluster randomized controlled trial. Lancet, 378, 1699–706.CrossRefGoogle Scholar
Naccarato, M1, Chiodo Grandi, F, Dennis, M, Sandercock, PA. (2010). Physical methods for preventing deep vein thrombosis in stroke. Cochrane Database Syst Rev, 8, CD001922. doi:10.1002/14651858.CD001922.pub3.CrossRefGoogle ScholarPubMed
Palli, C, Fandler, S, Doppelhofer, K, Niederkorn, K, Enzinger, C, Vetta, C, et al. (2017). Early dysphagia screening by trained nurses reduces pneumonia rate in stroke patients: a clinical intervention study. Stroke, 48, 2583–5.CrossRefGoogle ScholarPubMed
Panfili, Z, Metcalf, M, Griebling, TL. (2017). Contemporary evaluation and treatment of poststroke lower urinary tract dysfunction. Urol Clin North Am, 44, 403–14.CrossRefGoogle ScholarPubMed
Poisson, SN, Johnston, SC, Josephson, SA. (2010). Urinary tract infections complicating stroke: Mechanisms, consequences, and possible solutions. Stroke, 41, e180–4.CrossRefGoogle ScholarPubMed
Powers, WJ, Rabinstein, AA, Ackerson, T, Adeoye, OM, Bambakidis, NC, Becker, K, et al.; American Heart Association Stroke Council. (2018). 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 49, e46e110.CrossRefGoogle ScholarPubMed
Prasad, K, Krishnan, PR. (2010). Fever is associated with doubling of odds of short-term mortality in ischemic stroke: an updated meta-analysis. Acta Neurol Scand, 122, 404–8.CrossRefGoogle ScholarPubMed
Rai, N, Prasad, K, Bhatia, R, Vibha, D, Singh, MB, Rai, VK, Kumar, A. (2016). Development and implementation of acute stroke care pathway in a tertiary care hospital in India: a cluster-randomized study. Neurol India, 64(suppl), S39S45.Google Scholar
Reith, J, Jorgensen, HS, Pedersen, PM, Nakayama H, Raaschou HO, Jeppesen LL, et al. (1996). Body temperature in acute stroke: relation to stroke severity, infarct size, mortality, and outcome. Lancet, 347, 422–5.CrossRefGoogle Scholar
RIGHT-2 Investigators. (2019). Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet, 393, 1009–20.Google Scholar
Roffe, C, Sills, S, Halim, H, Wilde K, Allen MB, Jones PW, et al. (2003). Unexpected nocturnal hypoxia in patients with acute stroke. Stroke, 34, 2641–5.CrossRefGoogle ScholarPubMed
Roffe, C, Nevatte, T, Sim, J, Bishop, J, Ives, N, Ferdinand, P, et al. (2017). Effect of routine low-dose oxygen supplementation on death and disability in adults with acute stroke: The Stroke Oxygen Study randomized clinical trial. JAMA, 318, 1125–35.CrossRefGoogle ScholarPubMed
Rowat, A, Graham, C, Dennis, M. (2012). Dehydration in hospital-admitted stroke patents: Detection, frequency, and association. Stroke, 43, 857–9.CrossRefGoogle Scholar
Saint, S, Kaufman, SR, Rogers, MAM, Baker, PD, Ossenkop, K, Lipsky, BA. (2006). Condom versus indwelling urinary catheters: a randomized trial. J Am Geriatr Soc, 54, 1055–61.CrossRefGoogle ScholarPubMed
Sandercock, PAG, Counsell, C, Kane, EJ. (2015). Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev, 3, CD000024. doi:10.1002/14651858.CD000024.pub4.CrossRefGoogle ScholarPubMed
Sandercock, PAG, Counsell, C, Tseng, MC, Cecconi, E. (2014). Oral antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst Rev, 3, CD000029. doi:10.1002/14651858.CD000029.pub3.CrossRefGoogle ScholarPubMed
Schmidt, JF, Waldemar, G, Vorstrup, S, Andersen, AR, Gjerris, F, Paulson, OB. (1990). Computerised analysis of cerebral blood flow autoregulation in humans: validation of a method for pharmacologic studies. J Cerebrovasc Pharmacol, 15, 983–8.Google Scholar
Schwarz, S, Georgiadis, D, Aschoff, A, Schwab, S. (2002). Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke. Stroke, 33, 497501.CrossRefGoogle ScholarPubMed
Shi, Q, Presutti, R, Selchen, D, Saposnik, G. (2012). Delirium in acute stroke: a systematic review and meta-analysis. Stroke, 43, 645–9.CrossRefGoogle ScholarPubMed
Siddiqi, N, Harrison, JK, Clegg, A, Teale, EA, Young, J, Taylor, J, et al. (2016). Interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database Syst Rev, 3, CD005563. doi:10.1002/14651858.CD005563.pub3.CrossRefGoogle ScholarPubMed
Stayman, A, Abou-Khalil, BW, Lavin, P, Azar, NJ. (2013). Homonymous hemianopia in nonketotic hyperglycemia is an ictal phenomenon. Neurol Clin Pract, 3, 392–7.CrossRefGoogle ScholarPubMed
Steiner, T, Mendoza, G, De Georgia, M, Schellinger, P, Holle, R, Hacke, R. (1997). Prognosis of stroke patients requiring mechanical ventilation in a neurological critical care unit. Stroke, 28, 711–15.CrossRefGoogle Scholar
Strandgaard, S, Olesen, J, Skinhøj, E, Lassen, NA. (1973). Autoregulation of brain circulation in severe arterial hypertension. Br Med J, 1, 507–10.CrossRefGoogle ScholarPubMed
Strowd, RE, Wabnitz, A, Balakrishnan, N, Craig, J, Tegeler, CH. (2014). Clinical reasoning: acute-onset homonymous hemianopia with hyperglycemia. Neurology, 82, e129–33.CrossRefGoogle ScholarPubMed
Sulter, G, Elting, JW, Stewart, R, den Arend, A, De Keyser, J. (2000). Continuous pulse oximetry in acute hemiparetic stroke. J Neurol Sci, 179, 65–9.CrossRefGoogle ScholarPubMed
Sumer, M, Ozdemir, I, Erturk, O. (2003). Progression in acute ischemic stroke: frequency, risk factors and prognosis. J Clin Neurosci, 10, 177–80.CrossRefGoogle ScholarPubMed
Suntrup, S, Marian, T, Schroder, JB, Suttrup, I, Muhle, P, Oelenberg, S, et al. (2015). Electrical pharyngeal stimulation for dysphagia treatment in tracheotomized stroke patients: a randomized controlled trial. Intensive Care Med, 41, 1629–37.CrossRefGoogle ScholarPubMed
Suwanwela, NC, Chutinet, A, Mayotarn, S, Thanapiyachaikul, R, Chaisinanunkul, N, Asawavichienjinda, T, et al. (2017). A randomized controlled study of intravenous fluid in acute ischemic stroke. Clin Neurol Neurosurg, 161, 98103.CrossRefGoogle ScholarPubMed
Tyson, SF, Nightingale, P. (2004). The effects of position on oxygen saturation in acute stroke: a systematic review. Clin Rehabil, 18, 863–71.CrossRefGoogle ScholarPubMed
Vermeij, FH, Scholte op Reimer, WJM, de Man, P, van Oostenbrugge, RJ, Franke, CL, de Jong, G, et al., and the Netherlands Stroke Survey Investigators. (2009). Stroke-associated infection is an independent risk factor for poor outcome after acute ischemic stroke: data from the Netherlands Stroke Survey. Cerebrovasc Dis, 27, 465–71.CrossRefGoogle ScholarPubMed
Vermeij, JD, Westendorp, WF, Dippel, DW, van de Beek, D, Nederkoorn, PJ. (2018). Antibiotic therapy for preventing infections in people with acute stroke. Cochrane Database Syst Rev, 1, CD008530. doi:10.1002/14651858.CD008530.pub3.CrossRefGoogle ScholarPubMed
von Kummer, R, Broderick, JP, Campbell, BC, Demchuk, A, Goyal, M, Hill, MD, et al. (2015). The Heidelberg Bleeding Classification: classification of bleeding events after ischemic stroke and reperfusion therapy. Stroke, 46, 2981–6.CrossRefGoogle ScholarPubMed
Weimar, C, Mieck, T, Buchthal, J, Ehrenfeld, CE, Schmid, E, Diener H-C, MD, for the German Stroke Study Collaboration. (2005). Neurologic worsening during the acute phase of ischemic stroke. Arch Neurol, 62, 393–7.CrossRefGoogle ScholarPubMed
Williams, LS, Rotich, J, Qi, R, Fineberg, A, Espay, A, Bruno, SE, et al. (2002). Effects of admission hyperglycemia on mortality and costs in acute ischemic stroke. Neurology, 59, 6771.CrossRefGoogle ScholarPubMed
Wojner-Alexandrov, AW, Garami, Z, Chernyshev, OY, Alexandrov, AV. (2005). Heads down: flat positioning improves blood flow velocity in acute ischemic stroke. Neurology, 64, 1354–7.Google Scholar
Ye, Q, Xie, Y, Shi, J, Xu, Z, Ou, A, Xu, N. (2017). Systematic review on acupuncture for treatment of dysphagia after stroke. Evid Based Complement Alternat Med, 6421852. doi:10.1155/2017/6421852.CrossRefGoogle Scholar
Yoo, SH, Kim, JS, Kwon, SU, Yun, SC, Koh, JY, Kang, DW. (2008). Undernutrition as a predictor of poor clinical outcomes in acute ischemic stroke patients. Arch Neurol, 65, 3943.CrossRefGoogle ScholarPubMed
Acker, JE III, Pancioli, AM, Crocco, T J, Eckstein, MK, Jauch, EC, Larrabee, H, et al. (2007). Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/ American Stroke Association Expert Panel on Emergency Medical Services Systems and the Stroke Council. Stroke, 38(11), 3097–115.CrossRefGoogle Scholar
Adeoye, O, Sucharew, H, Khoury, J, Vagal, A, Schmit, PA, Ewing, I, et al. (2015). Combined approach to lysis utilizing eptifibatide and recombinant tissue-type plasminogen activator in acute ischemic stroke-full dose regimen stroke trial. Stroke, 46(9), 2529–33.CrossRefGoogle ScholarPubMed
Alberts, MJ, Latchaw, RE, Jagoda, A, Wechsler, LR, Crocco, T, George, MG, et al. (2011). Revised and updated recommendations for the establishment of primary stroke centers: a summary statement from the brain attack coalition. Stroke, 42(9), 2651–65.CrossRefGoogle ScholarPubMed
Alexandrov, AV, Kohrmann, M, Soinne, L, Mandava, P, Barreto, AD, Demchuk, AM, et al. (2016). Ultrasound enhanced thrombolysis for ischemic stroke: results of a multi-national phase iii trial – CLOTBUSTER. Paper presented at the European Stroke Organization Conference, Barcelona, Spain.Google Scholar
American College of Emergency Physicians; American Academy of Neurology (2013). Clinical policy: use of intravenous tPA for the management of acute ischemic stroke in the emergency department. Ann Emerg Med, 61, 225–43.Google Scholar
Anderson, CS, Robinson, T, Lindley, RI, Arima, H, Lavados, PM, Lee, TH, et al.; Investigators and Coordinators. (2016). Low-dose versus standard-dose intravenous alteplase in acute ischemic stroke. N Engl J Med, 374(24), 2313–23.CrossRefGoogle ScholarPubMed
Ankolekar, S, Fuller, M, Cross, I, Renton, C, Cox, P, Sprigg, N, et al. (2013). Feasibility of an ambulance-based stroke trial, and safety of glyceryl trinitrate in ultra-acute stroke: the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke Trial (RIGHT, ISRCTN66434824). Stroke, 44(11), 3120–8.CrossRefGoogle ScholarPubMed
Atallah, AM. (2012). Consensus on Diagnosis and Treatment of Acute Ischemic Stroke Council – Argentine Society of Cardiology. Argentine J Cardiol, 80, 389404.Google Scholar
Audebert, HJ, Schenkel, J, Heuschmann, PU, Bogdahn, U, Haberl, RL. (2006). Effects of the implementation of a telemedical stroke network: the Telemedic Pilot Project for Integrative Stroke Care (TEMPiS) in Bavaria, Germany. Lancet Neurol, 5(9), 742–8.CrossRefGoogle Scholar
Barreto, AD, Alexandrov, AV, Lyden, P, Lee, J, Martin-Schild, S, Shen, L, et al. (2012). The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study. Stroke, 43(3), 770–5.CrossRefGoogle ScholarPubMed
Bath, PM, Lees, KR, Schellinger, PD, Altman, H, Bland, M, Hogg, C, et al. (2012). Statistical analysis of the primary outcome in acute stroke trials. Stroke, 43(4), 1171–8.CrossRefGoogle ScholarPubMed
Bendszus, M, Donnan, G, Hacke, W, Molina, C, Leys, D, Ringleb, P, et al.; ECASS-4 Collaborators. (2018). ECASS-4:EXTEND: Extending the Time for Thrombolysis in Emergency Neurological Deficits. Eur Stroke J, 3(Suppl 1), 4 (abstract).Google Scholar
Bivard, A, Huang, X, Levi, CR, Spratt, N, Campbell, BCV, Cheripelli, BK, et al. (2017). Tenecteplase in ischemic stroke offers improved recanalization: analysis of 2 trials. Neurology, 89(1), 62–7.CrossRefGoogle ScholarPubMed
Bluhmki, E, Chamorro, A, Davalos, A, Machnig, T, Sauce, C, Wahlgren, N, et al. (2009). Stroke treatment with alteplase given 3.0–4.5 h after onset of acute ischaemic stroke (ECASS III): additional outcomes and subgroup analysis of a randomised controlled trial. Lancet Neurol, 8(12), 10951102.CrossRefGoogle ScholarPubMed
Bryer, A, Connor, M, Haug, P, Cheyip, B, Staub, H, Tipping, B, et al. (2010). South African guideline for management of ischaemic stroke and transient ischaemic attack 2010: a guideline from the South African Stroke Society (SASS) and the SASS Writing Committee. S Afr Med J, 100(11 Pt 2), 747–78.CrossRefGoogle ScholarPubMed
Campbell, BC; E-IT Investigators. (2018). Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): a multicenter, randomized, controlled trial. Paper presented at the International Stroke Conference, Los Angeles, CA.Google Scholar
Chao, AC, Liu, CK, Chen, CH, Lin, HJ, Liu, CH, Jeng, JS, et al. (2014). Different doses of recombinant tissue-type plasminogen activator for acute stroke in Chinese patients. Stroke, 45(8), 2359–65.CrossRefGoogle ScholarPubMed
Cho, KH, Ko, SB, Kim, SH, Park, HK, Cho, AH, Hong, KS, et al. (2012). Focused update of Korean Clinical Practice Guidelines for the Thrombolysis in Acute Stroke Management. Korean J Stroke, 14, 95105.CrossRefGoogle Scholar
Ciccone, A, Motto, C, Aritzu, E, Piana, A, Candelise, L. (2000). Negative interaction of aspirin and streptokinase in acute ischemic stroke: further analysis of the Multicenter Acute Stroke Trial – Italy. Cerebrovasc Dis, 10(1), 61–4.CrossRefGoogle ScholarPubMed
Daffertshofer, M, Gass, A, Ringleb, P, Sitzer, M, Sliwka, U, Els, T, et al. (2005). Transcranial low-frequency ultrasound-mediated thrombolysis in brain ischemia: increased risk of hemorrhage with combined ultrasound and tissue plasminogen activator: results of a phase II clinical trial. Stroke, 36(7), 1441–6.CrossRefGoogle ScholarPubMed
Davis, SM, Donnan, GA, Parsons, MW, Levi, C, Butcher, KS, Peeters, A, et al. (2008). Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol, 7(4), 299309.CrossRefGoogle ScholarPubMed
DeMers, G, Meurer, WJ, Shih, R, Rosenbaum, S, Vilke, GM. (2012). Tissue plasminogen activator and stroke: review of the literature for the clinician. J Emerg Med 43(6): 11491154.CrossRefGoogle ScholarPubMed
Diener, HC, Foerch, C, Riess, H, Rother, J, Schroth, G, Weber, R. (2013). Treatment of acute ischaemic stroke with thrombolysis or thrombectomy in patients receiving anti-thrombotic treatment. Lancet Neurol, 12(7), 677–88.CrossRefGoogle ScholarPubMed
Emberson, J, Lees, KR, Lyden, P, Blackwell, L, Albers, G, Bluhmki, E, et al. (2014). Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet, 384, 1929–35.CrossRefGoogle ScholarPubMed
European Stroke Organization Executive Committee and the ESO Writing Committee. (2008). Guidelines for the Management of Ischaemic Stroke and Transient Ischemic Attack 2008. www.eso-stroke.org/pdf/ESO08_Guidelines_Original_english.pdf. Accessed July 2013.Google Scholar
Fassbender, K, Grotta, JC, Walter, S, Grunwald, IQ, Ragoschke-Schumm, A, Saver, J. (2017). Mobile stroke units for prehospital thrombolysis, triage, and beyond: benefits and challenges. Lancet Neurol, 16(3), 227–37.CrossRefGoogle ScholarPubMed
Feigin, VL, Norrving, B, Mensah, GA. (2017). Global burden of stroke. Circ Res, 120(3), 439–48.CrossRefGoogle ScholarPubMed
Fischer, U, Kaesmacher, J, Mendes Pereira, V, Chapot, R, Siddiqui, AH, Froehler, MT, et al. (2017). Direct mechanical thrombectomy versus combined intravenous and mechanical thrombectomy in large-artery anterior circulation stroke: a topical review. Stroke, 48(10), 2912–18.CrossRefGoogle ScholarPubMed
Fisher, M, Saver, JL. (2015). Future directions of acute ischaemic stroke therapy. Lancet Neurol, 14(7), 758–67.CrossRefGoogle ScholarPubMed
Flynn, D, Nesbitt, DJ, Ford, GA, McMeekin, P, Rodgers, H, Price, C, et al. (2015). Development of a computerised decision aid for thrombolysis in acute stroke care. BMC Med Inform Decis Mak, 15(1), 6.CrossRefGoogle ScholarPubMed
Fonarow, GC, Cox, M, Smith, E, Saver, J, Reeves, M, Bhatt, D, et al. (2017). Abstract 86: progress in achieving more rapid door-to-needle times in acute ischemic stroke: interim findings from target: stroke phase II. Stroke, 48(Suppl 1), A86.Google Scholar
Fonarow, GC, Smith, EE, Saver, JL, Reeves, MJ, Bhatt, DL, Grau-Sepulveda, MV, et al. (2011a). Timeliness of tissue-type plasminogen activator therapy in acute ischemic stroke: patient characteristics, hospital factors, and outcomes associated with door-to-needle times within 60 minutes. Circulation, 123(7), 750–8.CrossRefGoogle ScholarPubMed
Fonarow, GC, Smith, EE, Saver, JL, Reeves, MJ, Hernandez, AF, Peterson, ED, et al. (2011b). Improving door-to-needle times in acute ischemic stroke: the design and rationale for the American Heart Association/American Stroke Association’s Target: Stroke initiative. Stroke, 42(10), 2983–9.CrossRefGoogle ScholarPubMed
Gadhia, J, Starkman, S, Ovbiagele, B, Ali, L, Liebeskind, D, Saver, JL. (2010). Assessment and improvement of figures to visually convey benefit and risk of stroke thrombolysis. Stroke, 41(2), 300–6.CrossRefGoogle ScholarPubMed
Goyal, M., Menon, BK, van Zwam, WH, Dippel, DW, Mitchell, PJ, Demchuk, AM, et al. (2016). Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet, 387(10029), 1723–31.CrossRefGoogle ScholarPubMed
Grotta, J. (2001). Combination therapy stroke trial: recombinant tissue-type plasminogen activator with/without lubeluzole. Cerebrovasc Dis, 12(3), 258–63.CrossRefGoogle ScholarPubMed
Hacke, W, Lyden, P, Emberson, J, Baigent, C, Blackwell, L, Albers, G, et al; Stroke Thrombolysis Trialists’ Collaborators. (2018). Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials. Int J Stroke, 13(2), 175–89.CrossRefGoogle ScholarPubMed
Higashida, R, Alberts, MJ, Alexander, DN, Crocco, TJ, Demaerschalk, BM, Derdeyn, CP, et al. (2013). Interactions within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association. Stroke, 44(10), 2961–84.CrossRefGoogle ScholarPubMed
Hill, MD, Buchan, AM. (2005). Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ, 172(10), 1307–12.CrossRefGoogle ScholarPubMed
Hougaard, KD, Hjort, N, Zeidler, D, Sorensen, L, Norgaard, A, Hansen, TM, et al. (2014). Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial. Stroke, 45(1), 159–67.CrossRefGoogle ScholarPubMed
Huang, X, MacIsaac, R, Thompson, JL, Levin, B, Buchsbaum, R, Haley, EC Jr., Levi, C, et al. (2016). Tenecteplase versus alteplase in stroke thrombolysis: an individual patient data meta-analysis of randomized controlled trials. Int J Stroke, 11(5), 534–43.CrossRefGoogle ScholarPubMed
Hughes, S. (2017). NOR-TEST: tenecteplase similar to alteplase in stroke. Medscape.Google Scholar
IST-3 Collaborative Group. (2015). Association between brain imaging signs, early and late outcomes, and response to intravenous alteplase after acute ischaemic stroke in the third International Stroke Trial (IST-3): secondary analysis of a randomised controlled trial. Lancet Neurol, 14(5), 485–96.Google Scholar
Jauch, EC, Saver, JL, Adams, HP Jr., Bruno, A, Connors, JJ, Demaerschalk, BM, et al. (2013). Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 44(3), 870947.CrossRefGoogle ScholarPubMed
Kermer, P, Eschenfelder, CC, Diener, HC, Grond, M, Abdalla, Y, Althaus, K, et al. (2017). Antagonizing dabigatran by idarucizumab in cases of ischemic stroke or intracranial hemorrhage in Germany – a national case collection. Int J Stroke, 12(4), 383–91.CrossRefGoogle ScholarPubMed
Khatri, P, Kleindorfer, DO, Devlin, T, Sawyer, RN Jr, Starr, M, Mejilla, J, et al.; P. Investigators. (2018). Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits: the PRISMS randomized clinical trial. JAMA, 320(2), 156–66.CrossRefGoogle ScholarPubMed
Kim, BJ, Han, MK, Park, TH, Park, SS, Lee, KB, Lee, BC, et al. (2015). Low-versus standard-dose alteplase for ischemic strokes within 4.5 hours: a comparative effectiveness and safety study. Stroke, 46(9), 2541–8.CrossRefGoogle ScholarPubMed
Kim, JT, Fonarow, GC, Smith, EE, Reeves, MJ, Navalkele, DD, Grotta, JC, et al. (2017). treatment with tissue plasminogen activator in the golden hour and the shape of the 4.5-hour time-benefit curve in the national United States Get with the Guidelines-Stroke population. Circulation, 135(2), 128–39.CrossRefGoogle ScholarPubMed
Lansberg, MG, Schrooten, M, Bluhmki, E, Thijs, VN, J. L. Saver, JL. (2009). Treatment time-specific number needed to treat estimates for tissue plasminogen activator therapy in acute stroke based on shifts over the entire range of the modified Rankin Scale. Stroke, 40(6), 2079–84.CrossRefGoogle ScholarPubMed
Lees, KR, Emberson, J, Blackwell, L, Bluhmki, E, Davis, SM, Donnan, GA, et al.; Stroke Thrombolysis Trialists’ Collaborators. (2016). Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of 9 trials. Stroke, 47(9), 2373–9.CrossRefGoogle ScholarPubMed
Legrand, L, Naggara, O, Turc, G, Mellerio, C, Roca, P, Calvet, D, et al. (2013). Clot burden score on admission T2*-MRI predicts recanalization in acute stroke. Stroke, 44(7), 1878–84.CrossRefGoogle ScholarPubMed
Liberatore, GT,. Samson, A, Bladin, C, Schleuning, WD, Medcalf, RL. (2003). Vampire bat salivary plasminogen activator (desmoteplase): a unique fibrinolytic enzyme that does not promote neurodegeneration. Stroke, 34(2), 537–43.CrossRefGoogle Scholar
Lindley, RI, Wardlaw, JM, Whiteley, WN, Cohen, G, Blackwell, L, Murray, GD, et al.; ISTC Group (2015). Alteplase for acute ischemic stroke: outcomes by clinically important subgroups in the Third International Stroke Trial. Stroke, 46(3), 746–56.CrossRefGoogle ScholarPubMed
Lindsay, P, Bayley, M, McDonald, A, Graham, ID, Warner, G, Phillips, S. (2008). Toward a more effective approach to stroke: Canadian Best Practice Recommendations for Stroke Care. CMAJ, 178(11), 1418–25.CrossRefGoogle Scholar
Logallo, N, Novotny, V, Assmus, J, Kvistad, CE, Alteheld, L, Ronning, OM, et al. (2017). Tenecteplase versus alteplase for management of acute ischaemic stroke (NOR-TEST): a phase 3, randomised, open-label, blinded endpoint trial. Lancet Neurol, 16(10), 781–8.CrossRefGoogle ScholarPubMed
Lorenzano, S, Toni, D, (2017). TESPI (Thrombolysis in elderly stroke patients in Italy). Paper presented at the European Stroke Organization Conference, Prague, Czech Republic.Google Scholar
Luo, S, Zhuang, M, Zeng, W, Tao, J. (2016). Intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy: a systematic review and meta-analysis of 19 studies. J Am Heart Assoc, 5(5), e003242.CrossRefGoogle ScholarPubMed
Lyden, P, Jacoby, M, Schim, J, Albers, G, Mazzeo, P, Ashwood, T, et al. (2001). The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results. Neurology, 57, 11991205.CrossRefGoogle ScholarPubMed
Ma, H, Campbell, BCV, Parsons, MW, Churilov, L, Levi, CR, Hsu, C, et al.; EXTEND Investigators. (2019). Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke. N Engl J Med, 380(19), 17951803.CrossRefGoogle ScholarPubMed
Meretoja, A, Strbian, D, Mustanoja, S, Tatlisumak, T, Lindsberg, PJ, Kaste, M. (2012). Reducing in-hospital delay to 20 minutes in stroke thrombolysis. Neurology, 79(4), 306–13.CrossRefGoogle ScholarPubMed
Montero, M, Tokunboh, I, Sharma, L, Szeder, SV, AM LD, Lansberg, M, et al. (2017). Harmonized visual decision aids to expedite physician, patient, and family decision-making regarding intravenous tPA for acute ischemic stroke in different time windows. Eur Stroke J, 2(IS), 155.Google Scholar
Mori, E, Minematsu, K, Nakagawara, J, Hasegawa, Y, Nagahiro, S, Okada, Y, Truelsen, T, et al.; D.-J. Investigators (2015). Safety and tolerability of desmoteplase within 3 to 9 hours after symptoms onset in Japanese patients with ischemic stroke. Stroke, 46(9), 2549–54.CrossRefGoogle ScholarPubMed
Nacu, A, Kvistad, CE, Naess, H, Oygarden, H, Logallo, N, J.Assmus, J, et al. (2017). NOR-SASS (Norwegian Sonothrombolysis in Acute Stroke Study): randomized controlled contrast-enhanced sonothrombolysis in an unselected acute ischemic stroke population. Stroke, 48(2), 335–41.CrossRefGoogle Scholar
Nakagawara, J, Minematsu, K, Okada, Y, Tanahashi, N, Nagahiro, S, Mori, E, et al. (2010). Thrombolysis with 0.6 mg/kg intravenous alteplase for acute ischemic stroke in routine clinical practice: the Japan post-Marketing Alteplase Registration Study (J-MARS). Stroke, 41(9), 1984–9.CrossRefGoogle ScholarPubMed
National Institute for Health and Clinical Excellence (NICE) – National Health Services. (2007). Final appraisal determination: alteplase for the treatment of acute ischaemic stroke. www.nice.org.uk/nicemedia/pdf/StokeAteplFAD.pdf. Accessed October 2009.Google Scholar
NINDS t-PA Stroke Trial Study Group. (1997). Generalized efficacy of t-PA for acute stroke. Subgroup analysis of the NINDS t-PA Stroke Trial. Stroke, 28(11), 2119–25.Google Scholar
Pancioli, AM, Adeoye, O, Schmit, PA, Khoury, J, Levine, SR, Tomsick, TA, et al.; and C.-E. Investigators. (2013). Combined approach to lysis utilizing eptifibatide and recombinant tissue plasminogen activator in acute ischemic stroke – enhanced regimen stroke trial. Stroke, 44(9): 2381–7.CrossRefGoogle ScholarPubMed
Pancioli, AM, Broderick, J, Brott, T, Tomsick, T, Khoury, J, Bean, J, et al. (2008). The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial. Stroke, 39(12), 3268–76.CrossRefGoogle ScholarPubMed
Parsons, M, Spratt, N, Bivard, A, Campbell, B, Chung, K, Miteff, F, et al. (2012). A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med, 366(12), 10991107.CrossRefGoogle ScholarPubMed
Picanco, MR, Christensen, S, Campbell, BC, Churilov, L, Parsons, MW, Desmond, PM, et al. (2014). Reperfusion after 4.5 hours reduces infarct growth and improves clinical outcomes. Int J Stroke, 9(3), 266–9.CrossRefGoogle ScholarPubMed
Pikija, S, Sztriha, LK, Sebastian Mutzenbach, J, Golaszewski, SM, Sellner, J. (2017). Idarucizumab in dabigatran-treated patients with acute ischemic stroke receiving alteplase: a systematic review of the available evidence. CNS Drugs, 31(9), 747–57.CrossRefGoogle ScholarPubMed
Reddrop, C, Moldrich, RX, Beart, PM, Farso, M, Liberatore, GT, Howells, DW, et al. (2005). Vampire bat salivary plasminogen activator (desmoteplase) inhibits tissue-type plasminogen activator-induced potentiation of excitotoxic injury. Stroke, 36(6), 1241–6.CrossRefGoogle ScholarPubMed
Sanossian, N. (2017). Before the angiography suite: prehospital stroke identification, routing, and treatment. Endovascular Today, 16, 4552.Google Scholar
Saposnik, G, Gladstone, D, Raptis, R, Zhou, L, Hart, RG; Investigators of the Registry of the Canadian Stroke Network and the Stroke Outcomes Research Canada Working Group. (2013). Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes. Stroke, 44(1), 99104.CrossRefGoogle ScholarPubMed
Saqqur, M, Tsivgoulis, G, Nicoli, F, Skoloudik, D, Sharma, VK, Larrue, V, et al. (2014). The role of sonolysis and sonothrombolysis in acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials and case-control studies. J Neuroimaging, 24(3), 209–20.CrossRefGoogle ScholarPubMed
Saver, JL. (2011). Optimal end points for acute stroke therapy trials: best ways to measure treatment effects of drugs and devices. Stroke, 42(8), 2356–62.CrossRefGoogle ScholarPubMed
Saver, JL, Fonarow, GC, Smith, EE, Reeves, MJ, Grau-Sepulveda, MV, Pan, W, et al. (2013). Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA, 309(23), 2480–8.CrossRefGoogle ScholarPubMed
Saver, JL, Gornbein, J, Grotta, J, Liebeskind, D, Lutsep, H, Schwamm, L, et al. (2009). Number needed to treat to benefit and to harm for intravenous tissue plasminogen activator therapy in the 3- to 4.5-hour window: joint outcome table analysis of the ECASS 3 trial. Stroke, 40(7), 2433–7.CrossRefGoogle ScholarPubMed
Seiffge, DJ, Hooff, RJ, Nolte, CH, Bejot, Y, Turc, G, Ikenberg, B, et al. (2015). Recanalization therapies in acute ischemic stroke patients: impact of prior treatment with novel oral anticoagulants on bleeding complications and outcome. Circulation, 132(13), 1261–9.CrossRefGoogle ScholarPubMed
Sharma, M, Clark, H, Armour, T, Stotts, G, Coté, R, Hill, MD, et al. (2005). Acute stroke: evaluation and treatment. Evid Rep Technol Assess (Summ), 127, 17.Google ScholarPubMed
Shobha, N., Fang, J, Hill, MD. (2013). Do lacunar strokes benefit from thrombolysis? Evidence from the Registry of the Canadian Stroke Network. Int J Stroke, 8 (Suppl A100), 4549.CrossRefGoogle ScholarPubMed
Thomalla, G, Simonsen, CZ, Boutitie, F, Andersen, G, Berthezene, Y, Cheng, B, et al.; W.-U. Investigators. (2018). MRI-guided thrombolysis for stroke with unknown time of onset. N Engl J Med, 379(7), 611–22.CrossRefGoogle ScholarPubMed
Tong, X, Liao, X, Pan, Y, Cao, Y, Wang, C, Liu, C, et al. (2016). Intravenous thrombolysis is more safe and effective for posterior circulation stroke: Data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). Medicine (Baltimore), 95(24), e3848.CrossRefGoogle ScholarPubMed
von Kummer, R, Mori, E, Truelsen, T, Jensen, JS, Gronning, BA, Fiebach, JB, et al. (2016). Desmoteplase 3 to 9 hours after major artery occlusion stroke: the DIAS-4 Trial (efficacy and safety study of desmoteplase to treat acute ischemic stroke). Stroke, 47(12), 2880–87.CrossRefGoogle ScholarPubMed
Wahlgren, N, Ahmed, N. (2016). SITS Report 2016. Stockholm: SITS International Coordination Team.Google Scholar
Warach, S, Al-Rawi, Y, Furlan, AJ, Fiebach, JB, Wintermark, M, Lindsten, A, et al. (2012). Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: insights from the desmoteplase in acute stroke trials. Stroke, 43(9), 2313–18.CrossRefGoogle ScholarPubMed
Wardlaw, JM, Koumellis, P, Liu, M. (2013). Thrombolysis (different doses, routes of administration and agents) for acute ischaemic stroke. Cochrane Database Syst Rev, 5, CD000514.CrossRefGoogle ScholarPubMed
Wardlaw, JM, Murray, V, Berge, E, del Zoppo, GJ. (2014). Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev, 7, CD000213.CrossRefGoogle ScholarPubMed
Wechsler, LR, Demaerschalk, BM, Schwamm, LH, Adeoye, OM, Audebert, HJ, Fanale, CV, et al. (2017). Telemedicine quality and outcomes in stroke: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 48(1), e3e25.CrossRefGoogle ScholarPubMed
Wheeler, HM, Mlynash, M, Inoue, M, Tipirnini, A, Liggins, J, Bammer, R, et al. (2015). The growth rate of early DWI lesions is highly variable and associated with penumbral salvage and clinical outcomes following endovascular reperfusion. Int J Stroke, 10(5), 723–9.CrossRefGoogle ScholarPubMed
Whiteley, WN, Emberson, J, Lees, KR, Blackwell, L, Albers, G, Bluhmki, E, et al; Stroke Thrombolysis Trialists. (2016). Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis. Lancet Neurol, 15(9), 925–33.CrossRefGoogle ScholarPubMed
Wright, L, Hill, KM, Bernhardt, J, Lindley, R, Ada, L, Bajorek, BV, et al. (2012). Stroke management: updated recommendations for treatment along the care continuum. Intern Med J, 42(5), 562–9.CrossRefGoogle ScholarPubMed
Xian, Y, Federspiel, JJ, Hernandez, AF, Laskowitz, DT, Schwamm, LH, Bhatt, DL, et al. (2017a). Use of intravenous recombinant tissue plasminogen activator in patients with acute ischemic stroke who take non-vitamin K antagonist oral anticoagulants before stroke. Circulation, 135(11), 1024–35.CrossRefGoogle ScholarPubMed
Xian, Y, Liang, L, Smith, EE, Schwamm, LH, Reeves, MJ, Olson, DM, et al. (2012). Risks of intracranial hemorrhage among patients with acute ischemic stroke receiving warfarin and treated with intravenous tissue plasminogen activator. JAMA, 307(24), 2600–8.CrossRefGoogle ScholarPubMed
Xian, Y, Xu, H, Lytle, B, Blevins, J, Peterson, ED, Hernandez, AF, et al. (2017b). Use of strategies to improve door-to-needle times with tissue-type plasminogen activator in acute ischemic stroke in clinical practice: findings from Target: Stroke. Circ Cardiovasc Qual Outcomes, 10(1).CrossRefGoogle ScholarPubMed
Yayan, J. (2013). Onset of orolingual angioedema after treatment of acute brain ischemia with alteplase depends on the site of brain ischemia: a meta-analysis. N Am J Med Sci, 5(10), 589–93.CrossRefGoogle ScholarPubMed
Zinkstok, SM, Roos, YB; ARTIS Investigators. (2012). Early administration of aspirin in patients treated with alteplase for acute ischaemic stroke: a randomised controlled trial. Lancet, 380(9843), 731–7.CrossRefGoogle ScholarPubMed
Acker, JE III, Pancioli, AM, Crocco, TJ, Eckstein, MK, Jauch, EC, Larrabee, H, et al. (2007). Implementation strategies for emergency medical services within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association Expert Panel on Emergency Medical Services Systems and the Stroke Council. Stroke, 38(11), 3097–115.CrossRefGoogle Scholar
Al-Mufti, F, Amuluru, K, Roth, W, Nuoman, R, El-Ghanem, M, Meyers, PM. (2018). Cerebral ischemic reperfusion injury following recanalization of large vessel occlusions. Neurosurgery, 82(6), 781–9.CrossRefGoogle ScholarPubMed
American Heart/Stroke Association Mission Lifeline Stroke Committee. (2017). Severity-based stroke triage algorithm for EMS. www.heart.org/idc/groups/ahaecc-public/@wcm/@gwtg/documents/downloadable/ucm_492025.pdf. Accessed March 2017.Google Scholar
Badhiwala, JH, Nassiri, F, Alhazzani, W, Selim, MH, Farrokhyar, F, Spears, J, et al. (2015). Endovascular thrombectomy for acute ischemic stroke: a meta-analysis. JAMA, 314(17), 1832–43.CrossRefGoogle ScholarPubMed
Bath, PM, Lees, KR, Schellinger, PD, Altman, H, Bland, M, Hogg, C, et al. (2012). Statistical analysis of the primary outcome in acute stroke trials. Stroke, 43(4), 1171–8.CrossRefGoogle ScholarPubMed
Bendszus, M, Thomalla, G, Hacke, W, Knauth, M, Gerloff, C, Bonekamp, S, et al.; THRILL Investigators. (2016). Early termination of THRILL, a prospective study of mechanical thrombectomy in patients with acute ischemic stroke ineligible for i.v. thrombolysis. Clin Neuroradiol, 26(4), 499500.CrossRefGoogle ScholarPubMed
Berkhemer, OA, Fransen, PSS, Beumer, D, van den Berg, LA, Lingsma, HF, Yoo, AJ, et al. (2015). A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med, 372(1): 1120.CrossRefGoogle ScholarPubMed
Casaubon, L, Boulanger, J, Blacquiere, D, Bucher, S, Brown, K, Goddard, T, et al.; Heart and Stroke Foundation of Canada Canadian Stroke Best Practices Advisory Committee. (2015). Canadian Stroke Best Practice Recommendations: Hyperacute Stroke Care Guidelines, update 2015. Int J Stroke, 10(6), 924–40.CrossRefGoogle ScholarPubMed
Chapman Smith, SN, Govindarajan, P, Padrick, MM, Lippman, JM, McMurry, TL, Resler, BL, et al. (2016). A low-cost, tablet-based option for prehospital neurologic assessment: The iTREAT Study. Neurology, 87(1), 1926.CrossRefGoogle ScholarPubMed
Ciccone, A, Valvassori, L, Nichelatti, M, Sgoifo, A, Ponzio, M, Sterzi, R, et al. (2013). Endovascular treatment for acute ischemic stroke. N Engl J Med, 368(10), 904–13.CrossRefGoogle ScholarPubMed
Ciccone, A, Valvassori, L, Ponzio, M, Ballabio, E, Gasparotti, R, Sessa, M, et al. (2010). Intra-arterial or intravenous thrombolysis for acute ischemic stroke? The SYNTHESIS pilot trial. J Neurointerv Surg, 2(1), 74–9.CrossRefGoogle ScholarPubMed
Ducrocq, X, Bracard, S, Taillandier, L, Anxionnat, R, Lacour, JC, Guillemin, F, et al. (2005). Comparison of intravenous and intra-arterial urokinase thrombolysis for acute ischaemic stroke. J Neuroradiol, 32(1), 2632.CrossRefGoogle ScholarPubMed
Fassbender, K, J. C. Grotta, JC, S. Walter, S, Grunwald, IQ, Ragoschke-Schumm, A, Saver, JL. (2017). Mobile stroke units for prehospital thrombolysis, triage, and beyond: benefits and challenges. Lancet Neurol, 16(3), 227–37.CrossRefGoogle ScholarPubMed
Feigin, VL, Norrving, B, Mensah, GA. (2017). Global burden of stroke. Circ Res, 120(3), 439–48.CrossRefGoogle ScholarPubMed
Goyal, M, Demchuk, AM, Menon, BK, Eesa, M, Rempel, JL, Thornton, J, et al.; ESCAPE Trial Investigators. (2015). Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med, 372(11), 1019–30.CrossRefGoogle ScholarPubMed
Goyal, M, Menon, BK, Hill, MD, Demchuk, A. (2014). Consistently achieving computed tomography to endovascular recanalization <90 minutes: solutions and innovations. Stroke, 45(12), e252–6.CrossRefGoogle ScholarPubMed
Goyal, M, Menon, BK, van Zwam, WH, Dippel, DW, Mitchell, PJ, Demchuk, AM, et al.; HERMES Collaborators. (2016). Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet, 387(10029), 1723–31.CrossRefGoogle ScholarPubMed
Goyal, N, Tsivgoulis, G, Pandhi, A, Chang, JJ, K. Dillard, K, Ishfaq, MF, et al. (2017). Blood pressure levels post mechanical thrombectomy and outcomes in large vessel occlusion strokes. Neurology, 89(6), 540–7.CrossRefGoogle ScholarPubMed
Herzberg, M, Boy, S, Holscher, T, Ertl, M, Zimmermann, M, Ittner, KP, et al. (2014). Prehospital stroke diagnostics based on neurological examination and transcranial ultrasound. Crit Ultrasound J, 6(1), 3.CrossRefGoogle ScholarPubMed
Higashida, R, Alberts, MJ, Alexander, DN, Crocco, TJ, Demaerschalk, BM, Derdeyn, CP, et al. (2013). Interactions within stroke systems of care: a policy statement from the American Heart Association/American Stroke Association. Stroke, 44(10), 2961–84.CrossRefGoogle ScholarPubMed
Hong, KS, Ko, SB, Yu, KH, Jung, C, Park, SQ, Kim, BM, et al. (2016). Update of the Korean Clinical Practice Guidelines for Endovascular Recanalization Therapy in Patients with Acute Ischemic Stroke. J Stroke, 18(1), 102–13.CrossRefGoogle ScholarPubMed
Jadhav, AP, Kenmuir, CL, Aghaebrahim, A, Limaye, K, Wechsler, LR, Hammer, MD, et al. (2017). Interfacility transfer directly to the neuroangiography suite in acute ischemic stroke patients undergoing thrombectomy. Stroke, 48(7), 1884–9.Google ScholarPubMed
Jauch, EC, Saver, JL, Adams, HP Jr., Bruno, A, Connors, JJ, Demaerschalk, BM, et al. (2013). Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 44(3), 870947.CrossRefGoogle ScholarPubMed
Jovin, TG, Chamorro, A, Cobo, E, de Miquel, MA, Molina, CA, Rovira, A, et al.; REVASCAT Trial Investigators. (2015). Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med, 372(24), 2296–306.CrossRefGoogle ScholarPubMed
Kim, DH, Kim, B, Jung, C, Nam, HS, Lee, JS, Kim, JW, et al.; Korean Society of Interventional Neuroradiology and Korean Stroke Society Joint Task Force Team. (2018). Consensus statements by Korean Society of Interventional Neuroradiology and Korean Stroke Society: hyperacute endovascular treatment workflow to reduce door-to-reperfusion time. J Korean Med Sci, 33(19), e143.CrossRefGoogle ScholarPubMed
Lapergue, B, Blanc, R, Gory, B, Labreuche, J, Duhamel, A, Marnat, G, et al.; ASTER Trial Investigators. (2017). Effect of endovascular contact aspiration vs stent retriever on revascularization in patients with acute ischemic stroke and large vessel occlusion: the ASTER randomized clinical trial. JAMA, 318(5), 443–52.CrossRefGoogle ScholarPubMed
Legrand, L, Naggara, O, G. Turc, G, Mellerio, C, Roca, P, Calvet, D, et al. (2013). Clot burden score on admission T2*-MRI predicts recanalization in acute stroke. Stroke, 44(7), 1878–84.CrossRefGoogle ScholarPubMed
Milne, MS, Holodinsky, JK, Hill, MD, Nygren, A, Qiu, C, Goyal, M, et al. (2017). Drip ‘n’ ship versus mothership for endovascular treatment: modeling the best transportation options for optimal outcomes. Stroke, 48(3), 791–4.CrossRefGoogle ScholarPubMed
Mocco, J, Siddiqui, A, Turk, A. (2018). A comparison of direct aspiration vs. stent retriever as a first approach (COMPASS): a randomized trial. Paper presented at the International Stroke Conference, Los Angeles, CA. https://professional.heart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_498785.pdf. Accessed June 2018.Google Scholar
Muir, KW, Ford, GA, Messow, CM, Ford, I, Murray, A, Clifton, A, et al.; PISTE Investigators. (2017). Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. J Neurol Neurosurg Psychiatry, 88(1), 3844.CrossRefGoogle ScholarPubMed
Nogueira, RG, Frei, D, Kirmani, JF, Zaidat, O, Lopes, D, Turk, AS 3rd, et al.; Penumbra Separator 3D Investigators. (2018). Safety and efficacy of a 3-dimensional stent retriever with aspiration-based thrombectomy vs aspiration-based thrombectomy alone in acute ischemic stroke intervention: a randomized clinical trial. JAMA Neurol, 75(3), 304–11.CrossRefGoogle ScholarPubMed
Nogueira, RG, Lutsep, HL, Gupta, R, Jovin, TG, Albers, GW, Walker, GA, et al. (2012). Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet, 380(9849), 1231–40.CrossRefGoogle ScholarPubMed
Noorian, AR, Sanossian, N, Shkirkova, K, Liebeskind, DS, Eckstein, M, Stratton, SJ, et al.; FAST-MAG Trial Investigators and Coordinators. (2018). Los Angeles Motor Scale to identify large vessel occlusion: prehospital validation and comparison with other screens. Stroke, 49(3), 565–72.CrossRefGoogle ScholarPubMed
Nour, M, Scalzo, F, Liebeskind, DS. (2013). Ischemia-reperfusion injury in stroke. Interv Neurol, 1(3–4), 185–99.Google ScholarPubMed
O’Rourke, K, Berge, E, Walsh, CD, Kelly, PJ. (2010). Percutaneous vascular interventions for acute ischaemic stroke. Cochrane Database Syst Rev, 10, CD007574.CrossRefGoogle ScholarPubMed
Persson, M, Fhager, A, Trefna, HD, Yu, Y, McKelvey, T, Pegenius, G, et al. (2014). Microwave-based stroke diagnosis making global prehospital thrombolytic treatment possible. IEEE Trans Biomed Eng, 61(11), 2806–17.CrossRefGoogle Scholar
Pontes-Neto, OM, Cougo, P, Martins, SC, Abud, DG, Nogueira, RG, Miranda, M, et al. (2017). Brazilian guidelines for endovascular treatment of patients with acute ischemic stroke. Arq Neuropsiquiatr, 75(1), 50–6.CrossRefGoogle ScholarPubMed
Powers, WJ, Rabinstein, AA, Ackerson, T, Adeoye, OM, Bambakidis, NC, Becker, K, et al.; American Heart Association Stroke Council. (2018). 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 49(3), e46–110.CrossRefGoogle ScholarPubMed
Rajajee, V, Kidwell, C, Starkman, S, Ovbiagele, B, Alger, JR, Villablanca, P, et al. (2006). Early MRI and outcomes of untreated patients with mild or improving ischemic stroke. Neurology, 67(6), 980–4.CrossRefGoogle ScholarPubMed
Ribo, M.; RACECAT Trialists. (2017). Direct transfer to an endovascular center compared to transfer to the closest stroke center in acute stroke patients with suspected large vessel occlusion (RACECAT). NCT02795962. https://clinicaltrials.gov/ct2/show/NCT02795962. Accessed June 2018.Google Scholar
Rodrigues, FB, Neves, JB, Caldeira, D, Ferro, JM, Ferreira, JJ, Costa, J. (2016). Endovascular treatment versus medical care alone for ischaemic stroke: systematic review and meta-analysis. BMJ, 353, i1754.CrossRefGoogle ScholarPubMed
Saver, JL. (2011). Optimal end points for acute stroke therapy trials: best ways to measure treatment effects of drugs and devices. Stroke, 42(8), 2356–62.CrossRefGoogle ScholarPubMed
Saver, JL. (2013). The 2012 Feinberg lecture: treatment swift and treatment sure. Stroke, 44(1), 270–7.CrossRefGoogle ScholarPubMed
Saver, JL, Goyal, M, van der Lugt, A, Menon, BK, Majoie, CB, Dippel, DW, et al.; HERMES Collaborators. (2016). Time to treatment with endovascular thrombectomy and outcomes from ischemic stroke: a meta-analysis. JAMA, 316(12), 1279–88.CrossRefGoogle ScholarPubMed
Saver, JL, Jahan, R, Levy, EI, Jovin, TG, Baxter, B, Nogueira, RG, et al. (2012). Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet, 380(9849), 1241–9.CrossRefGoogle ScholarPubMed
Smith, EE, Kent, DM, Bulsara, KR, Leung, LY, Lichtman, JH, Reeves, MJ, et al.; American Heart Association Stroke Council. (2018). Accuracy of prediction instruments for diagnosing large vessel occlusion in individuals with suspected stroke: a systematic review for the 2018 Guidelines for the Early Management of Patients with Acute Ischemic Stroke. Stroke, 49(3), e111–22.Google ScholarPubMed
Tokunboh, I, Vales Montero, M, Zopelaro Almeida, MF, Sharma, L, Starkman, S, Szeder, V, et al. (2018). Visual aids for patient, family, and physician decision making about endovascular thrombectomy for acute ischemic stroke. Stroke, 49(1), 90–7.CrossRefGoogle ScholarPubMed
Ventz, S, Barry, WT, Parmigiani, G, Trippa, L. (2017). Bayesian response-adaptive designs for basket trials. Biometrics, 73(3), 905–15.CrossRefGoogle ScholarPubMed
Wahlgren, N, Moreira, T, Michel, P, Steiner, T, Jansen, O, Cognard, C, et al. (2016). Mechanical thrombectomy in acute ischemic stroke: consensus statement by ESO-Karolinska Stroke Update 2014/2015, supported by ESO, ESMINT, ESNR and EAN. Int J Stroke, 11(1), 134–47.CrossRefGoogle Scholar
Wang, H, Thevathasan, A, Dowling, R, Bush, S, Mitchell, P, Yan, B. (2017). Streamlining workflow for endovascular mechanical thrombectomy: lessons learned from a comprehensive stroke center. J Stroke Cerebrovasc Dis, 26(8), 1655–62.CrossRefGoogle ScholarPubMed
Wardlaw, JM, Murray, V, Berge, E, del Zoppo, GJ. (2014). Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev, 7, CD000213.Google Scholar
Wheeler, HM, Mlynash, M, Inoue, M, Tipimini, A, Liggins, J, Bammer, R, et al.; DEFUSE 2 Investigators. (2015). The growth rate of early DWI lesions is highly variable and associated with penumbral salvage and clinical outcomes following endovascular reperfusion. Int J Stroke, 10(5), 723–9.CrossRefGoogle ScholarPubMed
Zaidat, OO, Bozorgchami, H, Ribo, M, Saver, JL, Mattle, HP, Chapot, R, et al. (2018a). Primary results of the multicenter ARISE II study (Analysis of Revascularization in Ischemic Stroke with EmboTrap). Stroke, 49(5), 1107–15.CrossRefGoogle ScholarPubMed
Zaidat, OO, Castonguay, AC, Linfante, I, Gupta, R, Martin, CO, Holloway, WE, et al. (2018b). First pass effect: a new measure for stroke thrombectomy devices. Stroke, 49(3): 660–6.CrossRefGoogle ScholarPubMed
Anderson, CS, Huang, Y, Lindley, RI, Chen, X, Arima, H, Chen, G, et al.; ENCHANTED Investigators and Coordinators. (2019). Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial. Lancet, 393(10174), 877–88.CrossRefGoogle ScholarPubMed
Asplund, K. (1991). Hemodilution in acute stroke. Cerebrovasc Dis, 1(Suppl. 1), 129–38.CrossRefGoogle Scholar
Bath, PM, Appleton, JP, Krishnan, K, Sprigg, N. (2018). Blood pressure in acute stroke: to treat or not to treat: that is still the question. Stroke, 49(7), 1784–90.CrossRefGoogle ScholarPubMed
Bath, PM, Bath-Hextall, FJ. (2004). Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke. Cochrane Database Syst Rev, 3. CD000162.CrossRefGoogle ScholarPubMed
Bath, PM, Krishnan, K. (2014). Interventions for deliberately altering blood pressure in acute stroke. Cochrane Database Syst Rev, 10. CD000039.CrossRefGoogle ScholarPubMed
Berge, E, Cohen, G, Lindley, RI, Sandercock, P, Wardlaw, JM, Sandset, EC, et al. (2015). Effects of blood pressure and blood pressure-lowering treatment during the first 24 hours among patients in the third International Stroke Trial of thrombolytic treatment for acute ischemic stroke. Stroke, 46(12), 3362–9.CrossRefGoogle ScholarPubMed
Chang, TS, Jensen, MB. (2014). Haemodilution for acute ischaemic stroke. Cochrane Database Syst Rev, 8. CD000103.CrossRefGoogle ScholarPubMed
Hao, Z, Liu, M, Counsell, C, Wardlaw, JM, Lin, S, Zhao, X. (2012). Fibrinogen depleting agents for acute ischaemic stroke. Cochrane Database Syst Rev, 3. CD000091.CrossRefGoogle ScholarPubMed
Immink, RV, van Montfrans, GA, Stam, J, Karemaker, JM, Diamant, M, van Lieshout, JJ. (2005). Dynamic cerebral autoregulation in acute lacunar and middle cerebral artery territory ischemic stroke. Stroke, 36(12), 25952600.CrossRefGoogle ScholarPubMed
Leonardi-Bee, J, Bath, PM, Phillips, SJ,. Sandercock, PA. (2002). Blood pressure and clinical outcomes in the International Stroke Trial. Stroke, 33(5), 1315–20.CrossRefGoogle ScholarPubMed
Powers, WJ, Rabinstein, AA, Ackerson, T, Adeoye, OM, Bambakidis, NC, Becker, K, et al.; American Heart Association Stroke Council. (2018). 2018 Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 49(3), e46e110.CrossRefGoogle ScholarPubMed
Qureshi, AI. (2008). Acute hypertensive response in patients with stroke: pathophysiology and management. Circulation, 118(2), 176–87.CrossRefGoogle ScholarPubMed
Qureshi, AI, Ezzeddine, MA, Nasar, A, Suri, MF, Kirmani, JF, Hussein, HM, et al. (2007). Prevalence of elevated blood pressure in 563,704 adult patients with stroke presenting to the ED in the United States. Am J Emerg Med, 25(1), 32–8.CrossRefGoogle ScholarPubMed
RIGHT-2 Investigators. (2019). Prehospital transdermal glyceryl trinitrate in patients with ultra-acute presumed stroke (RIGHT-2): an ambulance-based, randomised, sham-controlled, blinded, phase 3 trial. Lancet, 393(10175), 1009–20.Google Scholar
Sandset, EC, Sanossian, N, Woodhouse, LJ, Anderson, C, Berge, E, Lees, KR, et al.; Blood Pressure in Acute Stroke Collaboration Investigators. (2018). Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: the Blood Pressure in Acute Stroke Collaboration, stage-3. Int J Stroke, 13(7), 759–65.CrossRefGoogle ScholarPubMed
Strandgaard, S, Paulson, OB. (1984). Cerebral autoregulation. Stroke, 15(3), 413–16.CrossRefGoogle ScholarPubMed
Vemmos, KN, Tsivgoulis, G, Spengos, K, Zakopoulos, N, Synetos, A, Manios, E, et al. (2004). U-shaped relationship between mortality and admission blood pressure in patients with acute stroke. J Intern Med, 255(2), 257–65.CrossRefGoogle ScholarPubMed
Wallace, JD, Levy, LL. (1981). Blood pressure after stroke. JAMA, 246(19), 2177–80.CrossRefGoogle ScholarPubMed
Willmot, M, Ghadami, A, Whysall, B, Clarke, W, Wardlaw, J, Bath, PM. (2006). Transdermal glyceryl trinitrate lowers blood pressure and maintains cerebral blood flow in recent stroke. Hypertension, 47(6), 1209–15.CrossRefGoogle ScholarPubMed
Woodhouse, LJ, Manning, L, Potter, JF, Berge, E, Sprigg, N, Wardlaw, J, et al; Blood Pressure in Acute Stroke Council. (2017). Continuing or temporarily stopping prestroke antihypertensive medication in acute stroke: an individual patient data meta-analysis. Hypertension, 69(5), 933–41.CrossRefGoogle ScholarPubMed
Abciximab Emergent Stroke Treatment Trial (AbESTT) Investigators. (2005). Emergency administration of abciximab for treatment of patients with acute ischemic stroke. Results of a randomized phase 2 trial. Stroke, 36, 880–90.Google Scholar
Abciximab in Ischemic Stroke (AIST) Investigators. (2000). Abciximab in acute ischemic stroke: a randomized, double-blind, placebo-controlled, dose-escalation study. Stroke, 31, 601–09.Google Scholar
Adams, HP Jr, Effron, MB, Torner, J, Davalos, A, Frayne, J, Teal, P, et al. (2008). Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial: Abciximab in Emergency Treatment of Stroke Trial (AbESTT-II). Stroke, 39, 8799.CrossRefGoogle Scholar
Adeoye, O, Sucharew, H, Khoury, J, Vagal, A, Schmit, PA, Ewing, I, et al. (2015). Combined approach to lysis utilizing eptifibatide and recombinant tissue-type plasminogen activator in acute ischemic stroke – full dose regimen stroke trial. Stroke, 46, 2529–33.CrossRefGoogle ScholarPubMed
Bath, PM, Cotton, D, Martin, RH, Palesch, Y, Yusuf, S, Sacco, R, et al.; PRoFESS Study Group. (2010). Effect of combined aspirin and extended-release dipyridamole versus clopidogrel on functional outcome and recurrence in acute, mild ischemic stroke: PRoFESS subgroup analysis. Stroke, 41, 732–8.CrossRefGoogle ScholarPubMed
Bath, PM, Woodhouse, LJ, Appleton, JP, Beridze, M, Christensen, H, Dineen, RA, et al.; TARDIS Investigators. (2018). Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomized, open-label, phase 3 superiority trial. Lancet, 391, 850–9.CrossRefGoogle ScholarPubMed
Berge, E, Abdelnoor, M, Nakstad, PH, Sandset, PM. (2000). Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. HAEST Study Group. Heparin in Acute Embolic Stroke Trial. Lancet, 355, 1205–10.CrossRefGoogle Scholar
Berge, E, Sandercock, PAG. (2002). Anticoagulants versus antiplatelet agents for acute ischaemic stroke. Cochrane Database Syst Rev, 4. CD003242.CrossRefGoogle ScholarPubMed
CAST (Chinese Acute Stroke Trial) Collaborative Group. (1997). CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet, 349, 1641–9.Google Scholar
Chen, ZM, Sandercock, P, Pan, HC, Counsell, C, Collins, R, Liu, LS, et al. (2000). Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40 000 randomized patients from the Chinese Acute Stroke Trial and the international stroke trial. On behalf of the CAST and IST collaborative groups. Stroke, 31, 1240–9.CrossRefGoogle Scholar
Ciccone, A, Motto, C, Abraha, I, Cozzolino, F, Santilli, I. (2014). Glycoprotein IIb-IIIa inhibitors for acute ischaemic stroke. Cochrane Database Syst Rev, 3. CD005208. doi:10.1002/14651858.CD005208.pub3.CrossRefGoogle ScholarPubMed
Ciuffetti, G, Aisa, G, Mercuri, M, Lombardini, R, Paltriccia, R, Neri, C, et al. (1990). Effects of ticlopidine on the neurologic outcome and the hemorheologic pattern in the post acute phase of ischemic stroke: a pilot study. Angiology, 41, 505–11.CrossRefGoogle Scholar
Cranston, JS, Kaplan, BD, Saver, JL. (2017). Minimally clinically important difference for safe and simple novel acute ischemic stroke therapies. Stroke, 48, 2946–51.CrossRefGoogle Scholar
Dengler, R, Diener, H-C, Schwartz, A, Grond, M, Schumacher, H, Machnig, T, et al.; for the EARLY Investigators. (2010). Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial. Lancet Neurol, 9, 159–66.CrossRefGoogle ScholarPubMed
He, F, Xia, C, Zhang, JH, Li, XQ, Zhou, ZH, Li, FP, et al. (2015). Clopidogrel plus aspirin versus aspirin alone for preventing early neurological deterioration in patients with acute ischemic stroke. J Clin Neurosci, 22, 83–6.CrossRefGoogle ScholarPubMed
International Stroke Trial Collaborative Group. (1997). The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet, 349, 1569–81.Google Scholar
Jing, J, Meng, X, Zhao, X, Liu, L, Wang, A, Pan, Y, et al. (2018). Dual antiplatelet therapy in transient ischemic attack and minor stroke with different infarction patterns: subgroup analysis of the CHANCE randomized clinical trial. JAMA Neurol, 75, 711–19.CrossRefGoogle ScholarPubMed
Johnston, SC, Amarenco, P, Albers, GW, Denison, H, Easton, JD, Evans, SR, et al; SOCRATES Steering Committee and Investigators. (2016). Ticagrelor versus aspirin in acute stroke or transient ischemic attack. N Engl J Med, 375, 3543.CrossRefGoogle ScholarPubMed
Johnston, SC, Easton, JD, Farrant, M, Barsan, W, Conwit, RA, Elm, JJ, et al.; Clinical Research Collaboration, Neurological Emergencies Treatment Trials Network, and the POINT Investigators. (2018). Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med, 379, 215–25.CrossRefGoogle ScholarPubMed
Johnston, SC, Leira, EC, Hansen, MD, Adams, HP Jr. (2003). Early recovery after cerebral ischemia risk of subsequent neurological deterioration. Ann Neurol, 54, 439–44.CrossRefGoogle ScholarPubMed
Kennedy, J, Hill, MD, Ryckborst, KJ, Eliasziw, M, Demchuk, AM, Buchan, AM; FASTER Investigators. (2007). Fast assessment of stroke and transient ischaemic attack to prevent early recurrence (FASTER): a randomised controlled pilot trial. Lancet Neurol, 6, 961–9.CrossRefGoogle ScholarPubMed
Lee, YS, Bae, HJ, Kang, DW, Lee, SH, Yu, K, Park, JM, et al. (2011). Cilostazol in Acute Ischemic Stroke Treatment (CAIST Trial): a randomized double-blind non-inferiority trial. Cerebrovasc Dis, 32, 6571.CrossRefGoogle ScholarPubMed
Liu, L, Wong, KS, Leng, X, Pu, Y, Wang, Y, Jing, J, et al.; CHANCE Investigators. (2015). Dual antiplatelet therapy in stroke and ICAS: subgroup analysis of CHANCE. Neurology, 85, 1154–62.CrossRefGoogle Scholar
Multicentre Acute Stroke Trial-Italy (MAST-I) Group. (1995). Randomised controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Lancet, 346, 1509–14.Google Scholar
Pan, Y, Jing, J, Chen, W, Meng, X, Li, H, Zhao, X, Liu, L, Wang, D, Johnston, SC, Wang, Y, Wang, Y; CHANCE Investigators. (2017a). Risks and benefits of clopidogrel-aspirin in minor stroke or TIA: time course analysis of CHANCE. Neurology, 88, 1906–11.CrossRefGoogle ScholarPubMed
Pan, Y, Meng, X, Jing, J, Li, H, Zhao, X, Liu, L, et al; CHANCE Investigators. (2017b). Association of multiple infarctions and ICAS with outcomes of minor stroke and TIA. Neurology, 88, 1081–8.CrossRefGoogle ScholarPubMed
Pancioli, AM, Adeoye, O, Schmit, PA, Khoury, J, Levine, SR, Tomsick, TA,et al.; CLEAR-ER Investigators. (2013). Combined approach to lysis utilizing eptifibatide and recombinant tissue plasminogen activator in acute ischemic stroke-enhanced regimen stroke trial. Stroke, 44, 2381–7.CrossRefGoogle ScholarPubMed
Rödén-Jüllig, Å, Britton, M, Malmkvist, K, Leijd, B. (2003). Aspirin in the prevention of progressing stroke: a randomized controlled study. J Intern Med, 254, 584–90.CrossRefGoogle ScholarPubMed
Sandercock, PAG, Counsell, C, Tseng, MC, Cecconi, E. (2014). Oral antiplatelet therapy for acute ischaemic stroke. Cochrane Database Syst Rev, 3. CD000029. doi:10.1002/14651858.CD000029.pub3.CrossRefGoogle ScholarPubMed
Siebler, M, Hennerici, MG, Schneider, D, von Reutern, GM, Seitz, RJ, Röther, J, et al. (2011). Safety of tirofiban in acute ischemic stroke: the SaTIS trial. Stroke, 42, 2388–92.CrossRefGoogle ScholarPubMed
Thompson, DD, Murray, GD, Candelise, L, Chen, Z, Sandercock, PA, Whiteley, WN. (2015). Targeting aspirin in acute disabling ischemic stroke: an individual patient data meta-analysis of three large randomized trials. Int J Stroke, 10, 1024–30.CrossRefGoogle ScholarPubMed
Torgano, G, Zecca, B, Monzani, V, Maestroni, A, Rossi, P, Cazzaniga, M, et al. (2010). Effect of intravenous tirofiban and aspirin in reducing short-term and long-term neurologic deficit in patients with ischemic stroke: a double-blind randomized trial. Cerebrovasc Dis, 29, 275–81.CrossRefGoogle ScholarPubMed
Wang, Y, Meng, X, Chen, W, Lin, Y, Pan, Y, Jing, J, et al.; PRiNCE Investigators. (2018). Ticagrelor with aspirin on platelet reactivity in acute non-disabling cerebrovascular events (PRINCE) trial – Final analysis. International Stroke Conference. https://professional.heart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_498791.pdf. Accessed August 2018.Google Scholar
Wang, Y, Wang, Y, Zhao, X, Liu, L, Wang, D, Wang, C, et al.; CHANCE Investigators. (2013). Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med, 369, 1119.CrossRefGoogle ScholarPubMed
Wang, Y, Zhao, X, Lin, J, Li, H, Johnston, SC, Lin, Y, et al.; CHANCE Investigators. (2016). Association between CYP2C19 loss-of-function allele status and efficacy of clopidogrel for risk reduction among patients with minor stroke or transient ischemic attack. JAMA, 316, 70–8.CrossRefGoogle ScholarPubMed
Wong, KS, Chen, C, Ng, PW, Tsoi, TH, Li, HL, Fong, WC, et al.; FISS-tris Study Investigators. (2007). Low-molecular-weight heparin compared with aspirin for the treatment of acute ischaemic stroke in Asian patients with large artery occlusive disease: a randomised study. Lancet Neurol, 6, 407–13.CrossRefGoogle ScholarPubMed
Wong, KS, Wang, Y, Leng, X, Mao, C, Tang, J, Bath, PM, et al. (2013). Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation, 128, 1656–66.CrossRefGoogle ScholarPubMed
Yang, Y, Zhou, M, Zhong, X, Wang, Y, Zhao, X, Liu, L, et al. (2018). Dual versus mono antiplatelet therapy for acute non-cardioembolic ischaemic stroke or transient ischaemic attack: a systematic review and meta-analysis. Stroke Vasc Neurol, 3, 107–16.CrossRefGoogle ScholarPubMed
Yi, X, Lin, J, Wang, C, Zhang, B, Chi, W. (2014). Low-molecular-weight heparin is more effective than aspirin in preventing early neurologic deterioration and improving six-month outcome. J Stroke Cerebrovasc Dis, 23, 1537–44.CrossRefGoogle ScholarPubMed
Abdul-Rahim, AH, Fulton, RL, Frank, B, Tatlisumak, T, Paciaroni, M, Caso, V, et al. (2015). Association of improved outcome in acute ischaemic stroke patients with atrial fibrillation who receive early antithrombotic therapy: analysis from VISTA. Eur J Neurol, 22, 1048–55.Google ScholarPubMed
Amarenco, P, Lavallée, PC, Labreuche, J. (2016). One-year risk of stroke after transient ischemic attack or minor ischemic stroke. N Engl J Med, 374, 1533–42.CrossRefGoogle ScholarPubMed
Ay, H, Gungor, L, Arsava, EM, Rosand, J, Vangel, M, Benner, T, et al. (2010). A score to predict early risk of recurrence after ischemic stroke. Neurology, 74, 128–35.CrossRefGoogle ScholarPubMed
Berge, E, Abdelnoor, M, Nakstad, PH, Sandset, PM on behalf of the Heparin in Acute Embolic Stroke Trial (HAEST) Study Group. (2000). Low molecular-weight heparin versus aspirin in patients with acute ischaemic stroke and atrial fibrillation: a double-blind randomised study. HAEST Study Group. Heparin in Acute Embolic Stroke Trial. Lancet, 355, 1205–10.CrossRefGoogle Scholar
Cazzato, G, Zorzon, M, Mase, G, Antonutto, L, Iona, LG. (1989). Il mesoglicano nelle ischemie cerebrali acute a focolaio [Mesoglycan in the treatment of acute cerebral infarction]. Rivista di Neurologia, 59, 121–6.Google Scholar
Cerebral Embolism Study Group. (1983). Immediate anticoagulation of embolic stroke: a randomized trial. The Cerebral Embolism Study Group. Stroke, 14, 668–76.Google Scholar
Chimowitz, MI, Lynn, MJ, Derdeyn, CP, Derdeyn, CP, Turan, TN, Fiorella, D, et al. (2011). Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med, 365, 9931003CrossRefGoogle ScholarPubMed
Dennis, M, Caso, V, Kappelle, LJ, Pavlovic, A, Sandercock, P, for the European Stroke Organisation. (2016). European Stroke Organisation (ESO) guidelines for prophylaxis for venous thromboembolism in immobile patients with acute ischaemic stroke. Eur Stroke J, 1, 619.CrossRefGoogle ScholarPubMed
Duke, RJ, Turpie, AGG, Bloch, RF, Trebilcock, RG. (1983). Clinical trial of low-dose subcutaneous heparin for the prevention of stroke progression: natural history of acute partial stroke and stroke-in-evolution. In Reivich, M, Hurtig, HI, eds., Cerebrovascular Disease. New York: Raven Press, pp. 399405.Google Scholar
Duke, RJ, Bloch, RF, Turpie, AGG, Trebilcock, RG, Bayer, N. (1986). Intravenous heparin for the prevention of stroke progression in acute partial stable stroke. Ann Intern Med, 105, 825–8.CrossRefGoogle ScholarPubMed
Elias, A, Milandre, L, Lagrange, G, Aillaud, MF, Alonzo, B, Toulemonde, F, et al. (1990). Prevention of deep venous thrombosis of the leg by a very low molecular weight heparin fraction (CY 222) in patients with hemiplegia following cerebral infarction: a randomized pilot study (30 patients). Revue de Médecine Interne, 11, 95–8.Google Scholar
Hommel, M, for the FISS-bis Investigators Group. (1998). Fraxiparine in Ischaemic Stroke Study (FISS bis). Cerebrovasc Dis, 8(Suppl 4), 19.Google Scholar
Hong, KS, Kwon, SU, Lee, SH, Lee, JS, Kim, YJ, Song, TJ, et al. (2017). Rivaroxaban vs warfarin sodium in the ultra-early period after atrial fibrillation-related mild ischemic stroke: a randomized clinical trial. JAMA Neurol, 74, 1206–15.CrossRefGoogle ScholarPubMed
International Stroke Trial Collaborative Group. (1997). The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischaemic stroke. Lancet, 349, 1569–81.Google Scholar
Johansson, E, Wester, P. (2014). Recurrent stroke risk is high after a single cerebrovascular event in patients with symptomatic 50–99% carotid stenosis: a cohort study. BMC Neurol, 14, 23.CrossRefGoogle ScholarPubMed
Kernan, WN, Ovbiagele, B, Black, HR, Bravata, DM, Chimowitz, MI, Ezekowitz, MD, et al. (2014). Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke, 45, 21602236.CrossRefGoogle ScholarPubMed
Kwiecinski, H, Pniewski, J, Kaminska, A, Szyluk, B. (1995). A randomized trial of fraxiparine in acute ischaemic stroke. Cerebrovasc Dis, 5, 234.Google Scholar
LaMonte, MP, Nash, ML, Wang, DZ, Woolfenden, AR, Schulz, J, Hursting, MJ, et al. (2004). Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1). Stroke, 35, 1677–82.CrossRefGoogle Scholar
Lansberg, MG, O’Donnell, MJ, Khatri, P, Lang, ES, Nguyen-Huynh, MN, Schwartz, NE, et al. (2012). Antithrombotic and thrombolytic therapy for ischemic stroke: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141, e601S636S.CrossRefGoogle ScholarPubMed
Liu, L, Wong, KSL, Leng, X, Pu, Y, Wang, Y, Jing, J, et al. (2015). Dual antiplatelet therapy in stroke and ICAS Subgroup analysis of CHANCE. Neurology, 85, 1154–62.CrossRefGoogle Scholar
McCarthy, ST, Turner, J. (1986). Low-dose subcutaneous heparin in the prevention of deep-vein thrombosis and pulmonary emboli following acute stroke. Age Ageing, 15, 84–8.CrossRefGoogle ScholarPubMed
McCarthy, ST, Turner, JJ, Robertson, D, Hawkey, CJ, Macey, DJ. (1997). Low dose heparin as a prophylaxis against deep-vein thrombosis after acute stroke. Lancet, ii:800–1.Google Scholar
Paciaroni, M, Agnelli, G, Falocci, N, Caso, V, Becattini, C, Marcheselli, S, et al. (2015). Early recurrence and cerebral bleeding in patients with acute ischemic stroke and atrial fibrillation: effect of anticoagulation and its timing: the RAF study. Stroke, 46, 2175–82.CrossRefGoogle Scholar
Paciaroni, M, Agnelli, G, Micheli, S, Caso, V. (2007). Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a meta-analysis of randomized controlled trials. Stroke, 38, 423–30.CrossRefGoogle ScholarPubMed
Pambianco, G, Orchard, T, Landau, P. (1995). Deep vein thrombosis: prevention in stroke patients during rehabilitation. Arch Phys Med Rehabil, 76, 324–30.CrossRefGoogle ScholarPubMed
Pince, J. (1981). Thromboses veineuses des membres inferieurs et embolies pulmonaires au cours des accidents vasculaires cerebraux. A propos d’un essai comparitif de traitement preventif. These pour le doctorat d’état en médecine, Toulouse: Université Paul Sabatier.Google Scholar
Prins, MH, Gelsema, R, Sing, AK, van Heerde, LR, den Ottolander, GJ. (1989). Prophylaxis of deep venous thrombosis with a low-molecular-weight heparin (Kabi 2165/Fragmin) in stroke patients. Haemostasis, 19, 245–50.Google Scholar
Rothwell, PM. (2008). Prediction and prevention of stroke in patients with symptomatic carotid stenosis: the high-risk period and the high-risk patient. Eur J Vasc Endovasc Surg, 35, 255–63.CrossRefGoogle ScholarPubMed
Sandercock, PAG, Counsell, C, Kane, EJ. (2015). Anticoagulants for acute ischaemic stroke. Cochrane Database Syst Rev, 3. CD000024.CrossRefGoogle ScholarPubMed
Sandercock, PAG, Leong, TS. (2017). Low-molecular-weight heparins or heparinoids versus standard unfractionated heparin for acute ischaemic stroke. Cochrane Database Syst Rev, 4. CD000119. doi:10.1002/14651858.CD000119.pub4.CrossRefGoogle ScholarPubMed
Sandset, PM, Dahl, T, Stiris, M, Rostad, B, Scheel, B, Abildgaard, U. (1990). A double-blind and randomized placebo-controlled trial of low molecular weight heparin once daily to prevent deep-vein thrombosis in acute ischemic stroke. Semin Thromb Hemost, 16(Suppl), 2533.Google ScholarPubMed
Saxena, R, Lewis, S, Berge, E, Sandercock, PAG, Koudstaal, PJ, for the International Stroke Trial Collaborative Group. (2001). Risk of early death and recurrent stroke and effect of heparin in 3169 patients with acute ischemic stroke and atrial fibrillation in the International Stroke Trial. Stroke, 32, 2333–7.CrossRefGoogle ScholarPubMed
Seiffge, DJ, Werring, DJ, Paciaroni, M, Dawson, J, Warach, S, Milling, TJ, et al. (2019). Timing of anticoagulation after recent ischaemic stroke in patients with atrial fibrillation. Lancet Neurol, 18, 117–26.CrossRefGoogle ScholarPubMed
Sherman, DG, Albers, GW, Bladin, C, Fieschi, C, Gabbai, AA, Kase, CS, et al. (2007). The efficacy and safety of enoxaparin versus unfractionated heparin for the prevention of venous thromboembolism after acute ischaemic stroke (PREVAIL Study): an open-label randomised comparison. Lancet, 369, 1347–55.CrossRefGoogle ScholarPubMed
Tazaki, Y, Kobayashi, S, Togi, H, Ohtomo, E, Goto, F, Araki, G, et al. (1986). Therapeutic effect of thrombin inhibitor MD-805 in acute phase of cerebral thrombosis – Phase II double-blinded clinical trial (English translation). Rinsho to Kenkyu, 63, 3047–57.Google Scholar
TOAST Investigators. (1998). Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischaemic stroke. JAMA, 279, 1265–72.Google Scholar
Turpie, AGG, Levine, MN, Hirsh, J, Carter, CJ, Jay, RM, Powers, PJ, et al. (1987). Double-blind randomised trial of Org 10172 low-molecular-weight heparinoid in prevention of deep-vein thrombosis in thrombotic stroke. Lancet, 1, 523–6.Google ScholarPubMed
Alexander, P, Heels-Ansdell, D, Siemieniuk, R, Bhatnagar, N, Chang, Y, Fei, Y, et al. (2016). Hemicraniectomy versus medical treatment with large MCA infarct: a review and meta-analysis. BMJ Open, 6(11), e014390. doi:10.1136/bmjopen-2016-014390.CrossRefGoogle ScholarPubMed
Bereczki, D, Liu, M, Fernandes do Prado, G, Fekete I, . (2007). Mannitol for acute stroke. Cochrane Database Syst Rev, 3. CD001153. doi:10.1002/14651858.CD001153.pub2.CrossRefGoogle ScholarPubMed
Biestro, A, Alberti, R, Galli, R, Cancela, M, Soca, A, Panzardo, H, et al. (1997). Osmotherapy for increased intracranial pressure: comparison between mannitol and glycerol. Acta Neurochir (Wien), 139, 725–32.CrossRefGoogle ScholarPubMed
Coles, JP, Fryer, TD, Coleman, MR, Smielewski, P, Gupta, AK, Minhas, PS, et al. (2007). Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism. Crit Care Med, 35, 568–78.CrossRefGoogle ScholarPubMed
Cruz-Flores, S, Berge, E, Whittle, IR. (2012). Surgical decompression for cerebral oedema in acute ischaemic stroke. Cochrane Database Syst Rev, 1. CD003435. doi:10.1002/14651858.CD003435.pub2.CrossRefGoogle ScholarPubMed
Davis, SM, Donnan, GA. (2004). Steroids for stroke: another potential therapy discarded prematurely? Stroke, 35, 230–1.CrossRefGoogle ScholarPubMed